CN101796020A - 用于癌症治疗的新型三氮烯化合物 - Google Patents

用于癌症治疗的新型三氮烯化合物 Download PDF

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Publication number
CN101796020A
CN101796020A CN200880105688A CN200880105688A CN101796020A CN 101796020 A CN101796020 A CN 101796020A CN 200880105688 A CN200880105688 A CN 200880105688A CN 200880105688 A CN200880105688 A CN 200880105688A CN 101796020 A CN101796020 A CN 101796020A
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China
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compound
alkyl
general formula
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CN200880105688A
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English (en)
Chinese (zh)
Inventor
R·赖特
J·卡尔比
H·富斯特
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TRIN PHARMA GmbH
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Three N Pharmaceutical Co ltd
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Publication of CN101796020A publication Critical patent/CN101796020A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/22—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond containing chains of three or more nitrogen atoms with one or more nitrogen-to-nitrogen double bonds
    • C07C245/24—Chains of only three nitrogen atoms, e.g. diazoamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • C07C309/15—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton the nitrogen atom of at least one of the amino groups being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200880105688A 2007-07-04 2008-07-03 用于癌症治疗的新型三氮烯化合物 Pending CN101796020A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07111716 2007-07-04
EP07111716.2 2007-07-04
PCT/EP2008/058600 WO2009004060A1 (de) 2007-07-04 2008-07-03 Neue triazenverbindungen zur behandlung von krebs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2011103288515A Division CN102424657A (zh) 2007-07-04 2008-07-03 用于癌症治疗的新型三氮烯化合物

Publications (1)

Publication Number Publication Date
CN101796020A true CN101796020A (zh) 2010-08-04

Family

ID=38606533

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2011103288515A Pending CN102424657A (zh) 2007-07-04 2008-07-03 用于癌症治疗的新型三氮烯化合物
CN200880105688A Pending CN101796020A (zh) 2007-07-04 2008-07-03 用于癌症治疗的新型三氮烯化合物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN2011103288515A Pending CN102424657A (zh) 2007-07-04 2008-07-03 用于癌症治疗的新型三氮烯化合物

Country Status (13)

Country Link
US (2) US8034797B2 (enExample)
EP (1) EP2167459A1 (enExample)
JP (1) JP2010531855A (enExample)
KR (1) KR20100031620A (enExample)
CN (2) CN102424657A (enExample)
AU (1) AU2008270269B2 (enExample)
BR (2) BRPI0823332A2 (enExample)
CA (1) CA2691178A1 (enExample)
EA (1) EA201000141A1 (enExample)
MX (1) MX2010000223A (enExample)
NZ (1) NZ582346A (enExample)
TW (1) TW200908986A (enExample)
WO (1) WO2009004060A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103492365A (zh) * 2011-03-16 2014-01-01 创新治疗有限公司 取代的联苯衍生物
CN105566153A (zh) * 2014-10-14 2016-05-11 中国医学科学院药物研究所 偶氮苯衍生物及其制法和药物组合物与用途
CN109776526A (zh) * 2019-01-23 2019-05-21 西南医科大学 稠环三唑-(磺酰基)三氮烯类衍生物及其合成方法和用途

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012130850A1 (de) 2011-03-31 2012-10-04 Bayer Pharma Aktiengesellschaft Gewebetargeting mit onkoziden verbrückten diphenylderivaten zur selektiven behandlung von sexualorgantumoren
EP2557075A1 (de) 2011-08-09 2013-02-13 Trin Therapeutics GmbH Neue Triazenverbindungen zur Behandlung von Krebs
RU2014116229A (ru) 2011-09-23 2015-10-27 Даблхил Гмбх Новые соединения изоцианата и изотиоцианата для лечения злокачественных новообразований
DE102020125641A1 (de) 2020-09-25 2022-03-31 Creative Therapeutics Gmbh Wirkstoffe und Arzneimittel für die Therapie von Viruserkrankungen, insbesondere Corona-Infektionen, insbesondere COVID-19

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1793115A1 (de) * 1968-08-03 1972-02-03 Bayer Ag Neue Triazenderivate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789138A (fr) * 1971-09-24 1973-03-22 Bayer Ag Nouveaux derives triazeniques, leur procede de preparation et medicament les contenant
DE10324496A1 (de) * 2003-05-30 2004-12-16 Bayer Healthcare Ag Targetorientierte Chemotherapie von Tumoren der Sexualorgane

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1793115A1 (de) * 1968-08-03 1972-02-03 Bayer Ag Neue Triazenderivate
GB1282757A (en) * 1968-08-03 1972-07-26 Bayer Ag New triazene derivatives and pharmaceutical compositions thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103492365A (zh) * 2011-03-16 2014-01-01 创新治疗有限公司 取代的联苯衍生物
CN105566153A (zh) * 2014-10-14 2016-05-11 中国医学科学院药物研究所 偶氮苯衍生物及其制法和药物组合物与用途
CN105566153B (zh) * 2014-10-14 2019-05-31 中国医学科学院药物研究所 偶氮苯衍生物及其制法和药物组合物与用途
CN109776526A (zh) * 2019-01-23 2019-05-21 西南医科大学 稠环三唑-(磺酰基)三氮烯类衍生物及其合成方法和用途

Also Published As

Publication number Publication date
EP2167459A1 (de) 2010-03-31
TW200908986A (en) 2009-03-01
AU2008270269B2 (en) 2013-04-04
BRPI0814614A2 (pt) 2011-11-29
MX2010000223A (es) 2010-04-30
NZ582346A (en) 2012-04-27
US20120028927A1 (en) 2012-02-02
AU2008270269A1 (en) 2009-01-08
US8034797B2 (en) 2011-10-11
JP2010531855A (ja) 2010-09-30
KR20100031620A (ko) 2010-03-23
US20100234327A1 (en) 2010-09-16
US8426390B2 (en) 2013-04-23
AU2008270269A2 (en) 2012-04-12
WO2009004060A1 (de) 2009-01-08
CN102424657A (zh) 2012-04-25
EA201000141A1 (ru) 2010-06-30
CA2691178A1 (en) 2009-01-08
BRPI0823332A2 (pt) 2013-07-30

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