CN102078493B - Preparation method and application of compound astragalus root preparation - Google Patents
Preparation method and application of compound astragalus root preparation Download PDFInfo
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- CN102078493B CN102078493B CN2011100096034A CN201110009603A CN102078493B CN 102078493 B CN102078493 B CN 102078493B CN 2011100096034 A CN2011100096034 A CN 2011100096034A CN 201110009603 A CN201110009603 A CN 201110009603A CN 102078493 B CN102078493 B CN 102078493B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
Abstract
The invention belongs to the technical field of medicine product research and development, and relates to a preparation method and application of a compound astragalus root preparation. The preparation method comprises the steps of: selecting 6-9g of astragalus root, 6-9g of lucid ganoderma, 6-9g of ginseng, 2-3g of honeysuckle flower, 2-3g of common andrographis herb, 1-2g of baikal skullcap root, 1-2g of golden cypress, 1-2g of drug sweetflag rhizome, 1-2g of isatis root, 1-2g of dandelion, 1-2g of radix sophorae falvescentis, 1-2g of Chinese rhubarb, 1-2g of garlic and 2-3g of liquorice root, with high quality, and cleaning, drying, crushing, adding water for boiling and extracting 3 times, mixing extract solutions, filtering to obtain filtrate, concentrating the filtrate into an extract, uniformly mixing in the proportion of the extract to starch of 1:4, and pelleting to obtain the compound astragalus root preparation. The product has the function of promoting the growth of the fancy carps and is beneficial to the industrialized production.
Description
Technical field
Medical product research and development technical field under the present invention.The present invention relates to a kind of preparation method and its usage of compound formulation of astragalus root.Product of the present invention has the effect of the fancy carp growth of promotion, and product of the present invention is beneficial to suitability for industrialized production.
Background technology
Advantage such as that Chinese herbal feed additive has is natural, economic, efficient, noresidue, no Drug resistance and side effect are little; And have the dual function of medical and trophism concurrently; The drawback of no antibiotics and chemicals; Be widely used in recent years in the aquaculture of aquatic animal, in order to prevent disease, growth promotion with improve aquatic product quality.Contain multiple nutritional components and bioactive substances such as polysaccharide, aminoacid, protein, organic acid, tannin, alkaloid, flavone, glycoside, inorganic salt in the Chinese traditional compound medicine; Can promote the synthetic of animal body metabolism and protein and enzyme; The scalable immunity function of animal is accelerated the speed of growth.Therefore it is generally acknowledged Chinese herbal medicine prevent disease and growth promoting function, main can to improve the animal body immunologic function relevant with it.The Cyprinus carpio L. body body-building, beautiful in colour, be a kind of integrate view and admire, fish, the large-scale famous and precious Fish of cuisines, have the title of " funny fellow's stone in the water ".The ornamental value of Cyprinus carpio L. mainly is body colour that it is bright-coloured and colourful figure.Simultaneously Cyprinus carpio L. is as the temperate zone fresh-water fishes, very easily caused disease by intrusion or other environmental factors of microorganisms such as virus, fungus, antibacterial and unicellular alga.Product of the present invention has the effect of the fancy carp growth of promotion, and product of the present invention is beneficial to suitability for industrialized production.
Summary of the invention
1, a kind of method for preparing of compound formulation of astragalus root is characterized in that method of making preparation comprises following process:
Step (one): select high-quality Radix Astragali 6g-9g, Ganoderma 6g-9g, Radix Ginseng 6g-9g, Flos Lonicerae 2g-3g, Herba Andrographis 2g-3g, Radix Scutellariae 1g-2g, Cortex Phellodendri 1g-2g, Rhizoma Acori Graminei 1g-2g, Radix Isatidis 1g-2g, Herba Taraxaci 1g-2g, Radix Sophorae Flavescentis 1g-2g, Radix Et Rhizoma Rhei 1g-2g, Bulbus Allii 1g-2g, Radix Glycyrrhizae 2g-3g and clean; Microwave drying, pulverizing are 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times; Add 6-8 times of water gaging first and soak 4.0h-6.0h, heated and boiled is extracted 2.0h-3.0h, adds 4 times of water gaging heated and boiled for the second time and extracts 1.5h-2.0h; Add 3 times of water gaging heated and boiled for the third time and extract 1.0h-1.5h; Merge extractive liquid, filters, and must filtrate;
Step (three): the filtrating in the step (two) is condensed into extractum, in extractum: starch=1: 4 ratio mixing, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got compound formulation of astragalus root.
2, a kind of purposes of compound formulation of astragalus root is characterized in that said preparation is used to prepare the pharmaceutical preparation with the effect of promotion fancy carp growth.
The specific embodiment
The preparation method and its usage that relates to a kind of compound formulation of astragalus root of the present invention comprises following examples, and following embodiment can further specify the present invention, but does not limit the present invention in any way.
