CN102085349B - Preparation method and application of compound barbary wolfberry fruit preparation - Google Patents
Preparation method and application of compound barbary wolfberry fruit preparation Download PDFInfo
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- CN102085349B CN102085349B CN2011100077940A CN201110007794A CN102085349B CN 102085349 B CN102085349 B CN 102085349B CN 2011100077940 A CN2011100077940 A CN 2011100077940A CN 201110007794 A CN201110007794 A CN 201110007794A CN 102085349 B CN102085349 B CN 102085349B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
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Abstract
The invention belongs to the technical field of research and development of medical products. The invention relates to a preparation method and application of a compound barbary wolfberry fruit preparation. The preparation method comprises the following steps: selecting 6-9g of high-quality barbary wolfberry fruit, 6-9g of ginseng, 6-9g of kelp, 4-6g of herba houttuyniae, 4-6g of spirulina, 4-6g of mushroom, 2-3g of star anise, 2-3g of ginger, 2-3g of garlic, 2-3g of hawthorn, 2-3g of Chinese date and 9-12g of shrimp meal, washing, carrying out microwave drying, and grinding into 50-mesh powder; adding water to the powder, boiling to extract three times, mixing the extracting solutions, and filtering to obtain the filtrate; and concentrating the filtrate into extract, uniformly mixing the extract and starch at a ratio of 1:4, granulating with a 10-mesh sieve, drying, and then sieving with a 14-mesh sieve, thus obtaining the compound barbary wolfberry fruit preparation. The product has the function of reducing the content of serum urea nitrogen of golden carps and is beneficial to industrial production.
Description
Technical field
Medical product research and development technical field under the present invention.The present invention relates to the preparation method and its usage of the sub-preparation of a kind of compound medlar.Product of the present invention has the effect that reduces Cyprinus carpio L. serum urea nitrogen content, and product of the present invention is beneficial to suitability for industrialized production.
Background technology
Advantage such as that Chinese herbal feed additive has is natural, economic, efficient, noresidue, no Drug resistance and side effect are little; And have the dual function of medical and trophism concurrently; The drawback of no antibiotics and chemicals; Be widely used in recent years in the aquaculture of aquatic animal, in order to prevent disease, growth promotion with improve aquatic product quality.Contain the various active composition in the Chinese herbal medicine, the scalable immunity function of animal.Therefore it is generally acknowledged Chinese herbal medicine prevent disease and growth promoting function, main can to improve the animal body immunologic function relevant with it.The feed additive of Fish has shortcomings such as the thawing of being prone to, poor stability at present, and a part can not be eaten by fish, and utilization rate is low, and waste is serious.Blood urea nitrogen (BUN) is the main dead end product of protein metabolism, and under the normal situation of renal function, the variation of serum urea nitrogen remains in certain scope.When blood serum urea nitrogen concentration raises, decreased renal function is described.In this test, compare with matched group, the Cyprinus carpio L. serum urea nitrogen content of the sub-preparation of compound medlar of throwing something and feeding is downward trend.Explain that the sub-preparation of compound medlar does not have Toxicity of Kidney and the renal function of Cyprinus carpio L. is had certain adjusting facilitation.
Summary of the invention
1, the method for preparing of the sub-preparation of a kind of compound medlar is characterized in that method of making preparation comprises following process:
Step (one): select high-quality Fructus Lycii 6g-9g, Radix Ginseng 6g-9g, Thallus Laminariae (Thallus Eckloniae) 6g-9g, Herba Houttuyniae 4g-6g, spirulina 4g-6g, Lentinus Edodes 4g-6g, Fructus Anisi Stellati 2g-3g, Rhizoma Zingiberis Recens 2g-3g, Bulbus Allii 2g-3g, Fructus Crataegi 2g-3g, Fructus Jujubae 2g-3g, shrimp meal 9g-12g and clean; Microwave drying, pulverizing are 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times; Add 6-8 times of water gaging first and soak 4.0h-6.0h, heated and boiled is extracted 2.0h-3.0h, adds 4 times of water gaging heated and boiled for the second time and extracts 1.5h-2.0h; Add 3 times of water gaging heated and boiled for the third time and extract 1.0h-1.5h; Merge extractive liquid, filters, and must filtrate;
Step (three): the filtrating in the step (two) is condensed into extractum, in extractum: starch=1: 4 ratio mixing, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got the sub-preparation of compound medlar.
2, the purposes of the sub-preparation of a kind of compound medlar as claimed in claim 1 is characterised in that it has the effect that reduces Cyprinus carpio L. serum urea nitrogen content.
According to the present invention, " % " among the present invention is percentage by weight.
