CN101917965B - Topical cosmetic skin lightening compositions and methods of use thereof - Google Patents

Abstract

Topical cosmetic compositions are provided that can comprise a Phyllanthus extract, a BeIHs extract, and a licorice (Glycyrrhiza) extract. These compositions are used for topical cosmetic applications, particularly to lighten skin. Methods for lightening skin are also provided and can comprise topically administering a therapeutically effective amount of a topical cosmetic composition comprising a Phyllanthus extract, a BeIHs extract, and a licorice extract, to skin of a subject in need thereof.

Description

Topical cosmetic skin lightening compositions and using method thereof

Technical field

The theme that the present invention puts down in writing relates to the topical cosmetic that contains plant extract and uses or skin composition.These compositionss are used for topical cosmetic to be used, and particularly is used for treating the cutaneous pigmentation (pigmentation) of not expecting.

Background of invention

The melanocyte that is positioned at the epidermis bottom (basal layer closes on basal cell) is the cell that forms pigment, and it according to skin type individually or the generation of cluster ground.Melanocyte contains melanosome, and melanosome forms melanin with very fast speed when being subject to the UV radiostimulation.Melanin is transported into keratinocyte, and has caused more or less outstanding brown and the brown colour of skin.

Melanin is the end-product of oxidizing process, in this oxidizing process tyrosine under the help of tryrosinase through 3,4-dihydroxyphenylalanine (DOPA), DOPA quinone, the dopachrome that fades (leucodopachrome), dopachrome, 5,6-dihydroxy indole and indole-5, the 6-quinone, the final conversion obtains melanin.

Needing especially safely and effectively, topical cosmetic skin lightening compositions is used for the treatment of the cutaneous pigmentation of not expecting, for example comprise: regionality (regional) hyperpigmentation that is caused by melanocyte superactivity, the constitutional chloasma (melasma) (mask of pregnancy or melasma (chloasma)) that for example occurs period of pregnancy, perhaps the constitutional chloasma of secondary after the Estrogen-Progestin contraception; By the local hyperpigmentation that optimum melanocyte superactivity and propagation cause, for example lentigo is known as the liver nevus; Sporadic hyperpigmentation, as damage rear photosensitization and scarring; Skin aging (for example lentigo senilis (lentigines seniles)); And the leukoderma of some form, such as white macula, if wherein injured skin can not be painted again, then all the other zones of normal skin can be by blast or the depigmentation (depigment) to give whole skin the uniform colour of skin.

Present known blast skin is namely resisted some active component and the preparation of cutaneous pigmentation.These products that use at present contain hydroquinone, but these products are owing to the toxicology reason has been considered to unacceptable.In fact, RDC 215 forbids using after in the December, 2007 hydroquinone in cosmetics.

A kind of cosmetic composition has been put down in writing in U.S.'s publication application 2006/0018867, it has improved anticorrosion and/or antibacterial action, said composition contains a kind of epsilon-polylysine chemical compound or two kinds and more kinds of combinations that contain the epsilon-polylysine chemical compound of polysiloxane that contain polysiloxane, this chemical compound obtains from epsilon-polylysine and polysiloxane or its physiologically acceptable salt and polyol reaction, and wherein said composition can be skin whitening composition.

International PCT applies for that openly WO2004/062635 has put down in writing the compositions that is used for skin lightening, and it contains two-pantoyl-cystamine.

A kind of cosmetic composition and using method thereof of the Embilica of containing officinalis extract put down in writing in U.S.'s publication application 2004/0028642.

U.S.'s publication application 2005/0271608 put down in writing a kind of based on the hydroxyaryl alkyl ketone and etc. row derivant skin whitening composition.

Method and sunscreen (sunscreen) compositions that promotes the tyrosinase inhibitory activity of skin whitening put down in writing in U.S.'s publication application 2004/0166069.

Still exist in the art the demand of improved topical cosmetic with compositions, this topical cosmetic contains the safely and effectively reagent of blast skin with compositions.The theme that the present invention describes is by providing topical cosmetic to satisfy these demands with compositions, and this topical cosmetic has been realized when the local application safely and effectively blast skin with compositions.Beat all discovery, the skin lightening component of describing theme according to the present invention has shown synergitic skin lightening effect.The effect of this concertedness skin lightening has realized using when the compositions at the preparation topical cosmetic skin lightening active component of reduction, this itself again so that the zest of compositions reduces and material cost lowers.

Summary of the invention

Theme of the present invention relates generally to and is used for the treatment of the various dermatosis relevant with the cutaneous pigmentation of not expecting and the topical cosmetic compositions of disease.Furthermore, theme of the present invention relates to the topical cosmetic compositions for cosmetic blast skin surface, and wherein the pigmentation of this skin area is applicable to individual skin type.

In one embodiment, theme of the present invention relates to the topical cosmetic compositions, and it contains or comprise that Leafflower (Phyllanthus) extract, Bellis perennis belong to (Bellis) extract and Glycyrrhiza extract.

In one embodiment, theme of the present invention relates to the topical cosmetic compositions, and it contains or comprise Fructus Phyllanthi (Phyllanthus embilica) extract, Bellis perennis (Bellis perennis) extract and Radix Glycyrrhizae extract.

In another embodiment, theme of the present invention relates to the topical cosmetic compositions that contains or comprise the skin lightening active component, and this skin lightening active component contains or comprise that Leafflower extract, Bellis perennis belong to extract and Glycyrrhiza extract; At least a sunscreen; With, acceptable carrier in the cosmetic.

In another embodiment, theme of the present invention relates to the topical cosmetic compositions that contains or comprise the skin lightening active component, and this skin lightening active component contains or comprise Fructus Phyllanthi extract, daisy extract and Radix Glycyrrhizae extract; At least a sunscreen; With, acceptable carrier in the cosmetic.

In one embodiment, theme of the present invention relates to the topical cosmetic compositions that contains and comprise the skin lightening active component, and this skin lightening active component contains or comprise that Leafflower extract, Bellis perennis belong to extract and Glycyrrhiza extract; With the non-skin lightening component that contains at least a sunscreen.

In one embodiment, theme of the present invention relates to the topical cosmetic compositions that contains and comprise the skin lightening active component, and this skin lightening active component contains or comprise Fructus Phyllanthi extract, daisy extract and Radix Glycyrrhizae extract; With the non-skin lightening component that contains at least a sunscreen.

In another embodiment, theme of the present invention relates to the method for a kind of blast (lighten) curee's cutaneous pigmentation, comprises to the described according to the inventive subject matter topical cosmetic compositions of the curee's that these needs are arranged topical application treatment effective dose.

In a further embodiment, theme of the present invention relates to a kind of curee's for the treatment of dermatosis or the method for disease, comprises to the described according to the inventive subject matter topical cosmetic compositions of the curee's that these needs are arranged topical application treatment effective dose.

Description of drawings

Fig. 1 has shown with the significant progressive blast in time that becomes statistically behind 21 days of 2% hydroquinone treatment site B.

Fig. 2 shown with topical cosmetic of the present invention with the significant progressive blast in time that becomes statistically behind 14 days of compositions-treated site E.

Fig. 3 has shown for undressed control zone (site F) with the progressive blast on the experimental period (natural degradation of synthesis of melanin), without any significance.

Fig. 4 has shown and is processing 1 (site B) and 2 (site E) and contrasting in (site F) comparison with the average chrominance value of evaluation time.

Detailed Description Of The Invention

Definition

As employed at this paper, term " administration ", " using " and similar terms refer to reasonably transmitting compositions so that any method to the positive interaction of dermatosis, disease and outward appearance to be provided to the curee in medicine and the practice of making up.Administration composition is so that they cover the whole zone that will treat like this." directly administration " refers to not use another compositions, transmission reagent or device to transmit any method of compositions to the curee in rational medicine and the practice of making up." indirectly administration " refer to use another compositions at least in reasonably medicine and the practice of making up, transmit reagent or device transmit any method from compositions to the curee.

As employed at this paper, " aqueous solvent " refers to for example be water or moisture solvent.Other dissolved constituents can be a small amount of existence, this component is salt, buffer agent and other components that may exist in aqueous solution that one of ordinary skill in the art will appreciate that for example.

" anhydrous formulation " refers to water-free topical cosmetic of the present invention arbitrary preparation of compositions.

" acceptable in the cosmetic " refers to nontoxic, inertia and/or the upper compatible compositions of physiology.

As employed at this paper, be enough to have positive interaction to using the zone at the phrase " effective dose " of this synonym or the activating agent of " treatment effective dose " or the amount that composition refers to activating agent.Therefore, in rational medicine and skin suggested range, this tittle is enough to improve dermatosis to be treated, disease or outward appearance, but enough low to avoid serious side effect.The activating agent for the treatment of effective dose can cause substantially alleviating of symptom when repeatedly using in time.The activating agent of effective dose can change with concrete component and the similar factor of persistent period of the seriousness of one or more the concrete diseases that will treat, disease, treatment, the compositions that will use.

As employed at this paper, " effect (effecting) " refers to the process to organic biological activity, function, health or situation generation effect, and this activity is maintained, strengthens, cuts down or treat in the mode consistent with organic general health and welfare in this organism.

As employed at this paper, " enhancing " organic biological activity, function and state refer to enlarge, consolidate, strengthen or improve the process of biological activity, function, health or situation.

As employed at this paper, " epithelium " or " epithelium " refers to form the top layer of cellular layer and mucosa and the serous coat of epiderm skin.Epithelial general utility functions are protections, absorb and secretion.Epithelial cell is often very near apart from blood vessel, although usually lack direct blood supply.

As employed at this paper, " extract " refers to that one or more are from the liquid of plant source separation or the component of powder type.Plant source can contain or comprise one or more parts of whole plant or plant, for example fruit, flower, leaf, root and/or skin.Fluid or liquid extract can drying (for example spray drying or oven dry) form powder.Extract can be the mixture from one or more components of plant of liquid and/or powder type.

" non-skin lightening " refers to contain or comprise any chemical compound, material or compositions or reagent or the component of one or more reagent, material, chemical compound or compositions, and it can not eliminate pigmentation or blast skin during to skin in local application.These reagent can comprise for example one or more activating agents, for example sunscreen, anti-acne agents (anti-acne agent), antibacterial (anti-microbial agent), anti-wrinkle agent (anti-wrinkle agent), anti-atrophy agent (anti-atrophy agent), antiinflammatory (anti-inflammatoryagent) and fluorescent whitening agent (optical brightener); And/or one or more upper acceptable excipient of making up, for example thickening agent, chelating agen, humidizer, emollient, wetting agent, gellant, pH adjusting agent, surfactant, stabilizing agent, vitamin, penetration enhancer, spice, coloring agent and solvent, and/or its combination, as described in this article.

As employed at this paper, " penetration enhancer " refers to the barrier resistance (barrier resistance) of reversible minimizing keratodermatitis thereby so that activating agent arrives living tissue chemical compound, material or compositions with higher rate.

As employed at this paper, " pH adjusting agent " or " pH improver " refers to add the specific pH regulator reagent that in the compositions pH of appointment is transferred to compositions.

As employed at this paper, " pharmaceutically acceptable free alkali, salt, ester or solvate " refers to free alkali, salt, ester or the solvate of target compound, it has the pharmacological activity identical with target compound, and biologically or in other situations does not expect.Salt, ester or solvate can use-case such as organic acid or mineral acid formation.The limiting examples of suitable acid comprises: acetic acid; acetylsalicylic acid; adipic acid; alginic acid; ascorbic acid; Aspartic Acid; benzoic acid; benzenesulfonic acid; pyrosulfuric acid (bisulfic acid); boric acid; butanoic acid; dextrocamphoric acid.; camphorsulfonic acid; carbonic acid; citric acid; the Pentamethylene. propanoic acid; diglucoside; lauryl sulphate acid (dodecylsulfic acid); ethyl sulfonic acid; formic acid; fumaric acid; glyceric acid; phosphoglycerol; glycerol; glucoheptonic acid; gluconic acid; glutamic acid; 1,3-propanedicarboxylic acid; hydroxyacetic acid; hemisulfic acid (hemisulfic acid); enanthic acid; caproic acid; hippuric acid; hydrobromic acid; hydrochloric acid; hydroiodic acid; ethylenehydrinsulfonic acid; lactic acid; maleic acid; malic acid; malonic acid; mandelic acid; methanesulfonic acid; glactaric acid; LOMAR PWA EINECS 246-676-2 (naphthylanesulfonic acid); naphthoic acid (naphthylic acid); nicotinic acid; nitrous acid; oxalic acid; n-nonanoic acid; phosphoric acid; propanoic acid; glucide; salicylic acid; sorbic acid; succinic acid; sulphuric acid; tartaric acid; Hydrogen thiocyanate; TGA; thiosulfuric acid; p-methyl benzenesulfonic acid; 9-undecylenic acid; ethanolamine; the aminoacid in natural and synthetic source.The limiting examples of alkali salt, ester or solvate comprises: ammonium salt; Alkali metal salt is such as sodium salt and potassium salt; Alkali salt is such as calcium salt and magnesium salt; With the salt of organic base formation, such as the salt of dicyclohexyl amine; Methyl D-glycosamine; With with amino acids formed salt, described aminoacid such as arginine, lysine etc.In addition, the nitrogen-containing group of alkalescence can be quaternized with following reagent: the low alkyl group chloride, as methyl and, chloride, bromide and the iodide of propyl group and butyl; Dialkyl sulfate (dialkyl sulfate) is such as the sulfate of dimethyl, diethyl, dibutyl and diamyl; The long-chain chloride is such as chloride, bromide and the iodide of decyl, lauryl, myristyl and stearyl; Asthma halogenide is such as the bromide of benzyl and phenethyl; And other.Obtained thus the product of water or oily solubility or dispersibility.

As employed at this paper, " milk surum (serum) " refers to the hydrophilic liquid preparation.Milk surum can be chosen wantonly and not contain one or more emollient, wax and siloxanes.

As employed at this paper, " skin lightening agent " refers at local application blast skin or eliminate arbitrary chemical compound, material or the compositions of cutaneous pigmentation during to skin.This skin lightening agent can include, but are not limited to: pigmentation inhibitor, tyrosinase inhibitor and melanocyte Melanin inhibitor.

As employed at this paper, " curee " or " individuality " or " animal " or " patient " or " mammal " need to refer to diagnose, arbitrary curee, the particularly mammalian subject of prognosis or treatment, such as the people.

As employed at this paper, " concertedness skin lightening system " or " concertedness skin lightening component " refers to the active component of blast skin, it contains or comprises Fructus Phyllanthi extract, daisy extract and Radix Glycyrrhizae extract, it is compared with the skin lightening effect of other independent skin lightening activating agents, demonstrates concertedness skin lightening effect.Aspect this, the combination of these compositions provide greater than add and the skin lightening effect.

As employed at this paper, " treatment " or " processing " dermatosis, disease or disease comprise and relax its at least a symptom, reduce its seriousness or delay, prevent or suppress its progress.Treatment need to not represent the fully healing of this disease, disease or disease.Useful compositions need to only reduce dermatosis herein, and the seriousness of disease or disease reduces the seriousness of relative symptom, improves Quality of Life, perhaps delays, prevents or suppress the generation of dermatosis, disease or disease.

It should be noted that as employed in this specification and the appended claims " " of singulative and " class " comprise the object of plural number, unless context clearly limits implication are arranged in addition.

Unless otherwise defined, all scientific and technical terminologies used herein all have as the present invention describe the theme those skilled in the art the identical meanings usually understood.

When the value that provides is scope, for example concentration range, percentage range or ratio ranges, the scope that should be understood that the theme of describing comprises each intermediate value between this scope bound, a precision of/10th to lower limit unit, unless context is clear the restriction in addition, and comprises the value that any other indicates or indicating the intermediate value of scope.These upper and lower bounds more among a small circle can be included in the less scope independently, and these embodiments also can be included in the theme of the present invention's description any scope that indicates of eliminating in described scope.When indicated scope comprises one or two scope, get rid of one or two scope in this scope and be also included within the theme that the present invention describes.

In whole the application, " containing " this word is used in the description of various embodiments; But, one skilled in the art will appreciate that in some special situations embodiment can alternatively use language " substantially to comprise " or " comprising " is described.

In order to understand better instruction of the present invention, and not limit the mode of the scope of the invention, all numerical value of expression quantity, percentage ratio or the share that uses in description and claims or other numerical value all should be understood to be modified by term " about " in all cases.Therefore, unless opposite indication is arranged, the numerical parameter that provides in following description and claims is approximation, can change according to the desirable properties that will obtain.At least, each numerical parameter should be explained according to the important numbers of reporting with by using the common method of rounding up at least.

