KR880001576A - 아미드 유도체 - Google Patents

아미드 유도체 Download PDF

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Publication number
KR880001576A
KR880001576A KR1019870008048A KR870008048A KR880001576A KR 880001576 A KR880001576 A KR 880001576A KR 1019870008048 A KR1019870008048 A KR 1019870008048A KR 870008048 A KR870008048 A KR 870008048A KR 880001576 A KR880001576 A KR 880001576A
Authority
KR
South Korea
Prior art keywords
formula
amino
pharmaceutically acceptable
compound
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019870008048A
Other languages
English (en)
Korean (ko)
Inventor
로이 홀로웨이 브라이언
호웨 랄프
신 라오 발비어
스트리브링 도날드
Original Assignee
원본미기재
임페리얼 케미칼 인더스트리스 피엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868617986A external-priority patent/GB8617986D0/en
Priority claimed from GB878701832A external-priority patent/GB8701832D0/en
Application filed by 원본미기재, 임페리얼 케미칼 인더스트리스 피엘씨 filed Critical 원본미기재
Publication of KR880001576A publication Critical patent/KR880001576A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compounds Of Unknown Constitution (AREA)
KR1019870008048A 1986-07-23 1987-07-23 아미드 유도체 Ceased KR880001576A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8617986 1986-07-23
GB868617986A GB8617986D0 (en) 1986-07-23 1986-07-23 Amide derivatives
GB8701832 1987-01-28
GB878701832A GB8701832D0 (en) 1987-01-28 1987-01-28 Carboxamides

Publications (1)

Publication Number Publication Date
KR880001576A true KR880001576A (ko) 1988-04-25

Family

ID=26291076

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870008048A Ceased KR880001576A (ko) 1986-07-23 1987-07-23 아미드 유도체

Country Status (24)

Country Link
US (2) US4927836A (enExample)
EP (1) EP0254532B1 (enExample)
JP (1) JPS6393755A (enExample)
KR (1) KR880001576A (enExample)
CN (1) CN1015707B (enExample)
AT (1) ATE52498T1 (enExample)
AU (1) AU604027B2 (enExample)
CA (1) CA1327576C (enExample)
CS (1) CS264145B2 (enExample)
DE (1) DE3762618D1 (enExample)
DK (1) DK385387A (enExample)
ES (1) ES2018832B3 (enExample)
FI (1) FI88289C (enExample)
GB (1) GB8714901D0 (enExample)
GR (1) GR3000571T3 (enExample)
HU (1) HU197293B (enExample)
IE (1) IE60887B1 (enExample)
IL (1) IL83026A0 (enExample)
MY (1) MY102866A (enExample)
NO (1) NO174044C (enExample)
NZ (1) NZ221158A (enExample)
PH (1) PH23607A (enExample)
PT (1) PT85379B (enExample)
SU (1) SU1549476A3 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8801306D0 (en) * 1988-01-21 1988-02-17 Ici Plc Chemical compounds
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
GB8925032D0 (en) * 1989-11-06 1989-12-28 Ici Plc Chemical compounds
GB8926083D0 (en) * 1989-11-17 1990-01-10 Ici Plc Therapeutic agents
GB9003185D0 (en) * 1990-02-13 1990-04-11 Ici Plc Pharmaceutical compositions
GB9016655D0 (en) * 1990-07-30 1990-09-12 Ici Plc Therapeutic agents
GB9111426D0 (en) * 1991-05-28 1991-07-17 Ici Plc Chemical compounds
US5502078A (en) * 1991-05-28 1996-03-26 Zeneca Limited Chemical compounds
GB9224740D0 (en) * 1992-11-26 1993-01-13 Ici Plc Therapeutic agents
CN1129443A (zh) * 1993-06-14 1996-08-21 美国辉瑞有限公司 仲胺用作治糖尿病和治肥胖病药物
US5563171A (en) * 1993-11-05 1996-10-08 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists
US5578638A (en) * 1993-11-05 1996-11-26 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists
US5627200A (en) * 1994-09-26 1997-05-06 Pfizer Inc β3 -Adrenoceptor agonists and antagonists for the treatment of intestinal motility disorders, depression, prostate disease and dyslipidemia
ZA967892B (en) * 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
US5808080A (en) 1996-09-05 1998-09-15 Eli Lilly And Company Selective β3 adrenergic agonists
ATE215369T1 (de) * 1996-09-05 2002-04-15 Lilly Co Eli Carbazolanaloge als selektive beta3-adrenergische agonisten
CO5011072A1 (es) * 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
US6344481B1 (en) 1999-03-01 2002-02-05 Pfizer Inc. Thyromimetic antiobesity agents
US7504435B2 (en) * 2001-01-31 2009-03-17 The Arizona Board Of Regents On Behalf Of The University Of Arizona Method for stimulating weight loss and/or for lowering triglycerides in patients
JP4350508B2 (ja) 2001-09-03 2009-10-21 ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー ガバペンチンまたはその類似体とα−アミノアミドとを含む薬剤組成物およびその鎮痛用途
US7202222B2 (en) * 2003-01-06 2007-04-10 National Bioscience Corporation Methods for treatment of obesity and effective fat loss promotion
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
SI1809271T1 (sl) * 2004-09-10 2010-10-29 Newron Pharm Spa Uporaba (R)-(halobenziloksi) benzilamino propanamidov kot selektivnih modulatorjev natrijevih in/ali kalcijevih kanalov
US8399518B2 (en) * 2007-02-27 2013-03-19 University Of Arizona Office Of Technology Transfer Administration of 3,5-diiodothyropropionic acid for stimulating weight loss, and/or lowering triglyceride levels, and/or treatment of metabolic syndrome
US9044606B2 (en) 2010-01-22 2015-06-02 Ethicon Endo-Surgery, Inc. Methods and devices for activating brown adipose tissue using electrical energy
US8476227B2 (en) 2010-01-22 2013-07-02 Ethicon Endo-Surgery, Inc. Methods of activating a melanocortin-4 receptor pathway in obese subjects
WO2011115763A1 (en) 2010-03-15 2011-09-22 The Trustees Of The University Of Pennsylvania Inhibitors of the tumor necrosis factor receptor complex
WO2014108449A1 (en) 2013-01-08 2014-07-17 Atrogi Ab A screening method, a kit, a method of treatment and a compound for use in a method of treatment
US10092738B2 (en) 2014-12-29 2018-10-09 Ethicon Llc Methods and devices for inhibiting nerves when activating brown adipose tissue
US10080884B2 (en) 2014-12-29 2018-09-25 Ethicon Llc Methods and devices for activating brown adipose tissue using electrical energy
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201903832D0 (en) 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods
GB202205895D0 (en) 2022-04-22 2022-06-08 Atrogi Ab New medical uses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903091A (en) * 1970-02-06 1975-09-02 Sumitomo Chemical Co 1,2,3,4-Tetrahydroisoquinoline derivatives
IE35386B1 (en) * 1970-05-27 1976-02-04 Ici Ltd Alkanolamine derivatives
US4088764A (en) * 1973-12-27 1978-05-09 Cassella Farbwerke Mainkur Aktiengesellschaft Pharmaceutically active derivatives of 1-phenoxy-3-amino-propan-2-ol
US4263323A (en) * 1976-10-07 1981-04-21 Aktiebolaget Hassle β-Receptor blocking compounds and treatment of cardiovascular disorders therewith
DD144050A5 (de) * 1978-06-05 1980-09-24 Ciba Geigy Ag Verfahren zur herstellung von n-alkylierten aminoalkoholen
DE2965655D1 (en) * 1978-06-28 1983-07-21 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
JPS57185243A (en) * 1981-05-08 1982-11-15 Ciba Geigy Ag Substituted 2-aminoethanol
GB8420837D0 (en) * 1984-08-16 1984-09-19 Beecham Group Plc Compounds
US4697033A (en) * 1985-12-24 1987-09-29 Sandoz Ltd. Carbamic and carbamothioic acid esters as pesticides
JPS6422898A (en) * 1987-07-17 1989-01-25 Asahi Breweries Ltd 2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative

Also Published As

Publication number Publication date
CN1015707B (zh) 1992-03-04
CS556587A2 (en) 1988-08-16
FI88289B (fi) 1993-01-15
PH23607A (en) 1989-09-11
CN87105189A (zh) 1988-04-06
NZ221158A (en) 1990-07-26
NO174044C (no) 1994-03-09
AU7503087A (en) 1988-01-28
JPS6393755A (ja) 1988-04-25
PT85379A (en) 1987-08-01
EP0254532B1 (en) 1990-05-09
NO174044B (no) 1993-11-29
DK385387A (da) 1988-01-24
CS264145B2 (en) 1989-06-13
NO873071D0 (no) 1987-07-22
PT85379B (pt) 1990-04-30
IE871733L (en) 1988-01-23
DE3762618D1 (de) 1990-06-13
GR3000571T3 (en) 1991-07-31
HU197293B (en) 1989-03-28
US4977148A (en) 1990-12-11
FI873154A7 (fi) 1988-01-24
US4927836A (en) 1990-05-22
ES2018832B3 (es) 1991-05-16
HUT44001A (en) 1988-01-28
FI873154A0 (fi) 1987-07-16
ATE52498T1 (de) 1990-05-15
SU1549476A3 (ru) 1990-03-07
CA1327576C (en) 1994-03-08
IL83026A0 (en) 1987-12-20
DK385387D0 (da) 1987-07-23
JPH0579057B2 (enExample) 1993-11-01
MY102866A (en) 1993-03-31
AU604027B2 (en) 1990-12-06
EP0254532A1 (en) 1988-01-27
IE60887B1 (en) 1994-08-24
NO873071L (no) 1988-01-25
GB8714901D0 (en) 1987-07-29
FI88289C (fi) 1993-04-26

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Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19870723

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19920714

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19870723

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19950331

Patent event code: PE09021S01D

E902 Notification of reason for refusal
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Comment text: Notification of reason for refusal

Patent event date: 19951011

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 19960112

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19951011

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

Patent event date: 19950331

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Patent event code: PE06011S01I