CN103127459B - Compound Chinese herbal medicine preparation preventing freshwater fish bacterial diseases and production method thereof - Google Patents
Compound Chinese herbal medicine preparation preventing freshwater fish bacterial diseases and production method thereof Download PDFInfo
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Abstract
The invention discloses a compound Chinese herbal medicine preparation preventing freshwater fish bacterial diseases and a production method of the compound Chinese herbal medicine preparation, and belongs to the technical field of fishery. The compound Chinese herbal medicine preparation preventing the freshwater fish bacterial diseases is prepared by the following raw materials: Chinese rhubarb, herba andrographitis, scutellaria baicalensis, oriental wormwood, cape jasmine, wrinkled giant hyssop, radix isatidis, mint, cortex phellodendri, abrotani herba, herba schizonepetae, radix curcuma, radix curcumae, fructus mume, fructus forsythiae, white paeony root, moutan bark, radix bupleuri, folium isatidis, melia toosendan, glycyrrhiza and aquatic product multivitamins. The compound Chinese herbal medicine preparation preventing the freshwater fish bacterial diseases is obtained by the raw materials after a procedure of step-by-step boiling, filtering, vacuum concentration and sterile filling. The compound Chinese herbal medicine preparation preventing the freshwater fish bacterial diseases adopts assistant and guide, combines prevention and treatment, is synchronously beneficial for a drug effect, strengthens immunity of freshwater fishes, and is prominent in prevention and treatment effects to the freshwater fish bacterial diseases, low in production cost, long in drug effect time, free of residual, and free of a toxic and side effect on the freshwater fishes and the environment.
Description
Technical field
The present invention relates to a kind of Chinese medicine formula and production method thereof of preventing and treating fresh water fish bacterial disease, belong to fishery technology field.
Background technology
During the nearly last ten years, China's freshwater aquaculture industry fast development, not only total output improves, Yi Zhan China cultivation the more than 70% of total output, and also breed variety is on the increase, and by the past traditional " four large Chinese carps ", expands the kinds such as shrimp, Eriocheir sinensis, shellfish, Trionyx sinensis Wiegmann and the frog to.From simple pond, swing cultivation, expand net cage, reservoir, pond on a hill, tidal land, rice field and industrialized culture to, aquaculture has become one of important channel of wealth accumulation in rural areas.Because breed variety is on the increase, cultivation density increases substantially, and the interchange between area of seed and live body is frequent, cause aquatic animal disease generation and be popularly also on the rise, often cause every year larger economic loss, thereby threaten the sustainable development of fresh water fishery.
Fresh water fish bacterial disease be the most common in freshwater aquiculture be also the maximum class disease of harm.Mainly contain bacterial gill rot disease, white skin disease, white head and mouth fish disease, erythroderma, scale protrusion disease, squama Baiyun Disease, bacterial septicemia, enteritis disease, stigmatosis, furunculosis, rotten fin disease, streptococcicosis and Vibrio anguillarum disease etc.The control of bacterial disease at present mainly relies on antibiotic and chemicals, not only polluted-water environment, and fish body is damaged, reduce fish body immunity, form vicious cycle.And use in a large number antibiotic, and endurance strain is constantly occurred, make disease more be difficult to control.
Summary of the invention
The deficiency existing for solving existing control fresh water fish bacterial disease technology, the invention provides a kind of Chinese medicine formula and production method thereof of preventing and treating fresh water fish bacterial disease, this Chinese medicine formula can significantly strengthen immunocompetence, anti-stress ability and the antibacterial ability of fresh-water fishes, and bactericidal properties is strong, drug effect is long, cost is low, noresidue, life-time service does not develop immunity to drugs, without injury, free from environmental pollution to fish.
Solving this technical problem adopted technical scheme is: a kind of Chinese medicine formula of preventing and treating fresh water fish bacterial disease, it is characterized in that, raw material by following weight portion is made: Radix Et Rhizoma Rhei 35～45, Herba Andrographis 20～30, Radix Scutellariae 5～10, Herba Artemisiae Scopariae 5～10, Fructus Gardeniae 3～5, Herba Pogostemonis 0.1～0.3, Radix Isatidis 1～2, Herba Menthae 1～2, Cortex Phellodendri 2～3, Herba Artemisiae Annuae 2～3, Herba Schizonepetae 1～2, Rhizoma Curcumae Longae 1～2, Radix Curcumae 1～2, Fructus Mume 0.5～1, Fructus Forsythiae 0.5～1, the Radix Paeoniae Alba 0.2～0.5, Cortex Moutan 0.2～0.5, Radix Bupleuri 0.5～1, Folium Isatidis 0.1～0.5, Fructus Toosendan 0.1～0.5, Radix Glycyrrhizae 0.1～0.5, Aquatic product multidimensional 2～3.
