CN102325769A - 单卡波姆 - Google Patents
单卡波姆 Download PDFInfo
- Publication number
- CN102325769A CN102325769A CN2009801569587A CN200980156958A CN102325769A CN 102325769 A CN102325769 A CN 102325769A CN 2009801569587 A CN2009801569587 A CN 2009801569587A CN 200980156958 A CN200980156958 A CN 200980156958A CN 102325769 A CN102325769 A CN 102325769A
- Authority
- CN
- China
- Prior art keywords
- compound
- pharmaceutically acceptable
- amino
- mmol
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCCN(C(C(NC=C1O)=CC1=O)NN1S(NC2OC2N(C[C@@]2NC(C(c3c[s]c(N)n3)NOC(C)(C)C(O)=O)=*)C2=O)(=O)=O)C1=O Chemical compound CCCN(C(C(NC=C1O)=CC1=O)NN1S(NC2OC2N(C[C@@]2NC(C(c3c[s]c(N)n3)NOC(C)(C)C(O)=O)=*)C2=O)(=O)=O)C1=O 0.000 description 3
- AALLRVSISIPCOY-ZZJQDLBXSA-N CC(C)(C(O)=O)O/N=C(\C(N[C@@H](CN1C(NS(N2N=C(C(NC=C3O)=CC3=O)N(CC(CO)O)C2=O)(=O)=O)=O)C1=O)=O)/c1c[s]c(N)n1 Chemical compound CC(C)(C(O)=O)O/N=C(\C(N[C@@H](CN1C(NS(N2N=C(C(NC=C3O)=CC3=O)N(CC(CO)O)C2=O)(=O)=O)=O)C1=O)=O)/c1c[s]c(N)n1 AALLRVSISIPCOY-ZZJQDLBXSA-N 0.000 description 1
- YOKRHMHCJXEHMC-IFXOJKCCSA-N CC(C)(C(O)=O)O/N=C(\C(N[C@H](C1)C1(CN1C(NS(N2N=C(C(NC=C3O)=CC3=O)N(CC(N)=O)C2=O)(=O)=O)=O)C1=O)=O)/c1c[s]c(N)n1 Chemical compound CC(C)(C(O)=O)O/N=C(\C(N[C@H](C1)C1(CN1C(NS(N2N=C(C(NC=C3O)=CC3=O)N(CC(N)=O)C2=O)(=O)=O)=O)C1=O)=O)/c1c[s]c(N)n1 YOKRHMHCJXEHMC-IFXOJKCCSA-N 0.000 description 1
- PZKSUVDYULNCOD-IBOSMSBMSA-N CC(C)(C)OC(C(C)(C)O/N=C(\C(N[C@@H](CN1C(C)=O)C1=O)=O)/c1c[s]c(NC(OC(C)(C)C)=O)n1)=O Chemical compound CC(C)(C)OC(C(C)(C)O/N=C(\C(N[C@@H](CN1C(C)=O)C1=O)=O)/c1c[s]c(NC(OC(C)(C)C)=O)n1)=O PZKSUVDYULNCOD-IBOSMSBMSA-N 0.000 description 1
- QQDUMDHTMMQMOE-CBEWMTJFSA-N CCCN(C(C(NC=C1O)=CC1=O)=NN1S(NC(N(C[C@]2(C3)[C@H]3NC(/C(/c3c[s]c(N)n3)=N\OC(C)(C)C(O)=O)=O)C2=O)=O)(=O)=O)C1=O Chemical compound CCCN(C(C(NC=C1O)=CC1=O)=NN1S(NC(N(C[C@]2(C3)[C@H]3NC(/C(/c3c[s]c(N)n3)=N\OC(C)(C)C(O)=O)=O)C2=O)=O)(=O)=O)C1=O QQDUMDHTMMQMOE-CBEWMTJFSA-N 0.000 description 1
- BTWJPGVTXDHRBV-UHFFFAOYSA-N NC(c(nc1)cc(OCc2ccccc2)c1OCc1ccccc1)=O Chemical compound NC(c(nc1)cc(OCc2ccccc2)c1OCc1ccccc1)=O BTWJPGVTXDHRBV-UHFFFAOYSA-N 0.000 description 1
- MTRFPMJISMFWQG-UHFFFAOYSA-N NNC(c(nc1)cc(OCc2ccccc2)c1OCc1ccccc1)=O Chemical compound NNC(c(nc1)cc(OCc2ccccc2)c1OCc1ccccc1)=O MTRFPMJISMFWQG-UHFFFAOYSA-N 0.000 description 1
- CKHOOPUZIMVJJG-YFKPBYRVSA-N OC[C@H](CN(C(C(NC=C1O)=CC1=O)=NN1)C1=O)O Chemical compound OC[C@H](CN(C(C(NC=C1O)=CC1=O)=NN1)C1=O)O CKHOOPUZIMVJJG-YFKPBYRVSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13915908P | 2008-12-19 | 2008-12-19 | |
| US61/139,159 | 2008-12-19 | ||
| PCT/IB2009/055544 WO2010070523A1 (en) | 2008-12-19 | 2009-12-07 | Monocarbams |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102325769A true CN102325769A (zh) | 2012-01-18 |
Family
ID=41727494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801569587A Pending CN102325769A (zh) | 2008-12-19 | 2009-12-07 | 单卡波姆 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8252782B2 (https=) |
| EP (1) | EP2379546A1 (https=) |
| JP (1) | JP2012512863A (https=) |
| KR (1) | KR20110086742A (https=) |
| CN (1) | CN102325769A (https=) |
| AR (1) | AR074801A1 (https=) |
| AU (1) | AU2009329169B2 (https=) |
| CA (1) | CA2744756C (https=) |
| IL (1) | IL213216A0 (https=) |