The topical cosmetic compositions

Theme of the present invention relates to the topical cosmetic compositions, and it contains or comprise that Leafflower extract, Bellis perennis belong to extract and Glycyrrhiza extract.

Main skin lightening activating agent

Theme having thus described the invention, topical cosmetic of the present invention can contain or comprise with compositions: Leafflower extract, i.e. Fructus Phyllanthi extract; Bellis perennis belongs to extract, i.e. daisy extract; With the Glycyrrhiza extract.

" Leafflower extract " refers to the extract that obtains from the member's of Leafflower fruit, and the member of Leafflower comprises for example Fructus Phyllanthi (Phyllanthus embilica), Herba Scopariae (Phyllanthus niruriL.), Phyllanthus elegans Wall, Herba Phyllanthi Urinariae (Phyllanthus iniruri), Phyllanthus reeiculaeuspoir (Phyllanthus reticulatus), Cacumen Securinegae Suffruticosae (Phyllanthus urinaria L.), massif bean (Phyllanthus reticulatus Poir), Phyllanthus conami Sw, Phyllanthus lathyroides H.B.K., Phyllanthus casticum Soy-Will and Phyllanthus madagascariensis.The Leafflower extract is the safely and effectively Natural antioxidant.

" Fructus Phyllanthi extract " refers to the standard extract of Fructus Phyllanthi, for example comprises

(Merck KGaA, Darmstadt, Germany, and EM industries, Inc., USA, the subsidiary of Merck KgaA).Fructus Phyllanthi also is known as " Emblica officinalis Gaertn " usually, and is a member of " Euphorbiaceae (Euphorbiaceae) ".Fructus Phyllanthi is ascorbic very rich in natural resources, and ascorbic acid content is 1000～1800mg/100g fruit.Fructus Phyllanthi extract is antioxidant safely and effectively, does not help oxidation (pro-oxidation) activity, can show dual-use function, such as chelating agen and antioxidant.Different to the antioxidant of inactivation form from activity from great majority, Fructus Phyllanthi extract can show the cascade effect, and lasting and stable antioxidant activity is provided.Fructus Phyllanthi extract can be by using such as United States Patent (USP) 6,124, and the water-based process extraction high-quality fruit of record and preparing in 268 is incorporated herein by reference this patent integral body.Fructus Phyllanthi extract contains low-molecular-weight tannins material (tannins) usually, be EmblicaninA and Emblicanin B, and Pedunculagin (Pedunculagin) and Pericarpium Granati gluconic acid tannin (Punigluconin), rutin (Rutin) and Gallo-ellagitannoids.

" Bellis perennis belongs to extract " refers to the extract that obtains from the member that Bellis perennis belongs to, for example comprises the extract that the member's who belongs to from Bellis perennis flower (for example flower of the flower of Bellis perennis and/or Spanish daisy (Bellis rotundifolia L.)) obtains.Bellis perennis belongs to extract can contain or comprise one or more bioactive molecules, comprises saponin (triterpene glucosides class), Polyphenols (phenolic acid), flavonoid glucosides, polysaccharide and inulin.

The extract that " daisy extract " expression obtains from the flower of Bellis perennis, it can contain or comprise one or more bioactive molecules, comprises saponin (triterpene glucosides class), Polyphenols (phenolic acid), flavonoid glucosides, polysaccharide and inulin.Suitable daisy extract can comprise

(from CLR Chemisches Laboratorium, Berlin, Germany).Bellis perennis also is known as Bellis alpina Hegetschw., Bellis hortensis Mill., Bellis hybrida Ten., Bellis integrifolia DC. and Bellis scaposa Gilib usually.

The extract that " Glycyrrhiza extract " expression obtains from the member of Glycyrrhiza (Glycyrrhiza genus), for example, the extract that obtains from Glycyrrhiza member's root." Glycyrrhiza " is the member of " Papilionaceae (Fabaceae) ".Suitable Glycyrrhiza extract can comprise oil-soluble Radix Glycyrrhizae extract (from Bioland, Korea).Other suitable Glycyrrhiza extracts can obtain from one or more following Glycyrrhiza members, and the Glycyrrhiza member comprises Glycyrrhiza ech inata (Glycyrrhiza echinata L.) (Chinese Radix Glycyrrhizae (Chinese licorice)), G1ycyrrhiza glabra (Glycyrrhiza glabra L.) (cultivation Radix Glycyrrhizae (cultivated licorice)), glycyrrhiza lepidota Purss (Glycyrrhiza lepidota L.), Glycyrrhiza glutinosa, sweet Rhizoma Polypodiodis Nipponicae (polypodium Glycyrrhiza), Glycyrrhiza brachycarpa Boiss., Glycyrrhiza germanica Tourn., Glycyrrhiza glandulifera Waldst.et Kit., Glycyrrhiza hirsuta L., Glycyrrhiza laevis Pall., Glycyrrhiza officinalis Lepech., Glycyrrhiza pallida Boiss., Glycyrrhiza siliquosa Tourn., Glycyrrhiza violacea Boiss., Glycyrrhiza viscosa Turcz.ex Ledeb., Glycyrrhiza vulgaris Gueldenst.ex Ledeb, Liquiritia officinalis Moench and Liquiritia officinarum Medik.

In one embodiment, topical cosmetic of the present invention can contain or comprise the skin lightening active component with compositions, and it can contain or comprise that Leafflower extract, Bellis perennis belong to extract and Glycyrrhiza extract.

In one embodiment, topical cosmetic of the present invention can contain or comprise the skin lightening active component with compositions, and it can contain or comprise Fructus Phyllanthi extract, daisy extract and Radix Glycyrrhizae extract.

In one embodiment, theme of the present invention relates to the topical cosmetic compositions, wherein all the skin lightening active component is from about 0.5 % by weight to about 43 % by weight, from about 1 % by weight to about 30 % by weight, from about 1.5 % by weight to about 23 % by weight, from about 1.5 % by weight to about 15 % by weight, from about 3 % by weight to about 10 % by weight, from about 6 % by weight to about 8 % by weight or about 7.05 % by weight, based on the gross weight of compositions at topical cosmetic with the amount in the compositions.

In another embodiment, theme of the present invention relates to the topical cosmetic compositions, Leafflower extract wherein, Fructus Phyllanthi extract for example, be from about 0.1 % by weight to about 8 % by weight, from about 0.25 % by weight to about 4 % by weight, from about 0.5 % by weight to about 3 % by weight, from about 0.5 % by weight to about 2 % by weight, from about 1 % by weight extremely about 2 % by weight or about 2 % by weight, based on the gross weight of compositions at topical cosmetic with the amount in the compositions.

In another embodiment, theme of the present invention relates to the topical cosmetic compositions, wherein Bellis perennis belongs to extract, daisy extract for example, be from about 0.5 % by weight to about 30 % by weight, from about 1 % by weight to about 20 % by weight, from about 2 % by weight to about 10 % by weight, from about 3 % by weight to about 7 % by weight, from about 4 % by weight extremely about 6 % by weight or about 5.0 % by weight, based on the gross weight of compositions at topical cosmetic with the amount in the compositions.

In a further embodiment, theme of the present invention relates to the topical cosmetic compositions, wherein Radix Glycyrrhizae extract is from about 0.005 % by weight to about 5 % by weight, from about 0.01 % by weight to about 2 % by weight, from about 0.01 % by weight to about 1 % by weight, from about 0.02 % by weight to about 0.08 % by weight, from about 0.03 % by weight to about 0.07 % by weight or about 0.05 % by weight, based on the gross weight of compositions at topical cosmetic with the amount in the compositions.

In another embodiment, theme of the present invention relates to the topical cosmetic compositions, Leafflower extract wherein, and for example, Fructus Phyllanthi extract be from about 0.50 % by weight about 2 % by weight extremely at topical cosmetic with the amount in the compositions; Bellis perennis belongs to extract, and for example daisy extract is from about 1 % by weight to about 20 % by weight at topical cosmetic with the amount in the compositions; And Radix Glycyrrhizae extract is from about 0.01 % by weight to about 1 % by weight at topical cosmetic with the amount in the compositions.

In a further embodiment, theme of the present invention relates to the topical cosmetic compositions, and wherein Fructus Phyllanthi extract is about 2 % by weight at topical cosmetic with the amount in the compositions; The amount of daisy extract is about 5 % by weight; And Radix Glycyrrhizae extract is about 0.05 % by weight at topical cosmetic with the amount in the compositions.

In one embodiment, theme of the present invention relates to the topical cosmetic compositions that contains or comprise the skin lightening active component, and this skin lightening active component contains or comprises: Leafflower extract, for example Fructus Phyllanthi extract; Bellis perennis belongs to extract, for example daisy extract; With the Glycyrrhiza extract; At least a sunscreen; With the upper acceptable carrier of making up.Acceptable carrier can contain or comprise one or more upper acceptable excipient of making up in the cosmetic.

In another embodiment, theme of the present invention relates to the topical cosmetic compositions that contains or comprise the skin lightening active component, and this skin lightening active component contains or comprises: Leafflower extract, for example Fructus Phyllanthi extract; Bellis perennis belongs to extract, for example daisy extract; With the Glycyrrhiza extract; With non-skin lightening component.This non-skin lightening component can contain or comprise one or more activating agents, for example sunscreen; Acceptable carrier in the cosmetic; And/or the upper acceptable excipient of making up, as described herein.

In further embodiment, theme of the present invention relates to the topical cosmetic compositions of describing theme according to the present invention, and it can contain one or more non-skin lightening activating agents.

In a further embodiment, topical cosmetic is with compositions and/or make up upper acceptable carrier and/or one or more upper acceptable excipient of making up, except containing Leafflower extract, for example Fructus Phyllanthi extract; Bellis perennis belongs to extract, for example daisy extract; Outside the Glycyrrhiza extract, can not contain any skin lightening agent.Topical cosmetic is with compositions and/or make up upper acceptable carrier and/or one or more upper acceptable excipient of making up, except containing Leafflower extract, for example Fructus Phyllanthi extract; Bellis perennis belongs to extract, for example daisy extract; Outside the Glycyrrhiza extract, can not contain any skin lightening agent of plant origin.Topical cosmetic can not contain any skin lightening agent in non-plant source with compositions and/or make up upper acceptable carrier and/or one or more upper acceptable excipient of making up.

In one embodiment, theme of the present invention relates to the topical cosmetic compositions, wherein said compositions and/or skin lightening active component and/or non-skin lightening active component, do not contain the hydroquinone or derivatives thereof, and/or do not contain the epsilon-polylysine chemical compound of polysiloxane, and/or do not contain flavane.

Concertedness skin lightening component

In another embodiment, theme of the present invention relates to the topical cosmetic compositions that can contain or comprise concertedness skin lightening active component, and this concertedness skin lightening active component contains or comprise Leafflower extract, for example Fructus Phyllanthi extract; Bellis perennis belongs to extract, for example daisy extract; With the Glycyrrhiza extract; Wherein this concertedness skin lightening active component is compared the collaborative skin lightening effect that shows with each single skin lightening activating agent.

In one embodiment, theme of the present invention relates to for the concertedness skin lightening component of topical cosmetic with compositions, and it contains or comprise Leafflower extract, for example Fructus Phyllanthi extract; Bellis perennis belongs to extract, for example daisy extract; With the Glycyrrhiza extract.

In another embodiment, theme of the present invention relates to for the concertedness skin lightening component of topical cosmetic with compositions, and it contains or comprise Leafflower extract, for example Fructus Phyllanthi extract; Bellis perennis belongs to extract, for example daisy extract; With the Glycyrrhiza extract; Wherein this concertedness skin lightening component shows the skin lightening effect of enhancing.This concertedness skin lightening component can not contain hydroquinone.

In one embodiment, the topical cosmetic of describing theme according to the present invention can contain or comprise the skin lightening active component with compositions, and it shows collaborative skin lightening effect.

In another embodiment, the topical cosmetic of describing theme according to the present invention can contain or comprise the skin lightening active component with compositions, and it shows collaborative skin lightening effect, and wherein this topical cosmetic does not contain hydroquinone with compositions.

In one embodiment, the topical cosmetic of describing theme according to the present invention can contain or comprise the skin lightening active component with compositions or concertedness skin lightening system, it shows collaborative skin lightening effect, and wherein this topical cosmetic does not contain hydroquinone and/or flavane with compositions and/or contains the epsilon-polylysine chemical compound of polysiloxane.

Acceptable carrier in the cosmetic

Any nontoxic, inertia or effectively on the topical cosmetic acceptable carrier can be used for preparing compositions described herein.Well-knownly be used for preparing other and can be used for these compositionss to topical therapeutics of people's administration with carriers of compositions.Be to those skilled in the art the case history of well-known these components in The MerckIndex, the 13rd edition, the people such as Budavari edit, Merck﹠amp; Co., Inc., Rahway, N.J. (2001): the CTFA (Cosmetic, Toiletry, and Fragrance Association) International Cosmetic Ingredient Dictionary and Handbook, the 10th edition (2004); And the " Inactive Ingredient Guide ", U.S.Food and Drug Administration (FDA) Center for Drug Evaluation and Research (CDER) Office of Management, among the January 1996, the content of these publications is incorporated herein by reference with its integral body.The example of acceptable excipient, carrier and wetting agent comprises that distilled water, normal saline, Ringer's mixture, glucose solution, Hank solution and DMSO and other are fit to as used herein those in these useful cosmetics.

Other inactive ingredients that these are extra and effective in the prior art well-known of preparation and medication, and be recorded in the standard textbook, Goodman and Gillman ' s:The Pharmacological Bases of Therapeutics for example, the 8th edition, the people such as Gilman compile, Pergamon Press (1990) and Remington ' s Pharmaceutical Sciences, the 17th edition, Mack Publishing Co., Easton, Pa. (1990), these two equal integral body of publication are incorporated herein by reference.

Sunscreen

In another embodiment, theme of the present invention relates to the topical cosmetic compositions that can contain at least a sunscreen.The amount of this at least a sunscreen based on topical cosmetic with compositions can for about 0.5 % by weight to about 30 % by weight, based on the gross weight of described compositions be about 1 % by weight to about 20 % by weight, or about 1 % by weight is to about 10 % by weight.

Suitable sunscreen can comprise the broad spectrum sunscreen that prevents UVA and UVB radiation or prevent UVA or the sunscreen of UVB radiation.The limiting examples of suitable sunscreen comprises such sunscreen, it can contain or comprise following composition one or more: Neo Heliopan AV, N, N-dimethyl-para-amino benzoic acid 2-Octyl Nitrite, para-amino benzoic acid, 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID, octocrylene (octocrylene), oxybenzone, salicylic acid height Ester (homomenthyl salicylate); ethylhexyl salicylate; 4; 4 '-methoxyl group-tert-butyl group dibenzoyl methane; 4-isopropyl diphenyl formoxyl methane; 3-benzylidene Camphora; 3-(4-methylbenzene methylene) Camphora; titanium dioxide; zinc oxide; silicon oxide; ferrum oxide; 2; the 4-N of 4-dihydroxy benaophenonel; N-(2-ethylhexyl) methylamino benzoate; the 4-N of 4-hydroxy benzophenone acyl group methane; N-(2-ethylhexyl)-methylamino benzoate; the 4-N of 2-hydroxyl-4-(2-hydroxyl-oxethyl) benzophenone; N-(2-ethylhexyl)-methylamino benzoate; the 4-N of 4-(2-hydroxyl-oxethyl) dibenzoyl methane; N-(2-ethylhexyl)-methylamino benzoate; dihydroxycinnamic acid; trihydroxy-cinnamic acid; diphenyl diethylene; Stilbene; dibenzalacetone; benzalacetophenone; naphthol sulfonate; beta naphthal-3; 6-disulfonic acid (2-naphthol-3; 6-disulfonic); beta naphthal-6; the 8-disulfonic acid; two-hydroxynaphthoic acid; adjacent and to hydroxy diphenyl disulfonate (disulfonates); coumarin; diazole; 2-acetyl group-3-bromo-indazole; Ben base benzoxazole; Jia Ji naphthoxazole; various aryl benzothiazoles; quinine salt; quinoline; oxine; the 2-phenylchinoline; hydroxyl-and the benzophenone of methoxyl group-replacement; uric acid (uric); violuric acid (violuricacid); tannic acid; benzophenone; phenol; sulisobenzone (sulisobenzone); 2; 2 '-dihydroxy-4-methoxyl group benzophenone (dioxybenzone); benzoyl group resorcinol (benzoresorcinol); 2; 2 '; 4; 4 '-tetrahydroxybenzophenone; 2; 2 '-dihydroxy-4; 4 '-dimethoxy-benzophenone; octabenzone; 4-isopropyl diphenyl formoxyl methane; PAROSOL 1789; etocryene (etocrylene); 2-cyano group-3; 3-diphenylacrylate-2-Octyl Nitrite; 3-(4 '-methylbenzene methylene Borneolum Syntheticum-2-ketone); the Terephthalidene Dicamphor Sulfonic Acid; 4-isopropyl-two-benzoyl methane; butyl methoxy dibenzoyl base-methane; ESCALOL 567; 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID; octyldimethyl-para-amino benzoic acid; 2-cyano group-3; 3-diphenylacrylate-2-Octyl Nitrite; 2; the 4-N of 4-dihydroxy benaophenonel; N-(2-ethylhexyl) methyl-Aminobenzoate; the N of 4-hydroxy benzophenone acyl group methane; N-two-(2-ethylhexyl)-PABA ester; the 4-N of 4-(2-hydroxyl-oxethyl) dibenzoyl methane; N-(2-ethylhexyl)-methylamino benzoate; the N of 2-hydroxyl-4-(2-hydroxyl-oxethyl) benzophenone; N-two-(2-ethylhexyl)-PABA ester; the N of 4-(2-hydroxyl-oxethyl) dibenzoyl methane; N-two-(2-ethylhexyl)-PABA ester; its pharmaceutically acceptable or upper acceptable salt of making up, and their mixture.

