CN102317269B - 新氨基氮杂杂环甲酰胺类 - Google Patents
新氨基氮杂杂环甲酰胺类 Download PDFInfo
- Publication number
- CN102317269B CN102317269B CN201080007165.1A CN201080007165A CN102317269B CN 102317269 B CN102317269 B CN 102317269B CN 201080007165 A CN201080007165 A CN 201080007165A CN 102317269 B CN102317269 B CN 102317269B
- Authority
- CN
- China
- Prior art keywords
- quinazoline
- carboxamide
- amino
- phenyl
- ethylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- OIFRKACFZYTQGT-ONJZDKRHSA-N CC(NC(c(cccc12)c1nccc2N[C@H](CN)c1cccc(OC)c1)=O)Oc1ccc(C(CN)Nc(c2ccc3)ccnc2c3C(N)=O)cc1 Chemical compound CC(NC(c(cccc12)c1nccc2N[C@H](CN)c1cccc(OC)c1)=O)Oc1ccc(C(CN)Nc(c2ccc3)ccnc2c3C(N)=O)cc1 OIFRKACFZYTQGT-ONJZDKRHSA-N 0.000 description 1
- NBNLHTFTPUKIHH-LDADJPATSA-N CCOc(cc1)ccc1/C(/Nc(c1ccc2)ccnc1c2C(N)=O)=C\N Chemical compound CCOc(cc1)ccc1/C(/Nc(c1ccc2)ccnc1c2C(N)=O)=C\N NBNLHTFTPUKIHH-LDADJPATSA-N 0.000 description 1
- OCOFFHFJRBHYPM-LJQANCHMSA-N CCOc1ccc([C@@H](CNC)Nc(c2ccc3)ccnc2c3C(N)=O)cc1 Chemical compound CCOc1ccc([C@@H](CNC)Nc(c2ccc3)ccnc2c3C(N)=O)cc1 OCOFFHFJRBHYPM-LJQANCHMSA-N 0.000 description 1
- ISTXZCWBPMHSCJ-UHFFFAOYSA-N CNCC(c1ccccc1)Nc(c1ccc2)ccnc1c2C(N)=O Chemical compound CNCC(c1ccccc1)Nc(c1ccc2)ccnc1c2C(N)=O ISTXZCWBPMHSCJ-UHFFFAOYSA-N 0.000 description 1
- DCVYZGHUYJNWSB-QGZVFWFLSA-N CNC[C@H](c(cc1Cl)ccc1OC)Nc(c1ccc2)ccnc1c2C(N)=O Chemical compound CNC[C@H](c(cc1Cl)ccc1OC)Nc(c1ccc2)ccnc1c2C(N)=O DCVYZGHUYJNWSB-QGZVFWFLSA-N 0.000 description 1
- LRQXOZUNUGNLEC-QGZVFWFLSA-N CNC[C@H](c(cc1F)ccc1OC)Nc(c1ccc2)ccnc1c2C(N)=O Chemical compound CNC[C@H](c(cc1F)ccc1OC)Nc(c1ccc2)ccnc1c2C(N)=O LRQXOZUNUGNLEC-QGZVFWFLSA-N 0.000 description 1
- YMQRVIPJQCDTBZ-QGZVFWFLSA-N CNC[C@H](c(cc1OC)ccc1OC)Nc(c1ccc2)ccnc1c2C(N)=O Chemical compound CNC[C@H](c(cc1OC)ccc1OC)Nc(c1ccc2)ccnc1c2C(N)=O YMQRVIPJQCDTBZ-QGZVFWFLSA-N 0.000 description 1
- YHVAOZNYGPWLNY-QGZVFWFLSA-N CNC[C@H](c1cccc(Cl)c1)Nc(c1ccc2)ccnc1c2C(N)=O Chemical compound CNC[C@H](c1cccc(Cl)c1)Nc(c1ccc2)ccnc1c2C(N)=O YHVAOZNYGPWLNY-QGZVFWFLSA-N 0.000 description 1
- UDDPBQSNNXTBAZ-QGZVFWFLSA-N CNC[C@H](c1cccc(F)c1)Nc(c1ccc2)ccnc1c2C(N)=O Chemical compound CNC[C@H](c1cccc(F)c1)Nc(c1ccc2)ccnc1c2C(N)=O UDDPBQSNNXTBAZ-QGZVFWFLSA-N 0.000 description 1
- IFNAPXNBCPXMCP-GOSISDBHSA-N CNC[C@H](c1cccc(OC)c1)Nc(c1ccc2)ccnc1c2C(N)=O Chemical compound CNC[C@H](c1cccc(OC)c1)Nc(c1ccc2)ccnc1c2C(N)=O IFNAPXNBCPXMCP-GOSISDBHSA-N 0.000 description 1
- ISTXZCWBPMHSCJ-QGZVFWFLSA-N CNC[C@H](c1ccccc1)Nc(c1ccc2)ccnc1c2C(N)=O Chemical compound CNC[C@H](c1ccccc1)Nc(c1ccc2)ccnc1c2C(N)=O ISTXZCWBPMHSCJ-QGZVFWFLSA-N 0.000 description 1
- LGRQTWLIJMEDHO-UHFFFAOYSA-N COc(ccc(C(CN)Nc(c1ccc2)ccnc1c2C(N)=O)c1)c1OC Chemical compound COc(ccc(C(CN)Nc(c1ccc2)ccnc1c2C(N)=O)c1)c1OC LGRQTWLIJMEDHO-UHFFFAOYSA-N 0.000 description 1
