CN101917965B - 局部化妆用皮肤增亮组合物及其使用方法 - Google Patents
局部化妆用皮肤增亮组合物及其使用方法 Download PDFInfo
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- CN101917965B CN101917965B CN2007801022167A CN200780102216A CN101917965B CN 101917965 B CN101917965 B CN 101917965B CN 2007801022167 A CN2007801022167 A CN 2007801022167A CN 200780102216 A CN200780102216 A CN 200780102216A CN 101917965 B CN101917965 B CN 101917965B
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- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
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Images
Classifications
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/US2007/024109 WO2009067095A1 (en) | 2007-11-19 | 2007-11-19 | Topical cosmetic skin lightening compositions and methods of use thereof |
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CN101917965A CN101917965A (zh) | 2010-12-15 |
CN101917965B true CN101917965B (zh) | 2013-01-02 |
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CN2007801022167A Expired - Fee Related CN101917965B (zh) | 2007-11-19 | 2007-11-19 | 局部化妆用皮肤增亮组合物及其使用方法 |
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EP (1) | EP2219600A4 (ja) |
JP (1) | JP2011504498A (ja) |
CN (1) | CN101917965B (ja) |
AU (1) | AU2007361455A1 (ja) |
BR (1) | BRPI0722043A2 (ja) |
CA (1) | CA2706797A1 (ja) |
MX (1) | MX299318B (ja) |
WO (1) | WO2009067095A1 (ja) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8916209B2 (en) | 2009-10-02 | 2014-12-23 | Johnson & Johnson Consumer Companies, Inc. | Extracts of Phyllanthus niruri |
US8075930B2 (en) | 2009-10-02 | 2011-12-13 | Johnson & Johnson Consumer Companies, Inc. | Extracts of Phyllanthus niruri |
US8084504B2 (en) | 2009-10-02 | 2011-12-27 | Johnson & Johnson Consumer Companies, Inc. | High-clarity aqueous concentrates of 4-hexylresorcinol |
US8906432B2 (en) | 2009-10-02 | 2014-12-09 | Johnson & Johnson Consumer Companies, Inc. | Compositions comprising an NFκB-inhibitor and a non-retinoid collagen promoter |
US8075931B2 (en) | 2009-10-02 | 2011-12-13 | Johnson & Johnson Consumer Companies, Inc. | Extracts of Phyllanthus niruri |
US20110081430A1 (en) | 2009-10-02 | 2011-04-07 | Simarna Kaur | COMPOSITIONS COMPRISING AN NFkB-INHIBITOR AND A TROPOELASTIN PROMOTER |
KR101800213B1 (ko) * | 2010-07-02 | 2017-11-24 | (주)아모레퍼시픽 | 청시닥나무, 개시닥나무 또는 시닥나무의 추출물을 함유하는 피부 미백용 화장료 조성물 |
KR101784940B1 (ko) * | 2010-08-31 | 2017-10-12 | (주)아모레퍼시픽 | 피부 탄력 개선용 화장료 조성물 |
US9867772B2 (en) | 2010-08-31 | 2018-01-16 | Amorepacific Corporation | Cosmetic composition for improving skin elasticity |
KR20240036130A (ko) | 2011-03-28 | 2024-03-19 | 마리 케이 인코포레이티드 | 식물 추출물을 포함하는 국소 스킨 케어 제형 |
CN102284066B (zh) * | 2011-05-09 | 2013-08-14 | 南开大学 | 液体石蜡作为光透明增强剂的用途 |
JP5806859B2 (ja) * | 2011-06-08 | 2015-11-10 | ポーラ化成工業株式会社 | スクリーニング方法 |
WO2013006613A1 (en) | 2011-07-05 | 2013-01-10 | Novan, Inc. | Methods of manufacturing topical compositions and apparatus for same |
WO2013006608A1 (en) | 2011-07-05 | 2013-01-10 | Novan, Inc. | Topical compositions |
DE102011117364A1 (de) * | 2011-10-29 | 2013-05-02 | Merck Patent Gmbh | Hautaufheller in der Phototherapie |
WO2013096645A1 (en) | 2011-12-20 | 2013-06-27 | The Procter & Gamble Company | Human skin sample methods and models for validating hypotheses for mechanisms driving skin pigmentation |
CN102772644B (zh) * | 2012-02-09 | 2014-05-14 | 北京工商大学 | 具有消肿修复功效的中药组合物、制剂及其制备方法 |
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US20140086859A1 (en) | 2012-09-24 | 2014-03-27 | Johnson & Johnson Consumer Companies, Inc. | Low oil compositions comprising a 4-substituted resorcinol and a high carbon chain ester |