In one embodiment; topical cosmetic of the present invention can contain sunscreen with compositions, and it contains or comprise following composition one or more: the zinc oxide of di-2-ethylhexylphosphine oxide-benzotriazole base tetramethyl phenol, DHHB, coating, ethylhexyl methoxy cinnamate, methoxy cinnamic acid isopentyl ester, salicylic acid height Ester, ethylhexyl salicylate, octocrylene, Dimethicodiethylbenzalmalonate (polysilicone-15), PAROSOL 1789, Antisolaire and ethylhexyl dimethyl PABA.

In another embodiment; topical cosmetic of the present invention can contain such sunscreen with compositions; it contains following composition one or more: methylene two-benzotriazole base tetramethyl phenol (TINOSORB M; obtained by CIBA), DHHB and the zinc oxide that applies; its amount is from about 1 % by weight to about 20 % by weight, from about 2 % by weight to about 10 % by weight or about 5 % by weight, based on the gross weight of compositions.For example, topical cosmetic of the present invention can contain such sunscreen with compositions, its amount is about 1 % by weight to about 20 % by weight, from about 2 % by weight to about 10 % by weight or the di-2-ethylhexylphosphine oxide of about 5 % by weight-benzotriazole base tetramethyl phenol, based on the gross weight of compositions.

In another embodiment, topical cosmetic of the present invention can contain such sunscreen with compositions, and it contains or comprise following composition one or more: ethylhexyl methoxy cinnamate (being obtained by BASF), methoxy cinnamic acid isopentyl ester, salicylic acid height

Ester, ethylhexyl salicylate, 2-cyano group-3; 3-diphenylacrylate-2-Octyl Nitrite, Dimethicodiethylbenzalmalonate, PAROSOL 1789, Antisolaire and ethylhexyl dimethyl PABA; its amount for from about 1 % by weight to about 10%, from about 5 % by weight to about 9% or about 7.5 % by weight, based on the gross weight of compositions.

In one embodiment, topical cosmetic of the present invention can contain one or more sunscreen with compositions, its amount is from about 0.5 % by weight to about 30 % by weight, from about 1 % by weight to about 20 % by weight or from about 1 % by weight to about 10 % by weight, based on the gross weight of compositions.

In one embodiment, this at least a sunscreen can contain or comprise the first sunscreen and the second sunscreen, and wherein the first sunscreen is selected from the zinc oxide of di-2-ethylhexylphosphine oxide-benzotriazole base tetramethyl phenol, DHHB and coating; The second sunscreen is selected from ethylhexyl methoxy cinnamate, methoxy cinnamic acid isopentyl ester, salicylic acid height

Ester, ethylhexyl salicylate, octocrylene, Dimethicodiethylbenzalmalonate, PAROSOL 1789, Antisolaire and ethylhexyl dimethyl PABA.The amount of the first sunscreen can be for from about 1 % by weight to about 20 % by weight, and the amount of the second sunscreen can be for from about 1 % by weight to about 10 % by weight, based on the gross weight of topical cosmetic with compositions.This first sunscreen can contain or comprise di-2-ethylhexylphosphine oxide-benzotriazole base tetramethyl phenol, and this second sunscreen can contain or comprise ethylhexyl methoxy cinnamate.

In one embodiment, theme of the present invention relates to following topical cosmetic compositions, and its SPF that has is greater than about 10, the SPF that has is greater than about 15, and SPF is about 15 at least about 15, SPF, SPF is from about 10 to about 45, and SPF is from about 15 to about 45, or SPF is from about 15 to about 25.

Aqueous solvent

Topical cosmetic of the present invention can also contain aqueous solvent with compositions.In one embodiment, the aqueous solvent that the present composition contains such as the amount of water for from about 5 % by weight to about 95 % by weight, from about 10 % by weight to about 90 % by weight, from about 25 % by weight to about 80 % by weight, from about 55 % by weight to about 75 % by weight, from about 60 % by weight to about 70 % by weight or about 63 % by weight, based on the gross weight of compositions.

But cosmetic excipient

In a further embodiment, theme of the present invention relates to the topical cosmetic compositions, and it can contain acceptable excipient in water and at least a cosmetic.Acceptable excipient comprises common those the known excipient for topical composition of those of ordinary skills in the suitable cosmetic.

In one embodiment, acceptable excipient can contain or comprise that one or more are selected from following material in the described at least a cosmetic: polysiloxanes and the combination thereof of antioxidant, chelating agen, pH adjusting agent, emollient, thickening agent, gellant, radical scavenger, antiseptic, emulsifying agent, wetting agent, humidizer, suspending agent, surfactant, stabilizing agent, vitamin, penetration enhancer, spice or essence, coloring agent, liquid alkylol, polysiloxanes (polysiloxanes), modification.

Antioxidant

Described topical cosmetic can be chosen wantonly with compositions and also contain one or more antioxidants.Can choose the suitable antioxidant that is included in these compositionss wantonly and can contain or comprise one or more of following composition: ascorbic acid; the acid ascorbyl ester of fatty acid; Ascorbic acid 2-phosphate magnesium; SAP; the ascorbic acid sorbate; tocopherol; tocopherol sorbic acid ester; tocopherol acetas; butylated hydroxy benzoic acid (butylated hydroxy benzoic acid); thioglycolate (thioglycolates); persulfate; 6-hydroxyl-2; 5; 7; 8-tetramethyl benzo dihydropyran-2-carboxylic acid; thioctic acid (lipoic acid); gallic acid; propyl gallate; uric acid; sorbic acid; thioctic acid; amine; N; N-diethyl hydroxylamine; ACETYLCYSTEINE; amino-guanidine; mercapto compound; glutathion; Dihydroxyfumaric acid; betanin pidolic acid ester (lycine pidolate); arginine pidolic acid ester; nor-dihydroguaiaretic acid (nordihydroguaiaretic acid); bioflavonoids; curcumin; lysine; the 1-methionine; proline; superoxide dismutase; silymarin (silymarin); tea extract; Pericarpium Vitis viniferae/seed extract; melanin; Herba Rosmarini Officinalis extract; its derivant, and combination.

In one embodiment, topical cosmetic of the present invention can comprise suitable antioxidant with compositions, it can contain or comprise in the following composition one or more: butylated hydroxytoluene (butylatedhydroxytoluene), metabisulfite sodium, butylated hydroxyanisol, ascorbic acid and derivant thereof, sulphite and derivant thereof, ester and tocopherol acetas, for example, its amount is from about 0.01 % by weight to about 0.5 % by weight, from about 0.01 % by weight to about 0.2 % by weight, from about 0.02 % by weight to about 0.1 % by weight, from about 0.03 % by weight to about 0.07 % by weight, or about 0.05 % by weight, based on the gross weight of compositions.Topical cosmetic of the present invention can comprise metabisulfite sodium with compositions, and for example, its amount is from about 0.1 % by weight to about 0.5 % by weight, from about 0.2 % by weight to about 0.4 % by weight or about 0.3 % by weight, based on the gross weight of compositions.In addition, topical cosmetic of the present invention can comprise butylated hydroxytoluene with compositions, for example, its amount is from about 0.01 % by weight to about 0.2 % by weight, from about 0.02 % by weight to about 0.1 % by weight, from about 0.03 % by weight to about 0.07 % by weight or about 0.05 % by weight, based on the gross weight of compositions.Topical cosmetic of the present invention can comprise following antioxidant with compositions, it can contain or comprise butylated hydroxytoluene and metabisulfite sodium, for example, the amount of its combination is from about 0.01 % by weight to about 0.6 % by weight, from about 0.2 % by weight to about 0.5 % by weight or about 0.35 % by weight, based on the gross weight of compositions.

These one or more antioxidants topical cosmetic with the amount in the compositions can for, for example, from about 0.01 % by weight to about 0.6 % by weight, from about 0.1 % by weight to about 0.5 % by weight or from about 0.2 % by weight to about 0.5 % by weight, based on the gross weight of compositions.

Chelating agen

Topical cosmetic of the present invention can be chosen wantonly with compositions and also contain one or more chelating agen.Can choose the suitable chelating agen that is included in these compositionss wantonly and can contain or comprise one or more of following composition: citric acid, (list) citric acid isopropyl ester, the citric acid stearyl ester, lecithin citric acid (lecithin citrate), gluconic acid, tartaric acid, oxalic acid, phosphoric acid, TSPP, dipotassium hydrogen phosphate (potassiummonophosphate), sodium hexameta phosphate, hexa metaphosphoric acid calcium, Sorbitol, glycine (glycine), methylglucosamine, triethanolamine (trolamine), EDTA, DEG (dihydroxyethylglycin), DPTA (diethylene-triamine pentaacetic acid), NTA (aminotriacetic acid), HEDTA (N-(hydroxyethyl)-ethylidene three amine triacetic acids), aminocarboxylate/ester, 2,3-dimercaprol (BAL), larixinic acid (maltol), monodentate ligand (fluoride and cyanide ion), diphenylthiocarbazone, the 0-phenanthroline, the diphenylamine barium sulfonate, gluceptate sodium, oxine, alkene complex (such as dicyclopentadieny iron), porphyrin, phosphate/ester, its pharmaceutically acceptable or upper acceptable salt of making up, its derivant, and their mixture.

Topical cosmetic of the present invention can comprise one or more chelating agen with compositions, measure into from about 0.05 % by weight to about 1 % by weight, from about 0.1 % by weight to about 0.5 % by weight or about 0.2 % by weight, based on the gross weight of compositions.

In one embodiment, topical cosmetic of the present invention can comprise following chelating agen with compositions, it can contain or comprise following composition one or more: disodiumedetate, EDTA, EDETATE SODIUM, EDTA trisodium and EDTA four sodium, for example, its amount is from about 0.2 % by weight to about 0.4 % by weight, based on the gross weight of compositions.

PH adjusting agent

Topical cosmetic of the present invention can be chosen wantonly with compositions and also contain one or more pH adjusting agents.Can choose wantonly and be included in suitable in these compositionss and pH adjusting agent can contain or comprise one or more of following composition: the inorganic salt of inorganic hydroxide, inorganic oxide, weak acid, its derivant, and their mixture.

The suitable inorganic hydroxide that can be used for this aspect can contain or comprise one or more of following composition: ammonium hydroxide, alkali metal hydroxide, alkaline earth metal hydroxide, its derivant, and their mixture.

The suitable inorganic hydroxide that can be used for this aspect can contain or comprise one or more of following composition: ammonium hydroxide, monoacidic base metal hydroxides such as sodium hydroxide and potassium hydroxide, divalent alkaline-earth metal hydroxide such as calcium hydroxide and magnesium hydroxide, its derivant, and their mixture.

The suitable inorganic oxide that can be used for this aspect can contain or comprise one or more of following composition: magnesium oxide, calcium oxide, and its derivant, and composition thereof.

The inorganic salt that can be used for the suitable weak acid of this aspect can contain or comprise following one or more: diammonium phosphate, the alkali metal salt of weak acid such as sodium acetate, sodium borate, sodium metaborate, sodium carbonate, sodium bicarbonate, tertiary sodium phosphate, sodium hydrogen phosphate, potassium carbonate, potassium bicarbonate, potassium citrate, potassium acetate, dipotassium hydrogen phosphate, tripotassium phosphate, the alkali salt of weak acid such as magnesium phosphate and calcium phosphate, its derivant, and their mixture.

In one embodiment, topical cosmetic of the present invention can comprise following pH adjusting agent with compositions, and it can contain or comprise following composition one or more: triethanolamine, amino methyl propanol and sodium hydroxide.The amount of pH adjusting agent in compositions can for, for example, from about 0.1 % by weight to about 1 % by weight, from about 0.2 % by weight to about 0.9 % by weight or about 0.6 % by weight, based on the gross weight of compositions.Topical cosmetic of the present invention with the pH of compositions can from about 2.5 to about 8 or from about 3 to about 7 scope.

Emollient

Topical cosmetic of the present invention can also contain emollient with compositions.The suitable limiting examples that can be used for the emollient in the present composition comprises one or more of following composition: Tetradecyl lactate, isopropyl palmitate, liquid paraffin,light, 16/octadecanol, lanoline, lanolin derivative, mineral oil, vaseline oil (petrolatum), whale ester type waxes, cholesterol, glycerol, glyceryl monostearate, myristic acid isopropyl esters, glycol, lecithin and composition thereof.

In one embodiment, suitable emollient can contain or comprise following one or more: glycerol; Glycol, for example propylene glycol, butanediol and pentanediol; Encircle five polydimethylsiloxane polydimethylsiloxane cross linked polymers (cyclopentasiloxane dimethicone crosspolymer) (DC9040, Dow Corning); Encircle five polydimethylsiloxane PEG/PPG-18/18 polydimethylsiloxane (cyclopentasiloxane PEG/PPG-18/18dimethicone) (DC5225C, Dow Corning); And siloxanes (silicon) derivant.The amount of emollient can be for from about 1 % by weight to about 20 % by weight, from about 2 % by weight to about 10 % by weight, from about 3 % by weight to about 8 % by weight or about 4 % by weight.

Thickening agent/gellant

Topical cosmetic of the present invention can be chosen wantonly with compositions and also contain one or more thickening agents.Can choose the suitable thickening agent that is included in these compositionss wantonly can contain or comprise, but be not limited to, one or more of following composition: cellulosic polymer, such as arabic gum, Tragacanth, carob gum, guar gum, Xanthan gun, sodium carboxymethyl cellulose, methylcellulose, hydroxy ethyl cellulose, hydroxy propyl cellulose and HYDROXY PROPYL METHYLCELLULOSE; Carbomer sodium; Carbomer (carbomer); Acrylic acid polymer (polyacrylicpolymer); The water gellant is such as neutrality, anionic and cation type polymer; Polymer is such as CVP Carbopol ETD2050, such as carbomer; Acrylate copolymer (acrylate copolymer); Polysorbate; Aliphatic alcohol, for example spermol and stearyl alcohol; Tristerin; Alkyl derivative; And composition thereof.Suitable acrylate copolymer can contain or include but not limited to one or more of following composition: 2-(Acryloyloxy)ethanol and acryloyl group dimethyl sodium taurocholate copolymer.

In one embodiment, suitable thickening agent can contain or comprise one or more of following composition: aliphatic alcohol, for example spermol and stearyl alcohol; Tristerin; Alkyl derivative; And combination; For example, its amount is from about 0.25 % by weight to about 4 % by weight, from about 0.5 % by weight to about 3 % by weight, from about 1 % by weight to about 2 % by weight or about 2 % by weight, based on the gross weight of compositions.

In one embodiment; suitable thickening agent can contain or comprise following one or more: 2-(Acryloyloxy)ethanol; acryloyl group dimethyl sodium taurocholate copolymer; squalane; anhydrous sorbitol polyoxyethylene (20) ether stearate (poly sorbate 60); the carbomer derivant; acrylate; acrylamide; Xanthan gun; antler glue; aluminium silicate; magnesium silicate and cellulose derivative; for example; its amount is from about 1 % by weight to about 10 % by weight; from about 2 % by weight to about 8 % by weight; from about 3 % by weight to about 7 % by weight; or about 5 % by weight, based on the gross weight of compositions.

Suitable thickening agent can contain or comprise 2-(Acryloyloxy)ethanol, acryloyl group dimethyl sodium taurocholate copolymer, squalane and anhydrous sorbitol polyoxyethylene (20) ether stearate; for example; its amount is from about 1 % by weight to about 10 % by weight or about 5 % by weight; based on the gross weight of compositions, this can with

From SEPPIC, Fairfield, NJ obtains.This thickening agent can be used for other thickening agents such as spermol combination the topical cosmetic compositions of the present invention's record, and the amount of other thickening agents is from about 0.5 % by weight to about 2 % by weight or about 2 % by weight, based on the gross weight of compositions.

