CN101784260A - 包含二氢吡啶钙通道拮抗剂的药物组合物及其制备方法 - Google Patents

包含二氢吡啶钙通道拮抗剂的药物组合物及其制备方法 Download PDF

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Publication number
CN101784260A
CN101784260A CN200780100025A CN200780100025A CN101784260A CN 101784260 A CN101784260 A CN 101784260A CN 200780100025 A CN200780100025 A CN 200780100025A CN 200780100025 A CN200780100025 A CN 200780100025A CN 101784260 A CN101784260 A CN 101784260A
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CN
China
Prior art keywords
pharmaceutical composition
lercanidipine
silicon dioxide
colloidal silicon
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200780100025A
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English (en)
Chinese (zh)
Inventor
E·卡拉瓦斯
E·库特瑞斯
I·库特瑞
E·斯塔萨奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmathen SA
Original Assignee
Pharmathen SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39223083&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101784260(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmathen SA filed Critical Pharmathen SA
Publication of CN101784260A publication Critical patent/CN101784260A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
CN200780100025A 2007-07-23 2007-07-23 包含二氢吡啶钙通道拮抗剂的药物组合物及其制备方法 Pending CN101784260A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2007/006517 WO2009012791A1 (en) 2007-07-23 2007-07-23 Pharmaceutical composition containing dihydropyridine calcium channel antagonist and method for the preparation thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201410092837.3A Division CN103893765A (zh) 2007-07-23 2007-07-23 包含二氢吡啶钙通道拮抗剂的药物组合物及其制备方法

Publications (1)

Publication Number Publication Date
CN101784260A true CN101784260A (zh) 2010-07-21

Family

ID=39223083

Family Applications (3)

Application Number Title Priority Date Filing Date
CN200780100025A Pending CN101784260A (zh) 2007-07-23 2007-07-23 包含二氢吡啶钙通道拮抗剂的药物组合物及其制备方法
CN201410243247.6A Pending CN103976968A (zh) 2007-07-23 2008-07-23 包含二氢吡啶类钙通道拮抗剂的改进的药物组合物及其制备方法
CN200880100075A Pending CN101801347A (zh) 2007-07-23 2008-07-23 包含二氢吡啶类钙通道拮抗剂的改进的药物组合物及其制备方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201410243247.6A Pending CN103976968A (zh) 2007-07-23 2008-07-23 包含二氢吡啶类钙通道拮抗剂的改进的药物组合物及其制备方法
CN200880100075A Pending CN101801347A (zh) 2007-07-23 2008-07-23 包含二氢吡啶类钙通道拮抗剂的改进的药物组合物及其制备方法

Country Status (20)

Country Link
EP (2) EP2180883B1 (enExample)
JP (2) JP5769963B2 (enExample)
KR (2) KR101632079B1 (enExample)
CN (3) CN101784260A (enExample)
AU (2) AU2007356942B2 (enExample)
BR (2) BRPI0721883A2 (enExample)
CA (2) CA2691752C (enExample)
CO (1) CO6290639A2 (enExample)
CR (1) CR11285A (enExample)
EA (2) EA021645B1 (enExample)
EC (1) ECSP109984A (enExample)
ES (2) ES2622495T3 (enExample)
MA (1) MA31684B1 (enExample)
MX (2) MX2010000856A (enExample)
MY (1) MY153857A (enExample)
NZ (2) NZ582648A (enExample)
TN (2) TN2010000011A1 (enExample)
UA (2) UA97161C2 (enExample)
WO (2) WO2009012791A1 (enExample)
ZA (2) ZA201000586B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104069500A (zh) * 2014-06-20 2014-10-01 湖南天地恒一制药有限公司 一种包含乐卡地平的药物组合物
CN105168165A (zh) * 2015-08-28 2015-12-23 江苏福邦药业有限公司 一种盐酸乐卡地平片及其制备方法
CN114533686A (zh) * 2022-02-15 2022-05-27 湖南普道医药技术有限公司 一种二氢吡啶类药物的口服固体制剂及其制备方法

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WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
SG183036A1 (en) 2007-07-17 2012-08-30 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
EA021645B1 (ru) * 2007-07-23 2015-08-31 Фарматен С.А. Твердая дозированная форма в виде таблетки и способ её приготовления
EA022924B1 (ru) * 2009-04-03 2016-03-31 Ф.Хоффманн-Ля Рош Аг ТВЁРДАЯ ФОРМА {3-[5-(4-ХЛОРФЕНИЛ)-1Н-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ И ЕЁ ПРИМЕНЕНИЕ
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
MA33975B1 (fr) 2009-11-06 2013-02-01 Plexxikon Inc Composés et méthodes de modulation des kinases et leurs indications d'emploi
JP5941069B2 (ja) 2011-02-07 2016-06-29 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． キナーゼ調節のための化合物および方法、ならびにそれに対する適応症
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
PL2919903T3 (pl) 2012-11-14 2020-12-14 W.R. Grace & Co. - Conn. Kompozycje zawierające materiał biologicznie aktywny i nieuporządkowany tlenek nieorganiczny
GR1008554B (el) * 2014-06-12 2015-09-03 ΦΑΡΜΑΤΕΝ ΑΝΩΝΥΜΟΣ ΒΙΟΜΗΧΑΝΙΚΗ ΚΑΙ ΕΜΠΟΡΙΚΗ ΕΤΑΙΡΕΙΑ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΙΑΤΡΙΚΩΝ ΚΑΙ ΚΑΛΛΥΝΤΙΚΩΝ ΠΡΟΪΟΝΤΩΝ με δ.τ. ΦΑΡΜΑΤΕΝ, Φαρμακευτικο σκευασμα περιεχον εναν αντιμυκητιασικο παραγοντα τριaζολης και μεθοδος για την παρασκευη αυτου
WO2018004379A1 (ru) * 2016-07-01 2018-01-04 Общество С Ограниченной Ответственностью "Гиостин" Средство в виде капсулы для лечения заболеваний суставов
CA3094115A1 (en) 2018-03-22 2019-09-26 Komipharm International Australia Pty Ltd Pharmaceutical composition comprising meta arsenite and method of manufacture
KR20240040407A (ko) * 2022-09-21 2024-03-28 주식회사 종근당 사쿠비트릴ㆍ발사르탄 칼슘염을 포함하는 약제학적 조성물

