CN102123699A - 降低血小板循环水平的药剂的控释组合物及其制备方法 - Google Patents

降低血小板循环水平的药剂的控释组合物及其制备方法 Download PDF

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CN102123699A
CN102123699A CN2009801319416A CN200980131941A CN102123699A CN 102123699 A CN102123699 A CN 102123699A CN 2009801319416 A CN2009801319416 A CN 2009801319416A CN 200980131941 A CN200980131941 A CN 200980131941A CN 102123699 A CN102123699 A CN 102123699A
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platelet
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P·F·格利登
A·J·皮尔格林
S·R·汉森
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BioVascular Inc
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BioVascular Inc
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109806250A (zh) * 2019-01-23 2019-05-28 吉林大学 一种含羟基脲的药物组合物的应用
CN112135603A (zh) * 2018-03-02 2020-12-25 诺瓦利克有限责任公司 包含奈必洛尔的药物组合物
CN114302712A (zh) * 2019-09-04 2022-04-08 鲁南贝特制药有限公司 一种阿昔莫司多单元缓释微丸片及其制备方法
CN115279346A (zh) * 2020-03-09 2022-11-01 苏什玛·保罗·伯利亚 包含屈他维林或其盐的控制释放制剂

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1216037A2 (en) * 1999-09-21 2002-06-26 Emory University Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents
UA96457C2 (ru) 2006-08-03 2011-11-10 Нитек Фарма Аг Лечение ревматоидного артрита глюкокортикоидами с отсроченным высвобождением
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
GB2460915B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
US20100034959A1 (en) * 2008-08-07 2010-02-11 Vector Corporation High solids, high molecular weight polymer coating
KR101193493B1 (ko) * 2010-02-02 2012-10-22 한미사이언스 주식회사 소수성 첨가제가 함유된 분리막으로 코팅된 아스피린 및 HMG?CoA 환원효소 억제제를 포함하는 복합제제
EP2533730A1 (en) * 2010-02-10 2012-12-19 Apertomed, L.L.C. Methods, systems and devices for treatment of cerebrospinal venous insufficiency and multiple sclerosis
AU2011231557B2 (en) * 2010-03-25 2016-05-26 Aop Orphan Pharmaceuticals Ag Novel composition for treatment of essential thrombocythemia
EP2598044B1 (en) 2010-07-27 2019-03-13 Incept, LLC Apparatus for treating neurovascular venous outflow obstruction
TR201007508A1 (tr) * 2010-09-14 2012-04-24 Sanovel İlaç San. Ve Ti̇c. A.Ş. Oral yolla dağılan bileşimler
EP2481411A1 (en) * 2011-01-27 2012-08-01 Ratiopharm GmbH Oral dosage forms for modified release comprising the JAK3 inhibitor tasocitinib
KR101446949B1 (ko) * 2011-10-13 2014-10-06 도쿠슈 도카이 세이시 가부시키가이샤 미다공막 및 그 제조 방법
JP5445885B2 (ja) * 2011-10-13 2014-03-19 特種東海製紙株式会社 電気化学素子用セパレータ及びその製造方法
BR112013018607A2 (pt) 2011-10-13 2016-10-18 Tokushu Tokai Paper Co Ltd membrana porosa, separador para um dispositivo eletroquímico, dispositivo eletroquímico, e, processo para preparar a membrana porosa
CN103958582B (zh) * 2011-10-13 2016-04-06 特种东海制纸株式会社 微多孔膜及其制造方法
US20130149383A1 (en) * 2011-12-12 2013-06-13 Cory Berkland Sustained release particle formulations of guaifenesin
CN110496108A (zh) 2011-12-14 2019-11-26 Lts勒曼治疗系统股份公司 用于非诺贝特的具有提高的溶出度的糯米纸囊制剂和胶囊制剂
CN103211785B (zh) * 2012-01-18 2017-06-27 北京天衡药物研究院有限公司 阿昔莫司膜控缓释微丸胶囊
ES2549106T3 (es) * 2014-03-07 2021-12-21 Galenicum Health S L U Composiciones farmacéuticas que comprenden anagrelida
ES2668379T3 (es) 2014-07-09 2018-05-17 Pierre Fabre Médicament Método para el tratamiento de trastornos del movimiento con befiradol
US10022377B2 (en) * 2015-12-02 2018-07-17 Cipla Limited Method of treating hypertension
SG11201804776SA (en) * 2015-12-08 2018-07-30 Biomatrica Inc Reduction of erythrocyte sedimentation rate
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
EP3823725A4 (en) * 2018-07-17 2023-05-10 Aronora, Inc. METHODS FOR SAFELY REDUCING THROMBOPOIETIN
US11524029B2 (en) 2018-08-13 2022-12-13 Viscera Labs, Inc. Therapeutic composition and methods
US11590161B2 (en) 2018-08-13 2023-02-28 Viscera Labs, Inc. Therapeutic composition and methods
JP7490813B2 (ja) * 2020-04-22 2024-05-27 ユンジン ファーム.カンパニー、リミテッド 安全性と安定性が改善されたピルフェニドンを含む腸溶性製剤およびその製造方法
