TW201023897A - Directly compressible granular microcrystalline cellulose based excipient, manufacturing process and use thereof - Google Patents

Directly compressible granular microcrystalline cellulose based excipient, manufacturing process and use thereof Download PDF

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Publication number
TW201023897A
TW201023897A TW098139345A TW98139345A TW201023897A TW 201023897 A TW201023897 A TW 201023897A TW 098139345 A TW098139345 A TW 098139345A TW 98139345 A TW98139345 A TW 98139345A TW 201023897 A TW201023897 A TW 201023897A
Authority
TW
Taiwan
Prior art keywords
binder
microcrystalline cellulose
excipient
slurry
disintegrant
Prior art date
Application number
TW098139345A
Other languages
English (en)
Chinese (zh)
Inventor
Nandu Deorkar
James Farina
Liliana Miinea
Sameer Randive
Original Assignee
Mallinckrodt Baker Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Baker Inc filed Critical Mallinckrodt Baker Inc
Publication of TW201023897A publication Critical patent/TW201023897A/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
TW098139345A 2008-11-19 2009-11-19 Directly compressible granular microcrystalline cellulose based excipient, manufacturing process and use thereof TW201023897A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11602508P 2008-11-19 2008-11-19

Publications (1)

Publication Number Publication Date
TW201023897A true TW201023897A (en) 2010-07-01

Family

ID=42077071

Family Applications (1)

Application Number Title Priority Date Filing Date
TW098139345A TW201023897A (en) 2008-11-19 2009-11-19 Directly compressible granular microcrystalline cellulose based excipient, manufacturing process and use thereof

Country Status (13)

Country Link
US (1) US20110288146A1 (OSRAM)
EP (1) EP2376067A2 (OSRAM)
JP (1) JP2012509329A (OSRAM)
KR (1) KR20110089180A (OSRAM)
CN (1) CN102215825A (OSRAM)
AU (1) AU2009316812A1 (OSRAM)
BR (1) BRPI0921507A2 (OSRAM)
CA (1) CA2744142A1 (OSRAM)
IL (1) IL212955A0 (OSRAM)
MX (1) MX2011005168A (OSRAM)
SG (1) SG171752A1 (OSRAM)
TW (1) TW201023897A (OSRAM)
WO (1) WO2010059534A2 (OSRAM)

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KR101298788B1 (ko) * 2011-03-15 2013-08-22 보령제약 주식회사 안정성이 개선된 복합제제
IN2014DN09313A (OSRAM) * 2012-04-27 2015-07-10 Japan Corn Starch Co Ltd
WO2014159609A1 (en) 2013-03-14 2014-10-02 Allergen Research Corporation Peanut formulations and uses thereof
EP2968529B1 (en) 2013-03-14 2020-08-05 Aimmune Therapeutics, Inc. Manufacture of peanut formulations for oral desensitization
WO2015187736A1 (en) * 2014-06-02 2015-12-10 Allergen Research Corporation Placebo formulations and uses thereof
CN104189915B (zh) * 2014-07-30 2016-08-10 上海新亚药业闵行有限公司 一种固体制剂预混剂及其制备方法
CN104258411A (zh) * 2014-09-19 2015-01-07 安徽山河药用辅料股份有限公司 一种硅化微晶纤维素复合辅料及其制备方法
CN106265077A (zh) * 2015-05-30 2017-01-04 天士力制药集团股份有限公司 一种中药浸膏雾化分散工艺及其制剂
JP6650750B2 (ja) * 2015-12-22 2020-02-19 アサヒグループ食品株式会社 錠剤の製造方法、錠剤原料用顆粒の製造方法、及び錠剤原料用顆粒
EP3836801A4 (en) 2018-08-16 2022-05-18 Société des Produits Nestlé S.A. Peanut oral immunotherapy with maintenance dose
AU2019401214B2 (en) 2018-12-20 2025-09-04 Société des Produits Nestlé S.A. Peanut oral immunotherapy dosing schedule for missed doses
US11229673B2 (en) 2019-05-10 2022-01-25 Société des Produits Nestlé S.A. Methods for improving the quality of life of a patient with a peanut allergy
US11957165B2 (en) 2019-07-05 2024-04-16 Swedish Match North Europe Ab Oral pouched nicotine product including a filling material comprising nicotine-containing particles
PL4061155T3 (pl) 2019-11-20 2024-01-29 Swedish Match North Europe Ab Doustny produkt nikotynowy w saszetce, zawierający materiał wypełniający zawierający cząstki nikotyny
EP4018848B1 (en) 2020-12-22 2024-09-18 Swedish Match North Europe AB A pouched product for oral use comprising a liquid permeable cover material and a filling material
CN116036291B (zh) * 2022-08-31 2025-08-26 瑞普（天津）生物药业有限公司 一种具有增溶作用的组合物及其制备方法与应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3505433A1 (de) * 1985-02-16 1986-08-21 Basf Ag, 6700 Ludwigshafen Direkttablettierhilfsmittel
BR9206996A (pt) * 1991-12-30 1995-12-05 Fmc Corp Composição adequada para preparar esferóides por esferoidização processo para produzir um material em partículas processo para produzir uma forma de dosagem de sólido esferoidizado em partículas e forma de dosagem sólida
US5686107A (en) * 1995-01-30 1997-11-11 Fmc Corporation Chewable pharmaceutical tablets
DE19628617A1 (de) * 1996-07-16 1998-01-22 Basf Ag Direkttablettierhilfsmittel
EP1070740B1 (de) * 1999-07-19 2008-01-02 fit GmbH Coprozessiertes Polysaccharidprodukt mit unlöslicher Carboxymethylcellulose
TWI290471B (en) * 2000-11-06 2007-12-01 Asahi Kasei Corp Cellulosic particles for pharmaceutical preparations
NZ528047A (en) * 2001-02-05 2006-03-31 Scherer Technologies Inc R P Methods and compositions for masking the taste of pharmaceutically active agents
CN103479582A (zh) * 2005-02-03 2014-01-01 武田奈科明有限公司 制备含钙组合物的快速湿聚结方法
WO2008020990A1 (en) * 2006-08-09 2008-02-21 Mallinckrodt Baker, Inc. New direct compressible excipient blend
EP2076249A2 (en) * 2006-10-27 2009-07-08 FMC Corporation Dry granulation binders, products, and use thereof
MY164765A (en) * 2007-10-10 2018-01-30 Avantor Performance Mat Llc Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof

Also Published As

Publication number Publication date
SG171752A1 (en) 2011-07-28
JP2012509329A (ja) 2012-04-19
WO2010059534A3 (en) 2011-01-20
AU2009316812A1 (en) 2011-07-07
US20110288146A1 (en) 2011-11-24
KR20110089180A (ko) 2011-08-04
MX2011005168A (es) 2011-05-30
BRPI0921507A2 (pt) 2016-01-19
WO2010059534A2 (en) 2010-05-27
EP2376067A2 (en) 2011-10-19
CA2744142A1 (en) 2010-05-27
IL212955A0 (en) 2011-07-31
CN102215825A (zh) 2011-10-12

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