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DE3720757A1 (de) * 1987-06-24 1989-01-05 Bayer Ag Dhp-manteltablette
US5209933A (en) * 1990-01-10 1993-05-11 Syntex (U.S.A.) Inc. Long acting calcium channel blocker composition
GB9025251D0 (en) * 1990-11-20 1991-01-02 Solomon Montague C Nifedipine dosage forms
BR9903490A (pt) * 1998-12-15 2000-09-26 Oscar Gold Processo para a preparação de composições farmacêuticas de liberação programada contendo nimodipine, que permitem a liberação gradual e a manuntenção da ação terapeutica
DE19944803A1 (de) * 1999-09-20 2001-03-29 Bayer Ag Kombination von Dihydropyridinverbindungen und HMG-CoA-Reduktase-Inhibitoren und ihre Verwendung in Arzneimitteln
US20040185097A1 (en) * 2003-01-31 2004-09-23 Glenmark Pharmaceuticals Ltd. Controlled release modifying complex and pharmaceutical compositions thereof
UA89177C2 (ru) * 2003-12-01 2010-01-11 Рекордати Айрленд Лимитед Фармацевтическая композиция с контролируемым высвобождением, которая содержит лерканидипин
WO2005053689A2 (en) * 2003-12-01 2005-06-16 Lifecycle Pharma A/S Pharmaceutical compositions comprising lercanidipine
EP2063871A1 (en) * 2006-08-30 2009-06-03 Jagotec AG Controlled release solid oral dosage formulations comprising nisoldipine
EP2101771A2 (en) * 2006-12-06 2009-09-23 Torrent Pharmaceuticals Ltd Stable lercanidipine formulation
EA021645B1 (ru) * 2007-07-23 2015-08-31 Фарматен С.А. Твердая дозированная форма в виде таблетки и способ её приготовления

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104069500A (zh) * 2014-06-20 2014-10-01 湖南天地恒一制药有限公司 一种包含乐卡地平的药物组合物
CN105168165A (zh) * 2015-08-28 2015-12-23 江苏福邦药业有限公司 一种盐酸乐卡地平片及其制备方法
CN105168165B (zh) * 2015-08-28 2018-06-26 江苏福邦药业有限公司 一种盐酸乐卡地平片及其制备方法
CN114533686A (zh) * 2022-02-15 2022-05-27 湖南普道医药技术有限公司 一种二氢吡啶类药物的口服固体制剂及其制备方法
CN114533686B (zh) * 2022-02-15 2023-10-20 湖南普道医药技术有限公司 一种二氢吡啶类药物的口服固体制剂及其制备方法

Also Published As

Publication number Publication date
CA2691752C (en) 2016-01-26
MX2010000801A (es) 2010-07-05
CA2691752A1 (en) 2009-01-29
JP2010534220A (ja) 2010-11-04
EP2170295B1 (en) 2015-04-22
ECSP109984A (es) 2010-04-30
CN101801347A (zh) 2010-08-11
WO2009013306A1 (en) 2009-01-29
UA97161C2 (ru) 2012-01-10
AU2007356942B2 (en) 2011-12-15
EP2180883B1 (en) 2017-01-11
ZA201000586B (en) 2011-03-30
EA201000220A1 (ru) 2010-08-30
KR20100045456A (ko) 2010-05-03
NZ582648A (en) 2012-06-29
CA2693233A1 (en) 2009-01-29
KR101512404B1 (ko) 2015-04-21
CR11285A (es) 2010-04-27
EA019614B1 (ru) 2014-05-30
AU2008280106A2 (en) 2010-02-25
AU2008280106B9 (en) 2014-08-07
KR101632079B1 (ko) 2016-06-20
MA31684B1 (fr) 2010-09-01
CO6290639A2 (es) 2011-06-20
ES2622495T3 (es) 2017-07-06
JP2010534211A (ja) 2010-11-04
CN103976968A (zh) 2014-08-13
BRPI0721883A2 (pt) 2014-02-18
TN2010000011A1 (en) 2011-09-26
AU2007356942A1 (en) 2009-01-29
ZA201001176B (en) 2010-11-24
AU2008280106B2 (en) 2014-03-20
EP2180883A1 (en) 2010-05-05
NZ582690A (en) 2011-12-22
JP5769963B2 (ja) 2015-08-26
TN2010000022A1 (en) 2011-09-26
EP2170295A1 (en) 2010-04-07
UA99136C2 (ru) 2012-07-25
KR20100047848A (ko) 2010-05-10
MY153857A (en) 2015-03-31
EA021645B1 (ru) 2015-08-31
MX2010000856A (es) 2010-04-30
BRPI0814666A2 (pt) 2017-05-09
EA201070160A1 (ru) 2010-06-30
WO2009012791A1 (en) 2009-01-29
AU2008280106A1 (en) 2009-01-29
ES2537063T3 (es) 2015-06-02

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