Aquatic product multidimensional: commercially available, main component is vitamin E and C.It can clear up bad hematic acid of non-viable non-apoptotic cell and harmful substance in body, raising body physical ability, promotes body intracellular metabolic; Significantly the various stress of opposing, strengthen immunologic function, improve the resistance to virus, antibacterial, thereby reduce avitaminosis.
Comprise the steps:
(1) substep boils: by above-mentioned weight portion, take raw material for standby; First water (amount of water is 2.5-3.5 times of raw material gross mass) is added in reactor, add Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Cortex Phellodendri, Rhizoma Curcumae Longae, Radix Curcumae, the Radix Paeoniae Alba, Cortex Moutan, Radix Bupleuri and Radix Glycyrrhizae, heating gradually, 100 ℃～110 ℃ temperature controls react 240 ± 5 minutes, add again Herba Andrographis, Herba Artemisiae Scopariae, Fructus Gardeniae, Herba Pogostemonis, Herba Artemisiae Annuae, Fructus Mume, Fructus Forsythiae, Folium Isatidis and Fructus Toosendan, 100 ℃～110 ℃ temperature controls react 90 ± 5 minutes, finally add Herba Menthae, Herba Schizonepetae and Aquatic product multidimensional, 100 ℃～110 ℃ temperature controls react 50 ± 5 minutes;
(2) filter: from reactor, get rid of and boil liquid, by flame filter press, compress filtration, obtain filtrate;
(3) vacuum concentration: filtrate is got to after spherical vacuum concentration pan by pump, spherical vacuum concentration pan vacuum is 620～660mmHg, concentrated 15～30 minutes, obtains concentrated solution (concentrated solution of 1 kilogram of raw material simmer down to 450-550ml) and opens outlet;
(4) sterile filling: concentrated solution is measured and packed into pail pack or packaging bag by filling machine.
Using method: per kilogram feedstuff adds 30 ± 2 milliliters of these compound preparations fish of feeding, every day 30 ± 2 grams, every fish feed material, 5-8 days continuously feeds.
The major function of reactor of the present invention is to carry out boiling and concentration response of raw material, reactor requires sealing, without leaking, high temperature resistant, high pressure, corrosion-resistant, speed of agitator is medium.The key technical indexes: volume 1000～10000L, working pressure≤10.0Mpa, temperature≤300 ℃, speed of agitator 20～500r/min is adjustable, mode of heating: electricity, steam, conduction oil, main material is corrosion-resistant.Workshop reaches GMP requirement, and subpackage workshop reaches 1,000,000 grades of aseptic requirements.
The invention has the beneficial effects as follows:
1, production method of the present invention is carried out in reactor, can reach accurate temperature controlling, pressure control, and mixing of materials is even, sufficient reacting, and contained active component boils, concentrates thoroughly, has greatly improved drug effect.
2, in the present invention formula, contain 21 kinds of Radix Et Rhizoma Rhei, Herba Andrographis etc. strengthen fresh-water fishes immunity, to the outstanding Chinese medicine of fresh-water fishes bacteriosis toxic effect, wherein Radix Et Rhizoma Rhei, Herba Andrographis are monarch drug, Radix Et Rhizoma Rhei is for constipation due to dry stool, stagnant dysentery, and constipation with heat retention, high fever yellow fur; Burning hot high Sheng, forcing blood overflow, and conjunctival congestion sudden pain, pyretic toxicity furuncle; The stagnant stomachache of the stasis of blood in puerperal, blood stasis stagnates, and traumatic injury, the stasis of blood is stagnant has a pain; Qinghua is damp and hot and for jaundice; Be the key medicine of pathogenic fire purging simply, removing mass, clots absorbing, use on a small quantity, have again digestion promoting function; Herba Andrographis is for antipyretic, and antiinflammatory, improves immunologic function, strengthens kidney, cardiovascular function, venom and muscarine, hepatic cholagogic effect, antitumor action etc.All the other 19 ministerial drugs, increase immunity and combine with antibacterial, monarch, prevention and treatment combine, entirety is prevented and treated fresh water fish bacterial disease, Aquatic product multidimensional add the anti-stress ability and the immunity that have strengthened fish.