- UZRIUPJMXGVURC-UHFFFAOYSA-N COc1ccc(C(CN)Nc(c2ccc3)ccnc2c3C(N)=O)cc1F Chemical compound COc1ccc(C(CN)Nc(c2ccc3)ccnc2c3C(N)=O)cc1F UZRIUPJMXGVURC-UHFFFAOYSA-N 0.000 description 1
- FLFWVPARQQIMJL-MRXNPFEDSA-N COc1ccc([C@@H](CN)Nc(c2ccc3)ccnc2c3C(N)=O)cc1Cl Chemical compound COc1ccc([C@@H](CN)Nc(c2ccc3)ccnc2c3C(N)=O)cc1Cl FLFWVPARQQIMJL-MRXNPFEDSA-N 0.000 description 1
- XZDZDYSQOWKTJE-IIYHCAQCSA-N N/C(/C(Nc1cc(C(CCO)Nc2ncnc3c2cccc3C(N)=O)ccc1)=O)=C\C(C1CC1)=N Chemical compound N/C(/C(Nc1cc(C(CCO)Nc2ncnc3c2cccc3C(N)=O)ccc1)=O)=C\C(C1CC1)=N XZDZDYSQOWKTJE-IIYHCAQCSA-N 0.000 description 1
- WMIQLQACYRJZKO-INWBGVQASA-N N/C(/C(Nc1cccc(C(CCN2CCOCC2)Nc2ncnc3c2cccc3C(N)=O)c1)=O)=C\C(C1CC1)=N Chemical compound N/C(/C(Nc1cccc(C(CCN2CCOCC2)Nc2ncnc3c2cccc3C(N)=O)c1)=O)=C\C(C1CC1)=N WMIQLQACYRJZKO-INWBGVQASA-N 0.000 description 1
- MCCOWFUKWQGOSO-UHFFFAOYSA-N NC(c(cccc12)c1ncnc2NC(CCN1CCCC1)c1cc(N)ccc1)=O Chemical compound NC(c(cccc12)c1ncnc2NC(CCN1CCCC1)c1cc(N)ccc1)=O MCCOWFUKWQGOSO-UHFFFAOYSA-N 0.000 description 1
- UNOCDJLXFCDLPR-UHFFFAOYSA-N NC(c1cc(C(CO)O)cc2c1ncnc2NCc1cccc(N)c1)=O Chemical compound NC(c1cc(C(CO)O)cc2c1ncnc2NCc1cccc(N)c1)=O UNOCDJLXFCDLPR-UHFFFAOYSA-N 0.000 description 1
- ZQQUOBJRRMKXNF-UHFFFAOYSA-O NC(c1cccc2c1ncnc2NC(CC=O)c1cc(NC(C([NH3+])=CC(C2CC2)=N)=O)ccc1)=O Chemical compound NC(c1cccc2c1ncnc2NC(CC=O)c1cc(NC(C([NH3+])=CC(C2CC2)=N)=O)ccc1)=O ZQQUOBJRRMKXNF-UHFFFAOYSA-O 0.000 description 1
- MUTXAXOXPDZSGG-UHFFFAOYSA-N NCC(c1ccccc1)Nc(c1ccc2)ccnc1c2C(N)=O Chemical compound NCC(c1ccccc1)Nc(c1ccc2)ccnc1c2C(N)=O MUTXAXOXPDZSGG-UHFFFAOYSA-N 0.000 description 1
- FEGLXPMDFRXMQG-MRXNPFEDSA-N NC[C@H](c1cccc(Cl)c1)Nc(c1ccc2)ccnc1c2C(N)=O Chemical compound NC[C@H](c1cccc(Cl)c1)Nc(c1ccc2)ccnc1c2C(N)=O FEGLXPMDFRXMQG-MRXNPFEDSA-N 0.000 description 1
- YVRRTWKZGBWQQP-MRXNPFEDSA-N NC[C@H](c1cccc(F)c1)Nc(c1ccc2)ccnc1c2C(N)=O Chemical compound NC[C@H](c1cccc(F)c1)Nc(c1ccc2)ccnc1c2C(N)=O YVRRTWKZGBWQQP-MRXNPFEDSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20735409P | 2009-02-11 | 2009-02-11 | |
| US61/207,354 | 2009-02-11 | ||
| PCT/US2010/000313 WO2010093419A1 (en) | 2009-02-11 | 2010-02-04 | Novel amino azaheterocyclic carboxamides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102317269A CN102317269A (zh) | 2012-01-11 |
| CN102317269B true CN102317269B (zh) | 2015-06-17 |
Family
ID=42199208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080007165.1A Active CN102317269B (zh) | 2009-02-11 | 2010-02-04 | 新氨基氮杂杂环甲酰胺类 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8637532B2 (enExample) |
| EP (1) | EP2396307B1 (enExample) |
| JP (1) | JP5642714B2 (enExample) |
| KR (1) | KR101699991B1 (enExample) |
| CN (1) | CN102317269B (enExample) |
| AR (1) | AR075396A1 (enExample) |
| AU (1) | AU2010214095B2 (enExample) |
| BR (1) | BRPI1008325A2 (enExample) |
| CA (1) | CA2751886C (enExample) |
