JPS6422898A - 2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative - Google Patents
2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivativeInfo
- Publication number
- JPS6422898A JPS6422898A JP62180655A JP18065587A JPS6422898A JP S6422898 A JPS6422898 A JP S6422898A JP 62180655 A JP62180655 A JP 62180655A JP 18065587 A JP18065587 A JP 18065587A JP S6422898 A JPS6422898 A JP S6422898A
- Authority
- JP
- Japan
- Prior art keywords
- alanyl
- carboxylic acid
- compound expressed
- formula
- tetrahydroisoquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I (R1 and R2 are H or 2-4C alkyl; A is amino, monoalkylamino, dialkylamino, nitrogen-containing saturated 3--6-membered heterocyclic ring which may optionally contain addi tional atoms of O, S or N; n is 1-12, but 7-12 only when A is amino, mono- or dialkylamino) and salt thereof. EXAMPLE:2-[N-1(S)-Carboxy-8-aminooctyl]-L-alanyl]-1,2,3,4-tetrahydrois oquinoli ne-3(S)-carboxylic acid. USE:A remedy for hypertension. PREPARATION:A compound expressed by formula II (X is Cl, Br, I or alkylsulfonyloxy) is reacted with a compound expressed by formula III to pro vide a condensation produce in a protected form. The protecting group is then removed.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62180655A JPS6422898A (en) | 1987-07-17 | 1987-07-17 | 2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62180655A JPS6422898A (en) | 1987-07-17 | 1987-07-17 | 2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6422898A true JPS6422898A (en) | 1989-01-25 |
Family
ID=16086999
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP62180655A Pending JPS6422898A (en) | 1987-07-17 | 1987-07-17 | 2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6422898A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4977148A (en) * | 1986-07-23 | 1990-12-11 | Imperial Chemical Industries | Amide derivatives |
US5187190A (en) * | 1989-11-06 | 1993-02-16 | Imperial Chemical Industries Plc | Phenoxypropanolamine compounds |
-
1987
- 1987-07-17 JP JP62180655A patent/JPS6422898A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4977148A (en) * | 1986-07-23 | 1990-12-11 | Imperial Chemical Industries | Amide derivatives |
US5187190A (en) * | 1989-11-06 | 1993-02-16 | Imperial Chemical Industries Plc | Phenoxypropanolamine compounds |
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