CA2744756C - Monocarbams and their use as antibacterial agent - Google Patents

Monocarbams and their use as antibacterial agent Download PDF

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Publication number
CA2744756C
CA2744756C CA2744756A CA2744756A CA2744756C CA 2744756 C CA2744756 C CA 2744756C CA 2744756 A CA2744756 A CA 2744756A CA 2744756 A CA2744756 A CA 2744756A CA 2744756 C CA2744756 C CA 2744756C
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CA
Canada
Prior art keywords
compound
oxo
mmol
compounds
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2744756A
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English (en)
French (fr)
Other versions
CA2744756A1 (en
Inventor
Steven Joseph Brickner
Mark Edward Flanagan
Manjinder Singh Lall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CA2744756A1 publication Critical patent/CA2744756A1/en
Application granted granted Critical
Publication of CA2744756C publication Critical patent/CA2744756C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
CA2744756A 2008-12-19 2009-12-07 Monocarbams and their use as antibacterial agent Expired - Fee Related CA2744756C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13915908P 2008-12-19 2008-12-19
US61/139,159 2008-12-19
PCT/IB2009/055544 WO2010070523A1 (en) 2008-12-19 2009-12-07 Monocarbams

Publications (2)

Publication Number Publication Date
CA2744756A1 CA2744756A1 (en) 2010-06-24
CA2744756C true CA2744756C (en) 2013-05-28

Family

ID=41727494

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2744756A Expired - Fee Related CA2744756C (en) 2008-12-19 2009-12-07 Monocarbams and their use as antibacterial agent

Country Status (15)