These one or more thickening agents topical cosmetic with the amount in the compositions can for about 0.25 % by weight to about 15 % by weight, from about 1 % by weight to about 12 % by weight, from about 4 % by weight to about 10 % by weight, from about 5 % by weight to about 9 % by weight, or about 7 % by weight, based on the gross weight of compositions.

Radical scavenger

The topical cosmetic of putting down in writing can be chosen the radical scavenger that also contains effective dose wantonly with compositions." effective dose " refers to enough provide the amount of protection when suitably using compositions, but again not as many as cause any side effect or disadvantageous dermoreaction; Be generally amount of composition from about 0.1 % by weight to about 20% or from about 1 % by weight to about 5%.The example of these radical scavengers (for example includes but not limited to ascorbic acid (vitamin C) and salt and derivant thereof, Ascorbic acid 2-phosphate magnesium, SAP, ascorbic palmitate etc.), tocopherol (vitamin E), Renascin (for example, tocopherol yl acetate, fertility phenolic group succinate, fertility phenolic group sorbate), butylated hydroxy benzoic acid and salt thereof, 6-hydroxyl-2,5,7,8-tetramethyl benzo dihydropyran-2-carboxylic acid is (with trade name Be purchased), the acid ascorbyl ester of gallic acid and Arrcostab (propyl gallate), uric acid and salt thereof and Arrcostab, sorbic acid and salt thereof, fatty acid, amine (for example, N, N-diethyl hydroxylamine, aminoguanidine), mercapto compound (for example, glutathion) and Dihydroxyfumaric acid and salt thereof.In addition, (for example can use catechin and Polyphenols, those that in green tea extract, find) and flavonoid (for example, the isoflavonoid of finding in the soybean extract such as genistein (genistein) and daidzein (daidxein), flavone, chalcone derivative, flavanone, coumarin etc.).

Antiseptic

The topical cosmetic of putting down in writing can be chosen wantonly with compositions and also contain one or more antiseptic.Can allow the optional suitable preservatives that is included in these compositionss can contain or include but not limited to one or more of following composition: propylene glycol, glycerol, butanediol, pentanediol, hexanediol, Sorbitol, benzyl alcohol, its derivant, and their mixture.

In one embodiment, suitable antiseptic can contain or comprise one or more of following composition: phenoxyethanol, Methylisothiazolinone, phenoxyethanol, p-Hydroxybenzoate, imidazolidinyl urea (imidazolynidyl urea), and combination.In addition, the amount of antiseptic can for from about 0.05 % by weight to about 1.5 % by weight, from about 0.1 % by weight to about 1 % by weight, from about 0.1 % by weight to about 0.6 % by weight or about 0.6 % by weight, based on the gross weight of compositions.In another embodiment, suitable antiseptic can contain or comprise phenoxyethanol and Methylisothiazolinone, for example, and NEOLONE (it is the formaldehydeless wide-spectrum bactericide based on Methylisothiazolinone and phenoxyethanol, Rohm﹠amp; Haas, Philadelphia, PA).

Emulsifying agent

Topical cosmetic can be chosen wantonly with compositions and also contain one or more emulsifying agents.The suitable emulsifying agent that is included in these compositionss can be chosen wantonly and in various nonionics, cationic, anionic, amphoteric ion type and the amphoteric emulsifying agent any can be contained or comprise.

The suitable limiting examples that can be used for the emulsifying agent of this aspect can comprise such emulsifying agent; it can contain or comprise one or more diol esters; fatty acid; aliphatic alcohol; the fatty acid diol ester; fatty ester; aliphatic ether; the ester of glycerol; the ester of propylene glycol; the fatty acid ester of Polyethylene Glycol; the fatty acid of polypropylene glycol; the ester of Sorbitol; the ester of sorbitan anhydride; polymers of carboxylic acid; the ester of glucose and ether; the ether of ethoxylation; the alcohol of ethoxylation; alkylphosphonate (phosphates); polyoxyethylene aliphatic ether phosphate ester (phosphates); fatty acid amide; acyl lactylates; soap; anhydrous sorbitol polyoxyethylene (20) ether laurate (polysorbate 20); Polyethylene Glycol 5 Generol 12ies (soya sterol); stearyl polyoxyethylene (2) ether (steareth-2); stearyl polyoxyethylene (20) ether (steareth-20); stearyl polyoxyethylene (21) ether (steareth-21); 16/octodecyl alcohol polyoxyethylene (20) ether (ceteareth-20); methyl glucose polyoxypropylene (2) distearate; cetyl polyoxyethylene (10) ether (ceteth-10); anhydrous sorbitol polyoxyethylene (20) oleic acid ester (polysorbate 80); phosphoric acid hexadecanol ester; phosphoric acid hexadecanol ester potassium salt; diethanolamine cetyl phosphate ester; anhydrous sorbitol polyoxyethylene (20) ether stearate; tristerin; polyoxyethylene (100) stearate; its derivant, and composition thereof.

In one embodiment, topical cosmetic of the present invention can comprise following emulsifying agent with compositions, and it can contain or comprise following composition one or more: C _14-22Pure and mild C _12-20Alkyl androstanediol, for example,

(it is the compositions of aliphatic alcohol and alkyl androstanediol, SEPPIC, Fairfield, NJ).Suitable emulsifying agent can comprise one or more of following composition: the aliphatic alcohol of cetyl phosphate ester potassium, alkyl phosphate salt, PEG 100-tristerin and composition thereof, ethoxylation and mixture and the alkyl sulfate salt of one or more aliphatic alcohol and/or tristerin.

In one embodiment, topical cosmetic skin lightening compositions of the present invention can comprise from about 0.5 % by weight to the emulsifying agent of about 10 % by weight, from about 1 % by weight to about 5 % by weight, from about 1.5 % by weight to about 3.5 % by weight or the emulsifying agent of about 2 % by weight, based on the gross weight of compositions.

Wetting agent (Humectants)

Topical cosmetic of the present invention can also contain wetting agent with compositions.The suitable limiting examples that can be used for the wetting agent in the present composition comprises glycerol, butanediol, propylene glycol, Sorbitol and glyceryl triacetate.

Humidizer (moisturizer)

Topical cosmetic can be chosen wantonly with compositions and also comprise one or more humidizers.Suitable humidizer can contain or include but not limited to one or more of following composition: glycerol, pentanediol, butanediol, Polyethylene Glycol, pyrrolidone sodium carboxylate, 'alpha '-hydroxy acids, beta-hydroxy acid, polyhydroxy-alcohol, ethoxylation and propenoxylated polyhydric alcohol (polyols), polyhydric alcohol, polysaccharide, pantothenylol, hexanediol, propylene glycol, dipropylene glycol, Sorbitol, and derivant, and their mixture.

Suspending agent

Topical cosmetic of the present invention can also contain suspending agent with compositions.The limiting examples that can be used for the suitable suspending agent in the present composition comprises one or more of following composition: alginic acid, bentonite, carbomer, carboxymethyl cellulose and salt thereof, hydroxyethyl-cellulose, hydroxypropyl cellulose, microcrystalline Cellulose, colloidal silica, dextrin, gelatin, guar gum, Xanthan gun, Kaolin, Magnesiumaluminumsilicate, maltose alcohol, triglyceride, methylcellulose, polyoxyethylene fatty acid ester, polyvinyl pyrrolidone, propylene glycol alginate, sodium alginate, sorbitan fatty acid esters, Tragacanth (tragacanth), and composition thereof.

Surfactant

Topical cosmetic can be chosen wantonly with compositions and also contain one or more surfactants.Can choose the suitable surfactant that is included in these compositionss wantonly and can contain or comprise following one or more: amphoteric ion type, amphoteric, anionic, cationic and nonionic surfactant and their mixture.Suitable amphoteric ion type, amphoteric, anionic, cationic and nonionic surfactant comprise that those are recorded in the surfactant among " McCutcheon ' s; Detergents and Emusifiers; NorthAmerican edition (1986); Allured Publishing Corporation publishes " and " McCutcheon ' s; Functional Materials; North American Edition (1992) ", are incorporated herein by reference these two pieces of equal integral body of document.

The limiting examples that is used for the surfactant of the present composition comprises nonionic surfactant, anionic surfactant, amphoteric surfactant, cationic surface active agent and composition thereof.

The limiting examples that is used for the amphoteric surfactant of the present composition is selected from following surfactant for those: alkyl betaine, alkyl amino betanin, aminopropan acid esters/salt (propionates), imino-diacetic propionic ester/salt, amino glycinate, imidazolinium betaine, sulfobetaines, and composition thereof.

The concrete limiting examples that is used for the amphoteric surfactant of the present composition is selected from following surfactant for those: 3-dodecyl-alanine sodium, 3-dodecyl aminopropanesulfonic acid sodium, N-lauroyl amido-N-ethoxy sodium acetate (sodium lauroamphoacetate), cocoyl dimethyl carboxyl methyl betaine, cocoyl aminopropyl betanin, coco betaine, lauryl aminopropyl betanin, oil-based betaine, lauryl dimethyl carboxyl methyl betaine, lauryl dimethyl α-carboxy ethyl betanin, cetyl dimethyl carboxyl methyl betaine, lauryl two-(2-hydroxyethyl) carboxyl methyl betaine, stearyl two-(2-hydroxypropyl) carboxyl methyl betaine, oil base dimethyl γ-carboxyl CAB, lauryl two-(2-hydroxypropyl) α-carboxy ethyl betanin, the oil base amido propyl betaine, the cocoyl dimethyl sulfopropyl betaine, the stearyl dimethyl sulfopropyl betaine, lauryl dimethyl sulfo group ethyl betanin, lauryl two-(2-hydroxyethyl) sulfopropyl betaine, and composition thereof

Similarly; the limiting examples that is used for the anionic surfactant of the present composition is to be selected from following surfactant: the sulfate of alkyl sulfate, alkyl ethoxylated, β-alkyl oxy alkylsulfonate, alkyl ether sulfate, alkyl glyceryl ether sulfonate, alkyl ether carboxy acid salt, acyl-hydroxyethyl sulfonate, acyl sarcosinates, acyl group taurine (taurines), succinate; its alkali metal salt, ammonium salt or alkanol ammonium salt, or their mixture.

Particularly, the limiting examples that is used for the anionic surfactant of the present composition is to be selected from following surfactant: ammonium lauryl sulfate, sodium lauryl sulfate, polyoxyethylene lauryl ether (laureth) ammonium sulfate, polyoxyethylene lauryl ether sodium sulfate, alkyl glyceryl ether sulfonate, the triethanolamine lauryl sulfate, the triethanolamine lauryl alcohol polyoxyethylene ether sulfate, the triethanolamine lauryl sulfate, the triethanolamine lauryl alcohol polyoxyethylene ether sulfate, the monoethanolamine lauryl sulfate, monoethanolamine polyoxyethylene lauryl ether sulfate, the diethanolamine lauryl sulfate, diethanolamine polyoxyethylene lauryl ether sulfate, lauryl monoglyceride sodium sulfate, lauryl potassium sulfate, the polyoxyethylene lauryl ether potassium sulfate, sodium lauryl sarcosinate, sodium N-lauroyl sarcosinate, the lauryl sarcosine, the cocoyl sarcosine, cocoyl ammonium sulfate, lauroyl ammonium sulfate, cocoyl sodium sulfate, lauroyl sodium sulfate, the cocoyl potassium sulfate, lauryl potassium sulfate, the triethanolamine lauryl sulfate, the triethanolamine lauryl sulfate, monoethanolamine cocoyl sulfate, the monoethanolamine lauryl sulfate, three decyl benzene sulfonic acid sodium salts, dodecylbenzene sodium sulfonate, cocos nucifera oil alkyl triethylene glycol ether sodium sulfate salt and ammonium salt; Tallow alkyl triethylene glycol ether sulfate, tallow alkyl six oxygen ethylidene sulfate, N-disodium octadecyl sulfosuccinate, lauryl disodium sulfosuccinate, lauryl 2-Sulfosuccinic acid diammonium, N-(1,2-dicarboxyl ethyl)-N-octadecyl 2-Sulfosuccinic acid four sodium, the diamyl ester of sodium sulfosuccinate, the dihexyl of sodium sulfosuccinate, the dioctyl ester of sodium sulfosuccinate, docusate sodium (docusate sodium), and composition thereof.

The concrete limiting examples that is used for the cationic surface active agent of the present composition comprises and is selected from following surfactant: Shan Yu base trimethyl ammonium chloride; methylsulfuric acid two (acetyl group oxygen base ethyl) hydroxyethyl ammonium methyl; cetab; chlorination cetyl trimethylammonium; CTAB; cocos nucifera oil acylamino-propyl group amine oxide; VARISOFT TA100; ditallow dimethyl ammonium chloride; the guar gum hydroxypropyl-trimethyl ammonium chloride; lauryl benzyl dimethyl ammonium bromide; lauryl dimethyl amine oxide; lauryl dimethyl benzyl ammonium chloride; lauryl polyoxyethylene dimethyl oxidation amine; lauryl trimethyl ammonium chloride; methyl isophthalic acid-oil base amide ethyl-2-oil base imidazoles Methylsulfate; picoline benzyl ammonium chloride; polyquaternary ammonium salt (polyquaternium); stearyl dimethyl benzyl ammonium chloride (stearalkonium chloride); the stearyl dimethyl benzyl ammonium chloride; the stearyl trimethyl ammonium chloride; trimethyl glycerol, and composition thereof.

The concrete limiting examples that is used for the nonionic surfactant of the present composition comprises and is selected from following surfactant: polyoxyethylene fatty acid ester, sorbitan ester, Octanoic acid, hexadecyl ester, coconut oleoyl amine DEA, coconut oleoyl amine MEA, cocos nucifera oil acylamino-propyl-dimethyl amine oxide, the fatty acid distribution of coconut oil diglycollic amide, fatty monoethanol amide, two isostearic acids, two glyceride, single isostearic acid two glyceride, mono laurate two glyceride, single oleic acid two glyceride, diglycol stearate, Tego-stearate, the Oleum Ricini of ethoxylation, single glyceryl isostearate, glyceryl monolaurate, single myristin, glyceryl monooleate, glyceryl monostearate, three caprylic/capric glyceride, three glyceryl isostearates, glycerol trioleate, two isostearic acid glycol esters, Tego-stearate, Ethylhexyl stearate, lauramide DEA, lauric acid diethyl amide, lauric monoethanolamide, lauric acid/myristic acid diglycollic amide, lauryl dimethyl amine oxide, lauryl/myristyl amide DEA, lauryl/myristyl dimethyl amine oxide, methyl gluceth ether (methylgluceth), Glucate SS, oleamide (oleamide) DEA, the PEG-distearate, the polyoxyethylene butyl ether, polyoxyethylene cetyl base ether, the polyoxyethylene lauryl amine, the polyoxyethylene Lauryl Ester, polyoxyethylene lauryl ether, the polyoxyethylene nonylplenyl ether, the polyoxyethylene Octyl Ether, NONIN HS 240, polyoxyethylene oil base amine, polyoxyethylene oil base cetyl ether, the polyoxyethylene grease, polyoxyethylene oleyl ether, polyoxyethylene stearyl base amine, the polyoxyethylene stearyl ester, polyoxyethylene stearyl ether, the polyoxyethylene beef tallow amine, polyoxyethylene three decyl ethers, propylene glycol monostearate, the mono laurate sorbitan ester, single oleic acid sorbitan ester, single Palmic acid sorbitan ester, the monostearate sorbitan ester, sesquialter oleic acid sorbitan ester, three oleic acid sorbitan esters, stearmide DEA, Stearic acid diethanolamine salt, stearic acid monoethanolamide, lauryl alcohol polyethylene glycol oxide (4) ether (laureth-4) and composition thereof.

Vitamin

Topical cosmetic of the present invention can be chosen wantonly with compositions and also contain one or more vitamin or derivatives thereofs.In one embodiment, the topical cosmetic of the present invention of describing theme according to the present invention can contain vitamin C and/or vitamin E with compositions.For example, vitamin C and/or vitamin E can be effectively to be present in topical cosmetic of the present invention with in the compositions as the amount individualism of antioxidant or with other antioxidant combination.

