CL2007003686A1 - Compuestos derivados de indol con anillo unido en las posiciones 4,5; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para tratar una infeccion viral. - Google Patents
Compuestos derivados de indol con anillo unido en las posiciones 4,5; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para tratar una infeccion viral.Info
- Publication number
- CL2007003686A1 CL2007003686A1 CL200703686A CL2007003686A CL2007003686A1 CL 2007003686 A1 CL2007003686 A1 CL 2007003686A1 CL 200703686 A CL200703686 A CL 200703686A CL 2007003686 A CL2007003686 A CL 2007003686A CL 2007003686 A1 CL2007003686 A1 CL 2007003686A1
- Authority
- CL
- Chile
- Prior art keywords
- compound
- indol
- treat
- positions
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87687706P | 2006-12-22 | 2006-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2007003686A1 true CL2007003686A1 (es) | 2008-06-27 |
Family
ID=39186835
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL200703686A CL2007003686A1 (es) | 2006-12-22 | 2007-12-18 | Compuestos derivados de indol con anillo unido en las posiciones 4,5; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para tratar una infeccion viral. |
Country Status (18)
Country | Link |
---|---|
US (1) | US8557848B2 (es) |
EP (1) | EP2064180B1 (es) |
JP (1) | JP5079818B2 (es) |
KR (1) | KR20090094154A (es) |
CN (1) | CN101631773A (es) |
AR (1) | AR064428A1 (es) |
AU (1) | AU2007339382B2 (es) |
BR (1) | BRPI0720625A2 (es) |
CA (1) | CA2673249C (es) |
CL (1) | CL2007003686A1 (es) |
CO (1) | CO6190515A2 (es) |
EC (1) | ECSP099447A (es) |
MX (1) | MX2009006880A (es) |
NO (1) | NO20092742L (es) |
PE (1) | PE20081608A1 (es) |
RU (1) | RU2009127855A (es) |
TW (1) | TW200831496A (es) |
WO (1) | WO2008082484A1 (es) |
Families Citing this family (39)
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US20110104109A1 (en) * | 2005-07-13 | 2011-05-05 | Frank Bennett | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
WO2008082488A1 (en) | 2006-12-22 | 2008-07-10 | Schering Corporation | 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
ATE543808T1 (de) | 2006-12-22 | 2012-02-15 | Schering Corp | 5,6-ring-annelierte indolderivate und ihre verwendung |
JP5079818B2 (ja) | 2006-12-22 | 2012-11-21 | メルク・シャープ・アンド・ドーム・コーポレーション | Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体 |
US8404845B2 (en) * | 2007-08-29 | 2013-03-26 | Merck Sharp & Dohme Corp. | 2,3-substituted azaindole derivatives for treating viral infections |
US8143305B2 (en) * | 2007-08-29 | 2012-03-27 | Schering Corporation | 2,3-substituted indole derivatives for treating viral infections |
WO2009032124A1 (en) * | 2007-08-29 | 2009-03-12 | Schering Corporation | Substituted indole derivatives and methods of use thereof |
WO2009064852A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
CN102099351A (zh) | 2007-11-16 | 2011-06-15 | 先灵公司 | 3-杂环取代的吲哚衍生物及其使用方法 |
AR072088A1 (es) | 2008-06-13 | 2010-08-04 | Schering Corp | Derivados de indol triciclicos y sus metodos de uso |
CA2736472A1 (en) * | 2008-09-26 | 2010-04-01 | F. Hoffmann-La Roche Ag | Pyrine or pyrazine derivatives for treating hcv |
SG172778A1 (en) | 2008-12-22 | 2011-08-29 | Hoffmann La Roche | Heterocyclic antiviral compounds |
CA2752443A1 (en) * | 2009-03-06 | 2010-09-10 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
WO2010138791A1 (en) | 2009-05-29 | 2010-12-02 | Schering Corporation | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
