CN101935363B - 一种生产医药级透明质酸的方法 - Google Patents
一种生产医药级透明质酸的方法 Download PDFInfo
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- CN101935363B CN101935363B CN2009100541552A CN200910054155A CN101935363B CN 101935363 B CN101935363 B CN 101935363B CN 2009100541552 A CN2009100541552 A CN 2009100541552A CN 200910054155 A CN200910054155 A CN 200910054155A CN 101935363 B CN101935363 B CN 101935363B
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 34
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Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Description
试验过程 | 蛋白质含量(%) | 细菌内毒素 | 过滤时间 |
加入珍珠岩 | 0.0311 | <0.1EU/mg | 70分钟 |
不加珍珠岩 | 0.1323 | <0.1EU/mg | 147分钟 |
试验过程 | 蛋白质含量(%) | 细菌内毒素 | 过滤时间 |
纯化水配制 | 0.0181 | >0.5EU/mg | 65分钟 |
注射用水配制 | 0.0051 | <0.1EU/mg | 71分钟 |
PH值 | 6.0 |
糖醛酸含量(%) | 46.5% |
特性黏度(η) | 2316 |
蛋白含量(%) | 0.0041% |
0.2%吸收度 | OD257 0.007O D280 0.0058 |
0.1%透光率 | 99.89% |
炽灼残渣(%) | 14.57% |
重金属含量 | <10ppm |
细菌内毒素含量 | <0.05EU/mg |
无菌检测(医用等级) | 合格 |
PH值 | 6.18 |
糖醛酸含量(%) | 46.8% |
特性黏度(η) | 2242 |
蛋白含量(%) | 0.0029% |
0.2%吸收度 | OD257 0.0071 OD280 0.0050 |
0.1%透光率 | 99.91% |
炽灼残渣(%) | 14.55% |
重金属含量 | <10ppm |
细菌内毒素含量 | <0.05EU/mg |
无菌检测(医用等级) | 合格 |
PH值 | 6.2 |
糖醛酸含量(%) | 46.2% |
特性黏度(η) | 1522 |
蛋白含量(%) | 0.0565% |
0.2%吸收度 | OD257 0.0375 OD280 0.0258 |
0.1%透光率 | 98.65% |
炽灼残渣(%) | 15.1% |
重金属含量 | <10ppm |
细菌内毒素含量 | >0.5EU/mg |
无菌检测(医用等级) | 不合格 |
Claims (11)
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CN2009100541552A CN101935363B (zh) | 2009-06-30 | 2009-06-30 | 一种生产医药级透明质酸的方法 |
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CN2009100541552A CN101935363B (zh) | 2009-06-30 | 2009-06-30 | 一种生产医药级透明质酸的方法 |
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Publication Number | Publication Date |
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CN101935363A CN101935363A (zh) | 2011-01-05 |
CN101935363B true CN101935363B (zh) | 2012-08-08 |
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Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102392009A (zh) * | 2011-11-28 | 2012-03-28 | 上海景峰制药有限公司 | 一种木瓜蛋白酶的纯化方法 |
CN103304684B (zh) * | 2013-06-28 | 2015-07-15 | 四川柯森油田化学有限公司 | 一种提取纯化透明质酸的生产方法 |
CN104069021A (zh) * | 2014-06-11 | 2014-10-01 | 滨州安华生物工程有限公司 | 一种洁肤化妆品 |
CN104055686B (zh) * | 2014-06-11 | 2016-05-25 | 山东安华生物医药股份有限公司 | 一种皮肤保湿剂 |
CN104059169B (zh) * | 2014-06-11 | 2016-04-13 | 山东安华生物医药股份有限公司 | 一种透明质酸的提纯工艺 |
CN104055692B (zh) * | 2014-06-11 | 2016-05-25 | 山东安华生物医药股份有限公司 | 一种含有透明质酸的洁肤化妆品 |
CN107722139A (zh) * | 2017-09-22 | 2018-02-23 | 东辰控股集团有限公司 | 一种发酵液分级过滤快速制备透明质酸钠的方法 |
CN109913518A (zh) * | 2018-08-17 | 2019-06-21 | 上海昊海生物科技股份有限公司 | 一种透明质酸钠的管道化制备方法 |
CN110592163A (zh) * | 2019-09-19 | 2019-12-20 | 南京乔康生物科技有限公司 | 一种改善透明质酸钠色度的生产方法 |
CN112409509A (zh) * | 2020-11-17 | 2021-02-26 | 上海景峰制药有限公司 | 一种生产玻璃酸钠发酵原液的过滤方法 |
CN114259995A (zh) * | 2021-12-29 | 2022-04-01 | 内蒙古金达威药业有限公司 | 一种沸石珍珠岩粉凝胶壳聚糖树脂吸附剂及其制备方法和透明质酸的纯化和生产方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1587386A (zh) * | 2004-07-26 | 2005-03-02 | 清华大学 | 生产透明质酸的方法及其专用菌株 |
CN101089021A (zh) * | 2007-07-12 | 2007-12-19 | 华东理工大学 | 从微生物发酵液中分离提取透明质酸的方法 |
-
2009
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1587386A (zh) * | 2004-07-26 | 2005-03-02 | 清华大学 | 生产透明质酸的方法及其专用菌株 |
CN101089021A (zh) * | 2007-07-12 | 2007-12-19 | 华东理工大学 | 从微生物发酵液中分离提取透明质酸的方法 |
Non-Patent Citations (2)
Title |
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史鹏.发酵法生产透明质酸下游提取工艺方法的研究.《中国优秀博硕士学位论文全文数据库(硕士) 工程科技I辑》.2006,(第02期),B018-8. * |
孟庆繁.兽疫链球菌发酵法生产透明质酸.《中国优秀博硕士学位论文全文数据库(硕士) 工程科技I辑》.2004,(第04期),B018-100. * |
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