| CL (1) | CL2011001967A1 (enExample) |
| DK (1) | DK2396307T3 (enExample) |
| EA (1) | EA020731B1 (enExample) |
| ES (1) | ES2527940T3 (enExample) |
| HR (1) | HRP20141239T1 (enExample) |
| IL (1) | IL214412A0 (enExample) |
| MX (1) | MX338354B (enExample) |
| MY (1) | MY160468A (enExample) |
| NZ (1) | NZ595087A (enExample) |
| PL (1) | PL2396307T3 (enExample) |
| PT (1) | PT2396307E (enExample) |
| SG (1) | SG173473A1 (enExample) |
| SI (1) | SI2396307T1 (enExample) |
| UA (1) | UA107188C2 (enExample) |
| WO (1) | WO2010093419A1 (enExample) |
| ZA (1) | ZA201106624B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA110113C2 (xx) | 2010-07-29 | 2015-11-25 | Біциклічні азагетероциклічні карбоксаміди | |
| WO2012016001A1 (en) * | 2010-07-29 | 2012-02-02 | Merck Patent Gmbh | Cyclic amine azaheterocyclic carboxamides |
| CA2818706C (en) | 2010-11-24 | 2019-07-23 | Merck Patent Gmbh | Quinazoline carboxamide azetidines |
| JP6082011B2 (ja) | 2011-09-12 | 2017-02-15 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | キナーゼ活性のモジュレーターとして使用するためのアミノピリミジン誘導体 |
| ES2644536T3 (es) | 2011-09-12 | 2017-11-29 | Merck Patent Gmbh | Imidazol-aminas novedosas como moduladores de la actividad cinasa |
| CN104169258B (zh) | 2011-12-22 | 2017-03-01 | 默克专利有限公司 | 用作激酶活性调节剂的新颖的杂环羧酰胺 |
| ES2807539T3 (es) | 2012-11-16 | 2021-02-23 | Merck Patent Gmbh | Derivados de imidazol-piperidinilo como moduladores de la actividad de quinasa |
| ES2620119T3 (es) | 2012-11-16 | 2017-06-27 | Merck Patent Gmbh | Derivados heterocíclicos novedosos como moduladores de la actividad de quinasa |
| ES2821102T3 (es) * | 2012-11-29 | 2021-04-23 | Merck Patent Gmbh | Derivados de azaquinazolincarboxamida |
| EP2950649B1 (en) | 2013-02-01 | 2020-03-04 | Wellstat Therapeutics Corporation | Amine compounds having anti-inflammatory, antifungal, antiparasitic and anticancer activity |
| AR095202A1 (es) | 2013-03-11 | 2015-09-30 | Merck Patent Gmbh | Heterociclos como moduladores de la actividad quinasa |
| GB201317609D0 (en) | 2013-10-04 | 2013-11-20 | Cancer Rec Tech Ltd | Inhibitor compounds |
| KR102410696B1 (ko) | 2014-04-03 | 2022-06-17 | 메르크 파텐트 게엠베하 | 암 치료법의 조합 |
| CN104292170B (zh) * | 2014-09-22 | 2016-06-29 | 广西师范大学 | 具有抗肿瘤作用的喹唑啉-芳基脲衍生物及其应用 |
| CA2965336A1 (en) * | 2014-10-22 | 2016-04-28 | The Board Of Regents Of The University Of Texas System | Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof |
| GB201505658D0 (en) | 2015-04-01 | 2015-05-13 | Cancer Rec Tech Ltd | Inhibitor compounds |
| GB201617103D0 (en) | 2016-10-07 | 2016-11-23 | Cancer Research Technology Limited | Compound |
| FR3066761B1 (fr) | 2017-05-23 | 2020-10-30 | Centre Nat Rech Scient | Nouveaux composes inhibiteurs des canaux ioniques |
| KR20200035029A (ko) * | 2017-06-30 | 2020-04-01 | 더 유니버시티 오브 노스캐롤라이나 앳 채플 힐 | 이질염색질 유전자 억제 저해제 |
