CN101848689A - 子宫内沉积物 - Google Patents
子宫内沉积物 Download PDFInfo
- Publication number
- CN101848689A CN101848689A CN200880114942A CN200880114942A CN101848689A CN 101848689 A CN101848689 A CN 101848689A CN 200880114942 A CN200880114942 A CN 200880114942A CN 200880114942 A CN200880114942 A CN 200880114942A CN 101848689 A CN101848689 A CN 101848689A
- Authority
- CN
- China
- Prior art keywords
- framework
- deposit
- aforementioned
- inner space
- intrauterine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims abstract description 21
- 210000004291 uterus Anatomy 0.000 claims abstract description 13
- 241000124008 Mammalia Species 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 21
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 12
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 8
- 239000000583 progesterone congener Substances 0.000 claims description 8
- 239000011159 matrix material Substances 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 7
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims description 5
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims description 5
- 229960004400 levonorgestrel Drugs 0.000 claims description 5
- 238000010276 construction Methods 0.000 claims description 4
- 229960002941 etonogestrel Drugs 0.000 claims description 4
- GCKFUYQCUCGESZ-BPIQYHPVSA-N etonogestrel Chemical compound O=C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 GCKFUYQCUCGESZ-BPIQYHPVSA-N 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- -1 nesterone Chemical compound 0.000 claims description 4
- 230000003637 steroidlike Effects 0.000 claims description 4
- 239000002131 composite material Substances 0.000 claims description 3
- 238000001125 extrusion Methods 0.000 claims description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
- XURCMZMFZXXQDJ-UKNJCJGYSA-N Gestonorone caproate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)CCCCC)[C@@]1(C)CC2 XURCMZMFZXXQDJ-UKNJCJGYSA-N 0.000 claims description 2
- YNVGQYHLRCDXFQ-XGXHKTLJSA-N Lynestrenol Chemical compound C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 YNVGQYHLRCDXFQ-XGXHKTLJSA-N 0.000 claims description 2
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 claims description 2
- ICTXHFFSOAJUMG-SLHNCBLASA-N Norethynodrel Chemical compound C1CC(=O)CC2=C1[C@H]1CC[C@](C)([C@](CC3)(O)C#C)[C@@H]3[C@@H]1CC2 ICTXHFFSOAJUMG-SLHNCBLASA-N 0.000 claims description 2
- 229940022663 acetate Drugs 0.000 claims description 2
- 229960000583 acetic acid Drugs 0.000 claims description 2
- 229960003996 chlormadinone Drugs 0.000 claims description 2
- VUHJZBBCZGVNDZ-TTYLFXKOSA-N chlormadinone Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 VUHJZBBCZGVNDZ-TTYLFXKOSA-N 0.000 claims description 2
- 229960001853 demegestone Drugs 0.000 claims description 2
- JWAHBTQSSMYISL-MHTWAQMVSA-N demegestone Chemical compound C1CC2=CC(=O)CCC2=C2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(C)[C@@]1(C)CC2 JWAHBTQSSMYISL-MHTWAQMVSA-N 0.000 claims description 2
- 229960003309 dienogest Drugs 0.000 claims description 2
- AZFLJNIPTRTECV-FUMNGEBKSA-N dienogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC#N)CC3)C3=C21 AZFLJNIPTRTECV-FUMNGEBKSA-N 0.000 claims description 2
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 claims description 2
- 229960004845 drospirenone Drugs 0.000 claims description 2
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 claims description 2
- 229960004913 dydrogesterone Drugs 0.000 claims description 2
- JGMOKGBVKVMRFX-HQZYFCCVSA-N dydrogesterone Chemical compound C1=CC2=CC(=O)CC[C@@]2(C)[C@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 JGMOKGBVKVMRFX-HQZYFCCVSA-N 0.000 claims description 2