Penetration enhancer

Topical cosmetic of the present invention can be chosen wantonly with compositions and contain one or more penetration enhancers.The limiting examples of suitable penetration enhancer comprises the penetration enhancer that those contain or comprise one or more hydrophilic solvents, described hydrophilic solvent for example: DMSO, DMF, DMA, glycerol, Polyethylene Glycol, pyrrolidinone derivatives, N-decyl-methyl sulfoxide (Brij 36T), lower alcohol, fatty acid and/or ester; Lipotropy promoter, for example, dodecyl-aza-cycloheptane alkane-2-ketone (azone (azone)), ethyl acetate, ethyl propionate, liquid paraffin, laminin，LN (lamonin), leaf fat (lard), hexadecanol, oleyl alcohol, ethoxy lactamide, solketal (solketal), tetrahydrochysene furfuryl ether (glycofural), tetrahydrofurfuryl alcohol, oleic acid, isopropyl myristate, lauryl alcohol, miglyol are oily, linoleic acid, lauric acid, dodecyl-L-Glutimic acid ester and methyl laurate; Surfactant, anionic surfactant for example, comprise, for example, sodium lauryl sulfate, dioctyl sodium sulphosuccinate, single Palmic acid sorbitan ester, poloxamer (poloxamers), polyoxyethylene (8) stearate (polyoxy-8-stearate), polyoxyethylene oleyl ether (polyoxyethelene-o-oleyl-ether), chain alkyl sulfoxide, lauryl ether, Brij 36T, cetyl trimethylammonium bromide and enuatrol; Sunscreen comprises, for example octyl methoxycinnamate, oxybenzone, salicylic acid height

Ester, ethylhexyl salicylate, p-(dimethylamino)-benzoic acid pentyl ester (padimate-o) and sulisobenzone; Polymer; Urea and derivant thereof; Liposome; And/or its combination.

Spice

Topical cosmetic of the present invention also can be chosen wantonly with compositions and contain spice.The suitable limiting examples of spice comprises quintessence oil and mixture, for example Perfume FAV22000 ( Obtained by Firmenich) and any spice (perfume).

Coloring agent

Topical cosmetic of the present invention also can be chosen wantonly with compositions and contain coloring agent, and coloring agent includes but not limited to one or more of following composition: dyestuff, colorant, pigment, nano dye and/or its combination.

The amount of pigment in compositions can be the scope of 0.01 % by weight to 25 % by weight of final composition, for example 3 % by weight to 10 % by weight.They can be white or colored, inorganic or organic.Limiting examples comprises titanium oxide, zirconium oxide or cerium oxide, and zinc oxide, ferrum oxide or chromium oxide, barba hispanica (ferric blue), chromic oxide gel, white carbon black, ultramarine (ultramarines) (polysulfide of aluminosilicate), manganese pyrophosphate and some metal dust such as argentum powder or aluminium powder.Other limiting examples comprise D﹠amp; C pigment and color lake (lakes), they are commonly used to labiad and skin is given dressing effect, comprise calcium salt, barium salt, aluminum salt, strontium salt or zirconates.

These are fat-soluble or water-soluble dye independent or can be the scope of from 0.001 to 15 % by weight as the amount of mixture in compositions, for example from from 0.01 to 5 % by weight or from 0.1 to 2 % by weight, with respect to the gross weight of compositions.Limiting examples comprise Ponceaux (ponceau) if disodium salt, disodium salt, D C Yellow No. 10, amaranth trisodium salt, the single sodium salt of tartrazines disodium salt tannin (rhodamine), pinkish red disodium salt, xanthophyll, methylene blue, fuchsin, halogenated acid (halo-acid), azo dye and anthraquinone dye, copper sulfate or iron sulfate, sudan brown (udan brown), tonyred and the carmine (annatto) of Alizarin Green, and beet root juice and carotene, and/or its combination.

Other embodiments

In one embodiment, the topical cosmetic of putting down in writing can be chosen wantonly with compositions and also contain acceptable excipient at least a cosmetic, the upper acceptable excipient of this cosmetic can contain or comprise: at least a antioxidant, this antioxidant can contain or comprise one or more that are selected from following composition: butylated hydroxytoluene, metabisulfite sodium, butylated BHA, ascorbic acid and derivant, sulphite and derivant thereof, ester, tocopherol acetate base ester, and combination; Chelating agen, it can contain or comprise one or more that are selected from following composition: disodiumedetate, EDTA, EDETATE SODIUM, EDTA trisodium, EDTA four sodium, and combination; Emollient, this emollient can contain or comprise one or more that are selected from following composition: glycols, siliceous emollient, and combination; Thickening agent, this thickening agent can contain or comprise one or more that are selected from following composition: acrylate copolymer, acrylate, acrylamide, poly-sorbitol ester (polysorbate), aliphatic alcohol, natural gum (gum), silicate, carbomer derivant, cellulose derivative, and combination; Antiseptic, this antiseptic can contain or comprise one or more that are selected from following composition: phenoxyethanol, Methylisothiazolinone, phenoxyethanol, p-Hydroxybenzoate, imidazolidinyl urea, and combination; PH adjusting agent, this pH adjusting agent can contain or comprise one or more that are selected from following composition: triethanolamine, amino methyl propanol, sodium hydroxide, and combination; With, emulsifying agent, this emulsifying agent can contain or comprise one or more that are selected from following composition: C _14-22Alcohol, C _12-20Alkyl androstanediol, and combination.

In another embodiment; theme of the present invention relates to the topical cosmetic compositions; wherein this emollient can contain or comprise one or more that are selected from following composition: propylene glycol; glycerol; butanediol; pentanediol; encircle five polydimethylsiloxane polydimethylsiloxane cross linked polymers; encircle five polydimethylsiloxane PEG/PPG-18/18 polydimethylsiloxane and combinations thereof, and/or this thickening agent can contain or comprise one or more that are selected from following ingredients: 2-(Acryloyloxy)ethanol; acryloyl group dimethyl sodium taurocholate copolymer; squalane; anhydrous sorbitol polyoxyethylene (20) ether stearate; the carbomer derivant; Xanthan gun; antler glue; aluminium silicate; magnesium silicate; cellulose derivative; spermol; stearyl alcohol; spermol and stearyl alcohol; tristerin and combination thereof.

Topical formulations

In one embodiment, topical cosmetic of the present invention is mixed with milk surum (serum) with compositions, gel breast (gel cream), skin lotion (lotion), cream (cream), ointment (ointment), gel, aerosol (aerosol), foam (foam), but foaming liquid (foamable liquid), solution (solution) (solubilizing systems (solubilized system)), paste (paste), suspension (suspension), dispersion (dispersion), Emulsion (emulsion), skin cleaner (skin cleanser), emulsion (milk), facial film (mask), solid bar (solid stick), block (bar) (such as soap-cake), capsule preparations (encapsulatedformulation), microcapsule formulation (microencapsulated formulation), microsphere dispersion or nanosphere dispersion or microbubble dispersion (vesicular dispersions) or the upper acceptable topical formulations of other cosmetics.In the situation of microbubble dispersion (vesicular dispersions), the lipid that folliculus forms can be ion-type or nonionic, or its mixture.Said preparation can contain one or more in aqueous compositions and/or the anhydrous formulation.

In another embodiment, the topical cosmetic of the present invention of putting down in writing theme according to this paper can contain or comprise anhydrous formulation, aqueous compositions or Emulsion with compositions.

In a further embodiment, the topical cosmetic of the present invention of putting down in writing theme according to this paper is mixed with milk surum or gel breast form with compositions.

Other optional activating agents

The topical cosmetic of the present invention's record can be chosen wantonly except above-mentioned skin lightening activating agent with compositions and also contain one or more cosmetic activating agents or skin activating agent.These activating agents can comprise for example other skin lightening activating agents and/or non-skin lightening activating agent, this skin lightening activating agent comprises the skin lightening agent in plant origin or non-woven source, comprise for example pigmentation inhibitor, tyrosinase inhibitor and/or melanocyte Melanin inhibitor, this non-skin lightening activating agent comprises for example fluorescent whitening agent, sunscreen, antiinflammatory, antibacterial, antifungal, anti-wrinkle agent, anti-atrophy agent, anti-acne agents, radical scavenger, keratolytic (keratolytic agent), vitamin, elastase inhibitor and/or anticollagenase agent (anti-elastase and/or anti-collagenase agent), peptide, derivative of fatty acid, the steroid class, trace element, algae extract and/or plankton extractions, enzyme and/or coenzyme, flavonoid and/or ceramide, 'alpha '-hydroxy acids, and combination.

Other skin lightening activating agent

Described topical cosmetic can be chosen wantonly with compositions and also contain one or more other skin lightening agent.Other suitable skin lightening agent can contain or include, but are not limited to following one or more: Semen Ginkgo (gingko) extract, carob (carob) extract, Flos Rosae Rugosae (rose) fruit extract, Herba Erodii (geranium herb) extract, Fructus Perillae (Perilla) extract, Cortex Cinnamomi (cinnamon) extract, sweet Adeps Bovis seu Bubali (sweet marjoram) extract, Arnica (Arnica) extract, Concha Blanca extract, cola ed Caballo, Piri-Piri, Pinon Negro, Pinon Blanco, the extract of Flos Caryophylli (clove), alfalfa (alfalfa), speckle seed wood (Baliospermum montanum), Neem (Meliaazadirachta), Herba seu Flos Convolvuli arvensis (Convolvulus arvensis), Gaiyo, Sansonin, Syuroyo, Seimkko, Soukyo, Taiso, Hakusempi, Flos Woodfordiae Fruticosae (Woodfordia fructosa), Flos Caryophylli Lagerstroemia indica L. (Lagerstroemia speciosa), passiflorine (passiflorine), tepezcohite, amoule, Hobiyu, Baffalo uri, Achote, guayule (Guayule), Adhatoda vasica Nees (Adhatoda), Herba Cymbopogonis Citrari (Cymbopogon nardus), Da Ye beggarweed (Desmodium gangeticum), flavoring agent Folium Et Cacumen Murrayae (Murraya koenigii), Smilax zeylanica, Rhizoma Gastrodiae (Gastrodia elata), Karukeij a, Cacumen Platycladi (Biota orientalis), Kichiascoporia, Arecatachu, henon bamboo (Phyllostachys nigra) leaf, atractylodes japonica (Atractylodes japonica), Koidzumi, Tila, Camotede azafran, Jamaica, Poleo verde, Navo negro, Cyperus (Cyperus), Kanzo, the Moraceae structure belongs to (Broussonetia), Karojitsu, Radix Trichosanthis (Trichosanthis radix), Dioscorea phizoma and Lignum Aquilariae Resinatum (Aquilliaria).

Other skin lightening agent can also contain or comprise, but be not limited to be selected from following one or more: teprenone (teprenone), dihydroxy-isoquinolin, indomethacin (indomethacin), 3-hydroxyl manule, vitamin K is (such as vitamin K1-K7, its analog (homologue), salt and derivant), the thiazoline derovatives, cynruin (kynurenine) and derivant and salt, retinol and derivant thereof are (for example, tretinoin (Tretinoin), tretinoin), resorcinol and derivant thereof are (for example, 4-alkyl-resorcin etc.), reservatol, intacellin, ellagic acid (ellagic acid), linoleic acid and alpha-lipoic acid and amino phenols are for example, such as at United States Patent (USP) 6, those that put down in writing in 203,781 (formula I).The amount of other skin lightening agent is generally from about 0.01 % by weight to about 20%, based on the gross weight of compositions.Other suitable skin lightening agent are alpha-lipoic acid.

Cosmetic composition according to the inventive subject matter can randomly contain the pigmentation inhibitor.

Cosmetic composition according to the inventive subject matter can contain tyrosinase inhibitor.

Cosmetic composition according to the inventive subject matter can contain the melanocyte Melanin inhibitor.

Fluorescent whitening agent

Topical cosmetic can be chosen wantonly with compositions and contain one or more fluorescent whitening agents.Fluorescent whitening agent is described in Fluorescent Whitening Agent, Encyclopedia of Chemical Technology, and Kirk-Othmer, Vol.11, the 227-241 page or leaf, among 1994, the Wiley, is incorporated herein by reference its integral body by the 4th edition.Absorb in 300～390nm scope that fluorescent whitening agent can more specifically be defined as at UVA and the basic chemical compound of in 400～525nm scope, launching again.Suitable fluorescent whitening agent can contain or comprise, but be not limited to: one or more stilbene derivatives (for example, 4,4 '-two [(4,6-hexichol amidos-1,3,5-triazine-2-yl) amino] Stilbene-2,2 '-sodium disulfonate), coumarin derivative, oxazole and benzoxazole derivative (for example, 2,5-thiophene two base two (the 5-tert-butyl group-1,3-benzoxazole)) and imdazole derivatives.The amount of fluorescent whitening agent is usually in about 0.1% to about 5.0% scope, based on the gross weight of compositions.Suitable fluorescent whitening agent is oxazole.

Antiinflammatory

Topical cosmetic can be chosen wantonly with compositions and further contain one or more antiinflammatories.The suitable antiinflammatory that is used for this aspect can contain or include but not limited to following one or more: propanoic derivatives; acetogenin; fragrant that acid (fenamic acid) derivant; diphenyl carboxyl carboxylic acid derivates; former times health class (oxicams); acetylsalicylic acid; ibuprofen (ibuprofen); naproxen (naproxen) benoxaprofen (benoxaprofen); BTS-18322 (flurbiprofen); fenoprofen (fenoprofen); fenbufen; ketoprofen (ketoprofen); indoprofen (indoprofen); pirprofen fragrant (pirprofen); carprofen (carprofen); oxaprozin (oxaprozin); pranoprofen (pranoprofen); fragrant (microprofen) tioxaprofen (tioxaprofen) in little Lip river; suprofen (suprofen); alminoprofen (alminoprofen); tiaprofenic acid (tiaprofenic acid); fluprofen (fluprofen); bucloxic acid (bucloxic acid); azapropazone (apazone); bromfenac (bromfenac); celecoxib (celecoxib); diclofenac (diclofenac); difenpiramide (difenpiramide); diflunisal (diflunisal); etodolac (etodolac); flufenamic acid (flufenamic acid); indomethacin (indomethacin); ketorolac (ketorolac); meclofenamic acid (meclofenamate); mefenamic acid (mefenamic acid); meloxicam (meloxicam); nabumetone (nabumetone); Phenylbutazone (phenylbutazone); piroxicam (piroxicam); butibufen (butibufen); rofecoxib (rofecoxib); salicylic acid; sulindac (sulindac); tolmetin (tolmetin); ketorolac tromethamine (ketorolac tromethamine); hydryllin (antihistaminic agents); diphenhydramine (diphenhydramine); chlorphenamine (chlorpheniramine); diphenhydramine (diphenhydramine) hydrochlorate; chlorphenamine maleate (chlorpheniramine maleate); cortex steroid (corticosteroids); alclometasone (alclometasone); dexamethasone (dexamethasone); diflucortolone (flumethasone); hydrocortisone (hydrocortisone); hydrocortisone-21-monoesters (hydrocortisone-21-monoesters); hydrocortisone-21-acetas (hydrocortisone-21-acetate); hydrocortisone-21-butyrate (hydrocortisone-21-butyrate); hydrocortisone-21-propionic ester (hydrocortisone-21-propionate); hydrocortisone-21-valerate (hydrocortisone-21-valerate); hydrocortisone-17; 21-diester (hydrocortisone-17; 21-diesters); hydrocortisone-17; 21-diacetate esters (hydrocortisone-17; 21-diacetate); hydrocortisone-17-acetas-21-butyrate (hydrocortisone-17-acetate-21-butyrate); hydrocortisone-17; 21-dibutyrate (hydrocortisone-17; 21-dibutyrate); prednisolone (prednisolone); methylprednisolone (methylprednisolone); betamethasone benzoate (betamethasone benzoate); propanoic acid Anflogisto two (betamethasone diproprionate); clobetasol propionate (clobetasol propionate); diflorasone diacetate (diflorasone diacetate); fluocinolone acetonide (fluocinonide); fluticasone propionate (fluticasone propionate); momestasone furoate (mometasone furoate); triamcinolone ketal (triamcinolone acetonide); local cortex steroid (topical corticosteroids); hydroxyl triamcinolone (hydroxyltriamcinolone); α-oxygen dexamethasone (α-oxy dexamethasone); dexamethasone phosphate (dexamethasone-phosphate); valeric acid hydrogen dexamethasone (clobetasol valerate); desonide (desonide); desoximetasone (desoxymethasone); desoxycortone (desoxycorticosterone acetate); dexamethasone (dexamethasone); dichlorisone (dichlorisone); oxalic acid diflorasone (diflorasone diacetate); diflucortolone valerate (diflucortolone valerate); Cordran (fluadrenolone); fluclorolone (fluclorolone acetonide); fludrocortisone (fludrocortisone); valeric acid Cortexilar special (flumethasone pivalate); Cordran ketal (fluosinolone acetonide); fluocinolone acetonide (fluocinonide); flucortinebutylesters; fluocortolone (fluocortolone); acetic acid fluprednidene (fluprednidene (fluprednylidene) acetate); Cordran (flurandrenolone); halcinonide (halcinonide); hydrocortisone acetic acid (hydrocortisone acetate); hydrocortisone butanoic acid (hydrocortisone butyrate); methylprednisolone (methylprednisolone); triamcinolone ketal (triamcinolone acetonide); cortisone (cortisone); cortodoxone (cortodoxone); fluocinonide (flucetonide); medrysone (medrysone); amcinafal (amcinafel); amcinafide (amcinafide); betamethasone (betamethasone); chloroprednisone (chloroprednisone); acetic acid chloroprednisone (chlorprednisone acetate); clocortolone (clocortelone); descinolone (clescinolone); dichlorisone (dichlorisone); difluprednate (diflurprednate); flucloronide (flucloronide); flunisolide (flunisolide); fluorometholone (fluoromethalone); fluperolone (fluperolone); fluprednisolone (fluprednisolone); Westcort (hydrocortisone valerate); hydrocortisone cyclopentanepropanoiacid acid ester (hydrocortisone cycloamylpropionate); hydrocortamate (hydrocortamate); meprednisone (meprednisone); paramethasone (paramethasone); prednisone (prednisone); beclometasone dipropionic acid (beclomethasone dipropionate); triamcinolone (triamcinolone); isoxicam (isoxicam); tenoxicam (tenoxicam); sudoxicam (sudoxicam); CP-14,304; Salicylate (salicylates); salsalate (disalcid); benorylate (benorylate); Choline magnesium trisalicylate (trilisate); safapryn; probenecid (solprin); fendosal (fendosal); fenclofenac (fenclofenac); indomethacin (indomethacin); sulindac (sulindac); tolmetin (tolmetin); Isoxepac (isoxepac); hold up Luo Fen acid (furofenac); tiopinac (tiopinac); zidometacin (zidometacin); acemetacin (acematacin); fentiazac (fentiazac); zomepirac (zomepirac); clidanac (clindanac); Oxepinac (oxepinac); felbinac (felbinac); ketorolac (ketorolac); fragrant that acid esters (fenamates); mefenamic acid (mefenamic); meclofenamic acid (meclofenamic); flufenamic acid (flufenamic); niflumic acid (niflumic); tolfenamic acid (tolfenamic acid); pyrazoles; Phenylbutazone (phenylbutazone); oxyphenbutazone (oxyphenbutazone); feprazone (feprazone); azapropazone (azapropazone); trimetazone (trimethazone); ancylostomatic dermatitis wax (candelilla wax); bisabolol (bisabolol); α bisabolol (α bisabolol); (Aloe); plant sterol (plant sterols); plant sterol (phytosterol); Radix Rubiae (Manjistha); India's balosam (Guggal); kola (kola) extract; Flos Chrysanthemi (chamomile); red Herba Trifolii Pratentis (red clover) extract; piper methysticum (Piper methysticum) extract; Herba Bacopae monnieri (Bacopa monieri) extract; sea whip (sea whip) extract and composition thereof.

