CN102058806B - Preparation method and application of compound polygonum multiflorum preparation - Google Patents
Preparation method and application of compound polygonum multiflorum preparation Download PDFInfo
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- CN102058806B CN102058806B CN2011100087942A CN201110008794A CN102058806B CN 102058806 B CN102058806 B CN 102058806B CN 2011100087942 A CN2011100087942 A CN 2011100087942A CN 201110008794 A CN201110008794 A CN 201110008794A CN 102058806 B CN102058806 B CN 102058806B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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Abstract
The invention relates to a preparation method and application of a compound polygonum multiflorum preparation, belonging to the technical field of research and development of medical products. The preparation method of the compound polygonum multiflorum preparation comprises the following steps of: selecting 6-9 grams of high-quality polygonum multiflorum, 6-9 grams of angelica, 6-9 grams of gen-seng, 6-9 grams of acanthopanax, 6-9 grams of rhizoma polygonati, 4-6 grams of pericarpium citri reticulatae, , 4-6 grams of yams, 2-4 grams of umbellate pore fungus, 2-4 grams of hawthorns, 2-4 grams of malts and 2-4 grams of dates, and cleaning; carrying out microwave drying; crushing into powder of 50 meshes; adding water for boiling, and extracting for three times; merging extracting solutions; filtering to obtain filter liquor; concentrating the filter liquor into extractum; uniformly mixing the extractum with starches according to the proportion of 1:4; granulating by using a sieve of 10 meshes; drying, and then sieving by using a sieve of 14 meshes to obtain the compound polygonum multiflorum preparation. The product has the effect of reducing the content of the serum urea nitrogen of a fancy carp and is beneficial to industrialized production.
Description
Technical field
Medical product research and development technical field under the present invention.The present invention relates to a kind of preparation method and its usage of compound recipe Radix Polygoni Multiflori preparation.Product of the present invention has the effect that reduces Cyprinus carpio L. serum urea nitrogen content, and product of the present invention is beneficial to suitability for industrialized production.
Background technology
Advantage such as that Chinese herbal feed additive has is natural, economic, efficient, noresidue, no Drug resistance and side effect are little; And have the dual function of medical and trophism concurrently; The drawback of no antibiotics and chemicals; Be widely used in recent years in the aquaculture of aquatic animal, in order to prevent disease, growth promotion with improve aquatic product quality.Contain the various active composition in the Chinese herbal medicine, the scalable immunity function of animal.Therefore it is generally acknowledged Chinese herbal medicine prevent disease and growth promoting function, main can to improve the animal body immunologic function relevant with it.The feed additive of Fish has shortcomings such as the thawing of being prone to, poor stability at present, and a part can not be eaten by fish, and utilization rate is low, and waste is serious.Blood urea nitrogen (BUN) is the main dead end product of protein metabolism, and under the normal situation of renal function, the variation of serum urea nitrogen remains in certain scope.When blood serum urea nitrogen concentration raises, decreased renal function is described.In this test, compare with matched group, the Cyprinus carpio L. serum urea nitrogen content of the compound recipe Radix Polygoni Multiflori preparation of throwing something and feeding is downward trend.Explain that compound recipe Radix Polygoni Multiflori preparation does not have Toxicity of Kidney and the renal function of Cyprinus carpio L. is had certain adjusting facilitation.
Summary of the invention
1, a kind of method for preparing of compound recipe Radix Polygoni Multiflori preparation is characterized in that method of making preparation comprises following process:
Step (one): select high-quality Radix Polygoni Multiflori 6g-9g, Radix Angelicae Sinensis 6g-9g, Radix Panacis Quinquefolii 6g-9g, Radix Et Caulis Acanthopanacis Senticosi 6g-9g, Rhizoma Polygonati 6g-9g, Pericarpium Citri Reticulatae 4g-6g, Rhizoma Dioscoreae 4g-6g, Polyporus 2g-4g, Fructus Crataegi 2g-4g, Fructus Hordei Germinatus 2g-4g, Fructus Jujubae 2g-4g and clean; Microwave drying, pulverizing are 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times; Add 6-8 times of water gaging first and soak 4.0h-6.0h, heated and boiled is extracted 2.0h-3.0h, adds 4 times of water gaging heated and boiled for the second time and extracts 1.5h-2.0h; Add 3 times of water gaging heated and boiled for the third time and extract 1.0h-1.5h; Merge extractive liquid, filters, and must filtrate;
Step (three): the filtrating in the step (two) is condensed into extractum, in extractum: starch=1: 4 ratio mixing, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got compound recipe Radix Polygoni Multiflori preparation.
2, compound recipe Radix Polygoni Multiflori preparation is made an experiment, said preparation has the effect that reduces Cyprinus carpio L. serum urea nitrogen content.
According to the present invention, " % " among the present invention is percentage by weight.