- ONKUMRGIYFNPJW-KIEAKMPYSA-N ethynodiol diacetate Chemical compound C1C[C@]2(C)[C@@](C#C)(OC(C)=O)CC[C@H]2[C@@H]2CCC3=C[C@@H](OC(=O)C)CC[C@@H]3[C@H]21 ONKUMRGIYFNPJW-KIEAKMPYSA-N 0.000 claims description 2
- 229960000218 etynodiol Drugs 0.000 claims description 2
- 229960005352 gestodene Drugs 0.000 claims description 2
- SIGSPDASOTUPFS-XUDSTZEESA-N gestodene Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](C=C4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 SIGSPDASOTUPFS-XUDSTZEESA-N 0.000 claims description 2
- 229960003812 gestonorone caproate Drugs 0.000 claims description 2
- 229960001910 lynestrenol Drugs 0.000 claims description 2
- 229960000606 medrogestone Drugs 0.000 claims description 2
- HCFSGRMEEXUOSS-JXEXPEPMSA-N medrogestone Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(C)[C@@]1(C)CC2 HCFSGRMEEXUOSS-JXEXPEPMSA-N 0.000 claims description 2
- 229960002985 medroxyprogesterone acetate Drugs 0.000 claims description 2
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 claims description 2
- 229960004296 megestrol acetate Drugs 0.000 claims description 2
- RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 claims description 2
- 229960004911 nomegestrol Drugs 0.000 claims description 2
- KZUIYQJTUIACIG-YBZCJVABSA-N nomegestrol Chemical compound C1=C(C)C2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 KZUIYQJTUIACIG-YBZCJVABSA-N 0.000 claims description 2
- 229940053934 norethindrone Drugs 0.000 claims description 2
- 229960001652 norethindrone acetate Drugs 0.000 claims description 2
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims description 2
- 229960001858 norethynodrel Drugs 0.000 claims description 2
- 229960000417 norgestimate Drugs 0.000 claims description 2
- KIQQMECNKUGGKA-NMYWJIRASA-N norgestimate Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(OC(C)=O)C#C)[C@@H]4[C@@H]3CCC2=C\1 KIQQMECNKUGGKA-NMYWJIRASA-N 0.000 claims description 2
- 229960003387 progesterone Drugs 0.000 claims description 2
- 239000000186 progesterone Substances 0.000 claims description 2
- 229960001584 promegestone Drugs 0.000 claims description 2
- QFFCYTLOTYIJMR-XMGTWHOFSA-N promegestone Chemical compound C1CC2=CC(=O)CCC2=C2[C@@H]1[C@@H]1CC[C@@](C(=O)CC)(C)[C@@]1(C)CC2 QFFCYTLOTYIJMR-XMGTWHOFSA-N 0.000 claims description 2
- 229950008546 trimegestone Drugs 0.000 claims description 2
- JUNDJWOLDSCTFK-MTZCLOFQSA-N trimegestone Chemical compound C1CC2=CC(=O)CCC2=C2[C@@H]1[C@@H]1CC[C@@](C(=O)[C@@H](O)C)(C)[C@@]1(C)CC2 JUNDJWOLDSCTFK-MTZCLOFQSA-N 0.000 claims description 2
- 239000003814 drug Substances 0.000 description 14
- 238000003780 insertion Methods 0.000 description 13
- 230000037431 insertion Effects 0.000 description 13
- 239000011162 core material Substances 0.000 description 7
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- 210000003679 cervix uteri Anatomy 0.000 description 4
- 239000003433 contraceptive agent Substances 0.000 description 4
- 229910052802 copper Inorganic materials 0.000 description 4
- 239000010949 copper Substances 0.000 description 4
- 210000003141 lower extremity Anatomy 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 230000002254 contraceptive effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000013268 sustained release Methods 0.000 description 3
- 239000012730 sustained-release form Substances 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 210000004696 endometrium Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 235000010603 pastilles Nutrition 0.000 description 2
- 150000003180 prostaglandins Chemical class 0.000 description 2
- 229920006268 silicone film Polymers 0.000 description 2
