CN101801937A - 喹唑啉酮化合物及其使用方法 - Google Patents

喹唑啉酮化合物及其使用方法 Download PDF

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Publication number
CN101801937A
CN101801937A CN200880104552A CN200880104552A CN101801937A CN 101801937 A CN101801937 A CN 101801937A CN 200880104552 A CN200880104552 A CN 200880104552A CN 200880104552 A CN200880104552 A CN 200880104552A CN 101801937 A CN101801937 A CN 101801937A
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China
Prior art keywords
chloro
compound
oxo
amino
alkyl
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Pending
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CN200880104552A
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English (en)
Chinese (zh)
Inventor
刘吉丰
S·M·阿利
M·A·亚西威尔
叶萍
关裕升
吴西春
R·帕麦尔
D·约翰尼斯
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Arqule Inc
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Arqule Inc
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Publication of CN101801937A publication Critical patent/CN101801937A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200880104552A 2007-06-22 2008-06-19 喹唑啉酮化合物及其使用方法 Pending CN101801937A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94583807P 2007-06-22 2007-06-22
US60/945838 2007-06-22
PCT/US2008/067571 WO2009002808A2 (en) 2007-06-22 2008-06-19 Quinazolinone compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
CN101801937A true CN101801937A (zh) 2010-08-11

Family

ID=39846620

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880104552A Pending CN101801937A (zh) 2007-06-22 2008-06-19 喹唑啉酮化合物及其使用方法

Country Status (13)

Country Link
US (1) US8232285B2 (enExample)
EP (1) EP2173724B1 (enExample)
JP (1) JP2010530885A (enExample)
KR (1) KR20100024494A (enExample)
CN (1) CN101801937A (enExample)
AU (1) AU2008268613A1 (enExample)
BR (1) BRPI0813355A2 (enExample)
CA (1) CA2704282A1 (enExample)
IL (1) IL202740A0 (enExample)
MX (1) MX2009013815A (enExample)
TW (1) TW200918069A (enExample)
WO (1) WO2009002808A2 (enExample)
ZA (1) ZA201000183B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112334468A (zh) * 2018-05-11 2021-02-05 美国卫生和人力服务部 喹啉化合物及其制备和作为抗疟疾剂的用途
CN113354590A (zh) * 2020-03-05 2021-09-07 宁波康柏睿格医药科技有限公司 拮抗nod1/2受体信号通路的喹唑啉酮类化合物

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WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN108349985A (zh) 2015-09-14 2018-07-31 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
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WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112334468A (zh) * 2018-05-11 2021-02-05 美国卫生和人力服务部 喹啉化合物及其制备和作为抗疟疾剂的用途
CN113354590A (zh) * 2020-03-05 2021-09-07 宁波康柏睿格医药科技有限公司 拮抗nod1/2受体信号通路的喹唑啉酮类化合物

Also Published As

Publication number Publication date
CA2704282A1 (en) 2008-12-31
BRPI0813355A2 (pt) 2014-12-30
US20090130097A1 (en) 2009-05-21
WO2009002808A2 (en) 2008-12-31
MX2009013815A (es) 2010-03-01
ZA201000183B (en) 2011-03-30
IL202740A0 (en) 2010-06-30
EP2173724B1 (en) 2012-12-05
WO2009002808A3 (en) 2009-07-23
EP2173724A2 (en) 2010-04-14
AU2008268613A1 (en) 2008-12-31
US8232285B2 (en) 2012-07-31
TW200918069A (en) 2009-05-01
JP2010530885A (ja) 2010-09-16
KR20100024494A (ko) 2010-03-05

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Application publication date: 20100811