KR880001576A - 아미드 유도체 - Google Patents
아미드 유도체 Download PDFInfo
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- KR880001576A KR880001576A KR1019870008048A KR870008048A KR880001576A KR 880001576 A KR880001576 A KR 880001576A KR 1019870008048 A KR1019870008048 A KR 1019870008048A KR 870008048 A KR870008048 A KR 870008048A KR 880001576 A KR880001576 A KR 880001576A
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- South Korea
- Prior art keywords
- formula
- amino
- pharmaceutically acceptable
- compound
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- 150000001408 amides Chemical class 0.000 title claims 2
- -1 hydroxy, carbamoyl Chemical group 0.000 claims 27
- 239000002253 acid Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 239000000460 chlorine Chemical group 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims 2
- 125000004817 pentamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 claims 2
- 150000002989 phenols Chemical class 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims 2
- 125000006022 2-methyl-2-propenyl group Chemical group 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000006323 alkenyl amino group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229940047583 cetamide Drugs 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000002118 epoxides Chemical class 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Obesity (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (11)
- 하기식(Ⅰ)의 아미드 유도체 또는 그것의 약학적 허용 산 - 부가염이 식에서 R1은 수소 또는 불소;R2는 할로겐을 임의로 함유한 페놀, (1-4C)알킬, (1-4C)알콕시, 트리플루오로메틸, 시아노 또는 니트로 치환분, (3-6C)사이클로알킬, 또는 NR2R3의 질소에 결합된 탄소원이 하나 또는 두개의 수소를 함유하는 (1-4C)알킬, 또는 (3-4C)알케닐로, 이 두개의 후자는 임의로 하이드록시, 카르바모일 (1-4C)알콕시, 페닐 또는 클로로페닐 치환분을 함유할 수 있다 ;R3는 수소, 메틸 또는 에틸:또는 R2와 R3가 함께 (4-7C) 폴리메틸렌을 이루며, 하나의 메틸렌 단위는 NR2R3의 질소 원자에서 적어도 2탄소 원자가 떨어진 위치에서 산소 또는 황에 의해 임의로 치환될 수 있으며, 두개의 인접한 메틸렌 단위는 임의로 상기 (4-7C)폴리메틸렌에 융합된 벤젠링의 그 탄소원자에 의해 치환될수 있으며, 상기 벤젠링 자체는 임의로 할로게노(1-4C)알콕시, 트리풀루오로메틸, 시아노 또는 니트로 치환분을 함유할 수 있다.
- 제 1항에 있어서, R2가 임의로 불소, 염소, 브롬, 메톡시, 에톡시, 메틸, 에틸, 트리플루오로메틸, 시아노 및 니트로 치환분으로 부터 선택된 치환분을 갖는 페닐:사이클로부틸, 사이클로펜틸 또는 사이클로헬실;또는 메틸,에틸, 프로필, 이소프로필, 부틸, 이소부틸, 알릴 또는 2-메틸-2-프로페닐로, 하이드록시, 카르바모일, 메톡시, 에톡시, 페닐 및 P-클로로페닐로 부터 선택된 치환분을 임의로 함유할 수 있다.또는 R2와 R3가 함께 메틸렌옥시에틸렌 또는 메틸렌티오 에틸렌을 이루거나 또는 테트라메틸렌 또는 펜타메틸렌을 이루며, 그것의 두개의 인접한 메틸렌 단위가 상기 테트라메틸렌 또는 펜타메틸렌에 융합된 벤젠링의 2개 탄소 원자에의해 임의로 치환될수 있으며, 상기 벤젠링 자체는 불소, 염소, 브롬, 메톡시, 에톡시, 메틸, 에틸, 트리플루오로메틸, 시아노 또는 니트로 치환분을 임의로 갖을 수 있는 것을 특징응로 하는 화합물.
- 제 1항 또는 제 2항에 있어서, 기 NR2R3가 아닐리노, 벤질아미노, 알링아미노, 사이클로헥실아미노, 사이클로펜틸아미노, 모르포리노, 피페리디노, 피롤리디노, 디메틸아미노, 디에틸아미노, 메틸아미노, 에틸 아미노, 프로필아미노, 이소프로필아미노, 부틸아미노, 이소부틸아미노, (2-하이드록시에틸)아미노, (3-하이드록시프로필)아미노, (2-메톡시에틸)아미노, 인돌린-1-일,1,2,3,4-테트라하이드로이소퀴놀-2-일 및 1,2,3,4-테트라하이드로퀴놀-1-일로부터 선택되는 화합물.
- 제 1내지 제 3항중 어느 한 항에 있어서, 기 -OCH2·CO·NR2R3와 -O.CH2CH2.NH-가 파라-관계로 결합되는 화합물.