Embodiment 1:
Step (one): select high-quality Radix Astragali 6g, Ganoderma 6g, Radix Ginseng 6g, Flos Lonicerae 2g, Herba Andrographis 2g, Radix Scutellariae 1g, Cortex Phellodendri 1g, Rhizoma Acori Graminei 1g, Radix Isatidis 1g, Herba Taraxaci 1g, Radix Sophorae Flavescentis 1g, Radix Et Rhizoma Rhei 1g, Bulbus Allii 1g, Radix Glycyrrhizae 2g and clean; Microwave drying, pulverizing are 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times, add 6 times of water gagings first and soak 4.0h, heated and boiled is extracted 2.0h; Add for the second time 4 times of water gaging heated and boiled and extract 1.5h, add 3 times of water gaging heated and boiled for the third time and extract 1.0h, merge extractive liquid; Filter, must filtrate;
Step (three): the filtrating in the step (two) is condensed into extractum, in extractum: starch=1: 4 ratio mixing, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got compound formulation of astragalus root.
Embodiment 2:
Step (one): select high-quality Radix Astragali 9g, Ganoderma 9g, Radix Ginseng 9g, Flos Lonicerae 3g, Herba Andrographis 3g, Radix Scutellariae 2g, Cortex Phellodendri 2g, Rhizoma Acori Graminei 2g, Radix Isatidis 2g, Herba Taraxaci 2g, Radix Sophorae Flavescentis 2g, Radix Et Rhizoma Rhei 2g, Bulbus Allii 2g, Radix Glycyrrhizae 3g and clean; Microwave drying, pulverizing are 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times, add 8 times of water gagings first and soak 6.0h, heated and boiled is extracted 3.0h; Add for the second time 4 times of water gaging heated and boiled and extract 2.0h, add 3 times of water gaging heated and boiled for the third time and extract 1.5h, merge extractive liquid; Filter, must filtrate;
Step (three): the filtrating in the step (two) is condensed into extractum, in extractum: starch=1: 4 ratio mixing, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got compound formulation of astragalus root.
Pharmacological evaluation
Compound formulation of astragalus root promotes fancy carp growth effect experiment
1 materials and methods
1.1 the preparation of compound formulation of astragalus root test feed
Experiment consists of with compound formulation of astragalus root: Radix Astragali 9g, Ganoderma 9g, Radix Ginseng 9g, Flos Lonicerae 3g, Herba Andrographis 3g, Radix Scutellariae 2g, Cortex Phellodendri 2g, Rhizoma Acori Graminei 2g, Radix Isatidis 2g, Herba Taraxaci 2g, Radix Sophorae Flavescentis 2g, Radix Et Rhizoma Rhei 2g, Bulbus Allii 2g, Radix Glycyrrhizae 3g; The compound formulation of astragalus root composition is established three groups of Concentraton gradient; Promptly on each flavor dose basis, reduce or increase by 25% crude drug amount, be prepared into basic, normal, high dose groups.Select the high-quality Radix Astragali, Ganoderma, Radix Ginseng, Flos Lonicerae, Herba Andrographis, Radix Scutellariae, Cortex Phellodendri, Rhizoma Acori Graminei, Radix Isatidis, Herba Taraxaci, Radix Sophorae Flavescentis, Radix Et Rhizoma Rhei, Bulbus Allii, Radix Glycyrrhizae by three groups of Concentraton gradient of above-mentioned compound formulation of astragalus root, and clean microwave drying respectively; Pulverizing is 50 order powder, every group of powder is added water boil extract 3 times, adds 8 times of water gagings first and soaks 6.0h; Heated and boiled is extracted 3.0h, adds 4 times of water gaging heated and boiled for the second time and extracts 2.0h, adds 3 times of water gaging heated and boiled for the third time and extracts 1.5h; Merge extractive liquid, filters, and must filtrate; Filtrating is condensed into extractum; In extractum: starch=1: 4 ratio mixing, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got compound formulation of astragalus root; With the compound formulation of astragalus root of the basic, normal, high concentration that configures in 3: 5 foundation bait (shrimp meal 30g, bean cake powder 30g, multidimensional vitamin 0.5g, mixed inorganic 0.5g, sodium alginate 0.5g, starch 12.5g, flour 12.5g) ratio add, process basic, normal, high dose groups compound formulation of astragalus root test feed.Do blank with foundation bait.
1.2 experiment fish and feeding and management thereof
Experiment with Cyprinus carpio L. Cyprinus carpio L. available from Aquatic product market, Weihai, (41.4 ± 5.7) g, long (10.78 ± 0.48) cm of body, the male and female dual-purpose, experiment is supported in indoor glass aquarium before beginning temporarily, with commercial feed it is satiated with food and throws something and feeds.As source of recycled water (pH7.6), 24h continues aeration aerating, keeps dissolved oxygen in water amount 5.0mg/L with the tap water of abundant aeration dechlorination, and water temperature is controlled at (23 ± 1) ℃, raises and train to begin after 7 days to test.Experiment is divided into 4 groups with Cyprinus carpio L. by body weight at random, and three experimental grouies are thrown something and fed with the compound formulation of astragalus root test feed, the matched group normal feedstuff of throwing something and feeding, every group 20 tail, establish three parallel.Experimental period every other day feeding volume is 1.5%～2% of a fish body constitution amount, and regularly throw something and feed during 7:00 and during 19:00 every day, and be 15 days experimental period.
