CN101978959B - 含笑内酯及其衍生物用于治疗癌症的用途 - Google Patents
含笑内酯及其衍生物用于治疗癌症的用途 Download PDFInfo
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- CN101978959B CN101978959B CN2010105107261A CN201010510726A CN101978959B CN 101978959 B CN101978959 B CN 101978959B CN 2010105107261 A CN2010105107261 A CN 2010105107261A CN 201010510726 A CN201010510726 A CN 201010510726A CN 101978959 B CN101978959 B CN 101978959B
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- QNSLJVRYAJFVFH-PTKHLAPESA-N CCC(O[C@](C)(CCC1=C(C)CC[C@H]([C@@H]2OC3=O)C3=C)[C@@]12[N]#C)=O Chemical compound CCC(O[C@](C)(CCC1=C(C)CC[C@H]([C@@H]2OC3=O)C3=C)[C@@]12[N]#C)=O QNSLJVRYAJFVFH-PTKHLAPESA-N 0.000 description 1
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Abstract
Description
细胞 | 含笑内酯 | 化合物1 | 化合物2 | 化合物3 |
HepG-2 | 5.2 | 4.5 | 15.4 | 7.4 |
Ec9706 | 8.3 | 9.2 | 7.6 | 6.6 |
SGC7901 | 11.9 | 14.6 | 14.7 | 13.4 |
SW1116 | 21.5 | 11.5 | 31.5 | 11.7 |
A498 | 6.8 | 12.4 | 5.3 | 4.3 |
ASPC-1 | 6.1 | 3.9 | 15.1 | 26.4 |
HT-29 | 9.8 | 4.8 | 9.8 | 9.8 |
HeLa | 7.6 | 9.4 | 17.3 | 9.7 |
GL15 | 4.5 | 12.6 | 14.3 | 21.5 |
B16F1 | 3.4 | 3.4 | 13.2 | 5.2 |
T24 | 4.4 | 14.2 | 13.6 | 7.9 |
SKOV3 | 2.4 | 5.9 | 9.4 | 10.4 |
SW579 | 12.2 | 17.3 | 22.5 | 12.4 |
PC-3 | 14.2 | 8.7 | 11.4 | 17.2 |
Claims (3)
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010105107261A CN101978959B (zh) | 2010-10-18 | 2010-10-18 | 含笑内酯及其衍生物用于治疗癌症的用途 |
EP11771556.5A EP2562172B1 (en) | 2010-04-23 | 2011-04-14 | Sphaelactone derivatives, their pharmaceutical compositions, preparation methods and uses |
ES11771556.5T ES2575681T3 (es) | 2010-04-23 | 2011-04-14 | Derivados de Sphaelactona, sus composiciones farmacéuticas, métodos de preparación y usos |
KR1020127027257A KR101421140B1 (ko) | 2010-04-23 | 2011-04-14 | 메킬리아 락톤 유도체, 그 약제학적 조성물 및 그 제조방법과 용도 |
PT117715565T PT2562172E (pt) | 2010-04-23 | 2011-04-14 | Derivados de sfaelactona, as suas composições farmacológicas, métodos de preparação e usos |
RU2012144434/04A RU2537319C2 (ru) | 2010-04-23 | 2011-04-14 | Способы изготовления и назначение деривата sphaelactone и его композитные лекарства |
CN2011800201363A CN103038225A (zh) | 2010-04-23 | 2011-04-14 | 含笑内酯衍生物,其药物组合物及其制备方法和用途 |
PCT/CN2011/072782 WO2011131103A1 (zh) | 2010-04-23 | 2011-04-14 | 含笑内酯衍生物,其药物组合物及其制备方法和用途 |
CA2819408A CA2819408C (en) | 2010-04-23 | 2011-04-14 | Micheliolide derivatives, medicinal composition, producing method and usage thereof |
JP2013505317A JP5801873B2 (ja) | 2010-04-23 | 2011-04-14 | 含笑花から抽出したエステル誘導体、その薬物組み合わせもの及び調製方法と用途 |
PL11771556.5T PL2562172T3 (pl) | 2010-04-23 | 2011-04-14 | Pochodne sfelaktonu, ich kompozycje farmaceutyczne, sposoby wytwarzania i zastosowania |
DK11771556.5T DK2562172T3 (en) | 2010-04-23 | 2011-04-14 | Sphaelactonderivater, pharmaceutical compositions thereof, methods of preparation and uses |
US13/642,516 US9255078B2 (en) | 2010-04-23 | 2012-10-19 | Micheliolide derivatives, medicinal composition, producing method and usage thereof |
