CN101721530A - 金鸡制剂的质量控制方法 - Google Patents
金鸡制剂的质量控制方法 Download PDFInfo
- Publication number
- CN101721530A CN101721530A CN200910114567A CN200910114567A CN101721530A CN 101721530 A CN101721530 A CN 101721530A CN 200910114567 A CN200910114567 A CN 200910114567A CN 200910114567 A CN200910114567 A CN 200910114567A CN 101721530 A CN101721530 A CN 101721530A
- Authority
- CN
- China
- Prior art keywords
- reference substance
- preparation
- methanol
- solution
- dehydrorographolide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 90
- 238000002360 preparation method Methods 0.000 title claims abstract description 85
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 123
- 239000013558 reference substance Substances 0.000 claims description 122
- 239000000243 solution Substances 0.000 claims description 121
- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 claims description 67
- ASLUCFFROXVMFL-UHFFFAOYSA-N andrographolide Natural products CC1(CO)C(O)CCC2(C)C(CC=C3/C(O)OCC3=O)C(=C)CCC12 ASLUCFFROXVMFL-UHFFFAOYSA-N 0.000 claims description 67
- 238000012360 testing method Methods 0.000 claims description 59
- VKJGBAJNNALVAV-UHFFFAOYSA-M Berberine chloride (TN) Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VKJGBAJNNALVAV-UHFFFAOYSA-M 0.000 claims description 58
- RLQYRXCUPVKSAW-UHFFFAOYSA-M 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride Chemical compound [Cl-].COC1=C(OC)C=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=C1 RLQYRXCUPVKSAW-UHFFFAOYSA-M 0.000 claims description 57
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 46
- 239000011259 mixed solution Substances 0.000 claims description 45
- 239000000706 filtrate Substances 0.000 claims description 32
- 239000007788 liquid Substances 0.000 claims description 30
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 24
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 claims description 23
- 239000000377 silicon dioxide Substances 0.000 claims description 23
- PBCJIPOGFJYBJE-UHFFFAOYSA-N acetonitrile;hydrate Chemical compound O.CC#N PBCJIPOGFJYBJE-UHFFFAOYSA-N 0.000 claims description 22
- FUKUFMFMCZIRNT-UHFFFAOYSA-N hydron;methanol;chloride Chemical compound Cl.OC FUKUFMFMCZIRNT-UHFFFAOYSA-N 0.000 claims description 22
- 238000011003 system suitability test Methods 0.000 claims description 22
- 241000287828 Gallus gallus Species 0.000 claims description 21
- 239000000945 filler Substances 0.000 claims description 21
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 claims description 21
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 16
- 230000007935 neutral effect Effects 0.000 claims description 16
- 238000001514 detection method Methods 0.000 claims description 14
- 238000003908 quality control method Methods 0.000 claims description 14
- 238000005303 weighing Methods 0.000 claims description 13
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 10
- 239000003480 eluent Substances 0.000 claims description 10
- 239000000872 buffer Substances 0.000 claims description 6
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 3
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 3
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 3
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- 238000004128 high performance liquid chromatography Methods 0.000 abstract description 2
- 238000003556 assay Methods 0.000 description 22
- 239000000523 sample Substances 0.000 description 16
- 239000002775 capsule Substances 0.000 description 10
- 239000012488 sample solution Substances 0.000 description 10
- PTPHDVKWAYIFRX-UHFFFAOYSA-N Palmatine Natural products C1C2=C(OC)C(OC)=CC=C2C=C2N1CCC1=C2C=C(OC)C(OC)=C1 PTPHDVKWAYIFRX-UHFFFAOYSA-N 0.000 description 8
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 8
- 229940093265 berberine Drugs 0.000 description 8
