JPS6422898A - 2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative - Google Patents

2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative

Info

Publication number
JPS6422898A
JPS6422898A JP62180655A JP18065587A JPS6422898A JP S6422898 A JPS6422898 A JP S6422898A JP 62180655 A JP62180655 A JP 62180655A JP 18065587 A JP18065587 A JP 18065587A JP S6422898 A JPS6422898 A JP S6422898A
Authority
JP
Japan
Prior art keywords
alanyl
carboxylic acid
compound expressed
formula
tetrahydroisoquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62180655A
Other languages
Japanese (ja)
Inventor
Shizuo Saito
Hajime Watanabe
Toshiaki Waga
Shinichi Matsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Breweries Ltd
Original Assignee
Asahi Breweries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Breweries Ltd filed Critical Asahi Breweries Ltd
Priority to JP62180655A priority Critical patent/JPS6422898A/en
Publication of JPS6422898A publication Critical patent/JPS6422898A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:A compound expressed by formula I (R1 and R2 are H or 2-4C alkyl; A is amino, monoalkylamino, dialkylamino, nitrogen-containing saturated 3--6-membered heterocyclic ring which may optionally contain addi tional atoms of O, S or N; n is 1-12, but 7-12 only when A is amino, mono- or dialkylamino) and salt thereof. EXAMPLE:2-[N-1(S)-Carboxy-8-aminooctyl]-L-alanyl]-1,2,3,4-tetrahydrois oquinoli ne-3(S)-carboxylic acid. USE:A remedy for hypertension. PREPARATION:A compound expressed by formula II (X is Cl, Br, I or alkylsulfonyloxy) is reacted with a compound expressed by formula III to pro vide a condensation produce in a protected form. The protecting group is then removed.
JP62180655A 1987-07-17 1987-07-17 2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative Pending JPS6422898A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62180655A JPS6422898A (en) 1987-07-17 1987-07-17 2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62180655A JPS6422898A (en) 1987-07-17 1987-07-17 2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative

Publications (1)

Publication Number Publication Date
JPS6422898A true JPS6422898A (en) 1989-01-25

Family

ID=16086999

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62180655A Pending JPS6422898A (en) 1987-07-17 1987-07-17 2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative

Country Status (1)

Country Link
JP (1) JPS6422898A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4977148A (en) * 1986-07-23 1990-12-11 Imperial Chemical Industries Amide derivatives
US5187190A (en) * 1989-11-06 1993-02-16 Imperial Chemical Industries Plc Phenoxypropanolamine compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4977148A (en) * 1986-07-23 1990-12-11 Imperial Chemical Industries Amide derivatives
US5187190A (en) * 1989-11-06 1993-02-16 Imperial Chemical Industries Plc Phenoxypropanolamine compounds

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