CN102026666B - 促胰岛素肽缀合物制剂 - Google Patents

促胰岛素肽缀合物制剂 Download PDF

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Publication number
CN102026666B
CN102026666B CN2008801265943A CN200880126594A CN102026666B CN 102026666 B CN102026666 B CN 102026666B CN 2008801265943 A CN2008801265943 A CN 2008801265943A CN 200880126594 A CN200880126594 A CN 200880126594A CN 102026666 B CN102026666 B CN 102026666B
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conjugate
preparation
pharmaceutical formulation
albumin
concentration
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Chinese (zh)
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CN102026666A (zh
Inventor
托马斯·R·乌利希
马里夫·卡里尔
拜恩·赛昂·常
奥马尔·库雷希
玛吉·王
吉恩-菲利普·埃斯特拉迪耶
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Changshan Kaijiejian Biological Drug R & D Hebei Co ltd
Kangjiu LLC
ConjuChem Biotechnologies Inc
Abraxis Bioscience LLC
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Changshan Kaijie Health Bio Pharmaceutical Research (hebei) Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
CN2008801265943A 2007-12-11 2008-12-11 促胰岛素肽缀合物制剂 Active CN102026666B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US734607P 2007-12-11 2007-12-11
US61/007,346 2007-12-11
US2929508P 2008-02-15 2008-02-15
US61/029,295 2008-02-15
US20087908P 2008-12-03 2008-12-03
US61/200,879 2008-12-03
PCT/US2008/013599 WO2009075859A2 (en) 2007-12-11 2008-12-11 Formulation of insulinotropic peptide conjugates

Publications (2)

Publication Number Publication Date
CN102026666A CN102026666A (zh) 2011-04-20
CN102026666B true CN102026666B (zh) 2013-10-16

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CN2008801265943A Active CN102026666B (zh) 2007-12-11 2008-12-11 促胰岛素肽缀合物制剂

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US (1) US20090186819A1 (https=)
EP (1) EP2231191A2 (https=)
JP (1) JP2011506442A (https=)
CN (1) CN102026666B (https=)
CA (1) CA2708762A1 (https=)
WO (1) WO2009075859A2 (https=)

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