CN102123727B - 用于治疗β-淀粉样变的化合物 - Google Patents

用于治疗β-淀粉样变的化合物 Download PDF

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Publication number
CN102123727B
CN102123727B CN200980131375.9A CN200980131375A CN102123727B CN 102123727 B CN102123727 B CN 102123727B CN 200980131375 A CN200980131375 A CN 200980131375A CN 102123727 B CN102123727 B CN 102123727B
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CN
China
Prior art keywords
peptide
mimic epitope
amyloid
antibody
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200980131375.9A
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English (en)
Chinese (zh)
Other versions
CN102123727A (zh
Inventor
马库斯·曼德勒
克里斯琴·吉弗斯
弗兰克·马特纳
安德烈亚·多利希卡
奥莱克桑德尔·奥塔瓦
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Affiris AG
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Affiris AG
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Publication of CN102123727A publication Critical patent/CN102123727A/zh
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Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
CN200980131375.9A 2008-06-12 2009-06-12 用于治疗β-淀粉样变的化合物 Expired - Fee Related CN102123727B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ATA951/2008 2008-06-12
AT0095108A AT506819B1 (de) 2008-06-12 2008-06-12 Vakzin zur behandlung von alzheimer-krankheit
PCT/AT2009/000236 WO2009149486A2 (en) 2008-06-12 2009-06-12 Compounds for treating diseases

Publications (2)

Publication Number Publication Date
CN102123727A CN102123727A (zh) 2011-07-13
CN102123727B true CN102123727B (zh) 2015-06-10

Family

ID=41401982

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980131375.9A Expired - Fee Related CN102123727B (zh) 2008-06-12 2009-06-12 用于治疗β-淀粉样变的化合物

Country Status (22)

Country Link
US (2) US8613931B2 (de)
EP (1) EP2310034B9 (de)
JP (2) JP2011522841A (de)
KR (1) KR20110036808A (de)
CN (1) CN102123727B (de)
AT (3) AT506819B1 (de)
AU (1) AU2009257169B2 (de)
BR (1) BRPI0915137A2 (de)
CA (1) CA2723991A1 (de)
CY (1) CY1115316T1 (de)
DK (1) DK2310034T3 (de)
ES (1) ES2461492T3 (de)
HK (1) HK1152470A1 (de)
HR (1) HRP20140586T1 (de)
IL (1) IL209895A (de)
MX (1) MX2010013648A (de)
PL (1) PL2310034T3 (de)
PT (1) PT2310034E (de)
RS (1) RS53236B (de)
RU (1) RU2553345C2 (de)
SI (1) SI2310034T1 (de)
WO (1) WO2009149486A2 (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8795664B2 (en) 2010-06-04 2014-08-05 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Monoclonal antibodies targeting amyloid beta oligomers
US20120321694A1 (en) * 2010-10-27 2012-12-20 Daniel Larocque Compositions and uses
WO2012172427A2 (en) * 2011-06-14 2012-12-20 National Taiwan University Peptide compounds for inhibition of platelet aggregation
GB201113570D0 (en) 2011-08-05 2011-09-21 Glaxosmithkline Biolog Sa Vaccine
ES2496341T3 (es) 2011-10-04 2014-09-18 Affiris Ag Procedimiento para detectar anticuerpos Aß-específicos en una muestra biológica
EP2659908A1 (de) * 2012-05-01 2013-11-06 Affiris AG Zusammensetzungen
EP2787347A1 (de) 2013-04-03 2014-10-08 Affiris AG Verfahren zur Erkennung von Aß-spezifischen Antikörpern in einer biologischen Probe
WO2015165961A1 (en) 2014-04-29 2015-11-05 Affiris Ag Treatment and prevention of alzheimer's disease (ad)
ES2953381T3 (es) * 2014-04-29 2023-11-13 Advantage Therapeutics Inc Tratamiento y prevención de la enfermedad de Alzheimer (AD)
WO2015165968A1 (en) 2014-04-29 2015-11-05 Affiris Ag Treatment and prevention of alzheimer's disease (ad)
WO2015175769A1 (en) 2014-05-15 2015-11-19 Biogen Ma Inc. Methods for the detection of amyloid beta oligomers in biological samples
WO2017079835A1 (en) * 2015-11-09 2017-05-18 The University Of British Columbia Amyloid beta epitopes and antibodies thereto
EP3374379A4 (de) * 2015-11-09 2019-05-15 The University Of British Columbia N-terminale epitope in amyloid-beta und konformationsselektive antikörper dagegen
US10774120B2 (en) * 2015-11-09 2020-09-15 The University Of British Columbia Anti-amyloid beta antibodies binding to a cyclic amyloid beta peptide
ES2571055B1 (es) * 2016-02-15 2016-12-28 Araclon Biotech, S.L. Conjugado amiloide y usos y procedimientos del mismo
KR102554448B1 (ko) * 2016-06-29 2023-07-11 더 리전츠 오브 더 유니버시티 오브 캘리포니아 알파-시누클레인 응집의 구조-기반 펩타이드 저해제
US20180125920A1 (en) 2016-11-09 2018-05-10 The University Of British Columbia Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions
CN109985231A (zh) * 2018-01-02 2019-07-09 上海清流生物医药科技有限公司 一种蛋白在制备预防和治疗痴呆症的药物中的应用
IL301223A (en) * 2020-09-17 2023-05-01 Othair Prothena Ltd Beta-amyloid vaccine for the treatment of Alzheimer's disease
CN112608926A (zh) * 2020-12-08 2021-04-06 安徽大千生物工程有限公司 一种用于检测β淀粉样蛋白的基因序列组、杂交瘤细胞组及胶乳增强免疫比浊法试剂盒
CN113061161B (zh) * 2021-04-02 2023-09-12 河南省农业科学院动物免疫学重点实验室 靶向amyloid-beta结构的抑制性肽配基及应用
WO2023161528A1 (en) 2022-02-28 2023-08-31 Tridem Bioscience Gmbh & Co Kg A CONJUGATE COMPRISING AT LEAST A ß-GLUCAN