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000002357 endometrial effect Effects 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000004720 fertilization Effects 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002991 molded plastic Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003488 releasing hormone Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000934 spermatocidal agent Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
- A61F6/142—Wirelike structures, e.g. loops, rings, spirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
- A61F6/142—Wirelike structures, e.g. loops, rings, spirals
- A61F6/144—Wirelike structures, e.g. loops, rings, spirals with T-configuration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
- A61F6/18—Inserters or removers ; Apparatus for loading an intra-uterine device into an insertion tube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/4998—Combined manufacture including applying or shaping of fluent material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/4998—Combined manufacture including applying or shaping of fluent material
- Y10T29/49982—Coating
Landscapes
- Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Surgical Instruments (AREA)
Abstract
Description
Claims (24)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07120191.7 | 2007-11-07 | ||
EP20070120191 EP2057972A1 (en) | 2007-11-07 | 2007-11-07 | Intrauterine deposit |
PCT/EP2008/065149 WO2009060077A2 (en) | 2007-11-07 | 2008-11-07 | Intrauterine deposit |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101848689A true CN101848689A (zh) | 2010-09-29 |
CN101848689B CN101848689B (zh) | 2014-03-12 |
Family
ID=39155499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200880114942.5A Expired - Fee Related CN101848689B (zh) | 2007-11-07 | 2008-11-07 | 子宫内沉积物 |
Country Status (31)
Country | Link |
---|---|
US (3) | US8291910B2 (zh) |
EP (3) | EP2057972A1 (zh) |
JP (1) | JP5406844B2 (zh) |
KR (2) | KR101536025B1 (zh) |
CN (1) | CN101848689B (zh) |
AR (1) | AR070666A1 (zh) |
AU (1) | AU2008324109B2 (zh) |
BR (1) | BRPI0818883A8 (zh) |
CA (2) | CA2703539C (zh) |
CL (1) | CL2008003310A1 (zh) |
CO (1) | CO6270294A2 (zh) |
CY (1) | CY1116818T1 (zh) |
DK (1) | DK2211794T3 (zh) |
EC (1) | ECSP10010219A (zh) |
ES (2) | ES2616145T3 (zh) |
HK (2) | HK1146890A1 (zh) |
HR (1) | HRP20150847T1 (zh) |
HU (1) | HUE025379T2 (zh) |
IL (3) | IL204995A (zh) |
MX (1) | MX2010004685A (zh) |
MY (1) | MY188590A (zh) |
NZ (2) | NZ585094A (zh) |
PE (2) | PE20130816A1 (zh) |
PL (1) | PL2211794T3 (zh) |
PT (1) | PT2211794E (zh) |
RS (1) | RS54172B1 (zh) |
RU (1) | RU2503431C2 (zh) |
SI (1) | SI2211794T1 (zh) |
TW (1) | TWI457115B (zh) |
WO (1) | WO2009060077A2 (zh) |
ZA (1) | ZA201002579B (zh) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2057972A1 (en) * | 2007-11-07 | 2009-05-13 | N.V. Organon | Intrauterine deposit |
FI20080524A0 (fi) | 2008-09-17 | 2008-09-17 | Bayer Schering Pharma Oy | Insertteri |
FI20080523A0 (fi) | 2008-09-17 | 2008-09-17 | Bayer Schering Pharma Oy | Insertteri |
DK2349143T4 (en) | 2008-09-17 | 2016-11-28 | Bayer Oy | introducer |
US8568374B2 (en) * | 2009-05-04 | 2013-10-29 | Merck Sharp & Dohme B.V. | Intrauterine system |
US8597262B2 (en) * | 2009-07-09 | 2013-12-03 | Ams Research Corporation | Apparatus and methods of treatment of pathologic proliferative conditions uterine tissue |
CN103079632A (zh) * | 2009-09-29 | 2013-05-01 | 梅迪梅特里科斯个性化药物传输私人有限公司 | 用于施用物质的子宫内电子胶囊 |
US8573222B2 (en) * | 2010-03-21 | 2013-11-05 | David Weintraub | Intrauterine device and inserter for the same |
WO2012088446A1 (en) | 2010-12-22 | 2012-06-28 | Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
US10435269B2 (en) * | 2011-02-08 | 2019-10-08 | Odyssea Pharma S.P.R.L. | Apparatus for knotting drawstrings of medical devices or medical devices containing drugs |
