CN101626772A - 间充质干细胞及其用途 - Google Patents

间充质干细胞及其用途 Download PDF

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Publication number
CN101626772A
CN101626772A CN200880000168A CN200880000168A CN101626772A CN 101626772 A CN101626772 A CN 101626772A CN 200880000168 A CN200880000168 A CN 200880000168A CN 200880000168 A CN200880000168 A CN 200880000168A CN 101626772 A CN101626772 A CN 101626772A
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animal
mesenchymal stem
stem cells
cells
administered
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苏地塔·阿加尔沃
马克·F.·皮滕格
蒂莫西·瓦尼
阿拉·丹尼尔科维奇
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Osiris Therapeutics Inc
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells

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  • Wood Science & Technology (AREA)
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  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cardiology (AREA)
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CN200880000168A 2007-03-22 2008-03-21 间充质干细胞及其用途 Pending CN101626772A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/726,676 2007-03-22
US11/726,676 US20080095749A1 (en) 2004-03-22 2007-03-22 Mesenchymal stem cells and uses therefor

Publications (1)

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CN101626772A true CN101626772A (zh) 2010-01-13

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US (3) US20080095749A1 (https=)
EP (6) EP3095450B1 (https=)
JP (2) JP2010522212A (https=)
KR (7) KR20220166876A (https=)
CN (1) CN101626772A (https=)
BR (1) BRPI0802241A2 (https=)
CA (2) CA3134185A1 (https=)
DK (1) DK2123747T3 (https=)
ES (3) ES2988291T3 (https=)
WO (1) WO2008116157A2 (https=)

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CN101991880A (zh) * 2010-11-08 2011-03-30 中国人民解放军军事医学科学院基础医学研究所 由复合msc的plga/tcp和msc组成的制剂及其应用
CN101991878A (zh) * 2010-11-08 2011-03-30 中国人民解放军军事医学科学院基础医学研究所 由复合msc的plga和msc组成的制剂及其应用
CN103191154A (zh) * 2012-01-06 2013-07-10 上海交通大学医学院 充质干细胞及其提取方法在制备银屑病的药物中的应用
CN105377274A (zh) * 2012-12-12 2016-03-02 麦瑟布莱斯特公司 治疗或预防呼吸病症的方法
CN105769911A (zh) * 2016-03-23 2016-07-20 中国人民解放军第二军医大学 间充质干细胞诱导斑秃处毛发再生的方法及应用
CN106255884A (zh) * 2013-10-04 2016-12-21 赛尔爱迪尔私人有限公司 用于细胞治疗的生物标志物
CN106492194A (zh) * 2016-11-30 2017-03-15 广州赛莱拉干细胞科技股份有限公司 一种干细胞外泌体制剂及其制备方法和应用
CN108451981A (zh) * 2018-04-21 2018-08-28 洛阳轩智生物科技有限公司 使用皮肤间充质干细胞治疗系统性硬化症
CN109104869A (zh) * 2016-04-27 2018-12-28 日本乐敦制药株式会社 表达选自由cd201、cd46、cd56、cd147和cd165组成的组中的至少1种细胞表面标记物的间充质干细胞及其制备方法、以及包含上述间充质干细胞的药物组合物及其制备方法
CN109432126A (zh) * 2011-03-11 2019-03-08 儿童医学中心公司 与间充质干细胞外来体相关的方法和组合物
CN110139657A (zh) * 2017-02-15 2019-08-16 日本乐敦制药株式会社 肺纤维化治疗剂、ptprr表达促进剂及肺纤维化治疗用试剂盒
WO2020015264A1 (zh) * 2018-07-17 2020-01-23 北京三有利和泽生物科技有限公司 牙源干细胞及其用途
CN110772537A (zh) * 2019-11-07 2020-02-11 深圳科康干细胞技术有限公司 脐带血间充质干细胞组合物在治疗慢性阻塞性肺疾病中的应用
CN111568930A (zh) * 2020-05-23 2020-08-25 湖南源品细胞生物科技有限公司 一种msc用于调节nk细胞数量的应用
CN111840329A (zh) * 2012-12-12 2020-10-30 麦瑟布莱斯特公司 内皮功能障碍和炎症的疾病的治疗
CN112076217A (zh) * 2020-10-26 2020-12-15 重庆医科大学附属第一医院 一种间充质干细胞来源的抗炎症氧化脂质组合物的制备方法
CN115361958A (zh) * 2020-03-05 2022-11-18 迈索布拉斯特国际有限公司 使用间充质谱系前体或干细胞治疗炎症性肺病的方法
CN117398450A (zh) * 2023-10-31 2024-01-16 北京三有利和泽生物科技有限公司 过表达肝细胞生长因子的间充质干细胞在制备哮喘药物中的应用

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