CN102317306B - 丙型肝炎病毒抑制剂 - Google Patents

丙型肝炎病毒抑制剂 Download PDF

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Publication number
CN102317306B
CN102317306B CN200980156612.7A CN200980156612A CN102317306B CN 102317306 B CN102317306 B CN 102317306B CN 200980156612 A CN200980156612 A CN 200980156612A CN 102317306 B CN102317306 B CN 102317306B
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China
Prior art keywords
hcv
compound
compounds
pharmaceutically acceptable
alkyl
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Expired - Fee Related
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CN200980156612.7A
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English (en)
Chinese (zh)
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CN102317306A (zh
Inventor
王向东
保罗.M.斯科拉
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of CN102317306A publication Critical patent/CN102317306A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN200980156612.7A 2008-12-15 2009-12-11 丙型肝炎病毒抑制剂 Expired - Fee Related CN102317306B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12248708P 2008-12-15 2008-12-15
US61/122,487 2008-12-15
PCT/US2009/067712 WO2010077783A1 (en) 2008-12-15 2009-12-11 Hepatitis c virus inhibitors

Publications (2)

Publication Number Publication Date
CN102317306A CN102317306A (zh) 2012-01-11
CN102317306B true CN102317306B (zh) 2014-07-30

Family

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Family Applications (1)

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CN200980156612.7A Expired - Fee Related CN102317306B (zh) 2008-12-15 2009-12-11 丙型肝炎病毒抑制剂

Country Status (5)

Country Link
US (1) US8283310B2 (enExample)
EP (1) EP2365980B1 (enExample)
JP (1) JP2012512169A (enExample)
CN (1) CN102317306B (enExample)
WO (1) WO2010077783A1 (enExample)

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CN105164148A (zh) 2013-03-07 2015-12-16 百时美施贵宝公司 丙型肝炎病毒抑制剂
JP6511432B2 (ja) 2013-03-15 2019-05-15 ギリアード サイエンシーズ， インコーポレイテッド Ｃ型肝炎ウイルスの大環状二環式阻害剤
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Also Published As

Publication number Publication date
JP2012512169A (ja) 2012-05-31
WO2010077783A1 (en) 2010-07-08
EP2365980A1 (en) 2011-09-21
US20100150866A1 (en) 2010-06-17
US8283310B2 (en) 2012-10-09
EP2365980B1 (en) 2013-04-17
CN102317306A (zh) 2012-01-11

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