WO2013061341A1 (en) * | 2011-10-28 | 2013-05-02 | Sujoy Kumar Guha | An improved intra-uterine contraceptive device |
RU2015107717A (ru) * | 2012-08-09 | 2016-09-27 | Митра Фармасьютикалс С.А. | Внутриматочное устройство |
WO2014121332A1 (en) * | 2013-02-06 | 2014-08-14 | Sillender Mark | Therapeutic substance transfer catheter and method |
DE202013101276U1 (de) * | 2013-03-25 | 2013-04-08 | Pfm Medical Ag | Vorrichtung zur Einführung von Gegenständen |
CN105722860A (zh) | 2013-09-24 | 2016-06-29 | 梅迪塞纳医疗股份有限公司 | 白介素-2融合蛋白及其应用 |
WO2015164815A1 (en) | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
FR3042966B1 (fr) * | 2015-10-30 | 2017-11-24 | Anecova S A | Dispositif intra-uterin recuperable |
JP7433051B2 (ja) | 2017-06-19 | 2024-02-19 | メディシナ セラピューティクス インコーポレイテッド | Il-2スーパーアゴニスト、アゴニスト、およびそれらの融合体の使用および方法 |
US11571328B2 (en) | 2018-04-09 | 2023-02-07 | Medicines360 | IUD insertion devices |
CN112587211A (zh) * | 2020-11-10 | 2021-04-02 | 中国人民解放军空军军医大学 | 多功能妇科刮宫装置 |
TW202241537A (zh) * | 2021-02-22 | 2022-11-01 | 美商碩騰服務公司 | 藥劑遞送系統及相關聯方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3656483A (en) * | 1970-01-15 | 1972-04-18 | Biolog Concepts Inc | Intrauterine medicator |
US4188951A (en) * | 1972-08-17 | 1980-02-19 | Alza Corporation | Intrauterine system embracing selected copolymeric membranes for administering beneficial agent |
US4102998A (en) * | 1972-10-02 | 1978-07-25 | Morton Gutnick | Process for the prevention of venereal disease |
NL173707C (nl) | 1974-02-14 | 1984-03-01 | Multilan Sa | Samenstel van intra-uterine anticonceptiemiddel en bijbehorende inbrenghuls. |
US4341728A (en) * | 1979-12-20 | 1982-07-27 | The Population Council, Inc. | Method for making an IUD with shrinking of a medicated attachment onto a support |
US4547117A (en) | 1983-09-23 | 1985-10-15 | Westinghouse Electric Corp. | Nuclear fuel rod bundle drive apparatus |
DE4125575C2 (de) | 1991-08-02 | 1997-10-02 | Piening Wolf Dietrich Dr Med | Intrauterinpessar |
FI97944C (fi) * | 1994-07-05 | 1997-03-25 | Leiras Oy | Vaikuttavaa ainetta luovuttava laite |
FI97946C (fi) * | 1994-12-15 | 1997-03-25 | Leiras Oy | Kohdunsisäisesti käytettävän laitteen asettamiseksi tarkoitettu asetin |
US6476079B1 (en) * | 1999-12-23 | 2002-11-05 | Leiras Oy | Devices for the delivery of drugs having antiprogestinic properties |
PL367961A1 (en) * | 2001-08-31 | 2005-03-07 | Schering Oy | Drug delivery system |
BE1014635A3 (zh) * | 2002-02-12 | 2004-02-03 | Wildemeersch Dirk | |
EP1400258A1 (en) | 2002-09-18 | 2004-03-24 | Schering Oy | Pharmaceutical composition delivery device and its manufacturing process |
DE602004026173D1 (de) * | 2003-04-29 | 2010-05-06 | Gen Hospital Corp | Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln |
JP2006087609A (ja) * | 2004-09-22 | 2006-04-06 | Olympus Corp | 生体組織採取装置 |
FR2881046A1 (fr) * | 2005-01-25 | 2006-07-28 | 7 Med Ind Sa | Procede de fabrication d'un reservoir contenant une substance active diffusant a travers le reservoir et installation pour sa mise en oeuvre |
EP2057972A1 (en) * | 2007-11-07 | 2009-05-13 | N.V. Organon | Intrauterine deposit |
-
2007
- 2007-11-07 EP EP20070120191 patent/EP2057972A1/en not_active Ceased
-
2008
- 2008-10-29 TW TW97141600A patent/TWI457115B/zh not_active IP Right Cessation
- 2008-11-06 PE PE2013000255A patent/PE20130816A1/es not_active Application Discontinuation
- 2008-11-06 CL CL2008003310A patent/CL2008003310A1/es unknown
- 2008-11-06 PE PE2008001897A patent/PE20091159A1/es not_active Application Discontinuation
- 2008-11-07 WO PCT/EP2008/065149 patent/WO2009060077A2/en active Application Filing
- 2008-11-07 SI SI200831471T patent/SI2211794T1/sl unknown
- 2008-11-07 US US12/740,837 patent/US8291910B2/en active Active
- 2008-11-07 AU AU2008324109A patent/AU2008324109B2/en not_active Ceased
