CN101795727A - 作为钾通道调节剂的5-氨基-4,6-二取代吲哚和5-氨基-4,6-二取代二氢吲哚的衍生物 - Google Patents

作为钾通道调节剂的5-氨基-4,6-二取代吲哚和5-氨基-4,6-二取代二氢吲哚的衍生物 Download PDF

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Publication number
CN101795727A
CN101795727A CN200880103296A CN200880103296A CN101795727A CN 101795727 A CN101795727 A CN 101795727A CN 200880103296 A CN200880103296 A CN 200880103296A CN 200880103296 A CN200880103296 A CN 200880103296A CN 101795727 A CN101795727 A CN 101795727A
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China
Prior art keywords
compound
formula
dimethyl
pharmaceutically acceptable
alkyl
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CN200880103296A
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Chinese (zh)
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J-M·沃尼尔
H·陈
J·宋
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Bausch Health Americas Inc
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Valeant Pharmaceuticals International Inc USA
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Publication of CN101795727A publication Critical patent/CN101795727A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CN200880103296A 2007-08-13 2008-08-12 作为钾通道调节剂的5-氨基-4,6-二取代吲哚和5-氨基-4,6-二取代二氢吲哚的衍生物 Pending CN101795727A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US96452607P 2007-08-13 2007-08-13
US60/964,526 2007-08-13
US12/189,709 2008-08-11
US12/189,709 US7786146B2 (en) 2007-08-13 2008-08-11 Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
PCT/US2008/072926 WO2009023677A1 (en) 2007-08-13 2008-08-12 Derivatives of 5-amino-4, 6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators

Publications (1)

Publication Number Publication Date
CN101795727A true CN101795727A (zh) 2010-08-04

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CN200880103296A Pending CN101795727A (zh) 2007-08-13 2008-08-12 作为钾通道调节剂的5-氨基-4,6-二取代吲哚和5-氨基-4,6-二取代二氢吲哚的衍生物

Country Status (16)

Country Link
US (2) US7786146B2 (https=)
EP (1) EP2190534B1 (https=)
JP (1) JP2010536771A (https=)
KR (1) KR20100075436A (https=)
CN (1) CN101795727A (https=)
AU (1) AU2008286919B2 (https=)
BR (1) BRPI0815210A2 (https=)
CA (1) CA2696012C (https=)
ES (1) ES2531335T3 (https=)
HU (1) HUE025928T2 (https=)
MX (1) MX2010001712A (https=)
PL (1) PL2190534T3 (https=)
RU (1) RU2483060C2 (https=)
SG (1) SG183725A1 (https=)
TW (1) TW200927096A (https=)
WO (1) WO2009023677A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103508960A (zh) * 2012-06-29 2014-01-15 上海先声药物研究有限公司 苯并杂环衍生物
CN107098844A (zh) * 2017-05-17 2017-08-29 许昌学院 一种c‑5位硝基取代的酰基吲哚啉类化合物的合成方法
CN112010808A (zh) * 2019-05-31 2020-12-01 上海挚盟医药科技有限公司 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用
CN114539120A (zh) * 2022-03-09 2022-05-27 台州学院 一种吲哚类钾离子通道激动剂的制备方法

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US8563566B2 (en) * 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
CN102241608A (zh) * 2011-05-12 2011-11-16 天津市汉康医药生物技术有限公司 瑞替加滨化合物及其组合物
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WO2025231340A1 (en) * 2024-05-03 2025-11-06 Xenon Pharmaceuticals Inc. Azaindole and azaindoline compounds and uses thereof

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Cited By (9)

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Publication number Priority date Publication date Assignee Title
CN103508960A (zh) * 2012-06-29 2014-01-15 上海先声药物研究有限公司 苯并杂环衍生物
CN103508960B (zh) * 2012-06-29 2017-12-12 江苏先声药业有限公司 苯并杂环衍生物
CN107098844A (zh) * 2017-05-17 2017-08-29 许昌学院 一种c‑5位硝基取代的酰基吲哚啉类化合物的合成方法
CN107098844B (zh) * 2017-05-17 2019-07-30 许昌学院 一种c-5位硝基取代的酰基吲哚啉类化合物的合成方法
CN112010808A (zh) * 2019-05-31 2020-12-01 上海挚盟医药科技有限公司 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用
WO2020238917A1 (zh) * 2019-05-31 2020-12-03 上海挚盟医药科技有限公司 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用
CN112010808B (zh) * 2019-05-31 2021-11-30 上海挚盟医药科技有限公司 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用
CN113767091A (zh) * 2019-05-31 2021-12-07 上海挚盟医药科技有限公司 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用
CN114539120A (zh) * 2022-03-09 2022-05-27 台州学院 一种吲哚类钾离子通道激动剂的制备方法

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Publication number Publication date
RU2483060C2 (ru) 2013-05-27
US8211918B2 (en) 2012-07-03
US20090137635A1 (en) 2009-05-28
KR20100075436A (ko) 2010-07-02
PL2190534T3 (pl) 2015-11-30
MX2010001712A (es) 2010-07-28
EP2190534A1 (en) 2010-06-02
US7786146B2 (en) 2010-08-31
EP2190534B1 (en) 2015-02-18
BRPI0815210A2 (pt) 2015-03-31
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