- 제 1항에 있어서, R2가 임의로 하이드록시 또는 (1-4C)알콕시 치환분을 함유하며 NR2R3의 질소에 결합된 탄소 원자가 하나 또는 두개의 수소를 함유하는 (1-4C)알킬이거나; 또는 R2와 R3가 함께 하나의 메틸렌 단위가 NR2R3의 질소 원자로부터 적어도 2개 탄소 원자가 떨어져 위치한 산소 또는 황으로 임의로 치환될 수 있는 (4-6C) 폴리메틸렌을 이루는 화합물.
- 하기식(Ⅰ)의 화합물 또는 그것의 약학적 허용 산 부가염.이 식에서 NR2R3는 벤질아미노, 피페리디노, 피롤리디노, (3-4C)알케닐아미노, 모르포리노, 1,2,3,4-테트라하이드로퀴놀-2-일, 또는 질소에 결합된 탄소원자가 하나 또는 두개의 수소를 함유하는 (1-4C)알킬아미노이며; 기 -OCH2.CO.NR2R3와 -0.CH2CH2.NH- 는 파라관계로 결합된다.
- 하기식(Ⅰ)의 화합물 또는 그것의 약학적 허용 산 부가염.이 식에서 R1은 수소, 기 NR2R3는 메틸아미노, 에틸아미노, 프로필아미노, 이소프로필아미노, (2-하이드록시에틸)아미노, (3-하이드록시프로필)아미노, (2-메톡시에틸)아미노, (3-메톡시프로필)아미노 또는 1,2,3,4-테트라하이드로이소퀴놀-2-일이며 ; 기 -OCH2·CO·NR2R3와 -0·CH2CH2·NH-는 파라- 관계로 결합된다.
- N-메틸, N-프로필-, N(2-하이드록시에틸)-과N-알릴-2-P-(2-[(2-하이드록시-3-페녹시프로필)아미노]에톡시) 페녹시아세타미드와 그것의 약학적 허용산 부가염으로 부터 선택된 화합물.
- 제 1항 내지 제 8항 중 어느 한 항에 있어서, 약학적 허용 음이온을 제공하는 무기 또는 유기산과 이루어진 염.
- 약학적 허용 희석제 또는 담체와 함께 전술한 항들의 식 (Ⅰ)화합물 또는 약학적 허용산 -부가염을 함유하는 약학적 조성물.
- 전술한 항들에서 정의된 것이며 R1, R2,와 R3가 제 1항 내지 제 7항에서와 같은 의미인 식 (Ⅰ)화합물 또는 그것의 약학적 허용산- 부가염을 하기(a)-(b)를 특징으로 하여 제조하며, 약학적 허용산 부가염이 필요할 때는 제조된 식(Ⅰ)화합물의 유리 염기 형태를 통상 방법으로 적합한 산과 반응 시키며 식(Ⅰ)화합물의 엔안티오머가 필요할 때는 그 해당 라셈체가 분리되거나 또는 하기과정 (a)-(b)중 하나가 광학적 활성 출발물질을 사용하여 실시됨을 특징으로 하는 방법.(a)R4가 (1-6C)알콕시, 페녹시 또는 벤질옥시인 하기식(Ⅱ) 화합물 식HNR2R3의 아민과 반응시킨다.(b)하기식(Ⅲ)의 페놀 유도체를 -X.CH2 .CO.NR2R3의 알킬화제(X는 이탈기임)와 반응시킨다.(c)하기식(Ⅶ)의 아민 유도체를 식(V)의 에폭시드와 반응시킨다.(d)Q가 보호기인 식(Ⅷ)의 보호된 유도체를 탈보호시킨다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868617986A GB8617986D0 (en) | 1986-07-23 | 1986-07-23 | Amide derivatives |
| GB8617986 | 1986-07-23 | ||
| GB878701832A GB8701832D0 (en) | 1987-01-28 | 1987-01-28 | Carboxamides |
| GB8701832 | 1987-01-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR880001576A true KR880001576A (ko) | 1988-04-25 |
Family
ID=26291076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019870008048A KR880001576A (ko) | 1986-07-23 | 1987-07-23 | 아미드 유도체 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US4927836A (ko) |
| EP (1) | EP0254532B1 (ko) |
| JP (1) | JPS6393755A (ko) |
| KR (1) | KR880001576A (ko) |
| CN (1) | CN1015707B (ko) |
| AT (1) | ATE52498T1 (ko) |
| AU (1) | AU604027B2 (ko) |
| CA (1) | CA1327576C (ko) |
| CS (1) | CS264145B2 (ko) |
| DE (1) | DE3762618D1 (ko) |
| DK (1) | DK385387A (ko) |
| ES (1) | ES2018832B3 (ko) |
| FI (1) | FI88289C (ko) |
| GB (1) | GB8714901D0 (ko) |
| GR (1) | GR3000571T3 (ko) |
| HU (1) | HU197293B (ko) |
| IE (1) | IE60887B1 (ko) |
| IL (1) | IL83026A0 (ko) |
| MY (1) | MY102866A (ko) |
| NO (1) | NO174044C (ko) |
| NZ (1) | NZ221158A (ko) |
| PH (1) | PH23607A (ko) |
| PT (1) | PT85379B (ko) |
| SU (1) | SU1549476A3 (ko) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8801306D0 (en) * | 1988-01-21 | 1988-02-17 | Ici Plc | Chemical compounds |
| IL94466A (en) * | 1989-05-25 | 1995-01-24 | Erba Carlo Spa | Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation |
| GB8925032D0 (en) * | 1989-11-06 | 1989-12-28 | Ici Plc | Chemical compounds |
| GB8926083D0 (en) * | 1989-11-17 | 1990-01-10 | Ici Plc | Therapeutic agents |
| GB9003185D0 (en) * | 1990-02-13 | 1990-04-11 | Ici Plc | Pharmaceutical compositions |
| GB9016655D0 (en) * | 1990-07-30 | 1990-09-12 | Ici Plc | Therapeutic agents |
| US5502078A (en) * | 1991-05-28 | 1996-03-26 | Zeneca Limited | Chemical compounds |