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CN2010105107261A CN101978959B (zh) | 2010-10-18 | 2010-10-18 | 含笑内酯及其衍生物用于治疗癌症的用途 |
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CN101978959A CN101978959A (zh) | 2011-02-23 |
CN101978959B true CN101978959B (zh) | 2012-08-15 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015006893A1 (zh) * | 2013-07-15 | 2015-01-22 | 天津尚德药缘科技有限公司 | 倍半萜内酯类化合物及其衍生物在制备药物中的用途 |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102234258B (zh) * | 2010-04-23 | 2013-12-11 | 天津尚德药缘科技有限公司 | 含笑内酯的制备方法 |
WO2011131103A1 (zh) * | 2010-04-23 | 2011-10-27 | 天津尚德药缘科技有限公司 | 含笑内酯衍生物,其药物组合物及其制备方法和用途 |
CN102731454B (zh) * | 2011-04-15 | 2015-07-08 | 天津尚德药缘科技有限公司 | 去氢木香烃内酯衍生物,其药物组合物及其制备方法和用途 |
CN102872010B (zh) * | 2012-10-25 | 2014-04-16 | 南京大学 | Aphanamixoid A在治疗卵巢癌药物中的应用 |
CN104876899A (zh) * | 2014-02-28 | 2015-09-02 | 天津尚德药缘科技股份有限公司 | 二甲胺含笑内酯富马酸盐及其用途 |
CN109276553B (zh) * | 2017-07-21 | 2023-01-13 | 天津尚德药缘科技股份有限公司 | 二甲胺含笑内酯富马酸盐制剂、其制备方法和用途 |
CN108743581B (zh) * | 2018-05-07 | 2021-08-24 | 中国人民解放军第四军医大学 | 一种环氧含笑内酯的用途 |
CN108853088A (zh) * | 2018-06-11 | 2018-11-23 | 江苏食品药品职业技术学院 | 一种鹅掌楸内酯用作骨形成蛋白9抑制剂的生物医药用途 |
CN111303099B (zh) * | 2018-12-12 | 2022-12-02 | 天津尚德药缘科技股份有限公司 | 含笑内酯二甲基胺富马酸盐晶型f及其制备方法 |
CN111494366A (zh) * | 2019-01-31 | 2020-08-07 | 洛阳尚德药缘科技有限公司 | 二甲基氨基含笑内酯在制备抗衰老药物上的应用 |
CN112724109B (zh) * | 2019-10-28 | 2023-11-03 | 洛阳尚德药缘科技有限公司 | 倍半萜内酯氮甲基哌嗪衍生物及其盐,及其在药物制备中的用途 |
CN111803489B (zh) * | 2020-07-10 | 2021-08-06 | 温州医科大学附属第一医院 | 含笑内酯及其衍生物在垂体腺瘤治疗中的应用 |
CN115403546B (zh) * | 2021-05-28 | 2024-03-15 | 南京中医药大学 | 愈创木烷类倍半萜衍生物及其制药用途 |
CN114539195A (zh) * | 2022-03-04 | 2022-05-27 | 中国科学院昆明植物研究所 | Ludartin衍生物和其药物组合物及其制备方法和应用 |
CN116041361B (zh) * | 2023-03-02 | 2024-03-26 | 山东第一医科大学(山东省医学科学院) | 一种小白菊内酯的氨基酸衍生物及其制备方法和用途 |
CN116496288B (zh) * | 2023-03-02 | 2024-01-26 | 山东第一医科大学(山东省医学科学院) | 一种小白菊内酯Boc保护的胺类衍生物及其制备方法和用途 |
Citations (1)
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CN101037428A (zh) * | 2006-03-15 | 2007-09-19 | 河北医科大学 | 蓍草中倍半萜内酯a的提纯及其抗肿瘤细胞增殖活性 |
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2010
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Patent Citations (1)
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CN101037428A (zh) * | 2006-03-15 | 2007-09-19 | 河北医科大学 | 蓍草中倍半萜内酯a的提纯及其抗肿瘤细胞增殖活性 |
Non-Patent Citations (2)
Title |
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John M.Cassady,et al..dehydrolanuginolide,a cytotoxic constituent from the fruits of michelia doltsopa.《phytochemistry》.1979,第18卷 * |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015006893A1 (zh) * | 2013-07-15 | 2015-01-22 | 天津尚德药缘科技有限公司 | 倍半萜内酯类化合物及其衍生物在制备药物中的用途 |
AU2013394810B2 (en) * | 2013-07-15 | 2018-05-10 | Accendatech | Uses of sesquiterpene lactone compound and derivative thereof in preparation of drugs |
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