| IL277071B2 (en) | 2018-03-08 | 2024-07-01 | Incyte Corp | AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS |
| TWI853814B (zh) | 2018-05-31 | 2024-09-01 | 南韓商Ｃ＆Ｃ新藥研究所 | 雜環衍生物及其用途 |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| CN109369634B (zh) * | 2018-12-19 | 2021-07-27 | 陕西国际商贸学院 | 具有抗肿瘤活性的2-甲氧基烟酰胺衍生物制备方法及用途 |
| RU2723481C1 (ru) * | 2019-10-03 | 2020-06-11 | ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ УНИТАРНОЕ ПРЕДПРИЯТИЕ "ИНСТИТУТ ХИМИЧЕСКИХ РЕАКТИВОВ И ОСОБО ЧИСТЫХ ХИМИЧЕСКИХ ВЕЩЕСТВ НАЦИОНАЛЬНОГО ИССЛЕДОВАТЕЛЬСКОГО ЦЕНТРА "КУРЧАТОВСКИЙ ИНСТИТУТ" (НИЦ "Курчатовский институт - ИРЕА) | 4-[метил 4-(аминометил)циклогексанкарбоксилат]хиназолин и способ его получения |
| BR112022008131A2 (pt) | 2019-11-01 | 2022-07-19 | Syngenta Crop Protection Ag | Compostos heteroaromáticos bicíclicos fundidos pesticidamente ativos |
| CN112778217B (zh) * | 2019-11-08 | 2024-01-26 | 沈阳化工研究院有限公司 | 一种喹唑啉类化合物及其应用 |
| MX2023005520A (es) | 2020-11-16 | 2023-05-23 | Merck Patent Gmbh | Combinaciones de inhibidores de cinasa para tratamiento de cancer. |
| US20240294517A1 (en) | 2021-06-24 | 2024-09-05 | Syngenta Crop Protection Ag | 2-[3-[1 [(quinazolin-4-yl)amino]ethyl]pyrazin-2-yl]thiazole-5-carbonitrile derivatives and similar compounds as pesticides |
| TW202345806A (zh) | 2022-03-31 | 2023-12-01 | 美商艾伯維有限公司 | 噻唑并〔５，４－ｂ〕吡啶ｍａｌｔ－１抑制劑 |
| WO2023201185A1 (en) * | 2022-04-11 | 2023-10-19 | Merck Patent Gmbh | Pyrido[3,2-d]pyrimidines as hpk1 inhibitors |
| WO2023247360A1 (en) | 2022-06-21 | 2023-12-28 | Syngenta Crop Protection Ag | Pesticidally active fused bicyclic heteroaromatic compounds |
| CN115521474B (zh) * | 2022-09-30 | 2023-08-22 | 陕西科技大学 | 一种基于五重互穿氢键有机框架材料及其制备方法和应用 |
| WO2025228828A1 (en) * | 2024-04-29 | 2025-11-06 | Merck Patent Gmbh | Carboxamide compounds for the treatment and prevention of viral diseases |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999009024A1 (en) * | 1997-08-14 | 1999-02-25 | Smithkline Beecham Plc | Phenyl urea and phenyl thiourea derivatives as hfgan72 antagonists |
| CN1391562A (zh) * | 1999-09-21 | 2003-01-15 | 阿斯特拉曾尼卡有限公司 | 用作药物的喹唑啉衍生物 |
| CN1426398A (zh) * | 2000-04-27 | 2003-06-25 | 山之内制药株式会社 | 稠合杂芳基衍生物 |
| CN1496364A (zh) * | 2000-06-28 | 2004-05-12 | 取代的喹唑啉衍生物及其作为抑制剂的用途 | |
| CN1620296A (zh) * | 2001-12-24 | 2005-05-25 | 阿斯特拉曾尼卡有限公司 | 作为Aurora激酶抑制剂的取代喹唑啉衍生物 |
| WO2008049047A2 (en) * | 2006-10-18 | 2008-04-24 | Wyeth | Quinoline compounds |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5651457A (en) * | 1979-09-14 | 1981-05-09 | Dev Finance | Antitumoral compound and its manufacture |
| GB8804445D0 (en) * | 1988-02-25 | 1988-03-23 | Smithkline Beckman Intercredit | Compounds |
| US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| JP2006522124A (ja) | 2003-04-03 | 2006-09-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用な組成物 |