The specific embodiment
The preparation method and its usage that relates to a kind of compound recipe Radix Polygoni Multiflori preparation of the present invention comprises following examples, and following embodiment can further specify the present invention, but does not limit the present invention in any way.
Embodiment 1:
Step (one): select high-quality Radix Polygoni Multiflori 6g, Radix Angelicae Sinensis 6g, Radix Panacis Quinquefolii 6g, Radix Et Caulis Acanthopanacis Senticosi 6g, Rhizoma Polygonati 6g, Pericarpium Citri Reticulatae 4g, Rhizoma Dioscoreae 4g, Polyporus 2g, Fructus Crataegi 2g, Fructus Hordei Germinatus 2g, Fructus Jujubae 2g and clean, microwave drying, pulverizing is 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times, add 6 times of water gagings first and soak 4.0h, heated and boiled is extracted 2.0h; Add for the second time 4 times of water gaging heated and boiled and extract 1.5h, add 3 times of water gaging heated and boiled for the third time and extract 1.0h, merge extractive liquid; Filter, must filtrate;
Step (three): the filtrating in the step (two) is condensed into extractum, in extractum: starch=1: 4 ratio mixing, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got compound recipe Radix Polygoni Multiflori preparation.
Embodiment 2:
Step (one): select high-quality Radix Polygoni Multiflori 9g, Radix Angelicae Sinensis 9g, Radix Panacis Quinquefolii 9g, Radix Et Caulis Acanthopanacis Senticosi 9g, Rhizoma Polygonati 9g, Pericarpium Citri Reticulatae 6g, Rhizoma Dioscoreae 6g, Polyporus 4g, Fructus Crataegi 4g, Fructus Hordei Germinatus 4g, Fructus Jujubae 4g and clean, microwave drying, pulverizing is 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times, add 8 times of water gagings first and soak 6.0h, heated and boiled is extracted 3.0h; Add for the second time 4 times of water gaging heated and boiled and extract 2.0h, add 3 times of water gaging heated and boiled for the third time and extract 1.5h, merge extractive liquid; Filter, must filtrate;
Step (three): the filtrating in the step (two) is condensed into extractum, in extractum: starch=1: 4 ratio mixing, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got compound recipe Radix Polygoni Multiflori preparation.
Pharmacological evaluation
Compound recipe Radix Polygoni Multiflori preparation reduces the experiment of Cyprinus carpio L. serum urea nitrogen content effect
1 materials and methods
1.1 material
1.1.1 compound recipe Radix Polygoni Multiflori preparation
Compound recipe Radix Polygoni Multiflori preparation consists of: Radix Polygoni Multiflori 9g, Radix Angelicae Sinensis 9g, Radix Panacis Quinquefolii 9g, Radix Et Caulis Acanthopanacis Senticosi 9g, Rhizoma Polygonati 9g, Pericarpium Citri Reticulatae 6g, Rhizoma Dioscoreae 6g, Polyporus 4g, Fructus Crataegi 4g, Fructus Hordei Germinatus 4g, Fructus Jujubae 4g; Compound recipe Radix Polygoni Multiflori preparation composition is established three groups of Concentraton gradient; Promptly on each flavor dose basis, reduce or increase by 25% crude drug amount, be prepared into basic, normal, high dose groups.Form three groups of Concentraton gradient by compound recipe Radix Polygoni Multiflori preparation and select high-quality Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Panacis Quinquefolii, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Polygonati, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Polyporus, Fructus Crataegi, Fructus Hordei Germinatus, Fructus Jujubae and clean respectively, microwave drying, pulverizing is 50 order powder; Every group of powder added water boil extract 3 times, add 8 times of water gagings first and soak 6.0h, heated and boiled is extracted 3.0h; Add for the second time 4 times of water gaging heated and boiled and extract 2.0h, add 3 times of water gaging heated and boiled for the third time and extract 1.5h, merge extractive liquid; Filter, must filtrate, filtrating is condensed into extractum; In extractum: starch=1: 4 ratio mixing, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got compound recipe Radix Polygoni Multiflori preparation.
1.1.2 experiment feedstuff
By compound recipe Radix Polygoni Multiflori preparation: the mixed uniform preparation of normal feedstuff=3: 5 is a compound recipe Radix Polygoni Multiflori preparation experiment feedstuff, does blank with normal feedstuff.The normal feedstuff prescription is used in experiment, sees table 1.
Table 1 experiment is filled a prescription with normal feedstuff
1.2 method
1.2.1 experiment is raised with Cyprinus carpio L.
