JP5406844B2 - 子宮内デポジット - Google Patents
子宮内デポジット Download PDFInfo
- Publication number
- JP5406844B2 JP5406844B2 JP2010532607A JP2010532607A JP5406844B2 JP 5406844 B2 JP5406844 B2 JP 5406844B2 JP 2010532607 A JP2010532607 A JP 2010532607A JP 2010532607 A JP2010532607 A JP 2010532607A JP 5406844 B2 JP5406844 B2 JP 5406844B2
- Authority
- JP
- Japan
- Prior art keywords
- frame
- deposit
- stem
- iud
- matrix core
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
- A61F6/142—Wirelike structures, e.g. loops, rings, spirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
- A61F6/142—Wirelike structures, e.g. loops, rings, spirals
- A61F6/144—Wirelike structures, e.g. loops, rings, spirals with T-configuration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
- A61F6/18—Inserters or removers ; Apparatus for loading an intra-uterine device into an insertion tube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/4998—Combined manufacture including applying or shaping of fluent material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/4998—Combined manufacture including applying or shaping of fluent material
- Y10T29/49982—Coating
Description
本発明は、雌性哺乳動物、特にヒトの子宮内に、生物学的に活性な化合物を保持するための、子宮内システムを提供することによって、これらの問題に対処する。このシステムは、化合物のデポジット、即ち子宮内での化合物の放出速度を制御する速度制御構造を含んでいる化合物のデポジットを含み、このデポジットを受容するための内部空間を画定するフレーム、即ちデポジットの外面の実質的な部分へのアクセスを可能にする開放構造を有しさらにこのフレームを子宮内に保持するための1つまたは複数の保持要素を有するフレームを含む。フレームの開放構造により、挿入されたデポジットの表面のより広い部分が環境に直接曝され、したがって、子宮への化合物の定常状態放出に対する速度制御効果は、デポジットそのものの構造およびこのデポジットが配置される環境によって主に決定される。このことは、フレームが画定されると既存の薬物製剤または制御放出カプセル/ファイバーをこのフレーム内に挿入することができるので、製造の観点から極めて有益である。放出速度は、主にデポジットそのものによって決定されるので、フレーム内の放出速度は比較的容易に予測可能であるべきである。
Claims (13)
- 雌性哺乳動物の子宮内に生物学的に活性な化合物を保持するための子宮内システムであって、
生体適合性ポリマーマトリックスコア及び化合物を含むデポジットであって、ここで、化合物は、プロゲストゲンであり、
そしてここで、デポジットは、周方向の面および2つの端面を有する棒状であり、そして、形状安定であり、使用中に浸食されず、且つ、該デポジットは、マトリックスコアを囲む外膜を含む、デポジット;
デポジットを受容するための内部空間を画定するフレームであって、フレームは、デポジットの外面が少なくとも50%露出するような開放構造である、フレーム;および
フレームを子宮内に保持するための1つ又は複数のアーム;
を含む、システム。 - フレームが、内部空間へのデポジットの導入を可能にするための開口および開口を閉鎖するためのキャップを含む、請求項1に記載のシステム。
- キャップが、不浸透性のプラグを含む、請求項1又は2に記載のシステム。
- キャップがフレームの前端に位置付けられ、システムを抜き出すための糸を通すための目がフレームの後端に位置付けられる、請求項1から3のいずれかに記載のシステム。
- フレームが、不活性な材料で形成される、請求項1から4のいずれかに記載のシステム。
- アームがフレームと一体的に形成されている、請求項1から5のいずれかに記載のシステム。
- ポリマーマトリックスコアが、10%超の酢酸ビニルを含んだEVAポリマーを含み、デポジットが、1.0mmから3.0mmの直径、および20mmから45mmの長さを有する、請求項1から6のいずれかに記載のシステム。
- デポジットが、40%未満の酢酸ビニルを有するEVAポリマーを含むマトリックスコアを囲む外膜を含む、請求項1から7のいずれかに記載のシステム。
- フレームが、デポジットの外面が少なくとも60%露出するような開放構造である、請求項1から8のいずれかに記載のシステム。
- デポジットが、2つの端面を有し、ここで、フレームが前記2つの端面を覆うことにより、そこからのプロゲストゲンの放出を防止する、請求項1から9のいずれかに記載のシステム。
- フレームが、その内部に内部空間が位置付けられた細長いステムを含み、アームが前記ステムから横方向に延びている、請求項1から10のいずれかに記載のシステム。
- 挿入子をさらに含むシステムであって、該挿入子は、内部にフレームを受容することができるような中空チューブを含む、請求項1から11のいずれかに記載のシステム。
- 挿入子が、4.0mm未満の外径を有する、請求項12に記載のシステム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20070120191 EP2057972A1 (en) | 2007-11-07 | 2007-11-07 | Intrauterine deposit |
EP07120191.7 | 2007-11-07 | ||
PCT/EP2008/065149 WO2009060077A2 (en) | 2007-11-07 | 2008-11-07 | Intrauterine deposit |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011502604A JP2011502604A (ja) | 2011-01-27 |
