CN101623250A - 一种左乙拉西坦药物组合物及其制备方法 - Google Patents
一种左乙拉西坦药物组合物及其制备方法 Download PDFInfo
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- CN101623250A CN101623250A CN 200810116329 CN200810116329A CN101623250A CN 101623250 A CN101623250 A CN 101623250A CN 200810116329 CN200810116329 CN 200810116329 CN 200810116329 A CN200810116329 A CN 200810116329A CN 101623250 A CN101623250 A CN 101623250A
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- levetiracetam
- injection
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- HPHUVLMMVZITSG-ZCFIWIBFSA-N levetiracetam Chemical compound CC[C@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-ZCFIWIBFSA-N 0.000 title claims abstract description 21
- 229960004002 levetiracetam Drugs 0.000 title claims abstract description 21
- 239000000203 mixture Substances 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 238000002347 injection Methods 0.000 claims abstract description 13
- 239000007924 injection Substances 0.000 claims abstract description 13
- 206010015037 epilepsy Diseases 0.000 claims abstract description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000008215 water for injection Substances 0.000 claims description 7
- 229960000583 acetic acid Drugs 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 239000012362 glacial acetic acid Substances 0.000 claims description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 4
- 238000005261 decarburization Methods 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 4
- 238000013019 agitation Methods 0.000 claims description 3
- 239000003708 ampul Substances 0.000 claims description 3
- 230000002950 deficient Effects 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 238000007689 inspection Methods 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000000047 product Substances 0.000 claims description 3
- 239000011265 semifinished product Substances 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 2
- 239000003978 infusion fluid Substances 0.000 claims description 2
- 239000001509 sodium citrate Substances 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
- 239000001117 sulphuric acid Substances 0.000 claims description 2
- 235000011149 sulphuric acid Nutrition 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 208000030090 Acute Disease Diseases 0.000 description 1
- 208000000094 Chronic Pain Diseases 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010026749 Mania Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 208000021722 neuropathic pain Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- 229940083608 sodium hydroxide Drugs 0.000 description 1
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 200810116329 CN101623250B (zh) | 2008-07-09 | 2008-07-09 | 一种左乙拉西坦药物组合物及其制备方法 |
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CN 200810116329 CN101623250B (zh) | 2008-07-09 | 2008-07-09 | 一种左乙拉西坦药物组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN101623250A true CN101623250A (zh) | 2010-01-13 |
CN101623250B CN101623250B (zh) | 2013-02-27 |
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CN 200810116329 Active CN101623250B (zh) | 2008-07-09 | 2008-07-09 | 一种左乙拉西坦药物组合物及其制备方法 |
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CN (1) | CN101623250B (zh) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102525900A (zh) * | 2012-01-19 | 2012-07-04 | 南京恒道医药科技有限公司 | 左乙拉西坦注射液及其制备方法 |
CN102836123A (zh) * | 2012-04-09 | 2012-12-26 | 珠海亿邦制药股份有限公司 | 一种含有左乙拉西坦活性成分的注射剂及其制备工艺 |
CN103432070A (zh) * | 2013-09-13 | 2013-12-11 | 四川鼎诺泰宸科技有限公司 | 左乙拉西坦注射液和制法 |
CN103462886A (zh) * | 2013-09-13 | 2013-12-25 | 四川鼎诺泰宸科技有限公司 | 稳定的左乙拉西坦注射液 |
CN105412007A (zh) * | 2015-12-15 | 2016-03-23 | 河北仁合益康药业有限公司 | 一种左乙拉西坦氯化钠注射液组合物及其制备方法 |
CN105434339A (zh) * | 2015-12-15 | 2016-03-30 | 河北仁合益康药业有限公司 | 一种左乙拉西坦氯化钠注射液组合物及其制备方法 |
CN108578360A (zh) * | 2018-07-24 | 2018-09-28 | 南京正科医药股份有限公司 | 一种左乙拉西坦注射液及其制备方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107213114A (zh) * | 2017-05-19 | 2017-09-29 | 万特制药(海南)有限公司 | 一种含有左乙拉西坦药物组合物的注射剂及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA200707250B (en) * | 2005-01-27 | 2009-06-24 | Alembic Ltd | Extended release formulation of levetiracetam |
CN101172105A (zh) * | 2007-11-27 | 2008-05-07 | 北京润德康医药技术有限公司 | 左乙拉西坦在制备益智药物中的用途 |
-
2008
- 2008-07-09 CN CN 200810116329 patent/CN101623250B/zh active Active
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102525900A (zh) * | 2012-01-19 | 2012-07-04 | 南京恒道医药科技有限公司 | 左乙拉西坦注射液及其制备方法 |
CN102836123A (zh) * | 2012-04-09 | 2012-12-26 | 珠海亿邦制药股份有限公司 | 一种含有左乙拉西坦活性成分的注射剂及其制备工艺 |
CN103432070A (zh) * | 2013-09-13 | 2013-12-11 | 四川鼎诺泰宸科技有限公司 | 左乙拉西坦注射液和制法 |
CN103462886A (zh) * | 2013-09-13 | 2013-12-25 | 四川鼎诺泰宸科技有限公司 | 稳定的左乙拉西坦注射液 |
CN103432070B (zh) * | 2013-09-13 | 2015-10-07 | 四川鼎诺泰宸科技有限公司 | 左乙拉西坦注射液和制法 |
CN105412007A (zh) * | 2015-12-15 | 2016-03-23 | 河北仁合益康药业有限公司 | 一种左乙拉西坦氯化钠注射液组合物及其制备方法 |
CN105434339A (zh) * | 2015-12-15 | 2016-03-30 | 河北仁合益康药业有限公司 | 一种左乙拉西坦氯化钠注射液组合物及其制备方法 |
CN105412007B (zh) * | 2015-12-15 | 2018-05-25 | 河北仁合益康药业有限公司 | 一种左乙拉西坦氯化钠注射液组合物及其制备方法 |
CN108578360A (zh) * | 2018-07-24 | 2018-09-28 | 南京正科医药股份有限公司 | 一种左乙拉西坦注射液及其制备方法 |
Also Published As
Publication number | Publication date |
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CN101623250B (zh) | 2013-02-27 |
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Effective date of registration: 20201201 Address after: No. 279 Nanhai Road, Xiuying District 570314 Hainan city of Haikou Province Patentee after: AVENTIS PHARMA (HAINAN) Co.,Ltd. Address before: 100097, Wanquan mansion, 3 Jin Zhuang, Haidian District, Beijing, Sijiqing Patentee before: BEIJING D-VENTUREPHARM TECHNOLOGY DEVELOPMENT Co.,Ltd. |
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Addressee: Song Xuemei Document name: Notice of conformity |
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Denomination of invention: A drug combination of levetiracetam and its preparation method Granted publication date: 20130227 Pledgee: Sanya Rural Commercial Bank Co.,Ltd. Pledgor: AVENTIS PHARMA (HAINAN) Co.,Ltd. Registration number: Y2024980014810 |
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