3, general anthraquinone amount (the content >1% in preparation of the present invention, mainly from Radix Et Rhizoma Rhei), andrographolide (content >0.6%, mainly from Herba Andrographis) isoreactivity material composition, significantly strengthen fresh-water fishes immunity and treatment bacterial disease effect.
4, this preparation effective drug duration length, noresidue, have no side effect to fresh-water fishes and environment.
5, production cost is low.In this formula use Chinese herbal medicine, are all domestic leading Chinese crude drugs, low price is easily purchased, investment of production equipment, power consumption all lower.
Type testing situation is:
In Tang Wang fish farm, Jinan City, Shandong Province with Ctenopharyngodon idellus, Carassius auratus and Cyprinus carpio are subjects, per kilogram feedstuff adds 30 milliliters of these compound preparations fish of feeding, take 30 milliliters of pure water, add feedstuff and feed fish as contrast, every day 30 grams, every fish feed material, select period of disease to feed 6 days spring, investigation gill rot, intestinal inflammation, red skin, the sickness rate of stigmatosis and bacterial haemorrhage, mortality rate, result shows: after using this compound preparation, 3 kinds of fishes all find no above-mentioned disease (taking medicine in latter 30 days), M & M is 0, and 3 kinds of fish gill rots of contrast, intestinal inflammation, red skin, the average attack rate of stigmatosis and bacterial haemorrhage is 13.24%, 11.28%, 5.23%, 2.46%, 16.94%, mortality rate is 6.64%, 3.36%, 2.50%, 1.66% and 9.83%.
The specific embodiment
Embodiment 1
Proportioning (weight portion): Radix Et Rhizoma Rhei 45, Herba Andrographis 20, Radix Scutellariae 5, Herba Artemisiae Scopariae 5, Fructus Gardeniae 3, Herba Pogostemonis 0.1, Radix Isatidis 1, Herba Menthae 1, Cortex Phellodendri 2, Herba Artemisiae Annuae 2, Herba Schizonepetae 1, Rhizoma Curcumae Longae 1, Radix Curcumae 1, Fructus Mume 0.5, Fructus Forsythiae 0.5, the Radix Paeoniae Alba 0.5, Cortex Moutan 0.5, Radix Bupleuri 1, Folium Isatidis 0.5, Fructus Toosendan 0.5, Radix Glycyrrhizae 0.5, Aquatic product multidimensional 3.
This immunity of filling a prescription to strengthen fresh-water fishes is main, comprises the steps:
(1) substep boils: by above-mentioned weight portion, take raw material for standby; First water (amount of water is 3 times of Chinese medicine gross mass) is added in reactor, add Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Cortex Phellodendri, Rhizoma Curcumae Longae, Radix Curcumae, the Radix Paeoniae Alba, Cortex Moutan, Radix Bupleuri and Radix Glycyrrhizae, heating gradually, 100 ℃～110 ℃ temperature controls react 240 ± 5 minutes, add again Herba Andrographis, Herba Artemisiae Scopariae, Fructus Gardeniae, Herba Pogostemonis, Herba Artemisiae Annuae, Fructus Mume, Fructus Forsythiae, Folium Isatidis and Fructus Toosendan, 100 ℃～110 ℃ temperature controls react 90 ± 5 minutes, finally add Herba Menthae, Herba Schizonepetae and Aquatic product multidimensional, 100 ℃～110 ℃ temperature controls react 50 ± 5 minutes;
(2) filter: from reactor, get rid of and boil liquid, by flame filter press, compress filtration, obtain filtrate;
(3) vacuum concentration: filtrate is got to after spherical vacuum concentration pan (V=500L) by pump, vacuum is 620～660mmHg, concentrated 15～30 minutes, obtain concentrated solution (1 kilogram of concentrated solution that traditional Chinese drug inspissation is 450-550ml) and open outlet;
(4) sterile filling: concentrated solution is measured and packed into pail pack or packaging bag by filling machine.
Embodiment 2
Proportioning (weight portion): Radix Et Rhizoma Rhei 35, Herba Andrographis 30, Radix Scutellariae 10, Herba Artemisiae Scopariae 10, Fructus Gardeniae 3, Herba Pogostemonis 0.3, Radix Isatidis 2, Herba Menthae 2, Cortex Phellodendri 3, Herba Artemisiae Annuae 2, Herba Schizonepetae 2, Rhizoma Curcumae Longae 1, Radix Curcumae 1, Fructus Mume 0.5, Fructus Forsythiae 0.5, the Radix Paeoniae Alba 0.2, Cortex Moutan 0.2, Radix Bupleuri 0.5, Folium Isatidis 0.1, Fructus Toosendan 0.1, Radix Glycyrrhizae 0.1, Aquatic product multidimensional 2.