JP5406844B2 true JP5406844B2 (ja) | 2014-02-05 |
Family
ID=39155499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010532607A Expired - Fee Related JP5406844B2 (ja) | 2007-11-07 | 2008-11-07 | 子宮内デポジット |
Country Status (31)
Country | Link |
---|---|
US (3) | US8291910B2 (ja) |
EP (3) | EP2057972A1 (ja) |
JP (1) | JP5406844B2 (ja) |
KR (2) | KR101536025B1 (ja) |
CN (1) | CN101848689B (ja) |
AR (1) | AR070666A1 (ja) |
AU (1) | AU2008324109B2 (ja) |
BR (1) | BRPI0818883A8 (ja) |
CA (2) | CA2880300C (ja) |
CL (1) | CL2008003310A1 (ja) |
CO (1) | CO6270294A2 (ja) |
CY (1) | CY1116818T1 (ja) |
DK (1) | DK2211794T3 (ja) |
EC (1) | ECSP10010219A (ja) |
ES (2) | ES2544756T3 (ja) |
HK (2) | HK1146890A1 (ja) |
HR (1) | HRP20150847T1 (ja) |
HU (1) | HUE025379T2 (ja) |
IL (3) | IL204995A (ja) |
MX (1) | MX2010004685A (ja) |
MY (1) | MY188590A (ja) |
NZ (2) | NZ585094A (ja) |
PE (2) | PE20130816A1 (ja) |
PL (1) | PL2211794T3 (ja) |
PT (1) | PT2211794E (ja) |
RS (1) | RS54172B1 (ja) |
RU (1) | RU2503431C2 (ja) |
SI (1) | SI2211794T1 (ja) |
TW (1) | TWI457115B (ja) |
WO (1) | WO2009060077A2 (ja) |
ZA (1) | ZA201002579B (ja) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2057972A1 (en) * | 2007-11-07 | 2009-05-13 | N.V. Organon | Intrauterine deposit |
FI20080524A0 (fi) | 2008-09-17 | 2008-09-17 | Bayer Schering Pharma Oy | Insertteri |
JP5390618B2 (ja) | 2008-09-17 | 2014-01-15 | バイエル オサケユイチア | 挿入器 |
FI20080523A0 (fi) | 2008-09-17 | 2008-09-17 | Bayer Schering Pharma Oy | Insertteri |
US8568374B2 (en) | 2009-05-04 | 2013-10-29 | Merck Sharp & Dohme B.V. | Intrauterine system |
US8597262B2 (en) * | 2009-07-09 | 2013-12-03 | Ams Research Corporation | Apparatus and methods of treatment of pathologic proliferative conditions uterine tissue |
EP2482914A1 (en) * | 2009-09-29 | 2012-08-08 | Koninklijke Philips Electronics N.V. | Intrauterine electronic capsule for administering a substance |
WO2011117856A1 (en) * | 2010-03-21 | 2011-09-29 | Soroker, Eran | Intrauterine device and inserter for the same |
EP2673230B1 (en) * | 2011-02-08 | 2015-01-14 | Odyssea Pharma S.A. | Apparatus for knotting drawstrings of medical devices or medical devices containing drugs |
WO2013061341A1 (en) * | 2011-10-28 | 2013-05-02 | Sujoy Kumar Guha | An improved intra-uterine contraceptive device |
MX2015001661A (es) * | 2012-08-09 | 2015-08-14 | Mithra Pharmaceuticals S A | Dispositivo intrauterino. |
EP2953678B1 (en) * | 2013-02-06 | 2020-03-25 | Sillender, Mark | Therapeutic substance transfer catheter |
DE202013101276U1 (de) * | 2013-03-25 | 2013-04-08 | Pfm Medical Ag | Vorrichtung zur Einführung von Gegenständen |
CA2925421C (en) | 2013-09-24 | 2023-08-29 | Medicenna Therapeutics, Inc. | Interleukin-2 fusion proteins and uses thereof |
US10150802B2 (en) | 2014-04-24 | 2018-12-11 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
FR3042966B1 (fr) | 2015-10-30 | 2017-11-24 | Anecova S A | Dispositif intra-uterin recuperable |