The specific embodiment
The preparation method and its usage that relates to the sub-preparation of a kind of compound medlar of the present invention comprises following examples, and following embodiment can further specify the present invention, but does not limit the present invention in any way.
Embodiment 1:
Step (one): select high-quality Fructus Lycii 6g, Radix Ginseng 6g, Thallus Laminariae (Thallus Eckloniae) 6g, Herba Houttuyniae 4g, spirulina 4g, Lentinus Edodes 4g, Fructus Anisi Stellati 2g, Rhizoma Zingiberis Recens 2g, Bulbus Allii 2g, Fructus Crataegi 2g, Fructus Jujubae 2g, shrimp meal 9g and clean, microwave drying, pulverizing is 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times, add 6 times of water gagings first and soak 4.0h, heated and boiled is extracted 2.0h; Add for the second time 4 times of water gaging heated and boiled and extract 1.5h, add 3 times of water gaging heated and boiled for the third time and extract 1.0h, merge extractive liquid; Filter, must filtrate;
Step (three): the filtrating in the step (two) is condensed into extractum, in extractum: starch=1: 4 ratio mixing, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got the sub-preparation of compound medlar.
Embodiment 2:
Step (one): select high-quality Fructus Lycii 9g, Radix Ginseng 9g, Thallus Laminariae (Thallus Eckloniae) 9g, Herba Houttuyniae 6g, spirulina 6g, Lentinus Edodes 6g, Fructus Anisi Stellati 3g, Rhizoma Zingiberis Recens 3g, Bulbus Allii 3g, Fructus Crataegi 3g, Fructus Jujubae 3g, shrimp meal 12g and clean, microwave drying, pulverizing is 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times, add 8 times of water gagings first and soak 6.0h, heated and boiled is extracted 3.0h; Add for the second time 4 times of water gaging heated and boiled and extract 2.0h, add 3 times of water gaging heated and boiled for the third time and extract 1.5h, merge extractive liquid; Filter, must filtrate;
Step (three): the filtrating in the step (two) is condensed into extractum, in extractum: starch=1: 4 ratio mixing, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got the sub-preparation of compound medlar.
Pharmacological evaluation
The sub-preparation of compound medlar reduces the experiment of Cyprinus carpio L. serum urea nitrogen content effect
1 materials and methods
1.1 material
1.1.1 the sub-preparation of compound medlar
The sub-preparation of compound medlar consists of: Fructus Lycii 6g, Radix Ginseng 6g, Thallus Laminariae (Thallus Eckloniae) 6g, Herba Houttuyniae 6g, spirulina 6g, Lentinus Edodes 6g, Fructus Anisi Stellati 3g, Rhizoma Zingiberis Recens 3g, Bulbus Allii 3g, Fructus Crataegi 3g, Fructus Jujubae 3g, shrimp meal 12g; The sub-preparation composition of compound medlar is established three groups of Concentraton gradient; Promptly on each flavor dose basis, reduce or increase by 25% crude drug amount, be prepared into basic, normal, high dose groups.Form three groups of Concentraton gradient by the sub-preparation of compound medlar and select high-quality Fructus Lycii, Radix Ginseng, Thallus Laminariae (Thallus Eckloniae), Herba Houttuyniae, spirulina, Lentinus Edodes, Fructus Anisi Stellati, Rhizoma Zingiberis Recens, Bulbus Allii, Fructus Crataegi, Fructus Jujubae, shrimp meal and clean respectively, microwave drying, pulverizing is 50 order powder; Every group of powder added water boil extract 3 times, add 8 times of water gagings first and soak 6.0h, heated and boiled is extracted 3.0h; Add for the second time 4 times of water gaging heated and boiled and extract 2.0h, add 3 times of water gaging heated and boiled for the third time and extract 1.5h, merge extractive liquid; Filter, must filtrate, filtrating is condensed into extractum; In extractum: starch=1: 4 ratio mixing, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got the sub-preparation of compound medlar.
1.1.2 experiment feedstuff
By the sub-preparation of compound medlar: the mixed uniform preparation of normal feedstuff=3: 5 is the sub-preparation experiment of a compound medlar feedstuff, does blank with normal feedstuff.The normal feedstuff prescription is used in experiment, sees table 1.
Table 1 experiment is filled a prescription with normal feedstuff
1.2 method
1.2.1 experiment is raised with Cyprinus carpio L.