| JP2007507531A (ja) | 2003-09-30 | 2007-03-29 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤としての化合物および組成物 |
| JP4800216B2 (ja) | 2003-10-24 | 2011-10-26 | エグゼリクシス， インコーポレイテッド | ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法 |
| KR20060117329A (ko) | 2003-11-21 | 2006-11-16 | 노파르티스 아게 | 단백질 키나제 저해제로서의 1ｈ-이미다조퀴놀린 유도체 |
| US8044057B2 (en) | 2003-12-09 | 2011-10-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for suppressing an immune response or treating a proliferative disorder |
| AU2005249380C1 (en) | 2004-04-23 | 2012-09-20 | Exelixis, Inc. | Kinase modulators and methods of use |
| WO2006071819A1 (en) | 2004-12-28 | 2006-07-06 | Exelixis, Inc. | [1h-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases |
| GB0501999D0 (en) | 2005-02-01 | 2005-03-09 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| WO2006136821A1 (en) | 2005-06-22 | 2006-12-28 | Astex Therapeutics Limited | Pharmaceutical compounds |
| EP1925941B1 (en) * | 2005-08-01 | 2012-11-28 | Eisai R&D Management Co., Ltd. | Method for prediction of the efficacy of vascularization inhibitor |
| JP5516397B2 (ja) * | 2007-04-05 | 2014-06-11 | アムジエン・インコーポレーテツド | オーロラキナーゼ調節物質及び使用方法 |
| UA99284C2 (ru) | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
| US7829574B2 (en) * | 2008-05-09 | 2010-11-09 | Hutchison Medipharma Enterprises Limited | Substituted quinazoline compounds and their use in treating angiogenesis-related diseases |
-
2010
- 2010-02-04 CN CN201080007165.1A patent/CN102317269B/zh active Active
- 2010-02-04 PL PL10705453T patent/PL2396307T3/pl unknown
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- 2010-02-04 WO PCT/US2010/000313 patent/WO2010093419A1/en not_active Ceased
- 2010-02-04 CA CA2751886A patent/CA2751886C/en active Active
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-
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- 2011-08-02 IL IL214412A patent/IL214412A0/en active IP Right Grant
- 2011-08-11 CL CL2011001967A patent/CL2011001967A1/es unknown
- 2011-09-09 ZA ZA2011/06624A patent/ZA201106624B/en unknown
-
2013
- 2013-12-13 US US14/105,974 patent/US9040560B2/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999009024A1 (en) * | 1997-08-14 | 1999-02-25 | Smithkline Beecham Plc | Phenyl urea and phenyl thiourea derivatives as hfgan72 antagonists |
| CN1391562A (zh) * | 1999-09-21 | 2003-01-15 | 阿斯特拉曾尼卡有限公司 | 用作药物的喹唑啉衍生物 |
| CN1426398A (zh) * | 2000-04-27 | 2003-06-25 | 山之内制药株式会社 | 稠合杂芳基衍生物 |
| CN1496364A (zh) * | 2000-06-28 | 2004-05-12 | 取代的喹唑啉衍生物及其作为抑制剂的用途 | |
| CN1620296A (zh) * | 2001-12-24 | 2005-05-25 | 阿斯特拉曾尼卡有限公司 | 作为Aurora激酶抑制剂的取代喹唑啉衍生物 |
| WO2008049047A2 (en) * | 2006-10-18 | 2008-04-24 | Wyeth | Quinoline compounds |
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