- 2008-11-07 KR KR1020107012507A patent/KR101536025B1/ko not_active IP Right Cessation
- 2008-11-07 BR BRPI0818883A patent/BRPI0818883A8/pt not_active Application Discontinuation
- 2008-11-07 RU RU2010122904/14A patent/RU2503431C2/ru not_active IP Right Cessation
- 2008-11-07 HU HUE08848433A patent/HUE025379T2/en unknown
- 2008-11-07 KR KR20157001408A patent/KR20150016412A/ko not_active Application Discontinuation
- 2008-11-07 RS RS20150542A patent/RS54172B1/en unknown
- 2008-11-07 PT PT88484332T patent/PT2211794E/pt unknown
- 2008-11-07 ES ES15167719.2T patent/ES2616145T3/es active Active
- 2008-11-07 NZ NZ58509408A patent/NZ585094A/xx not_active IP Right Cessation
- 2008-11-07 MY MYPI2013002468A patent/MY188590A/en unknown
- 2008-11-07 EP EP15167719.2A patent/EP2942040B1/en active Active
- 2008-11-07 DK DK08848433.2T patent/DK2211794T3/en active
- 2008-11-07 JP JP2010532607A patent/JP5406844B2/ja not_active Expired - Fee Related
- 2008-11-07 PL PL08848433T patent/PL2211794T3/pl unknown
- 2008-11-07 EP EP20080848433 patent/EP2211794B1/en active Active
- 2008-11-07 ES ES08848433.2T patent/ES2544756T3/es active Active
- 2008-11-07 CA CA2703539A patent/CA2703539C/en not_active Expired - Fee Related
- 2008-11-07 CA CA2880300A patent/CA2880300C/en not_active Expired - Fee Related
- 2008-11-07 MX MX2010004685A patent/MX2010004685A/es active IP Right Grant
- 2008-11-07 CN CN200880114942.5A patent/CN101848689B/zh not_active Expired - Fee Related
- 2008-11-07 AR ARP080104876 patent/AR070666A1/es not_active Application Discontinuation
- 2008-11-07 NZ NZ60172508A patent/NZ601725A/xx not_active IP Right Cessation
-
2010
- 2010-04-11 IL IL204995A patent/IL204995A/en not_active IP Right Cessation
- 2010-04-13 ZA ZA2010/02579A patent/ZA201002579B/en unknown
- 2010-05-07 CO CO10054915A patent/CO6270294A2/es not_active Application Discontinuation
- 2010-05-31 EC ECSP10010219 patent/ECSP10010219A/es unknown
-
2011
- 2011-01-26 HK HK11100804.3A patent/HK1146890A1/zh not_active IP Right Cessation
-
2012
- 2012-04-30 IL IL219480A patent/IL219480A/en not_active IP Right Cessation
- 2012-04-30 IL IL219479A patent/IL219479A/en not_active IP Right Cessation
- 2012-09-18 US US13/622,031 patent/US20130014763A1/en not_active Abandoned
-
2015
- 2015-08-03 US US14/816,582 patent/US20150335464A1/en not_active Abandoned
- 2015-08-10 HR HRP20150847TT patent/HRP20150847T1/hr unknown
- 2015-08-18 CY CY20151100717T patent/CY1116818T1/el unknown
- 2015-11-23 HK HK15111525.4A patent/HK1210689A1/zh unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101848689B (zh) | 子宫内沉积物 | |
AU2010244494B2 (en) | Intrauterine system for use in medical treatment | |
AU2012258311B2 (en) | Intrauterine deposit |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Address after: Holland Applicant after: N.V. Organon Address before: Holland Applicant before: N.V. ORGANON |
|
COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: ORGANON NV TO: MSD OS CO., LTD. |
|
C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Address after: Haarlem Applicant after: MERCK SHARP & DOHME B.V. Address before: Haarlem Applicant before: Organon biological science Holland Co.,Ltd. Address after: Haarlem Applicant after: Organon biological science Holland Co.,Ltd. Address before: Holland Applicant before: N.V. Organon |
|
COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: MSD OUSI CO., LTD. TO: ORGANON BIOLOGICAL NETHERLANDS CO., LTD. Free format text: CORRECT: APPLICANT; FROM: ORGANON BIOLOGICAL NETHERLANDS CO., LTD. TO: MERCK SHARP + DOHME CORP. |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140312 Termination date: 20181107 |
|
CF01 | Termination of patent right due to non-payment of annual fee |