KR20110089180A - 직접 압축가능한 과립상 미세결정질 셀룰로스 기재 부형제, 그의 제조 방법 및 용도 - Google Patents

직접 압축가능한 과립상 미세결정질 셀룰로스 기재 부형제, 그의 제조 방법 및 용도 Download PDF

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Publication number
KR20110089180A
KR20110089180A KR1020117013939A KR20117013939A KR20110089180A KR 20110089180 A KR20110089180 A KR 20110089180A KR 1020117013939 A KR1020117013939 A KR 1020117013939A KR 20117013939 A KR20117013939 A KR 20117013939A KR 20110089180 A KR20110089180 A KR 20110089180A
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KR
South Korea
Prior art keywords
binder
microcrystalline cellulose
slurry
excipient
disintegrant
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020117013939A
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English (en)
Korean (ko)
Inventor
난두 데오르카르
제임스 파리나
릴리아나 미니아
사미어 란디브
Original Assignee
아반토르 퍼포먼스 머티리얼스, 인크.
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Publication of KR20110089180A publication Critical patent/KR20110089180A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
KR1020117013939A 2008-11-19 2009-11-16 직접 압축가능한 과립상 미세결정질 셀룰로스 기재 부형제, 그의 제조 방법 및 용도 Ceased KR20110089180A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11602508P 2008-11-19 2008-11-19
US61/116,025 2008-11-19

Publications (1)

Publication Number Publication Date
KR20110089180A true KR20110089180A (ko) 2011-08-04

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ID=42077071

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117013939A Ceased KR20110089180A (ko) 2008-11-19 2009-11-16 직접 압축가능한 과립상 미세결정질 셀룰로스 기재 부형제, 그의 제조 방법 및 용도

Country Status (13)

Country Link
US (1) US20110288146A1 (OSRAM)
EP (1) EP2376067A2 (OSRAM)
JP (1) JP2012509329A (OSRAM)
KR (1) KR20110089180A (OSRAM)
CN (1) CN102215825A (OSRAM)
AU (1) AU2009316812A1 (OSRAM)
BR (1) BRPI0921507A2 (OSRAM)
CA (1) CA2744142A1 (OSRAM)
IL (1) IL212955A0 (OSRAM)
MX (1) MX2011005168A (OSRAM)
SG (1) SG171752A1 (OSRAM)
TW (1) TW201023897A (OSRAM)
WO (1) WO2010059534A2 (OSRAM)

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KR101298788B1 (ko) * 2011-03-15 2013-08-22 보령제약 주식회사 안정성이 개선된 복합제제
JP5879668B2 (ja) * 2012-04-27 2016-03-08 日本コーンスターチ株式会社 澱粉顆粒の製造方法および口腔内崩壊錠
US9492535B2 (en) 2013-03-14 2016-11-15 Aimmune Therapeutics, Inc. Peanut formulations and uses thereof
ES2940686T3 (es) 2013-03-14 2023-05-10 Nestle Sa Fabricación de formulaciones de cacahuete para la desensibilización oral
WO2015187736A1 (en) * 2014-06-02 2015-12-10 Allergen Research Corporation Placebo formulations and uses thereof
CN104189915B (zh) * 2014-07-30 2016-08-10 上海新亚药业闵行有限公司 一种固体制剂预混剂及其制备方法
CN104258411A (zh) * 2014-09-19 2015-01-07 安徽山河药用辅料股份有限公司 一种硅化微晶纤维素复合辅料及其制备方法
CN106265077A (zh) * 2015-05-30 2017-01-04 天士力制药集团股份有限公司 一种中药浸膏雾化分散工艺及其制剂
JP6650750B2 (ja) * 2015-12-22 2020-02-19 アサヒグループ食品株式会社 錠剤の製造方法、錠剤原料用顆粒の製造方法、及び錠剤原料用顆粒
WO2020037151A1 (en) 2018-08-16 2020-02-20 Aimmune Therapeutics, Inc. Peanut oral immunotherapy with maintenance dose
JP2022514645A (ja) 2018-12-20 2022-02-14 アイミューン セラピューティクス，インコーポレイテッド ピーナツ経口免疫療法において投与が欠落した場合の投与スケジュール
EP3965815A4 (en) 2019-05-10 2023-05-31 Société des Produits Nestlé S.A. METHOD OF IMPROVING THE QUALITY OF LIFE IN A PEANUT ALLERGY PATIENT
PH12021553026A1 (en) 2019-07-05 2023-08-23 Swedish Match North Europe Ab An oral pouched nicotine product including a filling material comprising nicotine-containing particles
PL4061155T3 (pl) 2019-11-20 2024-01-29 Swedish Match North Europe Ab Doustny produkt nikotynowy w saszetce, zawierający materiał wypełniający zawierający cząstki nikotyny
PL4018848T3 (pl) 2020-12-22 2024-11-25 Swedish Match North Europe Ab Wyrób w saszetkach do użytku doustnego zawierający materiał pokrywający przepuszczalny dla cieczy oraz materiał wypełniający
CN116036291B (zh) * 2022-08-31 2025-08-26 瑞普（天津）生物药业有限公司 一种具有增溶作用的组合物及其制备方法与应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3505433A1 (de) * 1985-02-16 1986-08-21 Basf Ag, 6700 Ludwigshafen Direkttablettierhilfsmittel
BR9206996A (pt) * 1991-12-30 1995-12-05 Fmc Corp Composição adequada para preparar esferóides por esferoidização processo para produzir um material em partículas processo para produzir uma forma de dosagem de sólido esferoidizado em partículas e forma de dosagem sólida
US5686107A (en) * 1995-01-30 1997-11-11 Fmc Corporation Chewable pharmaceutical tablets
DE19628617A1 (de) * 1996-07-16 1998-01-22 Basf Ag Direkttablettierhilfsmittel
EP1070740B1 (de) * 1999-07-19 2008-01-02 fit GmbH Coprozessiertes Polysaccharidprodukt mit unlöslicher Carboxymethylcellulose
WO2002036168A1 (en) * 2000-11-06 2002-05-10 Asahi Kasei Kabushiki Kaisha Cellulosic particle for pharmaceutical preparation
AU2002242084B2 (en) * 2001-02-05 2006-11-16 R.P. Scherer Technologies, Inc. Methods and compositions for reducing the taste of pharmaceutically active agents
US8808735B2 (en) * 2005-02-03 2014-08-19 Takeda Nycomed As Fast wet-massing method for the preparation of calcium-containing compositions
WO2008020990A1 (en) * 2006-08-09 2008-02-21 Mallinckrodt Baker, Inc. New direct compressible excipient blend
US7998505B2 (en) * 2006-10-27 2011-08-16 Fmc Corporation Dry granulation binders, products, and use thereof
SG185257A1 (en) * 2007-10-10 2012-11-29 Avantor Performance Mat Inc Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof

Also Published As

Publication number Publication date
CN102215825A (zh) 2011-10-12
US20110288146A1 (en) 2011-11-24
CA2744142A1 (en) 2010-05-27
WO2010059534A2 (en) 2010-05-27
AU2009316812A1 (en) 2011-07-07
BRPI0921507A2 (pt) 2016-01-19
MX2011005168A (es) 2011-05-30
SG171752A1 (en) 2011-07-28
EP2376067A2 (en) 2011-10-19
IL212955A0 (en) 2011-07-31
JP2012509329A (ja) 2012-04-19
TW201023897A (en) 2010-07-01
WO2010059534A3 (en) 2011-01-20

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