CN112089883B (zh) * 2020-09-14 2022-01-04 海南希睿达生物技术有限公司 一种医用冷敷敷料及其制备方法
CN116981447A (zh) * 2021-03-09 2023-10-31 恩赛斯生物科学股份有限公司 奈莫司他的修饰释放组合物及其使用方法
US12599578B2 (en) 2021-03-09 2026-04-14 Ensysce Biosciences Inc. Compositions comprising enzyme-cleavable prodrugs and controlled release nafamostat and methods of use thereof

Family Cites Families (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US31617A (en) * 1861-03-05 photo-uthcqfupheh
US587224A (en) * 1894-10-10 1897-07-27 Stewart Dixon Mckelvey Head-rest pad
US3065143A (en) * 1960-04-19 1962-11-20 Richardson Merrell Inc Sustained release tablet
US3427378A (en) * 1965-02-12 1969-02-11 American Cyanamid Co Sustained release encapsulated formula
GB1093286A (en) * 1965-02-15 1967-11-29 Biorex Laboratories Ltd Improvements in or relating to dosage unit forms for the administration of medicaments and diagnostic agents
US3555151A (en) * 1966-12-21 1971-01-12 Richardson Merrell Inc Long acting solid antacid
US3458622A (en) * 1967-04-07 1969-07-29 Squibb & Sons Inc Controlled release tablet
US3574820A (en) * 1968-01-08 1971-04-13 Upjohn Co Medicinal dosage forms of unpolymerized thiolated gelatin with a cross-linking accelerating agent providing slowly released medication from a swollen matrix
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
USRE31617E (en) * 1972-02-04 1984-06-26 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
US4302386A (en) * 1978-08-25 1981-11-24 The Ohio State University Antigenic modification of polypeptides
JPS5512411B2 (https=) * 1974-03-12 1980-04-02
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4140755A (en) * 1976-02-13 1979-02-20 Hoffmann-La Roche Inc. Sustained release tablet formulations
US4123403A (en) * 1977-06-27 1978-10-31 The Dow Chemical Company Continuous process for preparing aqueous polymer microsuspensions
US4146718A (en) * 1978-04-10 1979-03-27 Bristol-Myers Company Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides
US4208521A (en) * 1978-07-31 1980-06-17 Bristol-Myers Company Process for the preparation of imidazo[2,1-b]quinazolinones
US4316906A (en) * 1978-08-11 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of substituted prolines
US4173626A (en) * 1978-12-11 1979-11-06 Merck & Co., Inc. Sustained release indomethacin
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4258030A (en) * 1979-03-07 1981-03-24 Zeria-Shinyaku Kogyo Kabushiki Kaisha Urokinase preparation for oral administration
US4309404A (en) * 1979-08-09 1982-01-05 American Home Products Corporation Sustained release pharmaceutical compositions
US4309405A (en) * 1979-08-09 1982-01-05 American Home Products Corporation Sustained release pharmaceutical compositions
US4248857A (en) * 1979-08-09 1981-02-03 American Home Products Corporation Sustained release pharmaceutical compositions
US4252786A (en) * 1979-11-16 1981-02-24 E. R. Squibb & Sons, Inc. Controlled release tablet
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
US4259314A (en) * 1979-12-10 1981-03-31 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4444777A (en) 1981-07-30 1984-04-24 Bristol-Myers Company Pharmaceutical compositions of anagrelide and sulfinpyrazone
US4357330A (en) * 1981-07-30 1982-11-02 Bristol-Myers Company Pharmaceutical compositions
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4614517A (en) * 1982-08-04 1986-09-30 La Jolla Cancer Research Foundation Tetrapeptide
US4452775A (en) 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
US4502888A (en) * 1982-12-13 1985-03-05 The Dow Chemical Company Aqueous dispersions of plasticized polymer particles
JPS6092299A (ja) * 1983-10-25 1985-05-23 Sanwa Kosan Kk 粉末マルト−スの製造法
US4568676A (en) 1983-11-25 1986-02-04 Thomas Jefferson University Method of inhibiting aggregation using thromboxane synthetase inhibitor in combination with a cyclic AMP phosphodiesterase inhibitor
KR920003400B1 (ko) * 1983-12-29 1992-04-30 가부시기가이샤 히다찌세이사꾸쇼 금속과 수지와의 복합체 및 그 제조방법
US4780401A (en) 1984-04-09 1988-10-25 Ciba-Geigy Corporation Novel monoclonal antibodies to human renin and hybridoma cells, processes for their preparation and their applications
US4661471A (en) * 1984-04-10 1987-04-28 New England Deaconess Hospital Method of inhibiting and inducing human platelet aggregation
AU576047B2 (en) * 1985-01-14 1988-08-11 Shiseido Company Ltd. Fibrinophilic urokinase complex and process for its preparation
IT1191674B (it) * 1986-03-07 1988-03-23 Eurand Spa Formulazioni per la preparazione di farmaci a rilascio prolungato adatte alla somministrazione per via orale
US4816463A (en) * 1986-04-01 1989-03-28 Warner-Lambert Company Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity
US4756911A (en) * 1986-04-16 1988-07-12 E. R. Squibb & Sons, Inc. Controlled release formulation
US5098840A (en) * 1986-07-03 1992-03-24 The Green Cross Corporation Human prourokinase mutants
CA1334092C (en) 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US4772684A (en) * 1987-01-20 1988-09-20 Triton Biosciences, Inc. Peptides affecting blood pressure regulation
US5033252A (en) * 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5052558A (en) * 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5081127A (en) * 1988-01-07 1992-01-14 E. I. Du Pont De Nemours And Company Substituted 1,2,3-triazole angiotensin II antagonists
US5446070A (en) 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5185323A (en) * 1988-03-31 1993-02-09 Temple University Suppression of megakaryocytopoiesis employing platelet factor 4 antimaturation factor
JPH0788352B2 (ja) * 1988-06-16 1995-09-27 エスエス製薬株式会社 ヒドロキシアルキルシステイン誘導体およびこれを含有する去痰剤
US4847276A (en) * 1988-09-06 1989-07-11 Merrell Dow Pharmaceuticals Inc. Treatment of thromobocytosis with 5-(4-chlorophenyl)-2,4-diemthyl-3H-1,2,4-triazole-3-thione
GB8903328D0 (en) * 1989-02-14 1989-04-05 Ethical Pharma Ltd Nifedipine-containing pharmaceutical compositions and process for the preparation thereof
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
US5686570A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
US5091187A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
US5085992A (en) * 1990-07-19 1992-02-04 Merck & Co., Inc. Microbial transformation process for antihypertensive products
US5087634A (en) * 1990-10-31 1992-02-11 G. D. Searle & Co. N-substituted imidazol-2-one compounds for treatment of circulatory disorders
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
WO1993009794A1 (en) * 1991-11-15 1993-05-27 University Of Pennsylvania Suppression of megakaryocytopoiesis by neutrophil activating peptide-2
US5306709A (en) * 1991-11-15 1994-04-26 The University Of Pennsylvania Suppression of megakaryocytopoiesis by macrophage inflammatory proteins
US5323907A (en) * 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
US5302401A (en) * 1992-12-09 1994-04-12 Sterling Winthrop Inc. Method to reduce particle size growth during lyophilization
US5336507A (en) * 1992-12-11 1994-08-09 Sterling Winthrop Inc. Use of charged phospholipids to reduce nanoparticle aggregation
US5604260A (en) * 1992-12-11 1997-02-18 Merck Frosst Canada Inc. 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
SE9301057L (sv) * 1993-03-30 1994-10-01 Pharmacia Ab Beredning med kontrollerad frisättning
US5342626A (en) * 1993-04-27 1994-08-30 Merck & Co., Inc. Composition and process for gelatin-free soft capsules
GB9602877D0 (en) * 1996-02-13 1996-04-10 Merck Frosst Canada Inc 3,4-Diaryl-2-hydroxy-2,5- dihydrofurans as prodrugs to cox-2 inhibitors
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
HUT74986A (en) 1994-01-10 1997-03-28 Merck Frosst Canada Inc Phenyl heterocycles as cox-2 inhibitors, pharmaceutical preparations containing them, and use of them
US5521213A (en) * 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
JPH10507765A (ja) * 1994-10-27 1998-07-28 メルク フロスト カナダ インコーポレーテツド シクロオキシゲナーゼ−2阻害剤として有用なスチルベン誘導体
US5660854A (en) * 1994-11-28 1997-08-26 Haynes; Duncan H Drug releasing surgical implant or dressing material
US5552422A (en) * 1995-01-11 1996-09-03 Merck Frosst Canada, Inc. Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents
US7070972B1 (en) * 1995-01-13 2006-07-04 The United States Of America As Represented By The Department Of Health And Human Services Janus family kinases and identification of immune modulators
US5871776A (en) * 1995-01-31 1999-02-16 Mehta; Atul M. Controlled-release nifedipine
IL112834A (en) * 1995-03-01 2000-12-06 Yeda Res & Dev Pharmaceutical compositions for controlled release of soluble receptors
US5612053A (en) * 1995-04-07 1997-03-18 Edward Mendell Co., Inc. Controlled release insufflation carrier for medicaments
US5691374A (en) * 1995-05-18 1997-11-25 Merck Frosst Canada Inc. Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors
US5604253A (en) * 1995-05-22 1997-02-18 Merck Frosst Canada, Inc. N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors
US5639780A (en) * 1995-05-22 1997-06-17 Merck Frosst Canada, Inc. N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors
US5643933A (en) * 1995-06-02 1997-07-01 G. D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
SE9502244D0 (sv) * 1995-06-20 1995-06-20 Bioglan Ab A composition and a process for the preparation thereof
US5877224A (en) * 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
JP3693270B2 (ja) 1995-10-12 2005-09-07 旭化成ケミカルズ株式会社 フィルムコーティング顆粒およびその製造方法
CA2171073A1 (en) * 1995-12-04 1997-06-05 Philip C. Lang Process for the preparation of ethyl-n-(2,3 dichloro-6- nitrobenzyl) glycine
US5733909A (en) * 1996-02-01 1998-03-31 Merck Frosst Canada, Inc. Diphenyl stilbenes as prodrugs to COX-2 inhibitors
US5789413A (en) * 1996-02-01 1998-08-04 Merck Frosst Canada, Inc. Alkylated styrenes as prodrugs to COX-2 inhibitors
EP0792647A1 (en) 1996-02-27 1997-09-03 Roche Diagnostics GmbH Porphyrins as urokinase-type plasminogen activator receptor antagonists
US5798246A (en) * 1996-03-25 1998-08-25 Incyte Pharmaceuticals, Inc. Cyclic nucleotide phosphodiesterase
GB9607503D0 (en) * 1996-04-11 1996-06-12 Merck Frosst Canada Inc Bisaryl cyclobutenes derivatives as cyclooxygenase inhibitors
US5922742A (en) * 1996-04-23 1999-07-13 Merck Frosst Canada Pyridinyl-2-cyclopenten-1-ones as selective cyclooxygenase-2 inhibitors
US5753702A (en) 1996-05-22 1998-05-19 University Of Vermont Arachidonic acid metabolite, 16-hete
US6451609B1 (en) 1996-05-30 2002-09-17 The Cleveland Clinic Foundation Method of detecting gynecological carcinomas
US5677318A (en) * 1996-07-11 1997-10-14 Merck Frosst Canada, Inc. Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents
US5861419A (en) * 1996-07-18 1999-01-19 Merck Frosst Canad, Inc. Substituted pyridines as selective cyclooxygenase-2 inhibitors
WO1998011896A1 (en) 1996-09-18 1998-03-26 Merck & Co., Inc. Combination therapy for reducing the risks associated with cardiovascular disease
WO1998055643A1 (en) 1997-06-03 1998-12-10 Kureha Chemical Industry Co., Ltd. Human adamts-1 protein, gene coding for the same, pharmaceutical composition, and method for immunologically assaying human adamts-1 protein
KR100343067B1 (ko) * 1997-07-31 2002-07-03 프리돌린 클라우스너, 롤란드 비. 보레르 항종양제 및 항전이제로서 산소-치환된하이드록시쿠마라논 유도체
US6214376B1 (en) * 1998-08-25 2001-04-10 Banner Pharmacaps, Inc. Non-gelatin substitutes for oral delivery capsules, their composition and process of manufacture
US6596298B2 (en) * 1998-09-25 2003-07-22 Warner-Lambert Company Fast dissolving orally comsumable films
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
JP4805461B2 (ja) * 1999-03-18 2011-11-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 血小板接着の阻止用タンパク質
JP3849428B2 (ja) * 1999-04-23 2006-11-22 日本新薬株式会社 微粉化法
EP1216037A2 (en) * 1999-09-21 2002-06-26 Emory University Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents
US20060034937A1 (en) * 1999-11-23 2006-02-16 Mahesh Patel Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6627223B2 (en) * 2000-02-11 2003-09-30 Eurand Pharmaceuticals Ltd. Timed pulsatile drug delivery systems
DE10006286C1 (de) * 2000-02-14 2001-10-18 3M Espe Ag Lichtwellenkonvertervorrichtung und deren Verwendung im Dentalbereich
CA2407027C (en) * 2000-04-20 2011-02-15 Rtp Pharma Inc. Improved water-insoluble drug particle process
KR100392501B1 (ko) * 2000-06-28 2003-07-22 동국제약 주식회사 다중 에멀젼법에 의한 서방출성 미립구의 제조방법
GB2364714A (en) 2000-07-17 2002-02-06 British Sugar Plc Spray-drying a material in the presence of a particulate solid
US6388073B1 (en) * 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
EP1311856A2 (en) * 2000-08-23 2003-05-21 Wilex AG Urokinase peptide structure mimetics
US6287599B1 (en) * 2000-12-20 2001-09-11 Shire Laboratories, Inc. Sustained release pharmaceutical dosage forms with minimized pH dependent dissolution profiles
US6656493B2 (en) 2001-07-30 2003-12-02 Wm. Wrigley Jr. Company Edible film formulations containing maltodextrin
US6669955B2 (en) * 2001-08-28 2003-12-30 Longwood Pharmaceutical Research, Inc. Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin
US6811794B2 (en) * 2001-12-20 2004-11-02 Shire Laboratories, Inc. Sustained release pharmaceutical dosage forms with minimized pH dependent dissolution profiles
KR100481444B1 (ko) * 2002-03-18 2005-04-11 원 호 이 에너지 절약형 조도 조절기
WO2003090723A1 (en) * 2002-04-23 2003-11-06 Bristol-Myers Squibb Company Modified-release vasopeptidase inhibitor formulation, combinations and method
AU2003231777C1 (en) * 2002-04-29 2009-10-29 Supernus Pharmaceuticals, Inc. Pharmaceutical formulations with improved bioavailability
US6735009B2 (en) 2002-07-16 2004-05-11 Motorola, Inc. Electroptic device
JP4133109B2 (ja) * 2002-08-20 2008-08-13 新キャタピラー三菱株式会社 建設機械におけるシャッター式のガード装置
US7241411B2 (en) * 2002-08-23 2007-07-10 Acupac Packaging, Inc. Thin film strips
WO2004049095A2 (en) * 2002-11-25 2004-06-10 Jallal Messadek Betaine and salicylic acid compositions
US20050214372A1 (en) * 2004-03-03 2005-09-29 Simona Di Capua Stable pharmaceutical composition comprising an acid labile drug
KR101194446B1 (ko) * 2004-04-29 2012-10-24 오쓰까 세이야꾸 가부시키가이샤 당단백 vi에 특이적인 항체 및 그의 제조방법
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
FR2891459B1 (fr) * 2005-09-30 2007-12-28 Flamel Technologies Sa Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant
WO2007070843A2 (en) * 2005-12-15 2007-06-21 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for oral administration
KR20080110998A (ko) 2006-01-30 2008-12-22 엑셀리시스, 인코포레이티드 Jak­2 조절자로서 4­아릴­2­아미노­피리미딘 또는 4­아릴­2­아미노알킬­피리미딘 및 이들을 포함하는 약제학적 조성물
GB0623750D0 (en) * 2006-11-28 2007-01-10 Shire Llc Substituted quinazolines
KR100870396B1 (ko) * 2006-12-07 2008-11-25 보령제약 주식회사 심혈관계 질환 치료용 경구투여제제
EP2114380A1 (en) * 2007-01-25 2009-11-11 Panacea Biotec Ltd. Modified release pharmaceutical composition and a process of making the same
AU2008300013A1 (en) 2007-09-07 2009-03-19 Qlt Inc. Drug cores for sustained release of therapeutic agents
GB2460915B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112135603A (zh) * 2018-03-02 2020-12-25 诺瓦利克有限责任公司 包含奈必洛尔的药物组合物
CN112135603B (zh) * 2018-03-02 2024-04-16 诺瓦利克有限责任公司 包含奈必洛尔的药物组合物
CN109806250A (zh) * 2019-01-23 2019-05-28 吉林大学 一种含羟基脲的药物组合物的应用
CN109806250B (zh) * 2019-01-23 2021-09-24 吉林大学 一种含羟基脲的药物组合物的应用
CN114302712A (zh) * 2019-09-04 2022-04-08 鲁南贝特制药有限公司 一种阿昔莫司多单元缓释微丸片及其制备方法
CN114302712B (zh) * 2019-09-04 2023-08-04 鲁南贝特制药有限公司 一种阿昔莫司多单元缓释微丸片及其制备方法
CN115279346A (zh) * 2020-03-09 2022-11-01 苏什玛·保罗·伯利亚 包含屈他维林或其盐的控制释放制剂

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