| MX (1) | MX2011006541A (https=) |
| PA (1) | PA8855001A1 (https=) |
| SG (1) | SG171781A1 (https=) |
| TW (1) | TW201026696A (https=) |
| UY (1) | UY32336A (https=) |
| WO (1) | WO2010070523A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105481812A (zh) * | 2015-11-30 | 2016-04-13 | 重庆天奕恒化科技有限公司 | 一种5-苄氧基-4-氧代-4h-吡喃-2-羧酸的制备方法 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012512863A (ja) * | 2008-12-19 | 2012-06-07 | ファイザー・インク | モノカルバム |
| DK2646436T3 (en) | 2010-11-29 | 2015-06-29 | Pfizer | monobactams |
| UY34585A (es) | 2012-01-24 | 2013-09-02 | Aicuris Gmbh & Co Kg | Compuestos b-lactámicos sustituidos con amidina, su preparación y uso |
| PL3353175T3 (pl) * | 2015-09-23 | 2021-02-22 | Novartis Ag | Sole i postacie stałe antybiotyku monobaktamowego |
| AU2017339587A1 (en) | 2016-12-21 | 2019-07-04 | Aicuris Gmbh & Co. Kg | Combination therapy with amidine substituted ß-lactam compounds and ß-lactamase inhibitors for infections with antibiotic resistant bacterial strains |
| JP7235718B2 (ja) | 2017-08-02 | 2023-03-08 | ノバルティス アーゲー | モノバクタム系抗生物質およびその中間体を製造するための化学的方法 |
| CN110997627B (zh) | 2017-08-23 | 2023-10-10 | 亥姆霍兹感染研究中心有限公司 | 孢囊菌酰胺衍生物 |
| JP7366746B2 (ja) | 2017-08-31 | 2023-10-23 | 北興化学工業株式会社 | １－（ｎ，ｎ－ジ置換カルバモイル）４－（置換スルホニル）トリアゾリン－５－オン誘導体、４－（ｎ，ｎ－ジ置換カルバモイル）１－（置換スルホニル）トリアゾリン－５－オン誘導体、およびそれらを有効成分として含有する除草剤 |
| WO2019144969A1 (zh) | 2018-01-29 | 2019-08-01 | 南京明德新药研发股份有限公司 | 用于治疗细菌感染的单环β-内酰胺化合物 |
| WO2020125670A1 (zh) | 2018-12-18 | 2020-06-25 | 南京明德新药研发有限公司 | 单环β-内酰胺化合物在制药中的应用 |
| CN114828850B (zh) | 2019-12-19 | 2024-08-13 | 深圳嘉科生物科技有限公司 | 化合物在制药中的应用 |
| WO2023205463A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4587047A (en) * | 1981-04-09 | 1986-05-06 | E. R. Squibb & Sons, Inc. | 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines |
| EP0281289A1 (en) * | 1987-03-03 | 1988-09-07 | The Upjohn Company | Antibiotic sulfonylaminocarbonyl activated beta-lactams |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ199981A (en) | 1981-04-09 | 1985-08-16 | Squibb & Sons Inc | 2-oxo-1-(((substituted sulphonyl)amino)carbonyl)azetidines |
| KR890700588A (ko) | 1987-02-11 | 1989-04-25 | 로버어트 에이 아미테이지 | 항생 물질로서 신규 N-1 치환된 β -락탐 |
| US5006650A (en) * | 1987-02-11 | 1991-04-09 | The Upjohn Company | Novel N-1 substituted beta-lactams as antibiotics |
| KR890700586A (ko) * | 1987-02-27 | 1989-04-25 | 로버어트 에이 아마테이지 | 피리돈 카르복실산 또는 산유도체를 함유하는 항균제 베타-락탐 |
| US4762922A (en) * | 1987-07-01 | 1988-08-09 | Squibb Corporation | 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines |
| US5015737A (en) * | 1987-07-22 | 1991-05-14 | The Upjohn Company | Therapeutically useful beta-lactams |
| US4777252A (en) * | 1987-08-13 | 1988-10-11 | E. R. Squibb & Sons, Inc. | 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines |
| US4889930A (en) | 1987-12-21 | 1989-12-26 | E. R. Squibb & Sons, Inc. | Process for making 2-oxo-1-((substituted sulfonyl)amino)carbonzyl)azetidines and intermediates used therein |
| JPH01305081A (ja) | 1988-04-04 | 1989-12-08 | E R Squibb & Sons Inc | ３―アシルアミノ―１―［［［（置換スルホニル）アミノ〕カルボニル〕アミノ〕―２―アゼチジノン類 |
| EP0344707A3 (en) | 1988-06-02 | 1990-04-18 | E.R. Squibb & Sons, Inc. | 2-Oxo-1-[[(substituted sulfonyl)-amino]carbonyl]-azetidine derivatives |
