PL2562172T3 - Pochodne sfelaktonu, ich kompozycje farmaceutyczne, sposoby wytwarzania i zastosowania - Google Patents

Pochodne sfelaktonu, ich kompozycje farmaceutyczne, sposoby wytwarzania i zastosowania

Info

Publication number
PL2562172T3
PL2562172T3 PL11771556.5T PL11771556T PL2562172T3 PL 2562172 T3 PL2562172 T3 PL 2562172T3 PL 11771556 T PL11771556 T PL 11771556T PL 2562172 T3 PL2562172 T3 PL 2562172T3
Authority
PL
Poland
Prior art keywords
sphaelactone
derivatives
pharmaceutical compositions
preparation methods
preparation
Prior art date
Application number
PL11771556.5T
Other languages
English (en)
Inventor
Yue Chen
Quan Zhang
Yaxin Lu
Jiadai Zhai
Yahui Ding
Jing Long
Hongxia Fan
Haoliang Zhang
Miao Wang
Weiwei Ma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN 201010153701 external-priority patent/CN102234259B/zh
Priority claimed from CN2010105107261A external-priority patent/CN101978959B/zh
Application filed filed Critical
Publication of PL2562172T3 publication Critical patent/PL2562172T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
PL11771556.5T 2010-04-23 2011-04-14 Pochodne sfelaktonu, ich kompozycje farmaceutyczne, sposoby wytwarzania i zastosowania PL2562172T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN 201010153701 CN102234259B (zh) 2010-04-23 2010-04-23 含笑内酯衍生物,其药物组合物及其制备方法和用途
CN2010105107261A CN101978959B (zh) 2010-10-18 2010-10-18 含笑内酯及其衍生物用于治疗癌症的用途

Publications (1)

Publication Number Publication Date
PL2562172T3 true PL2562172T3 (pl) 2016-09-30

Family

ID=44833708

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11771556.5T PL2562172T3 (pl) 2010-04-23 2011-04-14 Pochodne sfelaktonu, ich kompozycje farmaceutyczne, sposoby wytwarzania i zastosowania

Country Status (12)

