CN105617219A - Compound Chinese herb preparation for preventing and treating fresh water fish bacterial diseases, and production method thereof - Google Patents
Compound Chinese herb preparation for preventing and treating fresh water fish bacterial diseases, and production method thereof Download PDFInfo
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- CN105617219A CN105617219A CN201410574859.3A CN201410574859A CN105617219A CN 105617219 A CN105617219 A CN 105617219A CN 201410574859 A CN201410574859 A CN 201410574859A CN 105617219 A CN105617219 A CN 105617219A
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Abstract
The present invention discloses a compound Chinese herb preparation for preventing and treating fresh water fish bacterial diseases, and a production method thereof, and belongs to the technical field of fishing industry, wherein the compound Chinese herb preparation is prepared from the following raw materials: rheum palmatum, andrographis paniculata, scutellaria baicalensis, artemisia capillaris thunb, gardenia jasminoides, agastache rugosa, isatis tinctoria, peppermint, cortex phellodendri, artemisia carvifolia, nepeta cataria l, curcuma longa, radix curcumae, fructus mume, forsythia suspensa, cynanchum otophyllum, cortex moutan, radix bupleuri, folium isatidis, fructus toosendan, licorice root and aquatic multivitamin, and the raw materials are subjected to stepwise decocting, filtering, vacuum concentration and aseptic filling so as to prepare the compound Chinese herb preparation. According to the present invention, the compound Chinese herb preparation contains the assistant drug and the guide drug, combines prevention and treatment, synergistically promotes the efficacy, enhances the immunity of fresh water fishes, provides prominent prevention and treatment effects for fresh water fish bacterial diseases, and further has characteristics of low production cost, long efficacy lasting time, no residue, and no toxic-side effect on fresh water fishes and environment.
Description
Technical field
The present invention relates to a kind of Chinese medicine formula preventing and treating fresh water fish bacterial disease and production method thereof, belong to technical field of fishery.
Background technology
During the nearly last ten years, China's freshwater aquaculture industry fast development, not only total output improves, and oneself accounts for more than the 70% of China's cultivation total output, and breed variety is on the increase, and oneself is expanded to the kinds such as shrimp, Eriocheir sinensis, shellfish, Trionyx sinensis Wiegmann and the frog by " four large Chinese carps " that the past is traditional. From simple pond, swing cultivation, expand net cage, reservoir, pond on a hill, tidal land, rice field and industrialized culture to, one of oneself important channel becoming wealth accumulation in rural areas of aquaculture. Owing to breed variety is on the increase, cultivation density increases substantially, and the exchange between area of seed and live body is frequent, causes the generation of the disease of aquatic animal and popular is also on the rise, often result in bigger economic loss every year, thus threatening the sustainable development of fresh water fishery.
Fresh water fish bacterial disease is the most common in freshwater aquiculture is also endanger a maximum class disease. Mainly there are bacterial gill rot disease, white skin disease, white head and mouth fish disease, erythroderma, scale protrusion disease, squama Baiyun Disease, bacterial septicemia, enteritis disease, stigmatosis, furunculosis, rotten fin disease, streptococcicosis and Vibrio anguillarum sick. The preventing and treating of current bacterial disease relies primarily on antibiotic and chemicals, not only polluted-water environment, and fish body is damaged, and reduces fish body immunity, forms vicious cycle. And use antibiotic in a large number, make endurance strain constantly occur, make disease more be difficult to control to.
Summary of the invention
For solving the deficiency that existing preventing and treating fresh water fish bacterial disease technology exists, the invention provides a kind of Chinese medicine formula preventing and treating fresh water fish bacterial disease and production method thereof, this Chinese medicine formula can be obviously enhanced the immunocompetence of fresh-water fishes, anti-stress ability and antibacterial ability, and bactericidal properties is strong, drug effect length, cost are low, noresidue, life-time service does not develop immunity to drugs, to fish fanout free region, free from environmental pollution.
Solve this technical problem the technical scheme is that a kind of Chinese medicine formula preventing and treating fresh water fish bacterial disease, it is characterized in that, it is made up of the raw material of following weight portion: Radix Et Rhizoma Rhei 35��45, Herba Andrographis 20��30, Radix Scutellariae 5��10, Herba Artemisiae Scopariae 5��10, Fructus Gardeniae 3��5, Herba Pogostemonis 0.1��0.3, Radix Isatidis l��2, Herba Menthae l��2, Cortex Phellodendri 2��3, Herba Artemisiae Annuae 2��3, Herba Schizonepetae l��2, Rhizoma Curcumae Longae l��2, Radix Curcumae l��2, Fructus Mume 0.5��l, Fructus Forsythiae 0.5��l, the Radix Paeoniae Alba 0.2��0.5, Cortex Moutan 0.2��0.5, Radix Bupleuri 0.5��l, Folium Isatidis 0.1��0.5, Fructus Toosendan 0.1��0.5, Radix Glycyrrhizae 0.1��0.5, Aquatic product multidimensional 2��3.