Experiment with Cyprinus carpio L. Cyprinus carpio L. available from Aquatic product market, Weihai, body weight (41.1 ± 5.0) g, long (10.27 ± 0.48) cm of body, the male and female dual-purpose, experiment is supported in indoor glass aquarium before beginning temporarily, with commercial feed it is satiated with food and throws something and feeds.As source of recycled water, 24h continues aeration aerating, keeps dissolved oxygen in water amount 5.0mg/L with the tap water of abundant aeration dechlorination, and water temperature is controlled at (21 ± 1) ℃, raises and train to begin after 7 days to test.Experiment is divided into 2 groups with Cyprinus carpio L. by body weight at random, and experimental group is with compound recipe Radix Polygoni Multiflori preparation experiment feedstuff feeding, the matched group normal feedstuff of throwing something and feeding, every group 20 tail, establish 3 parallel.Experimental period every other day feeding volume is 2%～3% of a fish body constitution amount, and every day, 7:00 and 19:00 regularly threw something and fed, and be 15 days experimental period.
1.2.2 measure the collection of sample
Off-test began jejunitas 24h in preceding 1 day, got 5 tail fishes at random from each aquarium, got blood with disposable syringe tail vein, under 4 ℃, left standstill 2h, and the centrifugal 15min of 3000r/min draws supernatant and prepares serum then, is put in-4 ℃ of refrigerators and preserves subsequent use.
1.2.3 the mensuration of serum urea nitrogen
Take out the serum of freezing preservation, adopt the Fearon reaction assay serum urea nitrogen (BUN) of BUN test kit (bio-engineering research institute, lot number 20101101 are built up in Nanjing).
2 results
Compound recipe Radix Polygoni Multiflori preparation is seen table 1 to the result that influences of Cyprinus carpio L. serum urea nitrogen.
Table 1 compound recipe Radix Polygoni Multiflori preparation is to the result that influences of Cyprinus carpio L. serum urea nitrogen
Annotate: compare * P＜005 with matched group.
Visible by table 1, dose groups can significantly reduce the content of Cyprinus carpio L. serum urea nitrogen in the compound recipe Radix Polygoni Multiflori preparation.
Claims (2)
1. the method for preparing of a compound recipe Radix Polygoni Multiflori preparation is characterized in that method of making preparation comprises following process:
Step (one): select high-quality Radix Polygoni Multiflori 6g-9g, Radix Angelicae Sinensis 6g-9g, Radix Panacis Quinquefolii 6g-9g, Radix Et Caulis Acanthopanacis Senticosi 6g-9g, Rhizoma Polygonati 6g-9g, Pericarpium Citri Reticulatae 4g-6g, Rhizoma Dioscoreae 4g-6g, Polyporus 2g-4g, Fructus Crataegi 2g-4g, Fructus Hordei Germinatus 2g-4g, Fructus Jujubae 2g-4g and clean; Microwave drying, pulverizing are 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times; Add 6-8 times of water gaging first and soak 4.0h-6.0h, heated and boiled is extracted 2.0h-3.0h, adds 4 times of water gaging heated and boiled for the second time and extracts 1.5h-2.0h; Add 3 times of water gaging heated and boiled for the third time and extract 1.0h-1.5h; Merge extractive liquid, filters, and must filtrate;
Step (three): the filtrating in the step (two) is condensed into extractum, in extractum: starch=1: 4 ratio mixing, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got compound recipe Radix Polygoni Multiflori preparation.
2. the purposes of a kind of compound recipe Radix Polygoni Multiflori preparation as claimed in claim 1 is characterized in that said preparation is used to prepare the preparation that reduces the effect of Cyprinus carpio L. serum urea nitrogen content.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100087942A CN102058806B (en) | 2011-01-03 | 2011-01-03 | Preparation method and application of compound polygonum multiflorum preparation |
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| CN2011100087942A CN102058806B (en) | 2011-01-03 | 2011-01-03 | Preparation method and application of compound polygonum multiflorum preparation |
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| CN102058806A CN102058806A (en) | 2011-05-18 |
| CN102058806B true CN102058806B (en) | 2012-03-14 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102058807B (en) * | 2011-01-03 | 2012-07-25 | 山东大学威海分校 | Preparation method and application of compound rhizoma polygonati preparation |
| CN103652685B (en) * | 2012-09-17 | 2015-06-10 | 怀山堂生物科技股份有限公司 | Preparation method of Chinese yam nutrition powder |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1242951A (en) * | 1999-07-06 | 2000-02-02 | 付光全 | Preparation method for feed additive of pure traditional Chinese medicines |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1242951A (en) * | 1999-07-06 | 2000-02-02 | 付光全 | Preparation method for feed additive of pure traditional Chinese medicines |
Non-Patent Citations (2)
| Title |
|---|
| 张跃林.《天然植物性饲料添加剂的作用原理及其在生产上的应用》.《中国畜牧兽医》.2006,第33卷(第10期),20-23. * |
| 陈寒青灯.《中草药饲料添加剂研究进展》.《饲料工业》.2002,第23卷(第10期),18-23. * |
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Granted publication date: 20120314 Termination date: 20140103 |