WO2011000566A2 (en) * | 2009-06-30 | 2011-01-06 | Savira Pharmaceuticals Gmbh | Compounds and pharmaceutical compositions for the treatment of negative-sense ssrna virus infections |
CA2782024A1 (en) | 2009-11-25 | 2011-06-03 | Schering Corporation | Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases |
JP2013515068A (ja) | 2009-12-22 | 2013-05-02 | メルク・シャープ・アンド・ドーム・コーポレーション | ウイルス性疾患の治療のための縮合三環式化合物およびその使用方法 |
EA201290882A1 (ru) | 2010-03-09 | 2013-04-30 | Мерк Шарп Энд Домэ Корп. | Конденсированные трициклические силильные соединения и способы их применения для лечения вирусных заболеваний |
CA2805440A1 (en) | 2010-07-26 | 2012-02-09 | Merck Sharp & Dohme Corp. | Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases |
WO2012050848A1 (en) | 2010-09-29 | 2012-04-19 | Schering Corporation | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
EP2697242B1 (en) | 2011-04-13 | 2018-10-03 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
KR20130138840A (ko) | 2011-04-13 | 2013-12-19 | 머크 샤프 앤드 돔 코포레이션 | 2''-치환된 뉴클레오시드 유도체 및 바이러스성 질환의 치료를 위한 그의 사용 방법 |
WO2013033901A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases |
WO2013033900A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases |
WO2013033899A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases |
EP2755981A4 (en) | 2011-09-14 | 2015-03-25 | Merck Sharp & Dohme | HETEROCYCLIC COMPOUNDS CONTAINING SILYL AND METHODS OF USING THE SAME FOR TREATING VIRAL DISEASES |
US9457039B2 (en) | 2012-10-17 | 2016-10-04 | Merck Sharp & Dohme Corp. | 2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
US9242988B2 (en) | 2012-10-17 | 2016-01-26 | Merck Sharp & Dohme Corp. | 2′-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
AR092959A1 (es) | 2012-10-17 | 2015-05-06 | Merck Sharp & Dohme | Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales |
AU2013344757A1 (en) | 2012-11-19 | 2015-05-21 | Merck Sharp & Dohme Corp. | 2 -alkynyl substituted nucleoside derivatives for treating viral diseases |
WO2014205592A1 (en) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Heterocyclic compounds and methods of use thereof for treatment of hepatitis c |
WO2014205593A1 (en) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for treatment of viral diseases |
WO2015065817A1 (en) | 2013-10-30 | 2015-05-07 | Merck Sharp & Dohme Corp. | Pseudopolymorphs of an hcv ns5a inhibitor and uses thereof |
CN106810557B (zh) * | 2015-11-27 | 2021-05-04 | 南京圣和药物研发有限公司 | 杂环化合物及其应用 |
WO2017197036A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
EP3455218A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
WO2017223012A1 (en) | 2016-06-20 | 2017-12-28 | Merck Sharp & Dohme Corp. | Cyclic phosphate substituted nucleoside compounds and methods of use thereof for the treatment of viral diseases |
WO2018044986A1 (en) * | 2016-08-30 | 2018-03-08 | The Rockefeller University | Triazinoindole-based chemical inhibitors of eukaryotic ribosome biogenesis |
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PL1730110T3 (pl) | 2004-02-27 | 2010-11-30 | Merck Sharp & Dohme | Siarkowe związki jako inhibitory proteazy serynowej NS3 wirusa zapalenia wątroby typu C |
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JP4149429B2 (ja) | 2004-10-26 | 2008-09-10 | 本田技研工業株式会社 | 車両の走行安全装置 |