Country Link
US (1) US9255078B2 (pl)
EP (1) EP2562172B1 (pl)
JP (1) JP5801873B2 (pl)
KR (1) KR101421140B1 (pl)
CN (1) CN103038225A (pl)
CA (1) CA2819408C (pl)
DK (1) DK2562172T3 (pl)
ES (1) ES2575681T3 (pl)
PL (1) PL2562172T3 (pl)
PT (1) PT2562172E (pl)
RU (1) RU2537319C2 (pl)
WO (1) WO2011131103A1 (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2537319C2 (ru) 2010-04-23 2015-01-10 Эксендатек Способы изготовления и назначение деривата sphaelactone и его композитные лекарства
CN103724307B (zh) * 2012-10-12 2015-08-05 天津尚德药缘科技有限公司 含笑内酯二甲基胺富马酸盐的晶型及制备方法
CA2917343A1 (en) 2013-07-11 2015-01-15 Board Of Trustees Of The University Of Arkansas Dehydroleucodine derivatives and uses thereof
WO2015006893A1 (zh) * 2013-07-15 2015-01-22 天津尚德药缘科技有限公司 倍半萜内酯类化合物及其衍生物在制备药物中的用途
CN104876899A (zh) * 2014-02-28 2015-09-02 天津尚德药缘科技股份有限公司 二甲胺含笑内酯富马酸盐及其用途
CN105520933B (zh) * 2014-09-29 2020-05-12 天津国际生物医药联合研究院 含笑内酯二甲基胺的应用
CN105520934B (zh) * 2014-09-29 2020-05-12 天津国际生物医药联合研究院 含笑内酯二甲基胺的应用
WO2017128163A1 (zh) * 2016-01-28 2017-08-03 天津国际生物医药联合研究院 含笑内酯二甲基胺的应用
CN105726520B (zh) * 2016-02-02 2019-04-09 南开大学 含笑内酯二甲胺脂质体雾化吸入剂及其应用
US11634400B2 (en) 2017-08-19 2023-04-25 University Of Rochester Micheliolide derivatives, methods for their preparation and their use as anticancer and antiinflammatory agents
CN109897022B (zh) * 2017-12-07 2021-09-14 中国医学科学院药物研究所 含笑内酯衍生物、其药物组合物及其制备方法和用途
US20190314324A1 (en) * 2018-04-13 2019-10-17 The University Of Chicago Combination of micheliolide derivatives or nanoparticles with ionizing radiation and checkpoint inhibitors for cancer therapy
JP7591224B2 (ja) * 2020-03-26 2024-11-28 天津尚徳薬縁科技股▲フン▼有限公司 ジメチルアミノミケリオリドフマル酸塩水和物、その調製方法及び用途
CN115403546B (zh) * 2021-05-28 2024-03-15 南京中医药大学 愈创木烷类倍半萜衍生物及其制药用途
CN115403545B (zh) * 2021-05-28 2024-03-26 南京中医药大学 愈创木烷类倍半萜前药及其用途
CN119707897A (zh) * 2023-09-28 2025-03-28 鄂尔多斯市尚德艾康药业有限公司 含笑内酯衍生物的制备方法
CN117624098B (zh) * 2023-11-24 2026-01-30 南京中医药大学 一种愈创木烷型倍半萜内酯衍生物及其制法和应用
CN118184675A (zh) * 2024-03-15 2024-06-14 中国科学院昆明植物研究所 野艾蒿内酯i衍生物及其药物组合物和其制备方法与应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196164A (en) * 1963-01-18 1965-07-20 Ciba Geigy Corp Derivatives of lactones obtained from plants of the family compositae
US6051565A (en) * 1997-04-26 2000-04-18 International Phytochemistry Research Labs, Ltd. Farnesyl-protein transferase inhibitors
AU2001278155A1 (en) * 2000-08-03 2002-02-18 Kosan Biosciences, Inc. Fermentation and purification of mycolactones
KR100469612B1 (ko) * 2003-02-05 2005-02-02 주식회사 싸이제닉 흰씀바귀로부터 추출된 세스퀴테르펜 락톤계 화합물 및이를 함유하는 심혈관 질환 및 암 치료용 조성물
KR20040034655A (ko) * 2004-03-30 2004-04-28 한국생명공학연구원 세래스트롤, 세래판올, 세스퀴테르펜 에스터계 화합물 또는 노박덩굴 추출물을 유효성분으로 함유하는 염증질환,면역질환 또는 암 치료제
WO2009122447A1 (en) * 2008-03-31 2009-10-08 Council Of Scientific & Industrial Research Semi-synthetic sesquiterpene lactone parthenin compound useful for cytotoxicity against cancer cell lines and anticander agent
KR100929098B1 (ko) * 2009-07-29 2009-11-30 강화군 신규한 세스퀴테르펜 화합물
RU2537319C2 (ru) 2010-04-23 2015-01-10 Эксендатек Способы изготовления и назначение деривата sphaelactone и его композитные лекарства
CN101978959B (zh) * 2010-10-18 2012-08-15 天津尚德药缘科技有限公司 含笑内酯及其衍生物用于治疗癌症的用途
CN102234259B (zh) 2010-04-23 2013-05-01 天津尚德药缘科技有限公司 含笑内酯衍生物,其药物组合物及其制备方法和用途

Also Published As

Publication number Publication date
EP2562172B1 (en) 2016-04-13
US9255078B2 (en) 2016-02-09
PT2562172E (pt) 2016-06-07
JP5801873B2 (ja) 2015-10-28
EP2562172A4 (en) 2013-10-02
RU2012144434A (ru) 2014-05-27
CA2819408C (en) 2016-12-20
KR20130029380A (ko) 2013-03-22
CA2819408A1 (en) 2011-10-27
WO2011131103A1 (zh) 2011-10-27
RU2537319C2 (ru) 2015-01-10
JP2013525312A (ja) 2013-06-20
CN103038225A (zh) 2013-04-10
ES2575681T3 (es) 2016-06-30
US20130109749A1 (en) 2013-05-02
DK2562172T3 (en) 2016-06-20
KR101421140B1 (ko) 2014-07-18
EP2562172A1 (en) 2013-02-27

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