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 8
- QUCQEUCGKKTEBI-UHFFFAOYSA-N palmatine Chemical compound COC1=CC=C2C=C(C3=C(C=C(C(=C3)OC)OC)CC3)[N+]3=CC2=C1OC QUCQEUCGKKTEBI-UHFFFAOYSA-N 0.000 description 8
- 239000012528 membrane Substances 0.000 description 7
- 239000008057 potassium phosphate buffer Substances 0.000 description 7
- 241000746375 Andrographis Species 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 238000011084 recovery Methods 0.000 description 6
- 239000006189 buccal tablet Substances 0.000 description 5
- 239000012846 chemical reference substance Substances 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 241000288027 Chrysolophus pictus Species 0.000 description 3
- 229940046011 buccal tablet Drugs 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 235000011158 Prunus mume Nutrition 0.000 description 2
- 244000018795 Prunus mume Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 238000012417 linear regression Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- YGCYRQKJYWQXHG-RDNQFMDVSA-N 4-[2-[(1r,4as,5r,8as)-5,8a-dimethyl-2-methylidene-5-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl]ethyl]-2h-furan-5-one Chemical compound C([C@@]1(C)[C@H]2CCC(=C)[C@@H](CCC=3C(OCC=3)=O)[C@]2(C)CCC1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YGCYRQKJYWQXHG-RDNQFMDVSA-N 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- MXTLAHSTUOXGQF-UHFFFAOYSA-O Jatrorrhizine Chemical compound COC1=CC=C2C=C3C(C=C(C(=C4)O)OC)=C4CC[N+]3=CC2=C1OC MXTLAHSTUOXGQF-UHFFFAOYSA-O 0.000 description 1
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 1
- 206010049677 Salpingo-oophoritis Diseases 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- -1 dehydrorographolide Chemical compound 0.000 description 1
- MEEPUSVTMHGIPC-UHFFFAOYSA-N deoxyandrographiside Natural products OC1CCC2(C)C(CCC=3C(OCC=3)=O)C(=C)CCC2C1(C)COC1OC(CO)C(O)C(O)C1O MEEPUSVTMHGIPC-UHFFFAOYSA-N 0.000 description 1
- 229930004069 diterpene Natural products 0.000 description 1
- 150000004141 diterpene derivatives Chemical class 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000003512 furunculosis Diseases 0.000 description 1
- 229930184727 ginkgolide Natural products 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- BBGWVUQBIGGVLS-UHFFFAOYSA-N neoandrographolide Natural products CC1(COC2OC(CO)C(O)C(O)C2O)C(O)CCC3(C)C(CCC4=C(O)COC4=O)C(=C)CCC13 BBGWVUQBIGGVLS-UHFFFAOYSA-N 0.000 description 1
- YGCYRQKJYWQXHG-UHFFFAOYSA-N neoandrographoside Natural products C1CCC2(C)C(CCC=3C(OCC=3)=O)C(=C)CCC2C1(C)COC1OC(CO)C(O)C(O)C1O YGCYRQKJYWQXHG-UHFFFAOYSA-N 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940023488 pill Drugs 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000013094 purity test Methods 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009101145670A CN101721530B (zh) | 2009-11-18 | 2009-11-18 | 金鸡制剂的检测方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009101145670A CN101721530B (zh) | 2009-11-18 | 2009-11-18 | 金鸡制剂的检测方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101721530A true CN101721530A (zh) | 2010-06-09 |
CN101721530B CN101721530B (zh) | 2012-02-29 |
Family
ID=42443480
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009101145670A Active CN101721530B (zh) | 2009-11-18 | 2009-11-18 | 金鸡制剂的检测方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101721530B (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102226791A (zh) * | 2011-03-31 | 2011-10-26 | 宁波双伟制药有限公司 | 高效液相色谱法测定感冒清胶囊中脱水穿心莲内酯含量的方法 |
CN105403628A (zh) * | 2014-09-16 | 2016-03-16 | 广东青云山药业有限公司 | 和胃止痛胶囊中盐酸小檗碱含量的检测方法 |
CN105954457A (zh) * | 2016-06-24 | 2016-09-21 | 广西灵峰药业有限公司 | 一种金香胶囊的生产质量控制方法 |
CN106970167A (zh) * | 2017-04-28 | 2017-07-21 | 广西壮族自治区梧州食品药品检验所 | 一种测定两面针牙膏中氯化两面针碱含量的方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1733105B (zh) * | 2005-08-18 | 2011-04-20 | 贵阳云岩西创药物科技开发有限公司 | 治疗妇科疾病的金鸡制剂的检测方法 |