1.2 method
1.2.1 compound formulation of astragalus root is measured the facilitation and the feed coefficient of Cyprinus carpio L. body weight
The experiment initial stage is measured length of fish body and fish body weight, and record, when experiment finishes, length of fish body and fish body weight is measured again.Collect Excreta and the bait residue of experiment fish simultaneously, weigh after the oven dry.The matched group fish is raised the same experimental group of condition, and the foundation bait of throwing something and feeding is as contrast.
Rate of body weight gain=[(testing last fish body counterpoise-experiment fish body counterpoise just)/experiment is fish body counterpoise just] * 100%
Feed coefficient=(bait consumption/fish body weight gains amount) * 100%.
1.2.2 compound formulation of astragalus root is to the mensuration of Cyprinus carpio L. coefficient of condition influence
Coefficient of condition (%)=(test last fish body weight/test last length of fish body) * 100%
1.2.3 compound formulation of astragalus root is to the mensuration of Cyprinus carpio L. liver body than influence
Experimental group and matched group are all raised by daily mode.Randomly draw 6 of experiment fishes from each group during the experiment beginning, put to death the back of weighing, and dissects along cloacal aperture, and clip liver pancreas is also weighed.When finishing, experiment takes identical operations.Liver body ratio=(testing the last fish body weight of last fish body liver weight/experiment) * 100%
2 results
Compound formulation of astragalus root is to the result that influences of fancy carp growth index
See table 1.
Table 1 compound formulation of astragalus root is to the result that influences of fancy carp growth index
Annotate: compare * P＜0.05 with matched group
Can be known that by table 1 rate of body weight gain, coefficient of condition, the liver body of each group of test are higher than matched group than generally, feed coefficient all is lower than matched group.The compound formulation of astragalus root low dose group can significantly improve coefficient of condition; Dose groups can significantly improve rate of body weight gain, coefficient of condition, liver body ratio in the compound formulation of astragalus root, reduces feed coefficient; The compound formulation of astragalus root high dose group can significantly improve liver body ratio, reduces feed coefficient.
Claims (2)
1. the method for preparing of a compound formulation of astragalus root is characterized in that method of making preparation comprises following process:
Step (one): select high-quality Radix Astragali 6g-9g, Ganoderma 6g-9g, Radix Ginseng 6g-9g, Flos Lonicerae 2g-3g, Herba Andrographis 2g-3g, Radix Scutellariae 1g-2g, Cortex Phellodendri 1g-2g, Rhizoma Acori Graminei 1g-2g, Radix Isatidis 1g-2g, Herba Taraxaci 1g-2g, Radix Sophorae Flavescentis 1g-2g, Radix Et Rhizoma Rhei 1g-2g, Bulbus Allii 1g-2g, Radix Glycyrrhizae 2g-3g and clean; Microwave drying, pulverizing are 50 order powder;
Step (two): the powder in the step () is added water boil extract 3 times; Add 6-8 times of water gaging first and soak 4.0h-6.0h, heated and boiled is extracted 2.0h-3.0h, adds 4 times of water gaging heated and boiled for the second time and extracts 1.5h-2.0h; Add 3 times of water gaging heated and boiled for the third time and extract 1.0h-1.5h; Merge extractive liquid, filters, and must filtrate;
Step (three): the filtrating in the step (two) is condensed into extractum, in extractum: starch=1: 4 ratio mixing, to granulate with 10 mesh sieves, the oven dry back is crossed 14 mesh sieves and is promptly got compound formulation of astragalus root.
2. the purposes of a kind of compound formulation of astragalus root as claimed in claim 1 is characterized in that said preparation is used to prepare the pharmaceutical preparation with the effect of promotion fancy carp growth.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011100096034A CN102078493B (en) | 2011-01-03 | 2011-01-03 | Preparation method and application of compound astragalus root preparation |
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| CN2011100096034A CN102078493B (en) | 2011-01-03 | 2011-01-03 | Preparation method and application of compound astragalus root preparation |
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| CN102078493B true CN102078493B (en) | 2012-06-27 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1644077A (en) * | 2005-01-11 | 2005-07-27 | 冯绍宽 | Plant additive premixed forage for aquatic culture and bait therefrom |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1644077A (en) * | 2005-01-11 | 2005-07-27 | 冯绍宽 | Plant additive premixed forage for aquatic culture and bait therefrom |
Non-Patent Citations (1)
| Title |
|---|
| 禇衍伟，张太娥.中草药饲料添加剂在鱼类养殖中的应用（综述）.《北京水产》.2008,(第113期),57-60. * |
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Granted publication date: 20120627 Termination date: 20130103 |