CN102215825A - 可直接压制的颗粒状的基于微晶纤维素的赋形剂、其制备方法及应用 - Google Patents

可直接压制的颗粒状的基于微晶纤维素的赋形剂、其制备方法及应用 Download PDF

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Publication number
CN102215825A
CN102215825A CN2009801461591A CN200980146159A CN102215825A CN 102215825 A CN102215825 A CN 102215825A CN 2009801461591 A CN2009801461591 A CN 2009801461591A CN 200980146159 A CN200980146159 A CN 200980146159A CN 102215825 A CN102215825 A CN 102215825A
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CN
China
Prior art keywords
microcrystalline cellulose
binder
excipient
slurry
disintegrant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN2009801461591A
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English (en)
Chinese (zh)
Inventor
南杜·德奥卡
詹姆斯·法里纳
利利安娜·米尼
萨米尔·兰戴夫
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Anwantuo Spcial Materials Co Ltd
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Anwantuo Spcial Materials Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anwantuo Spcial Materials Co Ltd filed Critical Anwantuo Spcial Materials Co Ltd
Publication of CN102215825A publication Critical patent/CN102215825A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN2009801461591A 2008-11-19 2009-11-16 可直接压制的颗粒状的基于微晶纤维素的赋形剂、其制备方法及应用 Pending CN102215825A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11602508P 2008-11-19 2008-11-19
US61/116,025 2008-11-19
PCT/US2009/064498 WO2010059534A2 (en) 2008-11-19 2009-11-16 Directly compressible granular microcrystalline cellulose based excipient, manufacturing process and use thereof

Publications (1)

Publication Number Publication Date
CN102215825A true CN102215825A (zh) 2011-10-12

Family

ID=42077071

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801461591A Pending CN102215825A (zh) 2008-11-19 2009-11-16 可直接压制的颗粒状的基于微晶纤维素的赋形剂、其制备方法及应用

Country Status (13)

Country Link
US (1) US20110288146A1 (OSRAM)
EP (1) EP2376067A2 (OSRAM)
JP (1) JP2012509329A (OSRAM)
KR (1) KR20110089180A (OSRAM)
CN (1) CN102215825A (OSRAM)
AU (1) AU2009316812A1 (OSRAM)
BR (1) BRPI0921507A2 (OSRAM)
CA (1) CA2744142A1 (OSRAM)
IL (1) IL212955A0 (OSRAM)
MX (1) MX2011005168A (OSRAM)
SG (1) SG171752A1 (OSRAM)
TW (1) TW201023897A (OSRAM)
WO (1) WO2010059534A2 (OSRAM)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104189915A (zh) * 2014-07-30 2014-12-10 上海新亚药业闵行有限公司 一种固体制剂预混剂及其制备方法
CN104258411A (zh) * 2014-09-19 2015-01-07 安徽山河药用辅料股份有限公司 一种硅化微晶纤维素复合辅料及其制备方法
CN106265077A (zh) * 2015-05-30 2017-01-04 天士力制药集团股份有限公司 一种中药浸膏雾化分散工艺及其制剂
CN116036291A (zh) * 2022-08-31 2023-05-02 瑞普（天津）生物药业有限公司 一种具有增溶作用的组合物及其制备方法与应用

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101298788B1 (ko) * 2011-03-15 2013-08-22 보령제약 주식회사 안정성이 개선된 복합제제
JP5879668B2 (ja) * 2012-04-27 2016-03-08 日本コーンスターチ株式会社 澱粉顆粒の製造方法および口腔内崩壊錠
US9492535B2 (en) 2013-03-14 2016-11-15 Aimmune Therapeutics, Inc. Peanut formulations and uses thereof
ES2940686T3 (es) 2013-03-14 2023-05-10 Nestle Sa Fabricación de formulaciones de cacahuete para la desensibilización oral
WO2015187736A1 (en) * 2014-06-02 2015-12-10 Allergen Research Corporation Placebo formulations and uses thereof
JP6650750B2 (ja) * 2015-12-22 2020-02-19 アサヒグループ食品株式会社 錠剤の製造方法、錠剤原料用顆粒の製造方法、及び錠剤原料用顆粒
WO2020037151A1 (en) 2018-08-16 2020-02-20 Aimmune Therapeutics, Inc. Peanut oral immunotherapy with maintenance dose
JP2022514645A (ja) 2018-12-20 2022-02-14 アイミューン セラピューティクス，インコーポレイテッド ピーナツ経口免疫療法において投与が欠落した場合の投与スケジュール
EP3965815A4 (en) 2019-05-10 2023-05-31 Société des Produits Nestlé S.A. METHOD OF IMPROVING THE QUALITY OF LIFE IN A PEANUT ALLERGY PATIENT
PH12021553026A1 (en) 2019-07-05 2023-08-23 Swedish Match North Europe Ab An oral pouched nicotine product including a filling material comprising nicotine-containing particles
PL4061155T3 (pl) 2019-11-20 2024-01-29 Swedish Match North Europe Ab Doustny produkt nikotynowy w saszetce, zawierający materiał wypełniający zawierający cząstki nikotyny
PL4018848T3 (pl) 2020-12-22 2024-11-25 Swedish Match North Europe Ab Wyrób w saszetkach do użytku doustnego zawierający materiał pokrywający przepuszczalny dla cieczy oraz materiał wypełniający

