CN101506369A - 具有经修饰的用于在昆虫细胞中产生aav的aav-rep78翻译起始密码子的载体 - Google Patents
具有经修饰的用于在昆虫细胞中产生aav的aav-rep78翻译起始密码子的载体 Download PDFInfo
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Abstract
Description
代数 | 原始REP/PSCvg/ml | REP-ACG/PSCvg/ml | 原始REP/Bac-to-Bacvg/ml |
2 | 5.38E+09 | 3.04E+09 | 3.62E+10 |
3 | 9.57E+09 | 4.77E+09 | 7.28E+09 |
4 | 1.66E+09 | 7.81E+09 | 7.59E+08 |
5 | 7.35E+08 | 9.90E+09 | 2.03E+08 |
Claims (25)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201410001495.XA CN103849629B (zh) | 2006-06-21 | 2007-06-20 | 具有经修饰的用于在昆虫细胞中产生aav的aav‑rep78翻译起始密码子的载体 |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81526206P | 2006-06-21 | 2006-06-21 | |
EP06115804.4 | 2006-06-21 | ||
US60/815,262 | 2006-06-21 | ||
EP06115804 | 2006-06-21 | ||
PCT/NL2007/050298 WO2007148971A2 (en) | 2006-06-21 | 2007-06-20 | Vectors with modified initiation codon for the translation of aav-rep78 useful for production of aav in insect cells |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201410001495.XA Division CN103849629B (zh) | 2006-06-21 | 2007-06-20 | 具有经修饰的用于在昆虫细胞中产生aav的aav‑rep78翻译起始密码子的载体 |
Publications (2)
Publication Number | Publication Date |
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CN101506369A true CN101506369A (zh) | 2009-08-12 |
CN101506369B CN101506369B (zh) | 2014-02-12 |
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CN200780030443.3A Active CN101506369B (zh) | 2006-06-21 | 2007-06-20 | 具有经修饰的用于在昆虫细胞中产生aav的aav-rep78翻译起始密码子的载体 |
CN201410001495.XA Active CN103849629B (zh) | 2006-06-21 | 2007-06-20 | 具有经修饰的用于在昆虫细胞中产生aav的aav‑rep78翻译起始密码子的载体 |
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CN201410001495.XA Active CN103849629B (zh) | 2006-06-21 | 2007-06-20 | 具有经修饰的用于在昆虫细胞中产生aav的aav‑rep78翻译起始密码子的载体 |
Country Status (13)
Country | Link |
---|---|
US (10) | US8512981B2 (zh) |
EP (3) | EP3023500B1 (zh) |
JP (2) | JP5364903B2 (zh) |
KR (1) | KR101589259B1 (zh) |
CN (2) | CN101506369B (zh) |
AU (1) | AU2007261806B2 (zh) |
CA (2) | CA2655957C (zh) |
DK (1) | DK3023500T3 (zh) |
ES (1) | ES2785223T3 (zh) |
HK (2) | HK1127083A1 (zh) |
IL (1) | IL196091A (zh) |
RU (1) | RU2457252C2 (zh) |
WO (1) | WO2007148971A2 (zh) |
Cited By (5)
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CN103764831A (zh) * | 2011-03-11 | 2014-04-30 | 肌肉学研究协会 | 不含衣壳的aav载体、组合物以及制备载体和基因递送的方法 |
CN107502597A (zh) * | 2011-09-08 | 2017-12-22 | 尤尼克尔Ip股份有限公司 | 从aav制剂中去除污染病毒 |
CN111511922A (zh) * | 2018-01-19 | 2020-08-07 | 牛津遗传学有限公司 | 用于生产aav颗粒的载体 |
CN111527201A (zh) * | 2017-12-29 | 2020-08-11 | 优尼科Ip有限公司 | 修饰的病毒载体及其制备和使用方法 |
CN113454232A (zh) * | 2019-02-15 | 2021-09-28 | 世代生物公司 | 封闭端dna(cedna)产生中对rep蛋白活性的调节 |
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JP5634262B2 (ja) | 2007-07-26 | 2014-12-03 | ユニキュアー アイピー ビー.ブイ. | 差次的コドンバイアスを有する反復コード配列を含むバキュロウイルスベクター |
US20110030075A1 (en) | 2008-01-29 | 2011-02-03 | Proyecto De Biomedicina Cima S.L. | Methods and Compositions Capable of Causing Post-Transcriptional Silencing of Gene Expression in a Synergic Manner |
US8642314B2 (en) * | 2008-02-19 | 2014-02-04 | Amsterdam Molecular Therapeutics (Amt) B.V. | Optimization of expression of parvoviral rep and cap proteins in insect cells |
US11219696B2 (en) | 2008-12-19 | 2022-01-11 | Nationwide Children's Hospital | Delivery of polynucleotides using recombinant AAV9 |
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PL3254703T3 (pl) * | 2011-04-22 | 2020-10-05 | The Regents Of The University Of California | Wiriony wirusa towarzyszącego adenowirusom z różnymi kapsydami i sposoby ich zastosowania |
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