| GB9111426D0 (en) * | 1991-05-28 | 1991-07-17 | Ici Plc | Chemical compounds |
| GB9224740D0 (en) * | 1992-11-26 | 1993-01-13 | Ici Plc | Therapeutic agents |
| PL312005A1 (en) * | 1993-06-14 | 1996-04-01 | Pfizer | Binary amines as antidiabetic and antiobesitic agents |
| US5578638A (en) * | 1993-11-05 | 1996-11-26 | American Cyanamid Company | Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists |
| US5563171A (en) * | 1993-11-05 | 1996-10-08 | American Cyanamid Company | Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists |
| US5627200A (en) * | 1994-09-26 | 1997-05-06 | Pfizer Inc | β3 -Adrenoceptor agonists and antagonists for the treatment of intestinal motility disorders, depression, prostate disease and dyslipidemia |
| ZA967892B (en) * | 1995-09-21 | 1998-03-18 | Lilly Co Eli | Selective β3 adrenergic agonists. |
| US6075040A (en) * | 1996-09-05 | 2000-06-13 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| ATE215369T1 (de) | 1996-09-05 | 2002-04-15 | Lilly Co Eli | Carbazolanaloge als selektive beta3-adrenergische agonisten |
| CO5011072A1 (es) * | 1997-12-05 | 2001-02-28 | Lilly Co Eli | Etanolaminas pirazinil substituidas como agfonistas de los receptores |
| GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| US6344481B1 (en) | 1999-03-01 | 2002-02-05 | Pfizer Inc. | Thyromimetic antiobesity agents |
| US7504435B2 (en) * | 2001-01-31 | 2009-03-17 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Method for stimulating weight loss and/or for lowering triglycerides in patients |
| MXPA04002009A (es) * | 2001-09-03 | 2004-07-08 | Newron Pharm Spa | Composicion farmaceutica que comprende gabapentina o un analogo de la misma y alfa-aminoamida y su uso como analgesico. |
| US7202222B2 (en) * | 2003-01-06 | 2007-04-10 | National Bioscience Corporation | Methods for treatment of obesity and effective fat loss promotion |
| EP1438956A1 (en) * | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
| KR101277520B1 (ko) * | 2004-09-10 | 2013-06-21 | 뉴론 파마슈티칼즈 에스. 피. 에이. | （할로벤질옥시）벤질아미노－프로판아미드를 포함하는 선택적 나트륨 및／또는 칼슘 채널 조절제로서 유용한 약제학적 조성물 |
| WO2008106213A1 (en) * | 2007-02-27 | 2008-09-04 | Titan Pharmaceuticals, Inc. | Administration of 3,5-diiodothyropropionic acid for stimulating weight loss, and/or lowering triglyceride levels, and/or treatment of metabolic syndrome. |
| US9044606B2 (en) | 2010-01-22 | 2015-06-02 | Ethicon Endo-Surgery, Inc. | Methods and devices for activating brown adipose tissue using electrical energy |
| US8476227B2 (en) | 2010-01-22 | 2013-07-02 | Ethicon Endo-Surgery, Inc. | Methods of activating a melanocortin-4 receptor pathway in obese subjects |
| US9751830B2 (en) | 2010-03-15 | 2017-09-05 | The Trustees Of The University Of Pennsylvania | Inhibitors of the tumor necrosis factor receptor complex |
| WO2014108449A1 (en) | 2013-01-08 | 2014-07-17 | Atrogi Ab | A screening method, a kit, a method of treatment and a compound for use in a method of treatment |
| US10092738B2 (en) | 2014-12-29 | 2018-10-09 | Ethicon Llc | Methods and devices for inhibiting nerves when activating brown adipose tissue |
| US10080884B2 (en) | 2014-12-29 | 2018-09-25 | Ethicon Llc | Methods and devices for activating brown adipose tissue using electrical energy |