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1074228A (zh) * 1991-12-30 1993-07-14 Fmc有限公司 球团化微晶纤维素组合物
WO2002062320A1 (en) * 2001-02-05 2002-08-15 R.P. Scherer Technologies, Inc. Methods and compositions for reducing the taste of pharmaceutically active agents
CN1473054A (zh) * 2000-11-06 2004-02-04 ������������ʽ���� 制剂用纤维素粒子

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3505433A1 (de) * 1985-02-16 1986-08-21 Basf Ag, 6700 Ludwigshafen Direkttablettierhilfsmittel
US5686107A (en) * 1995-01-30 1997-11-11 Fmc Corporation Chewable pharmaceutical tablets
DE19628617A1 (de) * 1996-07-16 1998-01-22 Basf Ag Direkttablettierhilfsmittel
EP1070740B1 (de) * 1999-07-19 2008-01-02 fit GmbH Coprozessiertes Polysaccharidprodukt mit unlöslicher Carboxymethylcellulose
US8808735B2 (en) * 2005-02-03 2014-08-19 Takeda Nycomed As Fast wet-massing method for the preparation of calcium-containing compositions
WO2008020990A1 (en) * 2006-08-09 2008-02-21 Mallinckrodt Baker, Inc. New direct compressible excipient blend
US7998505B2 (en) * 2006-10-27 2011-08-16 Fmc Corporation Dry granulation binders, products, and use thereof
SG185257A1 (en) * 2007-10-10 2012-11-29 Avantor Performance Mat Inc Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1074228A (zh) * 1991-12-30 1993-07-14 Fmc有限公司 球团化微晶纤维素组合物
CN1473054A (zh) * 2000-11-06 2004-02-04 ������������ʽ���� 制剂用纤维素粒子
WO2002062320A1 (en) * 2001-02-05 2002-08-15 R.P. Scherer Technologies, Inc. Methods and compositions for reducing the taste of pharmaceutically active agents

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104189915A (zh) * 2014-07-30 2014-12-10 上海新亚药业闵行有限公司 一种固体制剂预混剂及其制备方法
CN104189915B (zh) * 2014-07-30 2016-08-10 上海新亚药业闵行有限公司 一种固体制剂预混剂及其制备方法
CN104258411A (zh) * 2014-09-19 2015-01-07 安徽山河药用辅料股份有限公司 一种硅化微晶纤维素复合辅料及其制备方法
CN106265077A (zh) * 2015-05-30 2017-01-04 天士力制药集团股份有限公司 一种中药浸膏雾化分散工艺及其制剂
CN116036291A (zh) * 2022-08-31 2023-05-02 瑞普（天津）生物药业有限公司 一种具有增溶作用的组合物及其制备方法与应用

Also Published As

Publication number Publication date
US20110288146A1 (en) 2011-11-24
CA2744142A1 (en) 2010-05-27
WO2010059534A2 (en) 2010-05-27
KR20110089180A (ko) 2011-08-04
AU2009316812A1 (en) 2011-07-07
BRPI0921507A2 (pt) 2016-01-19
MX2011005168A (es) 2011-05-30
SG171752A1 (en) 2011-07-28
EP2376067A2 (en) 2011-10-19
IL212955A0 (en) 2011-07-31
JP2012509329A (ja) 2012-04-19
TW201023897A (en) 2010-07-01
WO2010059534A3 (en) 2011-01-20

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