CN113767091A - 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用 - Google Patents

作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用 Download PDF

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CN113767091A
CN113767091A CN202080032892.7A CN202080032892A CN113767091A CN 113767091 A CN113767091 A CN 113767091A CN 202080032892 A CN202080032892 A CN 202080032892A CN 113767091 A CN113767091 A CN 113767091A
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梁波
金秋
陈焕明
张志军
华波
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Shanghai Zhimeng Biopharma Inc
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Shanghai Zhimeng Biopharma Inc
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
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    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

本发明涉及作为钾通道调节剂的四氢‑1H‑苯氮杂卓类化合物及其制备和应用。具体地，本发明化合物具有式A所示结构，其中各基团和取代基的定义如说明书中所述；本发明还公开了所述化合物的制备方法及其作为钾通道调节剂的用途。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202080032892.7A 2019-05-31 2020-05-26 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用 Pending CN113767091A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910473074X 2019-05-31
CN201910473074.XA CN112010808B (zh) 2019-05-31 2019-05-31 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用
PCT/CN2020/092401 WO2020238917A1 (zh) 2019-05-31 2020-05-26 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用

Publications (1)

Publication Number Publication Date
CN113767091A true CN113767091A (zh) 2021-12-07

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CN201910473074.XA Active CN112010808B (zh) 2019-05-31 2019-05-31 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用
CN202080032892.7A Pending CN113767091A (zh) 2019-05-31 2020-05-26 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用

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US (1) US20220227713A1 (zh)
EP (1) EP3978478B1 (zh)
JP (1) JP7327839B2 (zh)
KR (1) KR102672132B1 (zh)
CN (2) CN112010808B (zh)
ES (1) ES2973452T3 (zh)
WO (1) WO2020238917A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112010808B (zh) * 2019-05-31 2021-11-30 上海挚盟医药科技有限公司 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用
CN116535354A (zh) * 2022-01-25 2023-08-04 上海挚盟医药科技有限公司 作为钾通道调节剂的芳环并杂环类化合物及其制备和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1777582A (zh) * 2003-04-25 2006-05-24 H.隆德贝克有限公司 取代的二氢吲哚和吲哚衍生物
CN101084209A (zh) * 2004-12-21 2007-12-05 德福根有限公司 具有Kv4离子通道活性的化合物
WO2008038053A1 (en) * 2006-09-29 2008-04-03 Lectus Therapeutics Limited Ion channel modulators & uses thereof
CN101795727A (zh) * 2007-08-13 2010-08-04 威朗国际制药公司 作为钾通道调节剂的5-氨基-4,6-二取代吲哚和5-氨基-4,6-二取代二氢吲哚的衍生物
CN103508960A (zh) * 2012-06-29 2014-01-15 上海先声药物研究有限公司 苯并杂环衍生物
CN112010808B (zh) * 2019-05-31 2021-11-30 上海挚盟医药科技有限公司 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006524641A (ja) * 2003-04-25 2006-11-02 ハー・ルンドベック・アクチエゼルスカベット 置換されたインドリンおよびインドール誘導体
UA89503C2 (uk) * 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
CN103508943B (zh) * 2012-06-29 2017-06-09 江苏先声药业有限公司 作为钾通道调节剂的化合物
CN103694163A (zh) * 2012-09-27 2014-04-02 上海先声药物研究有限公司 作为钾通道调节剂的化合物
WO2018133845A1 (zh) * 2017-01-23 2018-07-26 上海长森药业有限公司 硫脲类、脲类化合物及其用途

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1777582A (zh) * 2003-04-25 2006-05-24 H.隆德贝克有限公司 取代的二氢吲哚和吲哚衍生物
CN101084209A (zh) * 2004-12-21 2007-12-05 德福根有限公司 具有Kv4离子通道活性的化合物
WO2008038053A1 (en) * 2006-09-29 2008-04-03 Lectus Therapeutics Limited Ion channel modulators & uses thereof
CN101795727A (zh) * 2007-08-13 2010-08-04 威朗国际制药公司 作为钾通道调节剂的5-氨基-4,6-二取代吲哚和5-氨基-4,6-二取代二氢吲哚的衍生物
CN103508960A (zh) * 2012-06-29 2014-01-15 上海先声药物研究有限公司 苯并杂环衍生物
CN112010808B (zh) * 2019-05-31 2021-11-30 上海挚盟医药科技有限公司 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用

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JP7327839B2 (ja) 2023-08-16
ES2973452T3 (es) 2024-06-20
US20220227713A1 (en) 2022-07-21
EP3978478C0 (en) 2024-02-14
WO2020238917A1 (zh) 2020-12-03
CN112010808A (zh) 2020-12-01
JP2022534533A (ja) 2022-08-01
KR20220016921A (ko) 2022-02-10
EP3978478A1 (en) 2022-04-06
KR102672132B1 (ko) 2024-06-04
EP3978478B1 (en) 2024-02-14
CN112010808B (zh) 2021-11-30
EP3978478A4 (en) 2023-01-04

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