Aquatic product multidimensional: commercially available, is mainly composed of vitamin E and c. It can clear up internal non-viable non-apoptotic cell bad hematic acid and harmful substance, raising body physical ability, promotes internal metabolism; Significantly resisting various stress, strengthen immunologic function, improving the resistance to virus, antibacterial, thus reducing avitaminosis.
Comprise the steps:
Substep boils: weigh raw material for standby by above-mentioned weight portion; First by water, (amount of water is raw material gross mass
2.5 3.5 times) add in reactor, add Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Cortex Phellodendri, Rhizoma Curcumae Longae, Radix Curcumae, the Radix Paeoniae Alba, Cortex Moutan, Radix Bupleuri and Radix Glycyrrhizae, it is gradually heated up, l () () DEG C��110 DEG C temperature controls react 240 �� 5 minutes, add Herba Andrographis, Herba Artemisiae Scopariae, Fructus Gardeniae, Herba Pogostemonis, Herba Artemisiae Annuae, Fructus Mume, Fructus Forsythiae, Folium Isatidis and Fructus Toosendan, l () () DEG C��110 DEG C temperature controls react 90 �� 5 minutes, being eventually adding Herba Menthae, Herba Schizonepetae and Aquatic product multidimensional, l () () DEG C��110 DEG C temperature controls react 50 �� 5 minutes;
Filter: get rid of from reactor and boil liquid, filtered by flame filter press compression, obtain filtrate;
Vacuum concentrates: after filtrate gets to spherical vacuum concentration pan by pump, spherical vacuum concentration pan vacuum is 620��660mini{g, concentrate 15��30 minutes, obtain the concentrated solution concentrated solution of 450 550ml (concentration of 1 kilogram of raw material be) and open outlet;
Sterile filling: concentrated solution is loaded pail pack or packaging bag by filling machine metering.
Using method: per kilogram feedstuff adds 30 �� and 2 milliliters of these compound preparations feed fish, and every day, 30 �� 2 grams of every fish feed material, fed 58 days continuously.
The major function of reactor of the present invention is by boiling and concentration response of raw material, and reactor requires sealing, No leakage, high temperature resistant, high pressure, corrosion-resistant, speed of agitator is medium. The key technical indexes: volume 1000��10000L, uses pressure��10.OMI] a, temperature��300 DEG C, speed of agitator 20��500r ,/min is adjustable, mode of heating: electricity, steam, conduction oil, main material is corrosion-resistant. Workshop reaches GMP requirement, and subpackage workshop reaches million grades of sterility requirements.
The invention has the beneficial effects as follows:
The production method of the present invention carries out in a kettle., it is possible to reach accurate temperature controlling, pressure control, and mixing of materials is uniform,
Fully, contained active component boils, concentrates thoroughly, substantially increases drug effect in reaction.
Inventive formulation strengthens fresh-water fishes immunity, the Chinese medicine that fresh-water fishes bacteriosis toxic effect is highlighted containing Radix Et Rhizoma Rhei, Herba Andrographis etc. 21 kinds, wherein Radix Et Rhizoma Rhei, Herba Andrographis are monarch drug, Radix Et Rhizoma Rhei is used for constipation due to dry stool, stagnant dysentery, and constipation with heat retention, high fever yellow fur; Burning hot high Sheng, forcing blood overflow, and conjunctival congestion sudden pain, pyretic toxicity furuncle; Puerperal the stagnant stomachache of the stasis of blood, blood stasis stagnates, and traumatic injury, the stasis of blood is stagnant has a pain; Qinghua is damp and hot and is used for jaundice; It is the key medicine of pathogenic fire purging simply, removing mass, clots absorbing, uses a small amount of, have again digestion promoting function; Herba Andrographis is used for antipyretic, antiinflammatory, improves immunologic function, strengthens kidney, cardiovascular function, venom and muscarine, hepatic cholagogic effect, antitumor action etc. All the other 19 ministerial drugs, increase immunity and combine with antibacterial, monarch, and prevention and treatment combine, and overall preventing and treating fresh water fish bacterial disease, the addition of Aquatic product multidimensional enhances anti-stress ability and the immunity of fish.
, quinone amount of always fearing in invention formulation (content > l%, essentially from Radix Et Rhizoma Rhei), andrographolide (content > 0.6%, essentially from Herba Andrographis) isoreactivity material composition, it is obviously enhanced fresh-water fishes immunity and treatment bacterial disease effect.
Fresh-water fishes and environment are had no side effect by this preparation effective drug duration length, noresidue.
Production cost is low. In this formula use Chinese herbal medicine, be all domestic leading Chinese crude drug, low price is easily purchased, investment of production equipment, power consumption all relatively low.