WO2014105878A1 (en) * | 2012-12-27 | 2014-07-03 | L'oreal | Meta-stable cosmetic or skin care composition |
US9855211B2 (en) * | 2013-02-28 | 2018-01-02 | Novan, Inc. | Topical compositions and methods of using the same |
WO2014138722A1 (en) * | 2013-03-08 | 2014-09-12 | Cognate3 Llc | Process for the preparation of a non-corrosive base solution and methods of using same |
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CN114668682B (zh) * | 2022-04-29 | 2023-07-07 | 广州睿森生物科技有限公司 | 一种保湿亮肤组合物及其应用 |
CN114869820B (zh) * | 2022-05-24 | 2023-06-06 | 安科化妆品(浙江)有限公司 | 一种含有北沙参叶提取物的防晒乳 |
WO2024065609A1 (en) * | 2022-09-30 | 2024-04-04 | L'oreal | Composition for caring for keratin materials and mask containing the same |
CN116115547A (zh) * | 2023-02-09 | 2023-05-16 | 深圳市沃英达生命科学有限公司 | 一种含有牛胎盘组织来源外泌体的祛斑组合物及其应用 |
CN116549474B (zh) * | 2023-06-07 | 2023-10-20 | 广东植肤生物科技有限公司 | 一种治疗黄褐斑的组合物及其乳膏 |
CN117427017B (zh) * | 2023-12-21 | 2024-03-05 | 北京世纪伟信医药科技有限公司 | 一种含牡丹提取物的润肤抗皱面霜及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1582894A (zh) * | 2004-06-02 | 2005-02-23 | 云南省天然药物中心 | 以余甘子为主要活性成分的系列化妆品组合物 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH068249B2 (ja) * | 1988-06-09 | 1994-02-02 | 丸善製薬株式会社 | メラニン生成抑制外用剤 |
JPH06271442A (ja) * | 1993-03-19 | 1994-09-27 | Shiseido Co Ltd | 皮膚外用剤 |
JPH0977638A (ja) * | 1995-09-19 | 1997-03-25 | Art Beauty Clinic Kk | 化粧用ファンデーション |
JP2003063925A (ja) * | 2001-08-23 | 2003-03-05 | Kose Corp | 皮膚外用剤 |
JP2003081749A (ja) * | 2001-09-13 | 2003-03-19 | Nonogawa Shoji Kk | 皮膚外用剤 |
US6649150B2 (en) * | 2002-04-11 | 2003-11-18 | Em Industries | Skin-lightening |
DE60331999D1 (de) * | 2002-01-18 | 2010-05-20 | Merck Patent Gmbh | Hautaufhellende zusammensetzung |
US20040028642A1 (en) * | 2002-04-26 | 2004-02-12 | Isabelle Hansenne | Cosmetic composition comprising an extract of emblica officinalis and methods of using same |
US20050064053A1 (en) * | 2002-11-08 | 2005-03-24 | Em Industries | Enriched aqueous components of emblica officinalis |
JP2004352697A (ja) * | 2003-05-30 | 2004-12-16 | Maruzen Pharmaceut Co Ltd | チロシナーゼ発現抑制剤 |
JP2005139070A (ja) * | 2003-11-04 | 2005-06-02 | Kanebo Cosmetics Inc | 皮膚化粧料 |
PT1737538E (pt) * | 2003-12-23 | 2013-12-17 | Clr Chemisches Lab Dr Kurt Richter Gmbh | Formulações de despigmentação tópicas compreendendo um extrato de bellis perennis |
KR101072133B1 (ko) * | 2004-01-15 | 2011-10-10 | (주)아모레퍼시픽 | 피부 미백 효능을 상승시키는 화장료 조성물 |
US20070020203A1 (en) * | 2005-07-07 | 2007-01-25 | Chaudhuri Ratan K | Skin care composition |
EP1842530A1 (en) * | 2006-03-23 | 2007-10-10 | Cognis IP Management GmbH | Cosmetic composition comprising a combination of a sugar fatty acid ester with a plant extract of waltheria indica or pisum sativum for skin whitening |
US20080050459A1 (en) * | 2006-08-22 | 2008-02-28 | 3Lab, Inc. | Cosmetic lightening preparation |
-
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1582894A (zh) * | 2004-06-02 | 2005-02-23 | 云南省天然药物中心 | 以余甘子为主要活性成分的系列化妆品组合物 |
Non-Patent Citations (2)
Title |
---|
JP特开2003-63925A 2003.03.05 |
余楚钦等.余甘子的药理研究及应用.《中国实用医药》.2007,第2卷(第36期),169-171. * |
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CA2706797A1 (en) | 2009-05-28 |
CN101917965A (zh) | 2010-12-15 |
JP2011504498A (ja) | 2011-02-10 |
WO2009067095A1 (en) | 2009-05-28 |
AU2007361455A1 (en) | 2009-05-28 |
MX299318B (es) | 2012-05-18 |
MX2010005548A (es) | 2010-08-06 |
BRPI0722043A2 (pt) | 2016-10-18 |
EP2219600A1 (en) | 2010-08-25 |
EP2219600A4 (en) | 2012-09-12 |
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