Country Link
US (2) US8252782B2 (https=)
EP (1) EP2379546A1 (https=)
JP (1) JP2012512863A (https=)
KR (1) KR20110086742A (https=)
CN (1) CN102325769A (https=)
AR (1) AR074801A1 (https=)
AU (1) AU2009329169B2 (https=)
CA (1) CA2744756C (https=)
IL (1) IL213216A0 (https=)
MX (1) MX2011006541A (https=)
PA (1) PA8855001A1 (https=)
SG (1) SG171781A1 (https=)
TW (1) TW201026696A (https=)
UY (1) UY32336A (https=)
WO (1) WO2010070523A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012512863A (ja) * 2008-12-19 2012-06-07 ファイザー・インク モノカルバム
DK2646436T3 (en) 2010-11-29 2015-06-29 Pfizer monobactams
UY34585A (es) 2012-01-24 2013-09-02 Aicuris Gmbh & Co Kg Compuestos b-lactámicos sustituidos con amidina, su preparación y uso
PL3353175T3 (pl) * 2015-09-23 2021-02-22 Novartis Ag Sole i postacie stałe antybiotyku monobaktamowego
CN105481812B (zh) * 2015-11-30 2020-04-21 重庆天奕恒化科技有限公司 一种5-苄氧基-4-氧代-4h-吡喃-2-羧酸的制备方法
AU2017339587A1 (en) 2016-12-21 2019-07-04 Aicuris Gmbh & Co. Kg Combination therapy with amidine substituted ß-lactam compounds and ß-lactamase inhibitors for infections with antibiotic resistant bacterial strains
JP7235718B2 (ja) 2017-08-02 2023-03-08 ノバルティス アーゲー モノバクタム系抗生物質およびその中間体を製造するための化学的方法
CN110997627B (zh) 2017-08-23 2023-10-10 亥姆霍兹感染研究中心有限公司 孢囊菌酰胺衍生物
JP7366746B2 (ja) 2017-08-31 2023-10-23 北興化学工業株式会社 １－（ｎ，ｎ－ジ置換カルバモイル）４－（置換スルホニル）トリアゾリン－５－オン誘導体、４－（ｎ，ｎ－ジ置換カルバモイル）１－（置換スルホニル）トリアゾリン－５－オン誘導体、およびそれらを有効成分として含有する除草剤
WO2019144969A1 (zh) 2018-01-29 2019-08-01 南京明德新药研发股份有限公司 用于治疗细菌感染的单环β-内酰胺化合物
WO2020125670A1 (zh) 2018-12-18 2020-06-25 南京明德新药研发有限公司 单环β-内酰胺化合物在制药中的应用
CN114828850B (zh) 2019-12-19 2024-08-13 深圳嘉科生物科技有限公司 化合物在制药中的应用
WO2023205463A1 (en) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4587047A (en) * 1981-04-09 1986-05-06 E. R. Squibb & Sons, Inc. 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
NZ199981A (en) 1981-04-09 1985-08-16 Squibb & Sons Inc 2-oxo-1-(((substituted sulphonyl)amino)carbonyl)azetidines
KR890700588A (ko) 1987-02-11 1989-04-25 로버어트 에이 아미테이지 항생 물질로서 신규 N-1 치환된 β -락탐
US5006650A (en) * 1987-02-11 1991-04-09 The Upjohn Company Novel N-1 substituted beta-lactams as antibiotics
KR890700586A (ko) * 1987-02-27 1989-04-25 로버어트 에이 아마테이지 피리돈 카르복실산 또는 산유도체를 함유하는 항균제 베타-락탐
CA1317298C (en) * 1987-03-03 1993-05-04 Upjohn Company (The) Antibiotic sulfonylaminocarbonyl activated .beta.-lactams
US4762922A (en) * 1987-07-01 1988-08-09 Squibb Corporation 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
US5015737A (en) * 1987-07-22 1991-05-14 The Upjohn Company Therapeutically useful beta-lactams
US4777252A (en) * 1987-08-13 1988-10-11 E. R. Squibb & Sons, Inc. 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
US4889930A (en) 1987-12-21 1989-12-26 E. R. Squibb & Sons, Inc. Process for making 2-oxo-1-((substituted sulfonyl)amino)carbonzyl)azetidines and intermediates used therein
JPH01305081A (ja) 1988-04-04 1989-12-08 E R Squibb & Sons Inc ３―アシルアミノ―１―［［［（置換スルホニル）アミノ〕カルボニル〕アミノ〕―２―アゼチジノン類
EP0344707A3 (en) 1988-06-02 1990-04-18 E.R. Squibb & Sons, Inc. 2-Oxo-1-[[(substituted sulfonyl)-amino]carbonyl]-azetidine derivatives
US4959470A (en) * 1988-08-17 1990-09-25 E. R. Squibb & Sons, Inc. 2-oxo-[[(substituted sulfonyl)-amino]carbonyl]-azetidines
AU4064089A (en) 1988-09-27 1990-04-18 Upjohn Company, The Dihydroxyaryl 4-substituted monocarbams as antibiotics
CA2210787A1 (en) 1997-07-17 1999-01-17 William R. Collier Self-contained work station
RU2488394C2 (ru) 2007-03-23 2013-07-27 Базилеа Фармацойтика Аг Комбинированные лекарственные средства для лечения бактериальных инфекций
JP2012512863A (ja) * 2008-12-19 2012-06-07 ファイザー・インク モノカルバム

Also Published As

Publication number Publication date
UY32336A (es) 2010-07-30
AU2009329169A1 (en) 2010-06-24
WO2010070523A1 (en) 2010-06-24
IL213216A0 (en) 2011-07-31
AU2009329169B2 (en) 2012-06-28
US8252782B2 (en) 2012-08-28
AR074801A1 (es) 2011-02-16
SG171781A1 (en) 2011-07-28
US20100160281A1 (en) 2010-06-24
CN102325769A (zh) 2012-01-18
JP2012512863A (ja) 2012-06-07
EP2379546A1 (en) 2011-10-26
US20120289455A1 (en) 2012-11-15
KR20110086742A (ko) 2011-07-29
CA2744756A1 (en) 2010-06-24
MX2011006541A (es) 2011-07-20
PA8855001A1 (es) 2010-07-27
US8324198B1 (en) 2012-12-04
TW201026696A (en) 2010-07-16

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Effective date: 20151207