CN1015707B - 酰胺衍生物的生产方法 - Google Patents

酰胺衍生物的生产方法

Info

Publication number
CN1015707B
CN1015707B CN87105189A CN87105189A CN1015707B CN 1015707 B CN1015707 B CN 1015707B CN 87105189 A CN87105189 A CN 87105189A CN 87105189 A CN87105189 A CN 87105189A CN 1015707 B CN1015707 B CN 1015707B
Authority
CN
China
Prior art keywords
formula
group
amino
hydroxyl
benzene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN87105189A
Other languages
English (en)
Chinese (zh)
Other versions
CN87105189A (zh
Inventor
布赖恩·罗伊·霍洛韦
拉尔夫·豪
包伯·星·拉奥
唐纳德·斯特里布林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868617986A external-priority patent/GB8617986D0/en
Priority claimed from GB878701832A external-priority patent/GB8701832D0/en
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of CN87105189A publication Critical patent/CN87105189A/zh
Publication of CN1015707B publication Critical patent/CN1015707B/zh
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Hydrogenated Pyridines (AREA)
CN87105189A 1986-07-23 1987-07-23 酰胺衍生物的生产方法 Expired CN1015707B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB868617986A GB8617986D0 (en) 1986-07-23 1986-07-23 Amide derivatives
GB8617986 1986-07-23
GB878701832A GB8701832D0 (en) 1987-01-28 1987-01-28 Carboxamides
GB8701832 1987-01-28

Publications (2)

Publication Number Publication Date
CN87105189A CN87105189A (zh) 1988-04-06
CN1015707B true CN1015707B (zh) 1992-03-04

Family

ID=26291076

Family Applications (1)

Application Number Title Priority Date Filing Date
CN87105189A Expired CN1015707B (zh) 1986-07-23 1987-07-23 酰胺衍生物的生产方法

Country Status (24)

Country Link
US (2) US4927836A (enExample)
EP (1) EP0254532B1 (enExample)
JP (1) JPS6393755A (enExample)
KR (1) KR880001576A (enExample)
CN (1) CN1015707B (enExample)
AT (1) ATE52498T1 (enExample)
AU (1) AU604027B2 (enExample)
CA (1) CA1327576C (enExample)
CS (1) CS264145B2 (enExample)
DE (1) DE3762618D1 (enExample)
DK (1) DK385387A (enExample)
ES (1) ES2018832B3 (enExample)
FI (1) FI88289C (enExample)
GB (1) GB8714901D0 (enExample)
GR (1) GR3000571T3 (enExample)
HU (1) HU197293B (enExample)
IE (1) IE60887B1 (enExample)
IL (1) IL83026A0 (enExample)
MY (1) MY102866A (enExample)
NO (1) NO174044C (enExample)
NZ (1) NZ221158A (enExample)
PH (1) PH23607A (enExample)
PT (1) PT85379B (enExample)
SU (1) SU1549476A3 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8801306D0 (en) * 1988-01-21 1988-02-17 Ici Plc Chemical compounds
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
GB8925032D0 (en) * 1989-11-06 1989-12-28 Ici Plc Chemical compounds
GB8926083D0 (en) * 1989-11-17 1990-01-10 Ici Plc Therapeutic agents
GB9003185D0 (en) * 1990-02-13 1990-04-11 Ici Plc Pharmaceutical compositions
GB9016655D0 (en) * 1990-07-30 1990-09-12 Ici Plc Therapeutic agents
GB9111426D0 (en) * 1991-05-28 1991-07-17 Ici Plc Chemical compounds
US5502078A (en) * 1991-05-28 1996-03-26 Zeneca Limited Chemical compounds
GB9224740D0 (en) * 1992-11-26 1993-01-13 Ici Plc Therapeutic agents
ATE154935T1 (de) * 1993-06-14 1997-07-15 Pfizer Zweite amine als antidiabetische mittel und für die behandlung von fettleibigkeit
US5578638A (en) * 1993-11-05 1996-11-26 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists
US5563171A (en) * 1993-11-05 1996-10-08 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists
US5627200A (en) * 1994-09-26 1997-05-06 Pfizer Inc β3 -Adrenoceptor agonists and antagonists for the treatment of intestinal motility disorders, depression, prostate disease and dyslipidemia
US6075040A (en) * 1996-09-05 2000-06-13 Eli Lilly And Company Selective β3 adrenergic agonists
ZA967892B (en) * 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
ES2171839T3 (es) 1996-09-05 2002-09-16 Lilly Co Eli Analogos de carbazol como agonistas adrenergicos selectivos de beta3.
CO5011072A1 (es) * 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
US6344481B1 (en) 1999-03-01 2002-02-05 Pfizer Inc. Thyromimetic antiobesity agents
US7504435B2 (en) * 2001-01-31 2009-03-17 The Arizona Board Of Regents On Behalf Of The University Of Arizona Method for stimulating weight loss and/or for lowering triglycerides in patients
PT1423168E (pt) * 2001-09-03 2006-05-31 Newron Pharm Spa Composicao farmaceutica que compreende gabapentina ou um seu analogo e uma x-aminoamida e a sua utilizacao como analgesico
US7202222B2 (en) * 2003-01-06 2007-04-10 National Bioscience Corporation Methods for treatment of obesity and effective fat loss promotion
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
DK1809271T5 (da) * 2004-09-10 2010-12-06 Newron Pharm Spa Anvendelse af (R)-(halogenbenzyloxy)benzylaminopropanamider som natrium- og/eller calciumkanalselektive modulatorer
AU2008219585A1 (en) * 2007-02-27 2008-09-04 The Arizona Board Of Regents On Behalf Of The University Of Arizona Administration of 3,5-diiodothyropropionic acid for stimulating weight loss, and/or lowering triglyceride levels, and/or treatment of metabolic syndrome.
US9044606B2 (en) 2010-01-22 2015-06-02 Ethicon Endo-Surgery, Inc. Methods and devices for activating brown adipose tissue using electrical energy
US8476227B2 (en) 2010-01-22 2013-07-02 Ethicon Endo-Surgery, Inc. Methods of activating a melanocortin-4 receptor pathway in obese subjects
US9751830B2 (en) 2010-03-15 2017-09-05 The Trustees Of The University Of Pennsylvania Inhibitors of the tumor necrosis factor receptor complex
WO2014108449A1 (en) 2013-01-08 2014-07-17 Atrogi Ab A screening method, a kit, a method of treatment and a compound for use in a method of treatment
US10080884B2 (en) 2014-12-29 2018-09-25 Ethicon Llc Methods and devices for activating brown adipose tissue using electrical energy
US10092738B2 (en) 2014-12-29 2018-10-09 Ethicon Llc Methods and devices for inhibiting nerves when activating brown adipose tissue
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201903832D0 (en) 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods
GB202205895D0 (en) 2022-04-22 2022-06-08 Atrogi Ab New medical uses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903091A (en) * 1970-02-06 1975-09-02 Sumitomo Chemical Co 1,2,3,4-Tetrahydroisoquinoline derivatives
IE35386B1 (en) * 1970-05-27 1976-02-04 Ici Ltd Alkanolamine derivatives
US4088764A (en) * 1973-12-27 1978-05-09 Cassella Farbwerke Mainkur Aktiengesellschaft Pharmaceutically active derivatives of 1-phenoxy-3-amino-propan-2-ol
US4263323A (en) * 1976-10-07 1981-04-21 Aktiebolaget Hassle β-Receptor blocking compounds and treatment of cardiovascular disorders therewith
FI791727A7 (fi) * 1978-06-05 1981-01-01 Ciba Geigy Ag Menetelmä N-alkyloitujen aminoalkoholien valmistamiseksi.
EP0006735B1 (en) * 1978-06-28 1983-06-15 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
JPS57185243A (en) * 1981-05-08 1982-11-15 Ciba Geigy Ag Substituted 2-aminoethanol
GB8420837D0 (en) * 1984-08-16 1984-09-19 Beecham Group Plc Compounds
US4697033A (en) * 1985-12-24 1987-09-29 Sandoz Ltd. Carbamic and carbamothioic acid esters as pesticides
JPS6422898A (en) * 1987-07-17 1989-01-25 Asahi Breweries Ltd 2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative

Also Published As

Publication number Publication date
SU1549476A3 (ru) 1990-03-07
HUT44001A (en) 1988-01-28
PT85379B (pt) 1990-04-30
FI88289C (fi) 1993-04-26
US4927836A (en) 1990-05-22
JPS6393755A (ja) 1988-04-25
CS556587A2 (en) 1988-08-16
FI873154A7 (fi) 1988-01-24
US4977148A (en) 1990-12-11
PH23607A (en) 1989-09-11
PT85379A (en) 1987-08-01
FI873154A0 (fi) 1987-07-16
IE60887B1 (en) 1994-08-24
ES2018832B3 (es) 1991-05-16
AU7503087A (en) 1988-01-28
EP0254532A1 (en) 1988-01-27
HU197293B (en) 1989-03-28
IL83026A0 (en) 1987-12-20
NZ221158A (en) 1990-07-26
NO174044C (no) 1994-03-09
CA1327576C (en) 1994-03-08
JPH0579057B2 (enExample) 1993-11-01
CS264145B2 (en) 1989-06-13
GR3000571T3 (en) 1991-07-31
NO873071D0 (no) 1987-07-22
EP0254532B1 (en) 1990-05-09
KR880001576A (ko) 1988-04-25
ATE52498T1 (de) 1990-05-15
NO873071L (no) 1988-01-25
AU604027B2 (en) 1990-12-06
DK385387D0 (da) 1987-07-23
GB8714901D0 (en) 1987-07-29
IE871733L (en) 1988-01-23
FI88289B (fi) 1993-01-15
MY102866A (en) 1993-03-31
DK385387A (da) 1988-01-24
DE3762618D1 (de) 1990-06-13
NO174044B (no) 1993-11-29
CN87105189A (zh) 1988-04-06

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C13 Decision
GR02 Examined patent application
C14 Grant of patent or utility model
GR01 Patent grant
C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Applicant after: Zeneca Limited

Applicant before: Imperial Chemical Industries PLC

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: IMPERIAL CHEMICAL CORPORATION TO: ZENECA CO., LTD.

CI01 Publication of corrected invention patent application

Correction item: Patentee

Correct: Zeneca Limited

False: Zeneca Limited

Number: 35

Page: 130

Volume: 10

ERR Gazette correction

Free format text: CORRECT: PATENTEE; FROM: ZENECA CO., LTD. TO: ZENECA LTD

C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee