CN102068586A - Preparation method and application of composite Chinese magnoliavine fruit preparation - Google Patents
Preparation method and application of composite Chinese magnoliavine fruit preparation Download PDFInfo
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- CN102068586A CN102068586A CN2011100093657A CN201110009365A CN102068586A CN 102068586 A CN102068586 A CN 102068586A CN 2011100093657 A CN2011100093657 A CN 2011100093657A CN 201110009365 A CN201110009365 A CN 201110009365A CN 102068586 A CN102068586 A CN 102068586A
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Abstract
The invention belongs to the technical field of research and development of medical products and relates to a preparation method and application of a composite Chinese magnoliavine fruit preparation. The method comprises the following steps of: selecting 6 to 9 grams of high-quality Chinese magnoliavine fruit, 6 to 9 grams of boschniakia rossica, 3 to 6 grams of eucommia bark, 3 to 6 grams of acanthopanax root, 3 to 6 grams of ginseng, 3 to 6 grams of lucid ganoderma, 3 to 6 grams of astragalus, 3 to 6 grams of mushroom, 2 to 4 grams of Indian buead, 2 to 4 grams of agaric, 2 to 4 grams of yam, 2 to 4 grams of hawthorn and 2 to 4 grams of Chinese date; washing; performing microwave drying; smashing into 50-mesh powder; adding water for boiling and extracting for three times; combining extracting solution; filtering to obtain filtrate; condensing the filtrate into extract; uniformly mixing the extract, agar and starch in the ratio of 4:1:16; and pelletizing by using a 10-mesh sieve; drying; sieving by using a 14-mesh sieve so as to obtain the composite Chinese magnoliavine fruit preparation. A product has the effects of promoting the liver function and protein metabolism of fancy carp, and is beneficial to industrial production.
Description
Technical field
Medical product research and development technical field under the present invention.The present invention relates to a kind of preparation method and its usage of compound recipe Fructus Schisandrae Chinensis preparation.Product of the present invention has the Cyprinus carpio L. liver function of promotion and protein metabolism effect, and product of the present invention is beneficial to suitability for industrialized production.
Background technology
Advantage such as that Chinese herbal feed additive has is natural, economic, efficient, noresidue, no Drug resistance and side effect are little, and have the dual function of medical and trophism concurrently, the drawback of no antibiotics and chemicals, be widely used in recent years in the aquaculture of aquatic animal, in order to prevent disease, growth promotion with improve aquatic product quality.Contain the various active composition in the Chinese herbal medicine, the scalable immunity function of animal.Therefore mainly can to improve the animal body immunologic function relevant with it to it is generally acknowledged Chinese herbal medicine prevent disease and growth promoting function.The feed additive of Fish has shortcomings such as easy thawing, poor stability at present, and a part can not be eaten by fish, and utilization rate is low, and waste is serious.Agar (Agar) claims agar again, is the hydrophilic macromolecule polysaccharide that extracts from the Bostrychia montagnei guiding principle, has good gelling and stability, be widely used in aspects such as food, medicine, biological engineering, but the application in the fish feed additive is not reported.Glutamate pyruvate transaminase (GPT), glutamic oxaloacetic transaminase, GOT (GOT) are aminotransferases important in the body protein metabolic process, and the active height of the two has reflected the situation of protein metabolism and liver function in the liver.The transaminase mainly is distributed in the cell under the normal condition, has a large amount of transaminases and be released into blood when liver dysfunction in hepatocyte, makes transaminase activity rising in the serum, and transaminase activity reduces in the hepatocyte simultaneously.Compound recipe Fructus Schisandrae Chinensis preparation can make that transaminase activity generally raises in the Cyprinus carpio L. liver, illustrates that compound recipe Fructus Schisandrae Chinensis preparation does not have hepatotoxicity and the liver function and the protein metabolism of Cyprinus carpio L. had facilitation.
Summary of the invention
1, a kind of preparation method of compound recipe Fructus Schisandrae Chinensis preparation is characterized in that the preparation method of said preparation comprises following process:
Step (one): select high-quality Fructus Schisandrae Chinensis 6g-9g, Herba Boschniakiae Rossicae 6g-9g, Cortex Eucommiae 3g-6g, Radix Et Caulis Acanthopanacis Senticosi 3g-6g, Radix Ginseng 3g-6g, Ganoderma 3g-6g, Radix Astragali 3g-6g, Lentinus Edodes 3g-6g, Poria 2g-4g, Polyporus 2g-4g, Rhizoma Dioscoreae 2g-4g, Fructus Crataegi 2g-4g, Fructus Jujubae 2g-4g and clean, microwave drying, pulverizing are 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times, add 6-8 times of water gaging first and soak 4.0h-6.0h, heated and boiled is extracted 2.0h-3.0h, add for the second time 4 times of water gaging heated and boiled and extract 1.5h-2.0h, add 3 times of water gaging heated and boiled for the third time and extract 1.0h-1.5h, merge extractive liquid, filters, and gets filtrate;
Step (three): the filtrate in the step (two) is condensed into extractum, in extractum: agar: starch=4: 1: 16 ratio mixings, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got compound recipe Fructus Schisandrae Chinensis preparation.
2, the purposes of a kind of compound recipe Fructus Schisandrae Chinensis preparation as claimed in claim 1 is characterised in that it has the Cyprinus carpio L. fish liver function of promotion and protein metabolism effect.
According to the present invention, " % " among the present invention is percentage by weight.
The specific embodiment
The preparation method and its usage that relates to a kind of compound recipe Fructus Schisandrae Chinensis preparation of the present invention comprises following examples, and the following examples can further specify the present invention, but do not limit the present invention in any way.
Embodiment 1:
Step (one): select high-quality Fructus Schisandrae Chinensis 6g, Herba Boschniakiae Rossicae 6g, Cortex Eucommiae 3g, Radix Et Caulis Acanthopanacis Senticosi 3g, Radix Ginseng 3g, Ganoderma 3g, Radix Astragali 3g, Lentinus Edodes 3g, Poria 2g, Polyporus 2g, Rhizoma Dioscoreae 2g, Fructus Crataegi 2g, Fructus Jujubae 2g and clean, microwave drying, pulverizing is 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times, add 6 times of water gagings first and soak 4.0, heated and boiled is extracted 2.0h, add for the second time 4 times of water gaging heated and boiled and extract 1.5h, add 3 times of water gaging heated and boiled for the third time and extract 1.0h, merge extractive liquid,, filter, get filtrate;
Step (three): the filtrate in the step (two) is condensed into extractum, in extractum: agar: starch=4: 1: 16 ratio mixings, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got compound recipe Fructus Schisandrae Chinensis preparation.
Embodiment 2:
Step (one): select high-quality Fructus Schisandrae Chinensis 9g, Herba Boschniakiae Rossicae 9g, Cortex Eucommiae 6g, Radix Et Caulis Acanthopanacis Senticosi 6g, Radix Ginseng 6g, Ganoderma 6g, Radix Astragali 6g, Lentinus Edodes 6g, Poria 4g, Polyporus 4g, Rhizoma Dioscoreae 4g, Fructus Crataegi 4g, Fructus Jujubae 4g and clean, microwave drying, pulverizing is 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times, add 8 times of water gagings first and soak 6.0h, heated and boiled is extracted 3.0h, add for the second time 4 times of water gaging heated and boiled and extract 2.0h, add 3 times of water gaging heated and boiled for the third time and extract 1.5h, merge extractive liquid,, filter, get filtrate;
Step (three): the filtrate in the step (two) is condensed into extractum, in extractum: agar: starch=4: 1: 16 ratio mixings, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got compound recipe Fructus Schisandrae Chinensis preparation.
Pharmacological evaluation
Compound recipe Fructus Schisandrae Chinensis preparation promotes Cyprinus carpio L. liver function and protein metabolism effect experiment
1 materials and methods
1.1 material
1.1.1 compound recipe Fructus Schisandrae Chinensis preparation
Select high-quality Fructus Schisandrae Chinensis 9g, Herba Boschniakiae Rossicae 9g, Cortex Eucommiae 6g, Radix Et Caulis Acanthopanacis Senticosi 6g, Radix Ginseng 6g, Ganoderma 6g, Radix Astragali 6g, Lentinus Edodes 6g, Poria 4g, Polyporus 4g, Rhizoma Dioscoreae 4g, Fructus Crataegi 4g, Fructus Jujubae 4g also cleans, microwave drying, pulverizing is 50 order powder, powder is added water boil to be extracted 3 times, add 8 times of water gagings first and soak 6.0h, heated and boiled is extracted 3.0h, add for the second time 4 times of water gaging heated and boiled and extract 2.0h, add 3 times of water gaging heated and boiled for the third time and extract 1.5h, merge extractive liquid,, filter, filtrate, filtrate is condensed into extractum, in extractum: agar: starch=4: 1: 16 ratio mixings, granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got compound recipe Fructus Schisandrae Chinensis preparation.
1.1.2 experiment feedstuff
By compound recipe Fructus Schisandrae Chinensis preparation: the mixed uniform preparation of normal feedstuff=3: 5 is a compound recipe Fructus Schisandrae Chinensis preparation experiment feedstuff, does blank with normal feedstuff.Experiment normal feedstuff prescription sees Table 1.
Table 1 experiment is filled a prescription with normal feedstuff
1.2 method
1.2.1 experiment is raised with Cyprinus carpio L.
Experiment uses Cyprinus carpio L. Cyprinus carpio L. available from Aquatic product market, Weihai, body weight (41.1 ± 5.0) g, and long (10.27 ± 0.48) cm of body, the male and female dual-purpose is supported in indoor glass aquarium before the experiment beginning temporarily, with commercial feed it is satiated with food and throws something and feeds.As source of recycled water, 24h continues aeration aerating, keeps dissolved oxygen in water amount 5.0mg/L with the tap water of abundant aeration dechlorination, and water temperature is controlled at (21 ± 1) ℃, raises and train to begin after 7 days to test.Experiment is divided into 2 groups with Cyprinus carpio L. at random by body weight, and experimental group is with compound recipe Fructus Schisandrae Chinensis preparation experiment feedstuff feeding, the matched group normal feedstuff of throwing something and feeding, every group 20 tail, establish 3 parallel.Experiment periods every other day feeding volume is 2%～3% of a fish body constitution amount, and regularly throw something and feed during 7:00 and during 19:00 every day, and be 15 days experimental period.
1.2.2 measure the collection of sample
1d began jejunitas 24h before experiment finished, and got 5 tail fishes at random from each aquarium, dissected and got liver, and is stand-by.
1.2.3 the mensuration of liver biochemical indexes
Get liver organization, with the clean back of 4 ℃ normal saline flushings absorbent paper suck dry moisture, weigh, get the 0.5g tissue, add the normal saline homogenate of 9 times of volumes, the centrifugal 15min of 3000r/min gets liver tissue homogenate's supernatant of 10%, with normal saline dilution is 1% homogenate, measures related biochemical indicator.
(1) gpt activity (GPT): the reitman-frankel method that adopts GPT test kit (bio-engineering research institute, lot number 20101112 are built up in Nanjing) to provide is measured.
(2) glutamic oxaloacetic transaminase, GOT (GOT): the reitman-frankel method that adopts GOT test kit (bio-engineering research institute, lot number 20101111 are built up in Nanjing) to provide is measured.
2 results
Compound recipe Fructus Schisandrae Chinensis preparation is to glutamate pyruvate transaminase (GPT), the active influence of glutamic oxaloacetic transaminase, GOT (GOT) in the Cyprinus carpio L. liver
See Table 2.
Table 2 compound recipe Fructus Schisandrae Chinensis preparation is to the influence of glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT in the Cyprinus carpio L. liver
Annotate: compare with matched group,
*P＜0.05
By table 2 as seen, with matched group relatively, can the raise activity of glutamate pyruvate transaminase in the Cyprinus carpio L. liver, glutamic oxaloacetic transaminase, GOT of compound recipe Fructus Schisandrae Chinensis preparation illustrates that compound recipe Fructus Schisandrae Chinensis preparation does not have hepatotoxicity and the liver function and the protein metabolism of Cyprinus carpio L. had facilitation.
Claims (2)
1. the preparation method of a compound recipe Fructus Schisandrae Chinensis preparation is characterized in that the preparation method of said preparation comprises following process:
Step (one): select high-quality Fructus Schisandrae Chinensis 6g-9g, Herba Boschniakiae Rossicae 6g-9g, Cortex Eucommiae 3g-6g, Radix Et Caulis Acanthopanacis Senticosi 3g-6g, Radix Ginseng 3g-6g, Ganoderma 3g-6g, Radix Astragali 3g-6g, Lentinus Edodes 3g-6g, Poria 2g-4g, Polyporus 2g-4g, Rhizoma Dioscoreae 2g-4g, Fructus Crataegi 2g-4g, Fructus Jujubae 2g-4g and clean, microwave drying, pulverizing are 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times, add 6-8 times of water gaging first and soak 4.0h-6.0h, heated and boiled is extracted 2.0h-3.0h, add for the second time 4 times of water gaging heated and boiled and extract 1.5h-2.0h, add 3 times of water gaging heated and boiled for the third time and extract 1.0h-1.5h, merge extractive liquid, filters, and gets filtrate;
Step (three): the filtrate in the step (two) is condensed into extractum, in extractum: agar: starch=4: 1: 16 ratio mixings, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got compound recipe Fructus Schisandrae Chinensis preparation.
2. the purposes of a kind of compound recipe Fructus Schisandrae Chinensis preparation as claimed in claim 1 is characterised in that it has the Cyprinus carpio L. fish liver function of promotion and protein metabolism effect.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102836334A (en) * | 2012-09-26 | 2012-12-26 | 商丘爱己爱牧动物药业有限公司 | Veterinary Chinese medicinal preparation for replenishing qi to invigorate spleen |
| CN103168916A (en) * | 2012-06-12 | 2013-06-26 | 北京伟嘉人生物技术有限公司 | Animal health-care feed |
| CN104026571A (en) * | 2014-05-23 | 2014-09-10 | 刘凯 | Health care food and preparation method thereof |
| CN104146244A (en) * | 2014-07-11 | 2014-11-19 | 通化三立保健品有限公司 | Acanthopanax root and boschniakia rossica oral solution and preparation method thereof |
| CN109556352A (en) * | 2018-11-30 | 2019-04-02 | 山西仁源堂药业有限公司 | The drying means of Chinese medicine liquid extract |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054175A (en) * | 1991-04-18 | 1991-09-04 | 王转京 | High-grade full-nutrient additive of protein feed and production method thereof |
| CN1094302A (en) * | 1993-04-29 | 1994-11-02 | 辽宁高新技术研究设计院 | A kind of pure Chinese medicine oral liquid |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4150101B2 (en) * | 1998-04-10 | 2008-09-17 | 富士通株式会社 | Wireless receiver |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054175A (en) * | 1991-04-18 | 1991-09-04 | 王转京 | High-grade full-nutrient additive of protein feed and production method thereof |
| CN1094302A (en) * | 1993-04-29 | 1994-11-02 | 辽宁高新技术研究设计院 | A kind of pure Chinese medicine oral liquid |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103168916A (en) * | 2012-06-12 | 2013-06-26 | 北京伟嘉人生物技术有限公司 | Animal health-care feed |
| CN102836334A (en) * | 2012-09-26 | 2012-12-26 | 商丘爱己爱牧动物药业有限公司 | Veterinary Chinese medicinal preparation for replenishing qi to invigorate spleen |
| CN104026571A (en) * | 2014-05-23 | 2014-09-10 | 刘凯 | Health care food and preparation method thereof |
| CN104146244A (en) * | 2014-07-11 | 2014-11-19 | 通化三立保健品有限公司 | Acanthopanax root and boschniakia rossica oral solution and preparation method thereof |
| CN109556352A (en) * | 2018-11-30 | 2019-04-02 | 山西仁源堂药业有限公司 | The drying means of Chinese medicine liquid extract |
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| CN102068586B (en) | 2012-01-11 |
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