CL2008000805A1 - Compuestos derivados de 4-o-substituidos de insoindolina; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer, un trastorno asociado con angiogenesis, dolor, un tratorno pulmonar, un tratorno del sistema nervioso central, aterosclerosis, inmunodeficiencia, entre otros. - Google Patents

Compuestos derivados de 4-o-substituidos de insoindolina; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer, un trastorno asociado con angiogenesis, dolor, un tratorno pulmonar, un tratorno del sistema nervioso central, aterosclerosis, inmunodeficiencia, entre otros.

Info

Publication number
CL2008000805A1
CL2008000805A1 CL2008000805A CL2008000805A CL2008000805A1 CL 2008000805 A1 CL2008000805 A1 CL 2008000805A1 CL 2008000805 A CL2008000805 A CL 2008000805A CL 2008000805 A CL2008000805 A CL 2008000805A CL 2008000805 A1 CL2008000805 A1 CL 2008000805A1
Authority
CL
Chile
Prior art keywords
disorder
compounds
insoindoline
substituted
pharmaceutical composition
Prior art date
Application number
CL2008000805A
Other languages
English (en)
Spanish (es)
Inventor
L Ruchelman Alexander
W Muller George
Man Hon-Wah
Original Assignee
Celgene Corporation Soc Organizada Bajo Las Leyes Del Estado De Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39719168&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008000805(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Corporation Soc Organizada Bajo Las Leyes Del Estado De Delaware filed Critical Celgene Corporation Soc Organizada Bajo Las Leyes Del Estado De Delaware
Publication of CL2008000805A1 publication Critical patent/CL2008000805A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/47—Quinolines; Isoquinolines
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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CL2008000805A 2007-03-20 2008-03-20 Compuestos derivados de 4-o-substituidos de insoindolina; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer, un trastorno asociado con angiogenesis, dolor, un tratorno pulmonar, un tratorno del sistema nervioso central, aterosclerosis, inmunodeficiencia, entre otros. CL2008000805A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91932307P 2007-03-20 2007-03-20

Publications (1)

Publication Number Publication Date
CL2008000805A1 true CL2008000805A1 (es) 2009-05-22

Family

ID=39719168

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008000805A CL2008000805A1 (es) 2007-03-20 2008-03-20 Compuestos derivados de 4-o-substituidos de insoindolina; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer, un trastorno asociado con angiogenesis, dolor, un tratorno pulmonar, un tratorno del sistema nervioso central, aterosclerosis, inmunodeficiencia, entre otros.

Country Status (25)

Country Link
US (6) US8153659B2 (enExample)
EP (2) EP3101017B1 (enExample)
JP (4) JP2010522170A (enExample)
KR (3) KR101791757B1 (enExample)
CN (2) CN103641814A (enExample)
AR (1) AR065810A1 (enExample)
AU (1) AU2008229383B2 (enExample)
BR (1) BRPI0809011A8 (enExample)
CA (1) CA2681633C (enExample)
CL (1) CL2008000805A1 (enExample)
CO (1) CO6231033A2 (enExample)
CR (2) CR11036A (enExample)
EC (1) ECSP099663A (enExample)
ES (2) ES2734253T3 (enExample)
IL (1) IL200990A (enExample)
MX (1) MX2009010082A (enExample)
MY (1) MY180812A (enExample)
NI (1) NI200900170A (enExample)
NZ (2) NZ599199A (enExample)
PE (1) PE20081894A1 (enExample)
RU (1) RU2471794C2 (enExample)
UA (1) UA97976C2 (enExample)
UY (1) UY30977A1 (enExample)
WO (1) WO2008115516A2 (enExample)
ZA (1) ZA200906497B (enExample)

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BRPI0809011A8 (pt) 2007-03-20 2019-01-15 Celgene Corp composto, composição farmacêutica, método de tratamento, controle ou prevenção de uma doença ou distúrbio, e, forma de dosagem unitária única
CA2710196A1 (en) * 2007-12-20 2009-07-09 Celgene Corporation Use of micro-rna as a biomarker of immunomodulatory drug activity
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AU2016203826B2 (en) * 2010-02-11 2018-05-17 Celgene Corporation Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
AU2013245487B2 (en) * 2010-02-11 2016-03-10 Celgene Corporation Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
ES2730763T3 (es) * 2010-02-11 2019-11-12 Celgene Corp Derivados de arilmetoxi isoindolina y composiciones que los comprenden y métodos de uso de los mismos
AU2012236655B2 (en) 2011-03-28 2016-09-22 Deuterx, Llc, 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
CA2839438C (en) * 2011-06-15 2020-08-04 Nono Inc. Agents and methods for treating ischemic and other diseases
CN102731851B (zh) * 2012-06-28 2013-11-27 芜湖宏达橡塑阀门制造有限公司 一种耐油橡胶
CN102731853B (zh) * 2012-06-28 2013-11-27 芜湖宏达橡塑阀门制造有限公司 耐油橡胶
CN102731850B (zh) * 2012-06-28 2013-11-27 芜湖宏达橡塑阀门制造有限公司 耐油耐磨橡胶
WO2014018866A1 (en) * 2012-07-27 2014-01-30 Celgene Corporation Processes for preparing isoindoline-1,3-dione compounds
AU2013299625B2 (en) 2012-08-09 2018-02-01 Celgene Corporation Treatment of immune-related and inflammatory diseases
EP2882442B1 (en) * 2012-08-09 2021-06-09 Celgene Corporation Methods of treating cancer using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
US20150038511A1 (en) 2012-08-09 2015-02-05 Celgene Corporation Treatment of immune-related and inflammatory diseases
KR20150041650A (ko) 2012-08-09 2015-04-16 셀진 코포레이션 (ｓ)-3-(4-((4-(모르폴리노메틸)벤질)옥시)-1-옥소이소인돌린-2-일)피페리딘-2,6-디온 및 이의 약학적으로 허용가능한 형태의 제조를 위한 공정
EP2943201B2 (en) 2013-01-14 2020-07-29 Deuterx, LLC 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
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US9242966B2 (en) 2013-03-11 2016-01-26 Bristol-Myers Squibb Company Phthalazines as potassium ion channel inhibitors
CA2941560A1 (en) 2013-03-14 2014-09-25 Deuterx, Llc 3-(substituted-4-oxo-quinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
KR102223060B1 (ko) 2013-04-17 2021-03-05 시그날 파마소티칼 엘엘씨 암 치료를 위한 TOR 키나제 억제제 및 ＩＭｉＤ 화합물을 포함하는 조합요법
UA117141C2 (uk) 2013-10-08 2018-06-25 Селджин Корпорейшн Склади (s)-3-(4-((4-(морфолінометил)бензил)оксі)-1-оксоізоіндолін-2-іл)піперидин-2,6-діону
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