| US4959470A (en) * | 1988-08-17 | 1990-09-25 | E. R. Squibb & Sons, Inc. | 2-oxo-[[(substituted sulfonyl)-amino]carbonyl]-azetidines |
| AU4064089A (en) | 1988-09-27 | 1990-04-18 | Upjohn Company, The | Dihydroxyaryl 4-substituted monocarbams as antibiotics |
| CA2210787A1 (en) | 1997-07-17 | 1999-01-17 | William R. Collier | Self-contained work station |
| RU2488394C2 (ru) | 2007-03-23 | 2013-07-27 | Базилеа Фармацойтика Аг | Комбинированные лекарственные средства для лечения бактериальных инфекций |
| JP2012512863A (ja) * | 2008-12-19 | 2012-06-07 | ファイザー・インク | モノカルバム |
-
2009
- 2009-12-07 JP JP2011541665A patent/JP2012512863A/ja active Pending
- 2009-12-07 SG SG2011036704A patent/SG171781A1/en unknown
- 2009-12-07 KR KR1020117013944A patent/KR20110086742A/ko not_active Abandoned
- 2009-12-07 CA CA2744756A patent/CA2744756C/en not_active Expired - Fee Related
- 2009-12-07 EP EP09795553A patent/EP2379546A1/en not_active Withdrawn
- 2009-12-07 MX MX2011006541A patent/MX2011006541A/es active IP Right Grant
- 2009-12-07 AU AU2009329169A patent/AU2009329169B2/en not_active Ceased
- 2009-12-07 WO PCT/IB2009/055544 patent/WO2010070523A1/en not_active Ceased
- 2009-12-07 CN CN2009801569587A patent/CN102325769A/zh active Pending
- 2009-12-17 UY UY0001032336A patent/UY32336A/es not_active Application Discontinuation
- 2009-12-18 US US12/641,343 patent/US8252782B2/en not_active Expired - Fee Related
- 2009-12-18 TW TW098143723A patent/TW201026696A/zh unknown
- 2009-12-18 AR ARP090104977A patent/AR074801A1/es not_active Application Discontinuation
- 2009-12-18 PA PA20098855001A patent/PA8855001A1/es unknown
-
2011
- 2011-05-30 IL IL213216A patent/IL213216A0/en unknown
-
2012
- 2012-07-26 US US13/558,989 patent/US8324198B1/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4587047A (en) * | 1981-04-09 | 1986-05-06 | E. R. Squibb & Sons, Inc. | 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines |
| EP0281289A1 (en) * | 1987-03-03 | 1988-09-07 | The Upjohn Company | Antibiotic sulfonylaminocarbonyl activated beta-lactams |
Non-Patent Citations (1)
| Title |
|---|
| GARY E.ZURENKO，ETC: "In vitro antibacterial activity and interactions with beta-lactamases and penicillin-binding proteins of the new monocarbam antibiotic U-78608.", 《ANTIMICROBIAL AGENTS AND CHEMOTHERAPY》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105481812A (zh) * | 2015-11-30 | 2016-04-13 | 重庆天奕恒化科技有限公司 | 一种5-苄氧基-4-氧代-4h-吡喃-2-羧酸的制备方法 |
| CN105481812B (zh) * | 2015-11-30 | 2020-04-21 | 重庆天奕恒化科技有限公司 | 一种5-苄氧基-4-氧代-4h-吡喃-2-羧酸的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| UY32336A (es) | 2010-07-30 |
| AU2009329169A1 (en) | 2010-06-24 |
| WO2010070523A1 (en) | 2010-06-24 |
| IL213216A0 (en) | 2011-07-31 |
| AU2009329169B2 (en) | 2012-06-28 |
| CA2744756C (en) | 2013-05-28 |
| US8252782B2 (en) | 2012-08-28 |
| AR074801A1 (es) | 2011-02-16 |
| SG171781A1 (en) | 2011-07-28 |
| US20100160281A1 (en) | 2010-06-24 |
| JP2012512863A (ja) | 2012-06-07 |
| EP2379546A1 (en) | 2011-10-26 |
| US20120289455A1 (en) | 2012-11-15 |
| KR20110086742A (ko) | 2011-07-29 |
| CA2744756A1 (en) | 2010-06-24 |
| MX2011006541A (es) | 2011-07-20 |
| PA8855001A1 (es) | 2010-07-27 |
| US8324198B1 (en) | 2012-12-04 |
| TW201026696A (en) | 2010-07-16 |
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