Antibacterial

Being used for the suitable antibacterial of this aspect and the limiting examples of antifungal includes but not limited to: β-lactam class medicine (β-lactam drugs); Du-6859a (quinolone drugs); ciprofloxacin (ciprofloxacin); norfloxacin (norfloxacin); tetracycline (tetracycline); erythromycin (erythromycin); amikacin (amikacin); 2; 4; 4 '-three chloro-2 '-hydroxy diphenyl ether; 3; 4; 4 '-trichlorine three phenylureas (3; 4; 4 '-trichlorine banilide); phenoxyethanol; phenoxypropanol; the phenoxy group isopropyl alcohol; doxycycline (doxycycline); capreomycin (capreomycin); hibitane (chlorhexidine); chlortetracycline (chlortetracycline); oxytetracycline (oxytetracycline); clindamycin (clindamycin); ethambutol (ethambutol); hydroxyethylsulfonic acid. hexamidine (hexamidine isethionate); metronidazole (metronidazole); pentamidine (pentamidine); gentamycin (gentamicin); kanamycin (kanamycin); lienomycin (lineomycin); metacycline (methacycline); hexamethylenamine (methenamine); minocycline (minocycline); neomycin (neomycin); netilmicin (netilmicin); paromomycin (paromomycin); streptomycin (streptomycin); tobramycin (tobramycin); MIKANGZUO (miconazole); quadracycline (tetracycline hydrochloride); zinc erythromycin (zinc erythromycin); erythromycin propionate lauryl sulfate (erythromycin estolate); erythromycin stearate (erythromycin steaerate); amikacin sulfate (amikacin sulfate); doxycycline hyclate (doxycycline hydrochloride); capreomycin sulfate Capastat sulfate (capreomycin sulfate); gluconic acid hibitane (chlorhexidine gluconate); chlorhexidine hydrochloride (chlorhexidine hydrochloride); chlortetracycline hydrochloride (chlortetracycline hydrochloride); tetramycin hydrochloride (oxytetracycline hydrochloride); Clindamycin Hydrochloride (clindamycin hydrochloride); ebutol (ethambutol hydrochloride); hydrochloric acid metronidazole (metronidazole hydrochloride); hydrochloric acid pentamidine (pentamidine hydrochloride); gentamycin sulfate (gentamicin sulfate); kanamycin sulfate (kanamycin sulfate); hydrochloric acid lienomycin (lineomycin hydrochloride); metacyclini chloridum (methacycline hydrochloride); methenamine hippu (methenamine hippurate); hexamine mandelate (methenamine mendelate); minocycline hydrochloride (minocycline hydrochloride); polygynax (neomycin sulfate); netilmicin sulfate (netilmicin sulfate); paromomycin sulfate (paromomycin sulfate); streptomycin sulfate (streptomycin sulfate); tobramycin sulfate (tobramycin sulfate); hydrochloric acid miconazole (miconazole hydrochloride); amantadine hydrochloride (amanfadine hydrochloride); PK-Merz (Merz) (amanfadine sulfate); Octopirox (octopirox); parachlorometaxylenol (parachlorometa xyleneol); nystatin (nystatin); tolnaftate (tolnaftate); clotrimazole (clotrimazole); benzoyl peroxide; Azelaic Acid; ethyl acetate; meclocycline (meclocycline); lincomycin class (lincomycinics); Tetracyclines (tetracyclinics); sulfenyl Tri-Biocin (sulfur-based antibiotics); sulfonamides (sulfonamides); mupirocin (mupirocin); magainin I (magainin I); magainin II (magainin II); lincomycin (lincomycin); ((6; 8-dideoxy-6-[[(1-methyl-4-propyl group-2-pyrrolidinyl)-and carbonyl] amino]-1-sulfo--L-Soviet Union-α-D-galactose-Xin pyranoside)); (7-chloro-6; 7; 8-three deoxidations-6-[[(1-methyl-4-propyl group-2-pyrrolidinyl) carbonyl]-amino]-1-sulfo--L-Soviet Union-α-D-galactose-Xin pyranoside); ((4-(dimethylamino)-1; 4; 4-α; 5; 5-α); (6; 11; 12-α-octahydro-3; 6; 12; 12-α-penta hydroxy group-6-methyl isophthalic acid; 11-dioxo-2-aphthacene-Methanamide)); chlortetracycline (chlortetracycline); demeclocycline (demeclocycline); Rolitetracycline (rolitetracycline); sulfacetamide (sulfacetamide); sulfabenzamide (sulfabenzamide); sulfadiazine (sulfadiazine); sulfadoxine (sulfadoxine); sulfamerazine (sulfamerazine); sulfamerazine (sulfamethazine); sulfamethizole (sulfamethizole); Sulfamethoxazole (sulfamethoxazole); sulphacetamide (sulfacetamide sodium); amphotericin B (amphotericin B); benzoic acid; Butenafine phenol (butenafine); hydrochloric acid Butenafine phenol (butenafine HCl); butoconazole (butoconazole); Nitric acid butoconazole (butoconazole nitrate); caprylic acid (caprylic acid); chloroxylenol (chloroxylenol); ciclopirox (ciclopirox); clotrimazole (clotrimazole); econazole (econazole); econazole nitrate (econazole nitrate); fluconazol (fluconazole); itraconazole (itraconazole); ketoconazole (ketoconazole); miconazole (miconazole); miconazole nitrate (miconazole nitrate); naftifine (naftifine); naftifine hydrochloride (naftifine hydrochloride); nystatin (nystatin); oxiconazole (oxiconazole); Oxiconazole Nitrate (oxiconazole nitrate); salicylic acid; selenium (selenium); Selenium Sulphate (selenium sulfide); sulconazole (sulconazole); sulconazole nitrate (sulconazole nitrate); terbinafine (terbinafine); hydrochloric acid terbinafine (terbinafine hydrochloride); terconazole (triaconazole) (terconazole); tioconazole (tioconazole); 9-undecylenic acid; Acitretin (acitretin); alclometasone dipropionic acid (alclometasone dipropionate); dithranol (anthralin); azathioprine (azathioprine); calcipotriene (calcipotriene); calcitriol (calcitriol); colchicine (colchicine); ciclosporin (cyclosporine); methoxsalen (methoxsalen); retinoid (retinoids); the 3-hydroxy benzoic acid; hydroxyacetic acid; lactic acid; 4-HBA; acetylsalicylic acid; the 2-hydroxybutyric acid; the 2-hydroxypentanoic acid; the 2-hydroxycaproic acid; Azelaic Acid; arachidonic acid (arachidonic acid); benzethonium chloride (benzethonium chloride); benzalkonium chloride (benzalkonium chloride); boric acid; benzoic acid oxine (8-quinolinol benzoate); sec-amyl cresol (secondary amyltricresols); cetylpyridinium chloride (cetylpyridinium chloride); chlorothymol (chlorothymol) and sulphuric acid oxine; and pharmaceutically or the upper acceptable salt of making up, and their mixture.

Anti-wrinkle agent and anti-atrophy agent

Described topical cosmetic can be chosen wantonly with compositions and also contain one or more anti-wrinkle agent and/or anti-atrophy agent.Be used for the anti-wrinkle agent of this aspect and/or the suitable limiting examples of anti-atrophy agent and can comprise following anti-wrinkle agent and/or anti-atrophy agent; it can contain or comprise following composition one or more: cis and trans retinoic acid; retinol; retinyl ester; salicylic acid; the D of sulfur-bearing and L aminoacid; the N-acetyl derivative; the D of sulfur-bearing and L aminoacid; ACETYLCYSTEINE; mercaptan; ethyl mercaptan; 'alpha '-hydroxy acids; hydroxyacetic acid; lactic acid; phytic acid; thioctic acid; lysophosphatidic acid; change skin agent (skin peel agent); phenol; its pharmaceutically acceptable or upper acceptable salt of making up, and their mixture.

Anti-acne agents

Described topical cosmetic can be chosen wantonly with compositions and also contain one or more anti-acne agents.The suitable limiting examples that is used for the anti-acne agents of this aspect can comprise following anti-acne agents; it can contain or comprise following composition one or more: keratolytic; salicylic acid (oxybenzoic acid); the 5-MEXORYL SAM; resorcinol; retinoid; cis and trans retinoic acid; the D of sulfur-bearing and L aminoacid; the D of N-acetyl group sulfur-bearing and L aminoacid; ACETYLCYSTEINE; thioctic acid; sebostats; flavonoid; bile salt; the scymnol sulfuric ester; dexycholate; cholate; adapalene (adapalene); Azelaic Acid; benzoyl peroxide; clindamycin (clindamycin); clindamycin phosphate; doxycycline (doxycycline); erythromycin (erythromycin); norgestimate (norgestimate); organic peroxide; isotretinoin; tretinoin; sulphacetamide (sulfacetamidesodium); tazarotene (tazarotene); and the pharmaceutically acceptable or upper acceptable salt of making up, and their mixture.

Therapeutic Method

In one embodiment, theme of the present invention relates to the method for the treatment of subject's skin, comprises to the topical cosmetic compositions of describing theme according to the present invention of the curee's that these needs are arranged topical application treatment effective dose.

In one embodiment, theme of the present invention relates to the method for blast curee's cutaneous pigmentation, comprises to the topical cosmetic compositions of describing theme according to the present invention of the curee's that these needs are arranged topical application treatment effective dose.

In another embodiment, theme of the present invention relates to the dermatosis for the treatment of the curee or the method for disease, comprises to the topical cosmetic compositions of describing theme according to the present invention of the curee's that these needs are arranged topical application treatment effective dose.Described dermatosis or disease can be disease or the disease relevant with the cutaneous pigmentation of not expecting.

In another embodiment, theme of the present invention relates to blast curee's cutaneous pigmentation or treatment curee's dermatosis or the method for disease, comprise to the topical cosmetic usefulness compositions of describing theme according to the present invention of the curee's that these needs are arranged topical application treatment effective dose continue at least one times every day at least 3 days, continued at least 5 days or continue at least 7 days.Thus, using topical composition of the present invention after 3 days, 5 days and 7 days, skin generation significant change respectively.

In one embodiment, theme of the present invention relates to blast curee's cutaneous pigmentation or treatment curee's dermatosis or the method for disease, comprise to the topical cosmetic of describing theme according to the present invention of the curee's that these needs are arranged topical application treatment effective dose and continued at least one times at least 3 weeks every day with compositions, wherein after 3 weeks, the obvious blast of skin.

Topical cosmetic of the present invention is treated various dermatosis and diseases take the cutaneous pigmentation do not expected as feature effectively with compositions.The limiting examples of these diseases and/or disease can comprise: the local hyperpigmentation that is caused by melanocyte superactivity, the constitutional chloasma (mask of pregnancy or melasma) that for example occurs period of pregnancy, perhaps the constitutional chloasma of secondary after the Estrogen-Progestin contraception; By the local hyperpigmentation that optimum melanocyte superactivity and propagation cause, for example lentigo is known as the liver nevus; Sporadic hyperpigmentation, as damage rear photosensitization and scarring; The passeris montani saturati speckle; Malpigmentation (malpigmentation); And the leukoderma of some form, such as white macula, if wherein injured skin can not be painted again, then all the other zones of normal skin can be by blast or the depigmentation to give whole skin with the uniform colour of skin.According to the present invention the method for record can for simple cosmetic blast skin area for example the purpose in the large zone of cutaneous pigmentation process skin, although the pigmentation of this skin area is this individual skin type that is suitable for of not expecting.In one embodiment, according to dermatosis to be treated of the present invention or the pigmentation of disease for not expecting.Topical cosmetic of the present invention is administered to contain with compositions do not expected Pigmented skin area, blast these zones.Therefore, the inventive method blast the skin area of administration topical cosmetic of the present invention with compositions.

Put down in writing the suitable treatment of theme and/or the skin area of blast can comprise thin skin skin (thin skin) zone according to this paper, it comprises the skin area of facial, cervical region for example and/or hand.The present composition described herein and method are suitable for masculinity and femininity, and are suitable on all skin types, comprise dry skin type and neutral skin type and oily skin type.

In another embodiment, theme of the present invention relates to the dermatosis for the treatment of among the curee or the method for disease, the method that perhaps relates to cutaneous pigmentation among the blast curee, wherein comprise that be administered once every day at least or be administered twice at least every day to the local skin administration continuing the time at least two weeks, wherein cutaneous pigmentation obtains blast.Topical can comprise that be administered once every day at least or be administered twice at least every day and continue the time at least three weeks that wherein cutaneous pigmentation obtains blast.Topical can comprise that be administered once every day at least or be administered twice at least every day time around continuing at least, and wherein cutaneous pigmentation obtains blast.Administration every day can comprise at least one times and being administered once in morning or evening.Administration every day at least twice can comprise be administered once morning and evening be administered once.

Preparation method

The topical cosmetic of the present invention various preparations of compositions of putting down in writing theme according to the present invention, those skilled in the art can need not excessive experiment and just can easily prepare according to the known method that is prepared as follows preparation, these preparations for example comprise: cream, gel, milk surum, skin lotion, or other preparations described herein.