Type testing situation is:
In Tang Wang fish farm, Jinan City, Shandong Province with Ctenopharyngodon idellus, Carassius auratus and Cyprinus carpio for subjects, per kilogram feedstuff adds 30 milliliters should
Compound preparation feeds fish, add feedstuff with 30 milliliters of pure water and feed fish for comparison, every day 30 grams of every fish feed material, select period of disease should feed 6 days spring, investigation gill rot, intestinal is scorching, red skin, the sickness rate of stigmatosis and bacterial haemorrhage, mortality rate, result shows: after using this compound preparation, 3 kinds of fishes all find no above-mentioned disease (taking medicine in latter 30 days), M & M is 0, and compare 3 kinds of fish gill rots, intestinal is scorching, red skin, the average attack rate of stigmatosis and bacterial haemorrhage is 13.24%, l1.28%, 5.23%, 2.46%, 16.94%, the bad E rate of dying is 6.64%, 3.36%, 2.50%, 1.66% parallel port 9.83%.
Claims (3)
1. the Chinese medicine formula preventing and treating fresh water fish bacterial disease, it is characterized in that, it is made up of the raw material of following weight portion: Radix Et Rhizoma Rhei 35��45, Herba Andrographis 20��30, Radix Scutellariae 5��10, Herba Artemisiae Scopariae 5��10, Fructus Gardeniae 3��5, Herba Pogostemonis 0.1��0.3, Radix Isatidis l��2, Herba Menthae l��2, Cortex Phellodendri 2��3, Herba Artemisiae Annuae 2��3, Herba Schizonepetae l��2, Rhizoma Curcumae Longae l��2, Radix Curcumae l��2, Fructus Mume 0.5��l, Fructus Forsythiae 0.5��l, the Radix Paeoniae Alba 0.2��0.5, Cortex Moutan 0.2��0.5, Radix Bupleuri 0.5��l, Folium Isatidis 0.1��0.5, Fructus Toosendan 0.1��0.5, Radix Glycyrrhizae 0.1��0.5, Aquatic product multidimensional 2��3.
2. the production method of the Chinese medicine formula described in claim l, is characterized in that,
(1) substep boils: weigh raw material for standby by weight portion described in claim l; First add water in reactor, add
Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Cortex Phellodendri, Rhizoma Curcumae Longae, Radix Curcumae, the Radix Paeoniae Alba, Cortex Moutan, Radix Bupleuri and Radix Glycyrrhizae, it is gradually heated up, l () () DEG C��110 DEG C temperature controls react 240 �� 5 minutes, add Herba Andrographis, Herba Artemisiae Scopariae, Fructus Gardeniae, Herba Pogostemonis, Herba Artemisiae Annuae, Fructus Mume, Fructus Forsythiae, Folium Isatidis and Fructus Toosendan, l () () DEG C��110 DEG C temperature controls react 90 �� 5 minutes, being eventually adding Herba Menthae, Herba Schizonepetae and Aquatic product multidimensional, l () () DEG C��110 DEG C temperature controls react 50 �� 5 minutes;
(2) filter: get rid of from reactor and boil liquid, filtered by flame filter press compression, obtain filtrate;
(3) vacuum concentration: after filtrate gets to spherical vacuum concentration pan by pump, under vacuum 620��660mmHg, concentration
15��30 minutes, obtain concentrated solution and open outlet;
(4) sterile filling: concentrated solution is loaded pail pack or packaging bag by filling machine metering.
3. the production method of Chinese medicine formula as claimed in claim 2, is characterized in that, amount of water is raw material gross mass 2.5 3.5 times of described step (1).
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491764A (en) * | 2016-11-04 | 2017-03-15 | 威海虹润海洋科技有限公司 | A kind of Chinese herbal and crude drugs preparationses for preventing and treating plant modification Pinna pectinata Common Diseases |
| CN106620099A (en) * | 2016-10-26 | 2017-05-10 | 临湘市东昇生物科技有限公司 | Inflammation-diminishing and antibacterial Chinese herbal medicine for aquatic animals and preparation method of Chinese herbal medicine |
| CN107047382A (en) * | 2016-11-30 | 2017-08-18 | 蚌埠市渔歌农业科技有限公司 | A kind of prevention and controls of Carp dropsy |
| CN107638457A (en) * | 2016-07-21 | 2018-01-30 | 施瑞客（天津）生物技术有限公司 | A kind of perch eyeball for the treatment of is lit up the Chinese medicine composition and preparation method thereof of disease in vain |
-
2014
- 2014-10-25 CN CN201410574859.3A patent/CN105617219A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107638457A (en) * | 2016-07-21 | 2018-01-30 | 施瑞客（天津）生物技术有限公司 | A kind of perch eyeball for the treatment of is lit up the Chinese medicine composition and preparation method thereof of disease in vain |
| CN106620099A (en) * | 2016-10-26 | 2017-05-10 | 临湘市东昇生物科技有限公司 | Inflammation-diminishing and antibacterial Chinese herbal medicine for aquatic animals and preparation method of Chinese herbal medicine |
| CN106491764A (en) * | 2016-11-04 | 2017-03-15 | 威海虹润海洋科技有限公司 | A kind of Chinese herbal and crude drugs preparationses for preventing and treating plant modification Pinna pectinata Common Diseases |
| CN107047382A (en) * | 2016-11-30 | 2017-08-18 | 蚌埠市渔歌农业科技有限公司 | A kind of prevention and controls of Carp dropsy |
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Application publication date: 20160601 |
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