Experiment with Cyprinus carpio L. Cyprinus carpio L. available from Aquatic product market, Weihai, body weight (41.1 ± 5.0) g, long (10.27 ± 0.48) cm of body, the male and female dual-purpose, experiment is supported in indoor glass aquarium before beginning temporarily, with commercial feed it is satiated with food and throws something and feeds.As source of recycled water, 24h continues aeration aerating, keeps dissolved oxygen in water amount 5.0mg/L with the tap water of abundant aeration dechlorination, and water temperature is controlled at (21 ± 1) ℃, raises and train to begin after 7 days to test.Experiment is divided into 2 groups with Cyprinus carpio L. by body weight at random, and experimental group is with the sub-preparation of compound medlar experiment feedstuff feeding, the matched group normal feedstuff of throwing something and feeding, every group 20 tail, establish 3 parallel.Experimental period every other day feeding volume is 2%～3% of a fish body constitution amount, and regularly throw something and feed during 7:00 and during 19:00 every day, and be 15 days experimental period.
1.2.2 measure the collection of sample
Off-test began jejunitas 24h in preceding 1 day, got 5 tail fishes at random from each aquarium, got blood with disposable syringe tail vein, under 4 ℃, left standstill 2h, and the centrifugal 15min of 3000r/min draws supernatant and prepares serum then, is put in-4 ℃ of refrigerators and preserves subsequent use.
1.2.3 the mensuration of serum urea nitrogen
Take out the serum of freezing preservation, adopt the Fearon reaction assay serum urea nitrogen (BUN) of BUN test kit (bio-engineering research institute, lot number 20101101 are built up in Nanjing).
2 results
The sub-preparation of compound medlar is seen table 1 to the result that influences of Cyprinus carpio L. serum urea nitrogen.
The sub-preparation of table 1 compound medlar is to the result that influences of Cyprinus carpio L. serum urea nitrogen
Annotate: compare * P＜005 with matched group.
Visible by table 1, dose groups can significantly reduce the content of Cyprinus carpio L. serum urea nitrogen in the sub-preparation of compound medlar.
Claims (2)
1. the method for preparing of the sub-preparation of compound medlar is characterized in that method of making preparation comprises following process:
Step (one): select high-quality Fructus Lycii 6g-9g, Radix Ginseng 6g-9g, Thallus Laminariae (Thallus Eckloniae) 6g-9g, Herba Houttuyniae 4g-6g, spirulina 4g-6g, Lentinus Edodes 4g-6g, Fructus Anisi Stellati 2g-3g, Rhizoma Zingiberis Recens 2g-3g, Bulbus Allii 2g-3g, Fructus Crataegi 2g-3g, Fructus Jujubae 2g-3g, shrimp meal 9g-12g and clean; Microwave drying, pulverizing are 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times; Add 6-8 times of water gaging first and soak 4.0h-6.0h, heated and boiled is extracted 2.0h-3.0h, adds 4 times of water gaging heated and boiled for the second time and extracts 1.5h-2.0h; Add 3 times of water gaging heated and boiled for the third time and extract 1.0h-1.5h; Merge extractive liquid, filters, and must filtrate;
Step (three): the filtrating in the step (two) is condensed into extractum, in extractum: starch=1: 4 ratio mixing, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got the sub-preparation of compound medlar.
2. the purposes of the sub-preparation of a kind of compound medlar as claimed in claim 1 is characterized in that said preparation is used to prepare the preparation with the effect of reduction Cyprinus carpio L. serum urea nitrogen content.
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| CN2011100077940A CN102085349B (en) | 2011-01-03 | 2011-01-03 | Preparation method and application of compound barbary wolfberry fruit preparation |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090503C (en) * | 1999-08-29 | 2002-09-11 | 王健 | Medical capsule for treating rheumatism and building up body and its preparing process |
| CN1129535C (en) * | 1998-07-28 | 2003-12-03 | 阿图尔-费希尔股份公司费希尔厂 | Folding desk mounted on back of long-distance bus or airplane chair |
| CN101804126A (en) * | 2010-05-01 | 2010-08-18 | 秦皇岛皇威制药有限公司 | Application of traditional Chinese medicine composition in treating qi-blood deficiency and spleen-kidney deficiency and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090503A (en) * | 1993-09-09 | 1994-08-10 | 唐术平 | A kind of adjuvant drug for tumor therapy |
| CN1129535A (en) * | 1995-02-21 | 1996-08-28 | 王振宝 | Northern Chinese Magnoliarine jam for strengthening body |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1129535C (en) * | 1998-07-28 | 2003-12-03 | 阿图尔-费希尔股份公司费希尔厂 | Folding desk mounted on back of long-distance bus or airplane chair |
| CN1090503C (en) * | 1999-08-29 | 2002-09-11 | 王健 | Medical capsule for treating rheumatism and building up body and its preparing process |
| CN101804126A (en) * | 2010-05-01 | 2010-08-18 | 秦皇岛皇威制药有限公司 | Application of traditional Chinese medicine composition in treating qi-blood deficiency and spleen-kidney deficiency and preparation method thereof |
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Granted publication date: 20120314 Termination date: 20140103 |