EP3641814A4 (en) | 2017-06-19 | 2021-06-23 | Medicenna Therapeutics Inc. | USES AND METHODS FOR IL-2 SUPERAGONISTS, AGONISTS, AND FUSIONS THEREOF |
US11571328B2 (en) | 2018-04-09 | 2023-02-07 | Medicines360 | IUD insertion devices |
CN112587211A (zh) * | 2020-11-10 | 2021-04-02 | 中国人民解放军空军军医大学 | 多功能妇科刮宫装置 |
US20220331516A1 (en) * | 2021-02-22 | 2022-10-20 | Zoetis Services Llc | Medicament delivery system, and associated method |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3656483A (en) * | 1970-01-15 | 1972-04-18 | Biolog Concepts Inc | Intrauterine medicator |
US4188951A (en) * | 1972-08-17 | 1980-02-19 | Alza Corporation | Intrauterine system embracing selected copolymeric membranes for administering beneficial agent |
US4102998A (en) * | 1972-10-02 | 1978-07-25 | Morton Gutnick | Process for the prevention of venereal disease |
NL173707C (nl) | 1974-02-14 | 1984-03-01 | Multilan Sa | Samenstel van intra-uterine anticonceptiemiddel en bijbehorende inbrenghuls. |
US4341728A (en) | 1979-12-20 | 1982-07-27 | The Population Council, Inc. | Method for making an IUD with shrinking of a medicated attachment onto a support |
US4547117A (en) | 1983-09-23 | 1985-10-15 | Westinghouse Electric Corp. | Nuclear fuel rod bundle drive apparatus |
DE4125575C2 (de) | 1991-08-02 | 1997-10-02 | Piening Wolf Dietrich Dr Med | Intrauterinpessar |
FI97944C (fi) | 1994-07-05 | 1997-03-25 | Leiras Oy | Vaikuttavaa ainetta luovuttava laite |
FI97946C (fi) * | 1994-12-15 | 1997-03-25 | Leiras Oy | Kohdunsisäisesti käytettävän laitteen asettamiseksi tarkoitettu asetin |
US6476079B1 (en) * | 1999-12-23 | 2002-11-05 | Leiras Oy | Devices for the delivery of drugs having antiprogestinic properties |
JP2005503389A (ja) * | 2001-08-31 | 2005-02-03 | シエーリング オサケユイチア | 薬物送達システム |
BE1014635A3 (ja) | 2002-02-12 | 2004-02-03 | Wildemeersch Dirk | |
EP1400258A1 (en) | 2002-09-18 | 2004-03-24 | Schering Oy | Pharmaceutical composition delivery device and its manufacturing process |
AU2004233997C1 (en) * | 2003-04-29 | 2014-01-30 | Massachusetts Institiute Of Technology | Methods and devices for the sustained release of multiple drugs |
JP2006087609A (ja) * | 2004-09-22 | 2006-04-06 | Olympus Corp | 生体組織採取装置 |
FR2881046A1 (fr) | 2005-01-25 | 2006-07-28 | 7 Med Ind Sa | Procede de fabrication d'un reservoir contenant une substance active diffusant a travers le reservoir et installation pour sa mise en oeuvre |
EP2057972A1 (en) * | 2007-11-07 | 2009-05-13 | N.V. Organon | Intrauterine deposit |
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2007
- 2007-11-07 EP EP20070120191 patent/EP2057972A1/en not_active Ceased
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2008
- 2008-10-29 TW TW97141600A patent/TWI457115B/zh not_active IP Right Cessation
- 2008-11-06 CL CL2008003310A patent/CL2008003310A1/es unknown
- 2008-11-06 PE PE2013000255A patent/PE20130816A1/es not_active Application Discontinuation
- 2008-11-06 PE PE2008001897A patent/PE20091159A1/es not_active Application Discontinuation
- 2008-11-07 SI SI200831471T patent/SI2211794T1/sl unknown
- 2008-11-07 PL PL08848433T patent/PL2211794T3/pl unknown