| GB201714740D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714745D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB202205895D0 (en) | 2022-04-22 | 2022-06-08 | Atrogi Ab | New medical uses |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3903091A (en) * | 1970-02-06 | 1975-09-02 | Sumitomo Chemical Co | 1,2,3,4-Tetrahydroisoquinoline derivatives |
| IE35386B1 (en) * | 1970-05-27 | 1976-02-04 | Ici Ltd | Alkanolamine derivatives |
| US4088764A (en) * | 1973-12-27 | 1978-05-09 | Cassella Farbwerke Mainkur Aktiengesellschaft | Pharmaceutically active derivatives of 1-phenoxy-3-amino-propan-2-ol |
| US4263323A (en) * | 1976-10-07 | 1981-04-21 | Aktiebolaget Hassle | β-Receptor blocking compounds and treatment of cardiovascular disorders therewith |
| FI791727A (fi) * | 1978-06-05 | 1979-12-06 | Ciba Geigy Ag | Foerfarande foer framstaellning av n-alkylerade aminoalkoholer |
| DE2965655D1 (en) * | 1978-06-28 | 1983-07-21 | Beecham Group Plc | Secondary amines, their preparation, pharmaceutical compositions containing them and their use |
| JPS57185243A (en) * | 1981-05-08 | 1982-11-15 | Ciba Geigy Ag | Substituted 2-aminoethanol |
| GB8420837D0 (en) * | 1984-08-16 | 1984-09-19 | Beecham Group Plc | Compounds |
| US4697033A (en) * | 1985-12-24 | 1987-09-29 | Sandoz Ltd. | Carbamic and carbamothioic acid esters as pesticides |
| JPS6422898A (en) * | 1987-07-17 | 1989-01-25 | Asahi Breweries Ltd | 2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative |
-
1987
- 1987-06-24 GB GB878714901A patent/GB8714901D0/en active Pending
- 1987-06-29 IE IE173387A patent/IE60887B1/en not_active IP Right Cessation
- 1987-06-30 IL IL83026A patent/IL83026A0/xx not_active IP Right Cessation
- 1987-07-02 PH PH35488A patent/PH23607A/en unknown
- 1987-07-02 AU AU75030/87A patent/AU604027B2/en not_active Ceased
- 1987-07-07 MY MYPI87000956A patent/MY102866A/en unknown
- 1987-07-16 FI FI873154A patent/FI88289C/fi not_active IP Right Cessation
- 1987-07-20 HU HU873333A patent/HU197293B/hu not_active IP Right Cessation
- 1987-07-21 EP EP87306442A patent/EP0254532B1/en not_active Expired - Lifetime
- 1987-07-21 AT AT87306442T patent/ATE52498T1/de not_active IP Right Cessation
- 1987-07-21 DE DE8787306442T patent/DE3762618D1/de not_active Expired - Lifetime
- 1987-07-21 ES ES87306442T patent/ES2018832B3/es not_active Expired - Lifetime
- 1987-07-22 NZ NZ221158A patent/NZ221158A/xx unknown
- 1987-07-22 NO NO873071A patent/NO174044C/no unknown
- 1987-07-22 SU SU874202958A patent/SU1549476A3/ru active
- 1987-07-22 CA CA000542721A patent/CA1327576C/en not_active Expired - Fee Related
- 1987-07-22 PT PT85379A patent/PT85379B/pt not_active IP Right Cessation
- 1987-07-22 JP JP62181304A patent/JPS6393755A/ja active Granted
- 1987-07-23 DK DK385387A patent/DK385387A/da not_active Application Discontinuation
- 1987-07-23 CN CN87105189A patent/CN1015707B/zh not_active Expired
- 1987-07-23 CS CS875565A patent/CS264145B2/cs unknown
- 1987-07-23 KR KR1019870008048A patent/KR880001576A/ko not_active Application Discontinuation
-
1988
- 1988-06-29 US US07/213,259 patent/US4927836A/en not_active Expired - Lifetime
-
1990
- 1990-03-08 US US07/490,406 patent/US4977148A/en not_active Expired - Lifetime
- 1990-06-21 GR GR89400210T patent/GR3000571T3/el unknown
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