The present invention is a kind of take treatment fresh water fish bacterial disease as main formula, comprises the steps:
(1) substep boils: by above-mentioned weight portion, take raw material for standby; First water (amount of water is 3 times of Chinese medicine gross mass) is added in reactor, add Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Cortex Phellodendri, Rhizoma Curcumae Longae, Radix Curcumae, the Radix Paeoniae Alba, Cortex Moutan, Radix Bupleuri and Radix Glycyrrhizae, heating gradually, 100 ℃～110 ℃ temperature controls react 240 ± 5 minutes, add again Herba Andrographis, Herba Artemisiae Scopariae, Fructus Gardeniae, Herba Pogostemonis, Herba Artemisiae Annuae, Fructus Mume, Fructus Forsythiae, Folium Isatidis and Fructus Toosendan, 100 ℃～110 ℃ temperature controls react 90 ± 5 minutes, finally add Herba Menthae, Herba Schizonepetae and Aquatic product multidimensional, 100 ℃～110 ℃ temperature controls react 50 ± 5 minutes;
(2) filter: from reactor, get rid of and boil liquid, by flame filter press, compress filtration, obtain filtrate;
(3) vacuum concentration: filtrate is got to after spherical vacuum concentration pan (V=500L) by pump, vacuum is 620～660mmHg, concentrated 15～30 minutes, obtain concentrated solution (1 kilogram of concentrated solution that traditional Chinese drug inspissation is 450-550ml) and open outlet;
(4) sterile filling: concentrated solution is measured and packed into pail pack or packaging bag by filling machine.
Claims (3)
1. a Chinese medicine formula of preventing and treating fresh water fish bacterial disease, is characterized in that, by the raw material of following weight portion, is made: Radix Et Rhizoma Rhei 35～45, Herba Andrographis 20～30, Radix Scutellariae 5～10, Herba Artemisiae Scopariae 5～10, Fructus Gardeniae 3～5, Herba Pogostemonis 0.1～0.3, Radix Isatidis 1～2, Herba Menthae 1～2, Cortex Phellodendri 2～3, Herba Artemisiae Annuae 2～3, Herba Schizonepetae 1～2, Rhizoma Curcumae Longae 1～2, Radix Curcumae 1～2, Fructus Mume 0.5～1, Fructus Forsythiae 0.5～1, the Radix Paeoniae Alba 0.2～0.5, Cortex Moutan 0.2～0.5, Radix Bupleuri 0.5～1, Folium Isatidis 0.1～0.5, Fructus Toosendan 0.1～0.5, Radix Glycyrrhizae 0.1～0.5, Aquatic product multidimensional 2～3.
2. the production method of Chinese medicine formula claimed in claim 1, is characterized in that,
(1) substep boils: by weight portion described in claim 1, take raw material for standby; First water is added in reactor, add Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Cortex Phellodendri, Rhizoma Curcumae Longae, Radix Curcumae, the Radix Paeoniae Alba, Cortex Moutan, Radix Bupleuri and Radix Glycyrrhizae, heating gradually, 100 ℃～110 ℃ temperature controls react 240 ± 5 minutes, add again Herba Andrographis, Herba Artemisiae Scopariae, Fructus Gardeniae, Herba Pogostemonis, Herba Artemisiae Annuae, Fructus Mume, Fructus Forsythiae, Folium Isatidis and Fructus Toosendan, 100 ℃～110 ℃ temperature controls react 90 ± 5 minutes, finally add Herba Menthae, Herba Schizonepetae and Aquatic product multidimensional, and 100 ℃～110 ℃ temperature controls react 50 ± 5 minutes;
(2) filter: from reactor, discharge and boil liquid, by flame filter press, compress filtration, obtain filtrate;
(3) vacuum concentration: filtrate is got to after spherical vacuum concentration pan by pump, under vacuum 620～660mmHg, concentrated 15～30 minutes, obtains concentrated solution and opens outlet;
(4) sterile filling: concentrated solution is measured and packed into pail pack or packaging bag by filling machine.
3. the production method of Chinese medicine formula as claimed in claim 2, is characterized in that, the amount of water of described step (1) is 2.5-3.5 times of raw material gross mass.
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