The method for preparing cream or Emulsion can comprise: prepare respectively water and oil phase, oil phase is added water, for example all change into Emulsion by mixing and/or (using high shear).After preparing Emulsion, can choose wantonly to wherein (for example with following order) and add one or more following components to prepare final Emulsion or cream: one or more skin lightening activating agents; One or more pH adjusting agents; One or more emollient; One or more skin lightening activating agents; One or more sunscreen actives agent; One or more thickening agents; One or more antioxidants; With one or more spice.Before forming Emulsion, can be respectively with water and oil phase be heated to from about 70 ℃ to about 99 ℃, from about 75 ℃ to about 95 ℃, from about 80 ℃ of extremely about 90 ℃ or about 85 ℃ temperature.After the heating, oil phase can be added aqueous phase lentamente, for example by mixing and the high shear homogenize.Then, gained Emulsion can keep to mix and the high shear homogenize in be cooled to temperature, for example, from about 47 ℃ to about 27 ℃, from about 42 ℃ to about 30 ℃, from about 39 ℃ to about 35 ℃ or about 37 ℃.Then can in the Emulsion of cooling, add one or more above-mentioned optional components, for example, by mixing and/or the high shear homogenize.The Emulsion of preparation or the cream pH that can have be for from about 4.5 to 6.5, and/or the viscosity that has for approximately from about 5000cP about 15000cP extremely, and/or the density that has is from about 1.01 to about 1.06.

What further belong to subject area of the present invention is the topical cosmetic compositions for preparing according to said method.If prepared according to the methods of the invention, these compositionss show chemistry and the physical stability that is suitable for topical.

Topical cosmetic according to these method preparations can place suitable preserving container (containment vessel) with compositions, and this preserving container comprises the product contact surface that consists of by being selected from following material: glass, plastics, steel, rustless steel, aluminum, polyflon, polymer architecture, ceramic structure, alloy and composition thereof.These preserving containers be used for convenient described topical cosmetic with preparation, processing, the processing of compositions, pack, storage and administration.Can be selected from plastic tube, bottle, metal tube and combination in any thereof at preserving container suitable aspect this.

Route of administration/dosage

For the effectiveness purpose, the topical cosmetic that is used for the inventive method must directly act on the target skin area with the route of administration of compositions.In most of the cases, effectively the result can be by in the zone of action or seek to realize that the local application thin layer is realized on the zone of required effect.Effectively the result can use four times or more times is realized by using in per two days or three days once to every day.

Belong to topical cosmetic of the present invention and know to those skilled in the art with the appropriate dose level of the activating agent of compositions and method, and can select to maximize the effect of the above-mentioned dermatosis for the treatment of.The every kg body weight of known dose level is used for treating disease, disease and the disease of the scope of the invention to the skin lightening active component of about 5000mg at about 0.001mg.This effective dose of skin lightening active component can comprise that usually every kg of patient body weight every day is from about 0.001mg to about 100mg.In addition, be understandable that the dosage of this component can be with the form administration of single dosage unit or multiple dose unit, so that required therapeutic effect to be provided.

As required, the other treatment agent can be used for in combinations thereof, provide those be used in combination.Can change according to treatment main body, disease, disease or the character of the patient's condition, the character of active component with the amount that carrier mass makes up to prepare the active component of one-pack type.

The present composition can be with the form administration of single dose and multiple dose every day.In one embodiment, topical cosmetic of the present invention compositions administration every day 1 to 4 time.If needed, from once a day or twice low dosage, slowly increasing to high dose also is a strategy.Can change according to treatment main body, disease, disease or the character of the patient's condition, the character of active component with the amount that carrier mass makes up to prepare the active component of one-pack type.In one embodiment, topical cosmetic can local application every day one or many with compositions.In one embodiment, topical cosmetic of the present invention with compositions can local application every day once to four times.For example, as required, also be a strategy from the use that begins once a day to be increased to gradually higher frequency.

In one embodiment, topical cosmetic of the present invention with compositions local application every day once to four times, for example in the morning, noon, afternoon and/or evening use.For example, this topical composition can be used once in the morning, at noon, in the afternoon or at night in one day.This topical composition can be for example in the morning with evening, at noon with evening, in the morning with noon, in the morning with afternoon, in the afternoon with twice of local application in one day evening.This topical composition can be for example in the morning, noon or afternoon and local application in one day evening three times.This topical composition can be for example in the morning, noon, afternoon and local application in one day evening four times.

In one embodiment, topical cosmetic described herein with compositions can use every day time that one or many continues at least one week by or continue the time at least two weeks or continue the time at least all around or continue time at least eight weeks.This topical cosmetic with compositions can use every day one or many continue year nearly, nearly six months time, reach the trimestral time, reach the bimestrial time.This topical cosmetic can be used one or many every day with compositions and continue at least one thoughtful year, continue at least one thoughtful six months time, continue at least one thoughtful four months time, continue at least one thoughtful trimestral time, continue at least one thoughtful bimestrial time, continued at least two thoughtful bimestrial times, continued at least three thoughtful bimestrial times, continue at least one thoughtful one month time, continue the time at least one thoughtful three weeks, or continue at least all around to the bimestrial time.

But be understandable that, concrete dosage level for any particular patient can change according to many factors, and many factors comprises seriousness and the form of medication of the concrete disease of activity, the patient's of concrete activating agent age, body weight, general health situation, sex and diet, administration time, excretion rate, possible drug regimen, treatment.Those of ordinary skills will appreciate that the variability of these factors, and can be able to use conventional experimental technique to establish concrete dosage level.

The apparent capacity of pharmacokinetic parameter such as bioavailability, absorption rate constant, distribution, unbound fraction, CLTB, prototype are drained mark (fraction excreted unchanged), first pass metabolism, elimination rate constant, half-life and mean residence time and are known in the art.

For the Toiletry preparation of the best, those skilled in the art can consider to determine such as specific components and required dosage.Referring to, Remingtonn ' s Pharmaceutical Sciences for example, the 18th edition (1990, Mack Publishing Co., Easton, PA 18042), pp.1435-1712, " Harry ' sCosmeticology ", 8th ed. (2000, Chemical Publishing Co., Inc., New York, N.Y.10016), their content whole is incorporated herein by reference.These preparations can affect rate of release and the interior clearance rate of body in physical state, stability, the body.

In one embodiment, the topical cosmetic of the present invention of describing theme according to this paper with compositions can for be packaged in the gel breast in the pipe for example or be packaged in the non-foam pump-type container of non-aerosol or bottle in milk surum, the amount of the compositions that wherein contains in the container is in the scope of about 10gm to about 60gm, about 20gm to about 50gm, or about 30gm, or about 40gm.

Can prepare and contain once a day single dose test kit (Single dosage kit) and the packing of the compositions of amount.The single dose of the present composition, unit dose and once a day discardable type container all in the scope of theme of the present invention.

The topical cosmetic of the present invention of describing theme according to this paper can be mixed with for being stored in the stacked of basic anergy with compositions to be packed, to strengthen the stability of packing.Compare with other packings based on paper, this storage method provides the package stability that strengthens.

The amount of the compositions of every individual packaging can be at about 0.1ml to about 20.0ml, about 0.5 to about 5.0ml or about scope of 1 to about 3ml.

Especially, compositions formulated can long term storage and be need not ability that before application premixing or requirement be mixed also within the scope of the invention.Particularly, the present composition keeps beat all stable at about 3 months to about 3 years, about 3 months to about 2.5 years, about 3 months to about 2 years, about 3 months to about 20 months or in the storage cycle of about 6 months to about 18 months any times.

In one embodiment, the topical cosmetic of the present invention of describing theme according to the present invention was stablized 3 years in the temperature maintenance that is lower than 30 ℃ with preparation at least.In one embodiment, topical cosmetic of the present invention kept stable 2 years in the temperature of being less than or equal to 30 ℃ with preparation at least.In one embodiment, topical cosmetic of the present invention kept stable 2 years in the temperature of being less than or equal to 25 ℃ with preparation at least.

Embodiment

The following example has been described topical cosmetic compositions of the present invention, is not to limit.The molecular weight of any polymer all is weight average molecular weight.Unless otherwise, all percentage ratios all are based on the final transport system of preparation or the percentage by weight of preparation, and total equals 100 % by weight.

Embodiment 1

Following examples have been explained the clarification effect (clarifying efficacy) that topical cosmetic of the present invention is compared with 2% hydroquinone compositions with compositions, determine by the colorimeter instrumental method.

In the single center double-blind method comparative clinical trial that continued for 6 weeks, in 10 volunteers' previous Pigmented skin, assess each clarification effect (clarifyingefficacy) of two kinds of topical product.When being evaluated at research beginning and end, dermatosis carries out.Skin color is measured with colorimeter and the conclusive evidence (documentation) of taking a picture at T0, T07, T14 and T21 place.Namely induce the UVB pigmentation with the sunlight simulator (solarsimulator) of Xenon arc light 601/300W (Solar Light Co preparation) at the Pigmented skin of the previous pigment of volunteer by using photo-emission source.

Use Minolta Chroma Meter CR400 to determine the dye degree by standard colored system CIE (TheCommission Internacional del ' Eclairage).Colored represent with the three-dimensional coordinate system, wherein L ^*Axle is corresponding to skin brightness, a ^*Axle is corresponding to green and red, b ^*Axle is corresponding to blue and yellow.

Sunlight simulator with Xenon arc light 601/300W (Solar Light Co preparation) is used as light source.This equipment provides the continuous light emission of 290～400nm scope in UVB and UVA spectrum.This equipment comprises that a cover absorbs or disperses the lens and the light filter that are lower than 320nm or are higher than the 400nm radiation.This radiation occurs for the radiation of using each dosage of setting up in advance through program setting by 6 optical fiberss of a cover that are called " ports ".Radiation detection using dosage control system (DCS) is carried out, and this system comprises UVB radiation detector and electronic detectors.In this research, only have three " ports " to be used for the various practical sites of test composition.

The assessment sample

1. hydroquinone 2% (positive control):

Component Function %W/W

Citric acid pH adjusting agent 0.08

Pure water carrier 67.08

BP-3 active sunscreen agent 1.5

Octyl methoxycinnamate active sunscreen agent 6

Hydroquinone brightener 2

Lanette emulsifying agent 13

Metabisulfite sodium antioxidant 0.14

Isopropyl palmitate emollient 5

Propylene glycol emollient 5

Nipagin antiseptic 0.15

The propyl parabene antiseptic 0.05

100.0％

2. topical cosmetic compositions of the present invention, contain:

Component Function %W/W

Pure water carrier 62.250

Spermol thickening agent 2.2

Butylated hydroxytoluene antioxidant 0.050

(the pure and mild C12-20 alkyl androstanediol of C14-22) emulsifying agent 5

Encircle five polydimethylsiloxane emollient 1

The PEG/PPG-18/18 polydimethylsiloxane

Encircle five polydimethylsiloxane emollient 1

The polydimethylsiloxane cross linked polymer

Sodium ethylene diamine tetracetate chelating agen 0.2

The Daisy extract, antioxidant/activating agent 5

Fructus Phyllanthi fruit extract antioxidant/activating agent 2

Radix Glycyrrhizae extract antioxidant/activating agent 0.050

Phenoxyethanol and Methylisothiazolinone antiseptic 0.6

Spice fragrance 0.3

2-(Acryloyloxy)ethanol, thickening agent 5

Acryloyl group dimethyl sodium taurocholate copolymer,

Squalane, and

Anhydrous sorbitol polyoxyethylene (20) ether stearate

Metabisulfite sodium antioxidant 0.3

Di-2-ethylhexylphosphine oxide-benzotriazole base tetramethyl phenol active sunscreen agent 5

Ethylhexyl methoxy cinnamate active sunscreen agent 7.5

Propylene glycol emollient 2

The triethanolamine pH adjusting agent 0.55

100.0％

Preparation:

Preparation method

1. in suitable solvent, di-2-ethylhexylphosphine oxide-benzotriazole base tetramethyl phenol is dispersed in a small amount of pure water.Mix until evenly.

2. in suitable container, hybrid ring five polydimethylsiloxane PEG/PPG-18/18 polydimethylsiloxane and ring five polydimethylsiloxane polydimethylsiloxane cross linked polymers are until evenly.

3. in suitable container, insert propylene glycol.Add and disperse Radix Glycyrrhizae extract.Mix until evenly.

4. in suitable container, the Fructus Phyllanthi fruit extract is dispersed in a small amount of pure water.Mix until evenly.

5. in suitable container, triethanolamine is dispersed in a small amount of pure water.Mix until evenly.

6. in suitable container, metabisulfite sodium is dispersed in a small amount of pure water.Mix until evenly.

7. in main preparation container, when mixing, add remaining pure water, add and disperse sodium ethylene diamine tetracetate.The heating inclusions is to about 85 ℃.

8. in suitable container, add spermol, the pure and mild C12-20 alkyl polyglucoside of C14-22, spermol, ethylhexyl methoxy cinnamate and butylated hydroxytoluene.Be heated to about 85 ℃, and mix until evenly.

9. the mixture with step 8 stirs lower being added in the mixture of step 7.Mix until evenly.

10. when mixing, batch of material is cooled to about 37 ℃.

11. add the mixture of step 4 and step 5 when mixing.Mix until evenly.

12. add phenoxyethanol and Methylisothiazolinone when mixing.

13. when mixing, add the mixture of step 2, then add the mixture of step 3.Mix until evenly.

14. add the Daisy extract, and mix until evenly.

15. when mixing, add the mixture of step 1, and mix until evenly.

16. add 2-(Acryloyloxy)ethanol, acryloyl group dimethyl sodium taurocholate copolymer, squalane and anhydrous sorbitol polyoxyethylene (20) ether stearate.Mix until evenly.

17. add the mixture of step 6 when mixing.Mix until evenly.

18. add spice when mixing.Mix until evenly.

Volunteer's screening

1. cluster sampling (POPULATION SAMPLING)

Age is that other 10 volunteers of two individual characteies of 18～60 years old screen be used to studying.The curee who participates in has four letters of head, the numbering of identity separately (being produced by electronic system) and the experiment numbers of four letters of head and the surname of name.

2. inclusion criteria:

● age level: 18 to 60 years old;

● Photosensitive (Phototype) II and III, classify according to Fitzpatrick;

● the skin complete of test site;

● agree to observe experimental arrangement and come the clinic at the assessment date and time of regulation;

● sign detailed consent form.

3. culling level

● pregnancy or breast feeding;

● use antibiotic medicine or immunosuppressant;

● atopic individual condition;

● use part or general photosensitive drug;

● the medical history of phototoxicity or photoallergy;

● the part is produced the responsive of (production) or stimulates history;

● photoinduced pathology, urticaria (sun hives) for example, the polymorphic rash under lupus erythematosus (1upus erythematosus), the illumination (polyform rash at light), the herpes simplex of recurrence;

● there is active inflammatory dermatosis in test site

● there is the nevus damage in test site;

● the viable skin pathology;

● to the responsive of part generation or stimulation history;

● frequently be exposed to the sun or tanning bed (tanning bed);

● use newtype drug 6 middle of the month in the past;

Method research

1. method program:

Behind initial program, in each volunteer, induce essential minimum erythema (erythematose) dosage of pigmentation to determine by following description.

A. calculate minimum erythema dose:

Each volunteers received pretest is with assessment minimum erythema dose (MED).To a series of six times contact of each volunteer's unshielded dermal administration (exposure), at every turn all once high by 12% than front with regard to geometric progression.Mean dose pre-determines according to the Fitzpatrick Photosensitive, shown in the following Table I:

Table I

Type	Color	Sensitivity	Reaction	MED
					I	The light eyes of white-pale (Pale) and hair	Very sensitive	Always burn (burn) never tanned (tan)	0.85
II	White	Very sensitive	Always burn is never tanned	1
					III	Darker white	Responsive	Moderate burn, moderate is tanned	1.3
IV	Light brown	More insensitive	The bottom line sunburn, always tanned	1.75
					V	Brown	More insensitive	Seldom sunburn is always tanned	2.3
VI	Black	Insensitive	Never tan severely, always pigmentation	4.6

Dismiss the volunteer after the radiation, and indicate them to return in 24 hours.Record each volunteer's contact data.

B. read:

After the radiation, dismiss each volunteer, and indicate them to return in 24 hours, read thus volunteer's the site that contacts in vertical dimension under predetermined distance and illumination, wherein illumination remains constant to each volunteer.Then determine each volunteer's MED.

Single minimum erythema dose (iMED) is defined as and generates clearly minimum ultraviolet (UV) radiation dose that needs of erythema of clear and profile boundary in the contact site, as the reference during test phase.

Therefore, the sublocus that does not demonstrate erythema is the required standard of testing evaluation.If this does not occur, must carry out new should being used for and determine iMED.

C. Pigmented inducing:

After iMED determines, be positioned between pelvis waist and the scapula waist (pelvic and scapular waist), each test site at the back of midspinal line both sides is identified at the upper and service marking of volunteer with horizontal level and identifies.(delimit) determined in three sites to the indication application product, i.e. site B, site E and site F.Each site is 35cm ²(07 * 05cm).Delimit site at each, the radiation of using the minimum erythema dose that is equal to 1.5 times calculates in advance each volunteer.Repeat this and use twice, so each site raying amounts to three times.