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Publication number Priority date Publication date Assignee Title
US7964192B1 (en) * 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US20110131679A2 (en) * 2000-04-19 2011-06-02 Thomas La Rosa Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
RU2294211C2 (ru) * 2001-01-19 2007-02-27 Цитос Байотекнолоджи Аг Композиция и способ для иммунизации, способ продуцирования неприродного, упорядоченного и повторяющегося массива антигенов
US20040265849A1 (en) 2002-11-22 2004-12-30 Applera Corporation Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof
AT413945B (de) * 2003-01-14 2006-07-15 Mattner Frank Dr Impfstoff für die alzheimer-krankheit
US7358331B2 (en) * 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
WO2005023985A2 (en) * 2003-09-03 2005-03-17 University Of Rochester Cytidine deaminase activators, deoxycytidine deaminase activators, vif antagonists, and methods of screening for molecules thereof
US20050176030A1 (en) 2003-10-28 2005-08-11 Li Gan Regulated nucleic acids in pathogenesis of Alzheimer's Disease
AT413946B (de) * 2004-07-13 2006-07-15 Mattner Frank Dr Impfstoff gegen die alzheimer-krankheit
AT500483B1 (de) * 2004-07-13 2006-01-15 Mattner Frank Dr Set zur vorbeugung oder behandlung der alzheimer'schen erkrankung
GB0421639D0 (en) 2004-09-29 2004-10-27 Proteome Sciences Plc Methods and compositions relating to alzheimer's disease
CA2584859C (en) 2004-10-25 2017-11-07 Merck & Co., Inc. Anti-addl antibodies and uses thereof
EP2397852B1 (de) * 2006-03-14 2013-12-04 Oregon Health and Science University Methoden zur Detektion einer Mycobakterium tuberculosis Infektion
WO2008002893A2 (en) 2006-06-29 2008-01-03 Centocor, Inc. Anti-amyloid antibodies, compositions, methods and uses
US20120017338A1 (en) * 2008-01-15 2012-01-19 Wei Wu Isolated novel nucleic acid and protein molecules from corn and methods of using those molecules to generate transgenic plant with enhanced agronomic traits

Also Published As

Publication number Publication date
AT506819A1 (de) 2009-12-15
JP2015147771A (ja) 2015-08-20
HRP20140586T1 (hr) 2014-09-12
WO2009149486A2 (en) 2009-12-17
CA2723991A1 (en) 2009-12-17
AU2009257169B2 (en) 2015-06-25
RS53236B (en) 2014-08-29
AT509105A1 (de) 2011-06-15
EP2310034A2 (de) 2011-04-20
US20110097351A1 (en) 2011-04-28
DK2310034T3 (da) 2014-04-28
JP2011522841A (ja) 2011-08-04
AT506819B1 (de) 2011-06-15
KR20110036808A (ko) 2011-04-11
AU2009257169A1 (en) 2009-12-17
AT509106B1 (de) 2011-12-15
MX2010013648A (es) 2011-04-05
JP6041917B2 (ja) 2016-12-14
RU2011100126A (ru) 2012-07-20
RU2553345C2 (ru) 2015-06-10
CN102123727A (zh) 2011-07-13
PL2310034T3 (pl) 2014-08-29
IL209895A0 (en) 2011-02-28
US8613931B2 (en) 2013-12-24
IL209895A (en) 2015-09-24
SI2310034T1 (sl) 2014-05-30
AT509105B1 (de) 2011-12-15
WO2009149486A3 (en) 2010-06-10
PT2310034E (pt) 2014-06-05
BRPI0915137A2 (pt) 2016-02-16
EP2310034B1 (de) 2014-03-26
HK1152470A1 (en) 2012-03-02
EP2310034B9 (de) 2014-12-17
ES2461492T3 (es) 2014-05-20
US20130230545A1 (en) 2013-09-05
CY1115316T1 (el) 2017-01-04
AT509106A1 (de) 2011-06-15

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Granted publication date: 20150610

Termination date: 20190612