-
2009
- 2009-11-18 CN CN2009101145670A patent/CN101721530B/zh active Active
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102226791A (zh) * | 2011-03-31 | 2011-10-26 | 宁波双伟制药有限公司 | 高效液相色谱法测定感冒清胶囊中脱水穿心莲内酯含量的方法 |
CN105403628A (zh) * | 2014-09-16 | 2016-03-16 | 广东青云山药业有限公司 | 和胃止痛胶囊中盐酸小檗碱含量的检测方法 |
CN105954457A (zh) * | 2016-06-24 | 2016-09-21 | 广西灵峰药业有限公司 | 一种金香胶囊的生产质量控制方法 |
CN106970167A (zh) * | 2017-04-28 | 2017-07-21 | 广西壮族自治区梧州食品药品检验所 | 一种测定两面针牙膏中氯化两面针碱含量的方法 |
Also Published As
Publication number | Publication date |
---|---|
CN101721530B (zh) | 2012-02-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101167788B (zh) | 一种用于久病虚损,气阴不足的贞芪扶正中药制剂质控方法 | |
CN101315355B (zh) | 一种康复新制剂的指纹图谱质量测定方法 | |
CN101721530B (zh) | 金鸡制剂的检测方法 | |
CN107064322A (zh) | 同时测定地榆或地榆类制剂中没食子酸和地榆皂苷i含量的hplc波长切换法 | |
CN114487242B (zh) | 鸡内金和/或醋鸡内金及制剂的特征图谱及其构建方法和含量测定方法 | |
CN101502549B (zh) | 一种三七总皂苷胶囊及其制备方法和含量测定方法 | |
CN102879516B (zh) | 补阳还五汤的鉴别和含量测定方法 | |
CN105510488B (zh) | 一种止痛贴剂的指纹图谱及其质量检测方法 | |
CN101474249B (zh) | 益母草及其制剂的质量检测方法 | |
CN103063789A (zh) | 同时检测大叶蒟中12个酰胺类生物碱的液相分析方法 | |
CN101700262A (zh) | 穿心莲滴丸的质量控制方法 | |
CN112730674B (zh) | 一种罗汉茶的质量检测方法 | |
CN112730647A (zh) | 一种昆仙胶囊中雷公藤甲素的鉴别及含量测定方法 | |
Ali et al. | Drug analyses in human plasma by chromatography | |
CN101816753B (zh) | 一种治疗感冒的复方制剂的质量检测方法 | |
CN111929378B (zh) | 一种清达颗粒中天麻6种指标成分的含量测定方法 | |
CN110687219B (zh) | 一种苏黄止咳胶囊指纹图谱的检测方法及其应用 | |
CN103513000A (zh) | 睡莲花的鉴别和含量测定方法 | |
CN112666278A (zh) | 华佗再造丸中士的宁的限量检测方法 | |
CN109856262B (zh) | 一种可同时用于二丁制剂主要成分定性与定量分析的方法 | |
CN103837627A (zh) | 一种落花生茎叶药材的指纹图谱建立方法 | |
CN103575823A (zh) | 一种糖敏灵制剂中8种化学成分的检测方法 | |
CN108593794B (zh) | 一种多指标成分uplc检测红花中有效成分含量方法 | |
CN101596229A (zh) | 猴耳环提取物及其制剂的质量控制方法 | |
CN101703552B (zh) | 复方板蓝根口服液中表告依春的含量测定方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: LINGFENG PHARMACEUTICAL CO., LTD., GUANGXI Free format text: FORMER OWNER: GUANGDONG HUIKE PHARMACEUTICAL RESEARCH COMPANY LIMITED Effective date: 20131216 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Huang Yuan Inventor after: Rong Yanli Inventor after: Liang Yuezhao Inventor after: Chen Xiaojun Inventor after: Liao Zhanwei Inventor before: Huang Yuan Inventor before: Rong Yanli Inventor before: Liang Yuezhao Inventor before: Chen Xiaojun |
|
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 530007 NANNING, GUANGXI ZHUANG AUTONOMOUS REGION TO: 542899 HEZHOU, GUANGXI ZHUANG AUTONOMOUS REGION Free format text: CORRECT: INVENTOR; FROM: HUANG YUAN RONG YANLI LIANG YUEZHAO CHEN XIAOJUN TO: HUANG YUAN RONG YANLI LIANG YUEZHAO CHEN XIAOJUN LIAO ZHANWEI |
|
TR01 | Transfer of patent right |
Effective date of registration: 20131216 Address after: 542899 No. 68 West Anshan Road, the Guangxi Zhuang Autonomous Region, Hezhou Patentee after: Guangxi LingFeng Pharmaceutical Co.,Ltd. Address before: 530007 development center, 56 Garden Avenue, Nanning, the Guangxi Zhuang Autonomous Region Patentee before: Guangxi Huike Medicine Research Co.,Ltd. |
|
CP03 | Change of name, title or address |
Address after: No. 68, Anshan West Road, Babu District, Hezhou City, Guangxi Zhuang Autonomous Region Patentee after: Jinji Pharmaceutical Co.,Ltd. Address before: 542899 No. 68 West Anshan Road, the Guangxi Zhuang Autonomous Region, Hezhou Patentee before: Guangxi LingFeng Pharmaceutical Co.,Ltd. |
|
CP03 | Change of name, title or address | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20200108 Address after: 535416, Lingshan Qinzhou land Industrial Park, the Guangxi Zhuang Autonomous Region Patentee after: GUANGXI GEHONGTANG PHARMACEUTICAL Co.,Ltd. Address before: No. 68, Anshan West Road, Babu District, Hezhou City, Guangxi Zhuang Autonomous Region Patentee before: Jinji Pharmaceutical Co.,Ltd. |