D. product is used:

After radiation, dismiss the volunteer, and indication is returned after 72 hours take a picture conclusive evidence and colourity of these sites is assessed.Test the curee three times at each site B, E and F corresponding to different radiation areas, whole three test site and 9 marked regions of each curee are provided.After the assessment, respectively use the test substances of 2mg to the labelling radiation areas of the upper test site of each curee according to following order, once a day:

Site B: hydroquinone 2%;

Site E: topical cosmetic compositions of the present invention;

Site F: negative control: the site that does not have products applied.

For optimizing product infiltration with avoid product migration, mobile and UV radiation, product is used the site and is used the filter paper sealing, and uses the semipermeability adhesive tape to fix.The volunteer returns the clinic and uses, reads and assess according to lower Table II.

Table II

Friday T-3

Monday T0

Wednesday T02

Friday T04

Monday T07

Wednesday T09

Friday T11

Monday T14

Wednesday T16

Friday T18

Monday T21

Skin assessment

X

X

The colourity assessment

X

X

X

X

Take a picture and prove conclusively

X

X

X

X

Reading of radiation site

X

X

Product is used

X

X

X

X

X

X

X

X

X

X

The UVB radiation

X

E. colourity assessment:

Use CHROMA METER to carry out the colourity assessment.All measurements are all carried out three times, record each volunteer's L ^*a ^*b ^*The meansigma methods of parameter.Work as L ^*When parameter value reduces, it is carried out respectively statistical analysis.

F. statistical analysis:

Inspection is between the site through treating and control site and whether have statistically-significant difference between these experimental period points, comparative parameter L ^*To every pair of data, this is relatively finished by the t-student test.

The result

Treat at T17, T14 and assessment in T21 days clinically and on colourity.The colourity meansigma methods of each experiment that contains the site B of positive control (hydroquinone 2%) is shown among Fig. 1.Fig. 1 explanation gradual blast in time, it became remarkable statistically after 21 days.Lower Table III explanation L ^*The T0 meansigma methods and the result of the contrast test between other times experiment of zone 1 (site B).Table IV illustrates each result's the initial data in each volunteer's zone 1 (site B), about each L among T0, T07, T14 and the T21 ^*, a ^*And b ^*

Table III

Assessment difference	The P-value	Conclusion *
			T0 and T7	0.3626	Do not negate hypothesis * *
T0 and T14	0.1049	It does not negate hypothesis
			T0 and T21	0.0182	It negate hypothesis

* significance level: 5%

* hypothesis: do not have difference between processing region and the control zone

Table IV: each result of hydroquinone processing region

Fig. 2 illustrates site E, and the topical cosmetic of the present invention of namely assessing is used the site acquired results with compositions.Fig. 2 shows, has gradual blast in time, and it became remarkable statistically after 14 days.Lower Table V explanation L ^*The T0 meansigma methods and the result of contrast test of other times experiment in zone 2 (site E).Table VI illustrates each result's the initial data in each volunteer's zone 2 (site E), about each L among T0, T07, T14 and the T21 ^*, a ^*And b ^*

Table V

Assessment difference	The P-value	Conclusion *
			T0 and T07	0.2228	Do not negate hypothesis * *
T0 and T14	0.0022	It negate hypothesis
			T0 and T21	0.0020	It negate hypothesis

* significance level: 5%

* hypothesis: do not have difference between processing region and the control zone

Table VI: topical cosmetic of the present invention each result of compositions

Fig. 3 shows for control site F, namely do not have the site of radiation treatment, gradual blast (natural degradation of synthesis of melanin) with experimental period without any significance.Lower Table VII explanation L ^*The T0 meansigma methods and the result of the contrast test of other times experiment of control zone (site F).Table VIII has shown each result's the initial data of each volunteer's control zone (site F), about each L among T0, T07, T14 and the T21 ^*, a ^*And b ^*

Table VII

Assessment difference	The P-value	Conclusion *
			T0 and T07	0.2220	Do not negate hypothesis * *
T0 and T14	0.2386	It does not negate hypothesis
			T0 and T21	0.2039	It does not negate hypothesis

* significance level: 5%

* hypothesis: do not have difference between processing region and the control zone

Table VIII: each result of control zone

Fig. 4 illustrate treatment 1 and 2 with the comparison of colourity meansigma methods of contrast about the evaluation number of times.Table I X shows, compares with the Pigmented spontaneous minimizing of observing in matched group, only has topical cosmetic of the present invention to show pigmentation remarkable minimizing statistically with preparation.

Table I X

Assessment difference	The P-value	Conclusion *
			Novel formulation and hydroquinone	0.13	Do not negate hypothesis * *
Novel formulation and contrast	0.02	It negate hypothesis
			Hydroquinone and contrast	0.10	Do not negate hypothesis .**tks

* significance level: 5%

* hypothesis: not there are differences between each zone.

Discuss

In the radiation-induced pigmentation of UV (melanin generation) and do not have in the handicapped experimental model of the pigment that is pre-existing in, in the in time spontaneous minimizing of clinical pigmentation of treated areas.Use colorimeter to assess, all positions comprise undressed contrast, have shown obvious Pigmented minimizing when as many as T21.

Therefore, which processing is this mode of testing to contrast assess and can cause the fastest and the most significant element effect of discoloring.Because all processing are applied to each volunteer simultaneously, so the changeableness of melanism ability is significantly reduced.Therefore, the element that discolors acts on all test positions of each volunteer and occurs with identical speed.

From this prerequisite, observe clinically each position brightening effect in time, this has allowed to carry out visual assessment and relative analysis.

In order to improve the accuracy of these observations, and for objective, one make peace and assess repeatablely, use as a supplement Instrument Evaluation of colorimeter, can detect the non-detectable difference of human eye.

According to colorimeter, the L that is provided by the colorimeter measurement ^*Parameter is the index directly related with skin brightness.L ^*Be worth highlyer, assessment area is brighter.

Be desirably in clinically with on the colorimeter and assess the processing that the gradual element that discolors is acted on, because it relates to the experiment melanism.Raying but undressed control zone are compared with hydroquinone, have shown L from T21 ^*Remarkable chromatic value improve, yet when comparing with the hydroquinone of T07 and T14, the blast level is lower statistically.

Still consider data in time, these results are different in the following areas.Hydroquinone: remarkable improvement from T21; Topical cosmetic compositions of the present invention: remarkable improvement from T14, significantly blast is higher statistically compared with the control.Therefore, topical cosmetic of the present invention is compared with hydroquinone with compositions faster more significant brightening effect (higher blast index is provided) is provided.

Embodiment 2

Following examples have been described the preparation of the emulsion of the theme of record according to the present invention:

Component Function %W/W

Pure water carrier 62.250

Spermol thickening agent 2

Xanthan gun thickening agent 0.2

Butylated hydroxytoluene antioxidant 0.050

The pure and mild C12-20 alkyl androstanediol of C14-22 emulsifying agent 2

Cetyl potassium phosphate emulsifying agent 1

Tristerin and stearic acid Polyethylene Glycol (100) ester emulsifying agent 2

Annular dimethyl polysiloxane (Cyclomethicone) emollient 2

Disodiumedetate chelating agen 0.2

Daisy extract antioxidant/activating agent 5

Fructus Phyllanthi fruit extract antioxidant/activating agent 2

Radix Glycyrrhizae extract antioxidant/activating agent 0.050

Phenoxyethanol and Methylisothiazolinone antiseptic 0.6

Spice FAV22000-blend of essential oils spice 0.3

2-(Acryloyloxy)ethanol, thickening agent 5

Acryloyl group dimethyl sodium taurocholate copolymer,

Squalane, and

Anhydrous sorbitol polyoxyethylene (20) ether stearate

Metabisulfite sodium antioxidant 0.3

Di-2-ethylhexylphosphine oxide-benzotriazole base tetramethyl phenol active sunscreen agent 5

Ethylhexyl methoxy cinnamate active sunscreen agent 7.5

Propylene glycol emollient 2

The triethanolamine pH adjusting agent 0.55

100.0％

Said composition prepares according to the method among the embodiment 1.More specifically, after premix (Premix E) adds Emulsion, under high shear homogenize condition, add Neolone PE (phenoxyethanol and Methylisothiazolinone) and annular dimethyl polysiloxane, and mixed about 15 minutes.In oil phase, add the thickening agent that contains Xanthan gun.

Embodiment 3

Following examples have been described the preparation of the emulsion of the theme of record according to the present invention:

Component Function %W/W

Pure water carrier 63.43

Butylated hydroxytoluene antioxidant 0.05

Disodiumedetate chelating agen 0.20

Propylene glycol emollient 2.00

Fructus Phyllanthi fruit extract antioxidant/activating agent 2.00

2-(Acryloyloxy)ethanol, thickening agent 5.00

Acryloyl group dimethyl sodium taurocholate copolymer,

Squalane, and

Anhydrous sorbitol polyoxyethylene (20) ether stearate

Di-2-ethylhexylphosphine oxide-benzotriazole base tetramethyl phenol active sunscreen agent 5.00

Daisy extract antioxidant/activating agent 5.00

Encircle five polydimethylsiloxane poly dimethyl emollient 2.00

Silicone cross-linked polymer

Encircle five polydimethylsiloxane emollient 2.00

The PEG/PPG-18/18 polydimethylsiloxane

Phenoxyethanol and Methylisothiazolinone antiseptic 0.60

Triethanolamine pH adjusting agent 0.57

Perfume perfume 0.30

Spermol thickening agent 2.00

The pure and mild C12-20 alkyl androstanediol of C14-22 emulsifying agent 2.00

Ethylhexyl methoxy cinnamate active sunscreen agent 7.50

Metabisulfite sodium antioxidant 0.30

Radix Glycyrrhizae extract antioxidant/activating agent 0.05

100.0％

Said composition prepares according to the method among the embodiment 1.

Embodiment 4

Following examples have been explained the general application process of the compositions of administration theme of the present invention:

By conventional methods with topical cosmetic with the skin of compositions topical to the curee who receives treatment.This is preferably by using milk surum or gel breast (cream gel) preparation to finish.So, topical formulations for example can use that finger tip (fingertip) is applied to desired skin surface area.

For the cosmetic composition of topical, should inform that the curee at first leniently cleans the zone that acts on, and then pats drying.Then, this topical cosmetic can be applied directly to the skin area of effect with compositions, perhaps be dispersed in the palm or in the suitable container, therefrom take out again material and be applied to skin to be processed by hand.

Embodiment 5

The curee suffers from the cutaneous pigmentation of not expecting.Topical cosmetic described herein is not expected to occur Pigmented zone with what compositions was administered to subject's skin partly.That can expect subject's skin does not expect that Pigmented zone occurs will obtain blast.

Embodiment 6

The curee suffers from white macula.Topical cosmetic described herein is administered to partly all the other zones of curee's normal skin with compositions.All the other zones of expection curee normal skin can obtain blast, thereby give whole skin with the uniform colour of skin.

Embodiment 7

The curee suffers from senile plaque.Topical cosmetic described herein is administered to the affected skin area of curee partly with compositions.The expection senile plaque can obtain blast.

All publications of quoting in this manual can be used for instructing the present invention to put down in writing those of ordinary skill in the field that theme relates to.Be incorporated herein by reference if each independent publication all specifically and respectively shows, all these publications all are incorporated herein by reference with same range as at this.

Theme of the present invention so is described, and it is evident that same theme can improve and changes in a lot of modes.These improvement and variation are considered to not depart from the spirit and scope of theme of the present invention, and all these improvements and changes all are included in the scope of claims of the present invention.

Claims (16)

1. be used for the topical cosmetic compositions of blast cutaneous pigmentation, it contains:

0.1 the Fructus Phyllanthi extract of % by weight～8 % by weight;

0.5 the daisy extract of % by weight～30 % by weight; With

0.005 the Radix Glycyrrhizae extract of % by weight～5 % by weight.

2. the topical cosmetic compositions of claim 1, wherein, described Fructus Phyllanthi extract comprises the Fructus Phyllanthi fruit extract; Described daisy extract comprises the Daisy extract; And described Radix Glycyrrhizae extract comprises licorice root extract.

3. the topical cosmetic compositions of claim 1, wherein, based on the gross weight of described compositions, the amount of described Fructus Phyllanthi extract is 0.25 % by weight～4 % by weight; The amount of described daisy extract is 1 % by weight～20 % by weight; The amount of described Radix Glycyrrhizae extract is 0.01 % by weight～2 % by weight.

4. the topical cosmetic compositions of claim 1, it also contains at least a sunscreen.

5. the topical cosmetic compositions of claim 4, wherein, based on the gross weight of described compositions, the amount of described at least a sunscreen is 0.5 % by weight～30 % by weight.

6. the topical cosmetic compositions of claim 4, wherein, described at least a sunscreen contains:

The first sunscreen, it is selected from the zinc oxide of methylene two-benzotriazole base tetramethyl phenol, diethylamino hydroxybenzoyl-hexyl-benzoate, coating, and combination; With

The second sunscreen, it is selected from ethylhexyl methoxy cinnamate, methoxy cinnamic acid isopentyl ester, salicylic acid height

Ester, ethylhexyl salicylate, octocrylene, Dimethicodiethylbenzalmalonate, PAROSOL 1789, Antisolaire, ethylhexyl dimethyl PABA, and combination.

7. the topical cosmetic compositions of claim 6, wherein, based on the gross weight of described compositions, the amount of described the first sunscreen is 1 % by weight～20 % by weight, the amount of described the second sunscreen is 1 % by weight～10 % by weight.

8. the topical cosmetic compositions of claim 6, wherein, described the first sunscreen is methylene two-benzotriazole base tetramethyl phenol, described the second sunscreen is ethylhexyl methoxy cinnamate.

9. the topical cosmetic compositions of claim 1 also contains acceptable excipient in water and at least a cosmetic.

10. the topical cosmetic compositions of claim 9, wherein, based on the gross weight of described compositions, the amount of water is 3 % by weight～95 % by weight.

11. the topical cosmetic compositions of claim 9, wherein, acceptable excipient comprises one or more that are selected from following composition in the described at least a cosmetic: antioxidant, chelating agen, pH adjusting agent, emollient, thickening agent, antiseptic, emulsifying agent, wetting agent, humidizer, suspending agent, fluorescent whitening agent, stabilizing agent, penetration enhancer, spice, coloring agent, and combination.

12. the topical cosmetic compositions of claim 9, wherein, acceptable excipient comprises and is selected from least a of following composition in the described at least a cosmetic:

Antioxidant comprises being selected from following one or more: butylated hydroxytoluene, sodium metabisulfite, Butylated hydroxyanisole, ascorbic acid, tocopherol acetas and combination thereof;

Chelating agen comprises being selected from following one or more: EDTA, EDETATE SODIUM, EDTA trisodium, EDTA four sodium and combination thereof;

Emollient comprises being selected from following one or more: glycol, siliceous emollient and combination thereof;

Thickening agent comprises being selected from following one or more: acrylate copolymer, acrylate, acrylamide, Polysorbate, aliphatic alcohol, natural gum, silicate, carbomer, cellulose derivative and combination thereof;

Antiseptic comprises being selected from following one or more: phenoxyethanol, Methylisothiazolinone, p-Hydroxybenzoate, imidazolidinyl urea and combination thereof;

PH adjusting agent comprises being selected from following one or more: triethanolamine, amino methyl propanol, sodium hydroxide and combination thereof; With

Emulsifying agent comprises being selected from following one or more: C _14-22Alcohol, C _12-20Alkyl androstanediol and combination thereof.

13. the topical cosmetic compositions of claim 1 also contains vitamin.

14. comprising, the topical cosmetic compositions of claim 1, wherein said compositions be selected from following preparation: milk surum, cream, gel, skin lotion, foam and ointment.

15. topical cosmetic is with the purposes of compositions at the cosmetics of the cutaneous pigmentation that the curee who needs is arranged for the preparation of blast, said composition contains:

0.1 the Fructus Phyllanthi extract of % by weight～8 % by weight;

0.5 the daisy extract of % by weight～30 % by weight; With

0.005 the Radix Glycyrrhizae extract of % by weight～5 % by weight.

16. topical cosmetic is with the purposes of compositions at the cosmetics of the dermatosis that the curee who needs is arranged for the preparation for the treatment of or disease, said composition contains:

0.1 the Fructus Phyllanthi extract of % by weight～8 % by weight;

0.5 the daisy extract of % by weight～30 % by weight; With

0.005 the Radix Glycyrrhizae extract of % by weight～5 % by weight,

Wherein, described dermatosis or disease are selected from hyperpigmentation, Malpigmentation, freckle, lentigo, senile plaque, constitutional chloasma, the rear photosensitization of damage and scarring and white macula.

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