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US20110104109A1 (en) | 2005-07-13 | 2011-05-05 | Frank Bennett | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
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WO2008082488A1 (en) | 2006-12-22 | 2008-07-10 | Schering Corporation | 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
ATE543808T1 (de) | 2006-12-22 | 2012-02-15 | Schering Corp | 5,6-ring-annelierte indolderivate und ihre verwendung |
JP5079818B2 (ja) | 2006-12-22 | 2012-11-21 | メルク・シャープ・アンド・ドーム・コーポレーション | Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体 |
US8143305B2 (en) | 2007-08-29 | 2012-03-27 | Schering Corporation | 2,3-substituted indole derivatives for treating viral infections |
WO2009032124A1 (en) | 2007-08-29 | 2009-03-12 | Schering Corporation | Substituted indole derivatives and methods of use thereof |
US8404845B2 (en) | 2007-08-29 | 2013-03-26 | Merck Sharp & Dohme Corp. | 2,3-substituted azaindole derivatives for treating viral infections |
CN102099351A (zh) | 2007-11-16 | 2011-06-15 | 先灵公司 | 3-杂环取代的吲哚衍生物及其使用方法 |
WO2009064852A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
AR072088A1 (es) | 2008-06-13 | 2010-08-04 | Schering Corp | Derivados de indol triciclicos y sus metodos de uso |
-
2007
- 2007-12-17 JP JP2009542835A patent/JP5079818B2/ja active Active
- 2007-12-17 EP EP07862998.7A patent/EP2064180B1/en active Active
- 2007-12-17 AU AU2007339382A patent/AU2007339382B2/en active Active
- 2007-12-17 CA CA2673249A patent/CA2673249C/en active Active
- 2007-12-17 WO PCT/US2007/025754 patent/WO2008082484A1/en active Application Filing
- 2007-12-17 MX MX2009006880A patent/MX2009006880A/es unknown
- 2007-12-17 RU RU2009127855/04A patent/RU2009127855A/ru not_active Application Discontinuation
- 2007-12-17 US US12/519,715 patent/US8557848B2/en active Active
- 2007-12-17 BR BRPI0720625-9A2A patent/BRPI0720625A2/pt not_active Application Discontinuation
- 2007-12-17 CN CN200780051419A patent/CN101631773A/zh active Pending
- 2007-12-17 KR KR1020097015298A patent/KR20090094154A/ko not_active Application Discontinuation
- 2007-12-18 TW TW096148504A patent/TW200831496A/zh unknown
- 2007-12-18 AR ARP070105705A patent/AR064428A1/es not_active Application Discontinuation
- 2007-12-18 CL CL200703686A patent/CL2007003686A1/es unknown
-
2008
- 2008-01-02 PE PE2008000053A patent/PE20081608A1/es not_active Application Discontinuation
-
2009
- 2009-06-18 CO CO09063496A patent/CO6190515A2/es not_active Application Discontinuation
- 2009-06-19 EC EC2009009447A patent/ECSP099447A/es unknown
- 2009-07-21 NO NO20092742A patent/NO20092742L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP5079818B2 (ja) | 2012-11-21 |
PE20081608A1 (es) | 2008-11-12 |
EP2064180B1 (en) | 2016-07-13 |
AU2007339382B2 (en) | 2013-05-02 |
EP2064180A1 (en) | 2009-06-03 |
US20100098661A1 (en) | 2010-04-22 |
AR064428A1 (es) | 2009-04-01 |
MX2009006880A (es) | 2009-07-03 |
CN101631773A (zh) | 2010-01-20 |
BRPI0720625A2 (pt) | 2014-03-25 |
CA2673249A1 (en) | 2008-07-10 |
WO2008082484A1 (en) | 2008-07-10 |
KR20090094154A (ko) | 2009-09-03 |
CA2673249C (en) | 2013-04-30 |
RU2009127855A (ru) | 2011-01-27 |
JP2010513490A (ja) | 2010-04-30 |
CO6190515A2 (es) | 2010-08-19 |
ECSP099447A (es) | 2009-07-31 |
TW200831496A (en) | 2008-08-01 |
AU2007339382A1 (en) | 2008-07-10 |
US8557848B2 (en) | 2013-10-15 |
NO20092742L (no) | 2009-09-21 |
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