- 2008-11-07 EP EP20080848433 patent/EP2211794B1/en active Active
- 2008-11-07 US US12/740,837 patent/US8291910B2/en active Active
- 2008-11-07 PT PT88484332T patent/PT2211794E/pt unknown
- 2008-11-07 HU HUE08848433A patent/HUE025379T2/en unknown
- 2008-11-07 MX MX2010004685A patent/MX2010004685A/es active IP Right Grant
- 2008-11-07 BR BRPI0818883A patent/BRPI0818883A8/pt not_active Application Discontinuation
- 2008-11-07 MY MYPI2013002468A patent/MY188590A/en unknown
- 2008-11-07 AU AU2008324109A patent/AU2008324109B2/en not_active Ceased
- 2008-11-07 RU RU2010122904/14A patent/RU2503431C2/ru not_active IP Right Cessation
- 2008-11-07 ES ES08848433.2T patent/ES2544756T3/es active Active
- 2008-11-07 KR KR1020107012507A patent/KR101536025B1/ko not_active IP Right Cessation
- 2008-11-07 ES ES15167719.2T patent/ES2616145T3/es active Active
- 2008-11-07 NZ NZ58509408A patent/NZ585094A/xx not_active IP Right Cessation
- 2008-11-07 KR KR20157001408A patent/KR20150016412A/ko not_active Application Discontinuation
- 2008-11-07 NZ NZ60172508A patent/NZ601725A/xx not_active IP Right Cessation
- 2008-11-07 AR ARP080104876 patent/AR070666A1/es not_active Application Discontinuation
- 2008-11-07 DK DK08848433.2T patent/DK2211794T3/en active
- 2008-11-07 CA CA2880300A patent/CA2880300C/en not_active Expired - Fee Related
- 2008-11-07 WO PCT/EP2008/065149 patent/WO2009060077A2/en active Application Filing
- 2008-11-07 CN CN200880114942.5A patent/CN101848689B/zh not_active Expired - Fee Related
- 2008-11-07 RS RS20150542A patent/RS54172B1/en unknown
- 2008-11-07 JP JP2010532607A patent/JP5406844B2/ja not_active Expired - Fee Related
- 2008-11-07 CA CA2703539A patent/CA2703539C/en not_active Expired - Fee Related
- 2008-11-07 EP EP15167719.2A patent/EP2942040B1/en active Active
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2010
- 2010-04-11 IL IL204995A patent/IL204995A/en not_active IP Right Cessation
- 2010-04-13 ZA ZA2010/02579A patent/ZA201002579B/en unknown
- 2010-05-07 CO CO10054915A patent/CO6270294A2/es not_active Application Discontinuation
- 2010-05-31 EC ECSP10010219 patent/ECSP10010219A/es unknown
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2011
- 2011-01-26 HK HK11100804.3A patent/HK1146890A1/xx not_active IP Right Cessation
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2012
- 2012-04-30 IL IL219480A patent/IL219480A/en not_active IP Right Cessation
- 2012-04-30 IL IL219479A patent/IL219479A/en not_active IP Right Cessation
- 2012-09-18 US US13/622,031 patent/US20130014763A1/en not_active Abandoned
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2015
- 2015-08-03 US US14/816,582 patent/US20150335464A1/en not_active Abandoned
- 2015-08-10 HR HRP20150847TT patent/HRP20150847T1/hr unknown
- 2015-08-18 CY CY20151100717T patent/CY1116818T1/el unknown
- 2015-11-23 HK HK15111525.4A patent/HK1210689A1/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5406844B2 (ja) | 子宮内デポジット | |
JP5555766B2 (ja) | 医療用子宮内システム | |
AU2012258311B2 (en) | Intrauterine deposit |
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