CN101679380A - 4’-o-取代的异吲哚啉衍生物和包含它的组合物及使用方法 - Google Patents

4’-o-取代的异吲哚啉衍生物和包含它的组合物及使用方法 Download PDF

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Publication number
CN101679380A
CN101679380A CN200880016715A CN200880016715A CN101679380A CN 101679380 A CN101679380 A CN 101679380A CN 200880016715 A CN200880016715 A CN 200880016715A CN 200880016715 A CN200880016715 A CN 200880016715A CN 101679380 A CN101679380 A CN 101679380A
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compound
mmol
methyl
disease
limited
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Chinese (zh)
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亚历山大·L·卢切尔曼
乔治·W·穆勒
宏-万·曼
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Celgene Corp
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Celgene Corp
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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CN200880016715A 2007-03-20 2008-03-19 4’-o-取代的异吲哚啉衍生物和包含它的组合物及使用方法 Pending CN101679380A (zh)

Applications Claiming Priority (3)

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US91932307P 2007-03-20 2007-03-20
US60/919,323 2007-03-20
PCT/US2008/003602 WO2008115516A2 (en) 2007-03-20 2008-03-19 4'-o-substituted isoindoline derivatives and compositions comprising and methods of using the same

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CN201310547773.7A Pending CN103641814A (zh) 2007-03-20 2008-03-19 4’-o-取代的异吲哚啉衍生物和包含它的组合物及使用方法

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EP (2) EP3101017B1 (enExample)
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KR (3) KR101791757B1 (enExample)
CN (2) CN101679380A (enExample)
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CN102731850A (zh) * 2012-06-28 2012-10-17 芜湖宏达橡塑阀门制造有限公司 耐油耐磨橡胶
CN102731853A (zh) * 2012-06-28 2012-10-17 芜湖宏达橡塑阀门制造有限公司 耐油橡胶
CN102731851A (zh) * 2012-06-28 2012-10-17 芜湖宏达橡塑阀门制造有限公司 一种耐油橡胶
CN108245518A (zh) * 2012-08-09 2018-07-06 细胞基因公司 利用3-(4-((4-(吗啉代甲基)苯甲基)氧基)-1-氧代异二氢吲哚-2-基)哌啶-2,6- 二酮治疗癌症的方法
WO2020064002A1 (zh) * 2018-09-30 2020-04-02 中国科学院上海药物研究所 异吲哚啉类化合物、其制备方法、药物组合物及用途
CN111747924A (zh) * 2019-03-29 2020-10-09 华东师范大学 一类来那度胺/泊马度胺类似物及其应用
WO2020239103A1 (zh) * 2019-05-31 2020-12-03 四川海思科制药有限公司 一种btk抑制剂环衍生物及其制备方法和药学上的应用
WO2021170021A1 (zh) * 2020-02-25 2021-09-02 上海科技大学 基于戊二酰亚胺骨架的化合物及其应用
WO2022017365A1 (zh) * 2020-07-20 2022-01-27 江苏恒瑞医药股份有限公司 含硫异吲哚啉类衍生物、其制备方法及其在医药上的应用
WO2022148358A1 (zh) * 2021-01-05 2022-07-14 江苏恒瑞医药股份有限公司 稠杂环基取代的环己二酰亚胺衍生物、其制备方法及其在医药上的应用
WO2022268066A1 (zh) * 2021-06-22 2022-12-29 苏州开拓药业股份有限公司 一种蛋白降解剂
CN116675786A (zh) * 2023-07-10 2023-09-01 盐城师范学院 一种靶向传递喜树碱的环糊精超分子药物及其制备方法和应用
US12564638B2 (en) 2019-08-05 2026-03-03 Shanghaitech University EGFR protein degradant and anti-tumor application thereof
US12582641B2 (en) 2019-02-25 2026-03-24 Shanghaitech University Sulfur-containing compound based on glutarimide skeleton and application thereof

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JP2929331B2 (ja) * 1990-07-18 1999-08-03 丸善石油化学株式会社 トラクションドライブ用流体
CN101111234A (zh) * 2004-12-01 2008-01-23 细胞基因公司 包含免疫调节化合物的组合物及其治疗免疫缺陷疾病的用途
KR101791757B1 (ko) 2007-03-20 2017-10-30 셀진 코포레이션 4'-ｏ-치환된 아이소인돌린 유도체 및 이를 포함하는 조성물 및 이의 사용 방법
US7964354B2 (en) * 2007-12-20 2011-06-21 Celgene Corporation Use of micro-RNA as a biomarker of immunomodulatory drug activity
AU2010327936B2 (en) 2009-12-11 2015-08-20 Nono Inc. Agents and methods for treating ischemic and other diseases
PL2536706T3 (pl) * 2010-02-11 2017-10-31 Celgene Corp Pochodne arylometoksyizoindoliny i zawierające je kompozycje oraz sposoby ich zastosowania
AU2013245487B2 (en) * 2010-02-11 2016-03-10 Celgene Corporation Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
AU2016203826B2 (en) * 2010-02-11 2018-05-17 Celgene Corporation Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
WO2012135299A1 (en) 2011-03-28 2012-10-04 Deuteria Pharmaceuticals Inc 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
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