DK3023500T3 - Insektceller til fremstilling af AAV-vektorer - Google Patents
Insektceller til fremstilling af AAV-vektorer Download PDFInfo
- Publication number
- DK3023500T3 DK3023500T3 DK15198010.9T DK15198010T DK3023500T3 DK 3023500 T3 DK3023500 T3 DK 3023500T3 DK 15198010 T DK15198010 T DK 15198010T DK 3023500 T3 DK3023500 T3 DK 3023500T3
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- DK
- Denmark
- Prior art keywords
- production
- insect cells
- aav vectors
- aav
- vectors
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/864—Parvoviral vectors, e.g. parvovirus, densovirus
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14041—Use of virus, viral particle or viral elements as a vector
- C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore
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- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14041—Use of virus, viral particle or viral elements as a vector
- C12N2710/14044—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
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- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
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- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14144—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
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- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14151—Methods of production or purification of viral material
- C12N2710/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/103—Plasmid DNA for invertebrates
- C12N2800/105—Plasmid DNA for invertebrates for insects
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- C12N2800/00—Nucleic acids vectors
- C12N2800/50—Vectors for producing vectors
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- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81526206P | 2006-06-21 | 2006-06-21 | |
EP06115804 | 2006-06-21 | ||
EP07747521.8A EP2035564B1 (en) | 2006-06-21 | 2007-06-20 | Vectors with modified initiation codon for the translation of aav-rep78 useful for production of aav in insect cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3023500T3 true DK3023500T3 (da) | 2020-04-20 |
Family
ID=38606198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15198010.9T DK3023500T3 (da) | 2006-06-21 | 2007-06-20 | Insektceller til fremstilling af AAV-vektorer |
Country Status (13)
Country | Link |
---|---|
US (10) | US8512981B2 (da) |
EP (3) | EP3023500B1 (da) |
JP (2) | JP5364903B2 (da) |
KR (1) | KR101589259B1 (da) |
CN (2) | CN101506369B (da) |
AU (1) | AU2007261806B2 (da) |
CA (2) | CA2921594A1 (da) |
DK (1) | DK3023500T3 (da) |
ES (1) | ES2785223T3 (da) |
HK (2) | HK1127083A1 (da) |
IL (1) | IL196091A (da) |
RU (1) | RU2457252C2 (da) |
WO (1) | WO2007148971A2 (da) |
Families Citing this family (149)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2410133T3 (es) * | 2005-10-20 | 2013-07-01 | Uniqure Ip B.V. | Vectores de VAA mejorados producidos en células de insecto. |
CN101506369B (zh) | 2006-06-21 | 2014-02-12 | 尤尼克尔生物制药股份有限公司 | 具有经修饰的用于在昆虫细胞中产生aav的aav-rep78翻译起始密码子的载体 |
DK3093345T3 (da) | 2007-07-26 | 2019-06-24 | Uniqure Ip Bv | Baculovirusvektorer omfattende gentagne kodende sekvenser med differentielle foretrukne kodoner |
CN101981189A (zh) | 2008-01-29 | 2011-02-23 | 西马生物医学计划公司 | 能够以协同方式引起基因表达转录后沉默的方法和组合物 |
ES2644880T3 (es) * | 2008-02-19 | 2017-11-30 | Uniqure Ip B.V. | Optimización de expresión de proteínas Rep y Cap parvovirales en las células de insecto |
US11219696B2 (en) | 2008-12-19 | 2022-01-11 | Nationwide Children's Hospital | Delivery of polynucleotides using recombinant AAV9 |
WO2010087709A1 (en) | 2009-01-30 | 2010-08-05 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Alanine-glyoxylate aminotransferase therapeutics |
EP2412387B1 (en) | 2009-03-27 | 2014-11-19 | Proyecto de Biomedicina Cima, S.L. | Methods and compositions for the treatment of cirrhosis and liver fibrosis |
GB0911870D0 (en) | 2009-07-08 | 2009-08-19 | Ucl Business Plc | Optimised coding sequence and promoter |
EP3792348A3 (en) * | 2010-03-11 | 2021-06-23 | uniQure IP B.V. | Mutated rep encoding sequences for use in aav production |
WO2011112090A2 (en) | 2010-03-11 | 2011-09-15 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Method for identifying variant rep protein encoding nucleic acids |
WO2011122950A1 (en) | 2010-04-01 | 2011-10-06 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Monomeric duplex aav vectors |
IT1400425B1 (it) | 2010-06-08 | 2013-05-31 | Amsterdam Molecular Therapeutics Bv | Modified snrnas for use in therapy. |
US10415056B2 (en) * | 2010-11-10 | 2019-09-17 | Fred Hutchinson Cancer Research Center | Compositions and methods for generating adeno-associated viral vectors with undetectable capsid gene contamination |
AU2011329872B2 (en) * | 2010-11-16 | 2017-04-13 | Excelimmune, Inc. | Methods for producing recombinant proteins |
EP2500434A1 (en) * | 2011-03-12 | 2012-09-19 | Association Institut de Myologie | Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery |
WO2012145509A2 (en) | 2011-04-19 | 2012-10-26 | The Research Foundation Of State University Of New York | Adeno-associated-virus rep sequences, vectors, and viruses |
DK2699270T3 (da) * | 2011-04-22 | 2017-10-02 | Univ California | Adenoassocieret virus-virions med variant capsid og fremgangsmåder til anvendelse deraf |
US20130039888A1 (en) | 2011-06-08 | 2013-02-14 | Nationwide Children's Hospital Inc. | Products and methods for delivery of polynucleotides by adeno-associated virus for lysosomal storage disorders |
US9840694B2 (en) * | 2011-09-08 | 2017-12-12 | Uniqure Ip B.V. | Removal of contaminating viruses from AAV preparations |
TWI702955B (zh) | 2012-05-15 | 2020-09-01 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
GB201210357D0 (en) | 2012-06-12 | 2012-07-25 | Ucl Business Plc | Factor VIII sequences |
CA2880653C (en) | 2012-08-01 | 2022-05-17 | Nationwide Children's Hospital | Intrathecal delivery of recombinant adeno-associated virus 9 |
SI2956477T1 (sl) | 2013-02-15 | 2021-03-31 | Bioverativ Therapeutics Inc. | Optimiran gen dejavnika VIII |
EP2970943A4 (en) * | 2013-03-15 | 2017-04-19 | The Children's Hospital of Philadelphia | Vectors comprising stuffer/filler polynucleotide sequences and methods of use |
WO2015038958A1 (en) | 2013-09-13 | 2015-03-19 | California Institute Of Technology | Selective recovery |
CN105745326A (zh) | 2013-10-24 | 2016-07-06 | 优尼科Ip有限公司 | 用于基因治疗神经疾病的aav-5假型载体 |
JP6875856B2 (ja) * | 2013-12-06 | 2021-05-26 | インセルム(インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル) | 対象の網膜色素上皮において目的のポリヌクレオチドを発現させるための方法および医薬組成物 |
US10837027B2 (en) * | 2014-03-10 | 2020-11-17 | Uniqure Ip B.V. | Further improved AAV vectors produced in insect cells |
CN106414474B (zh) | 2014-03-17 | 2021-01-15 | 阿德夫拉姆生物技术股份有限公司 | 用于视锥细胞中增强的基因表达的组合物和方法 |
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SG11201703148TA (en) | 2014-11-05 | 2017-05-30 | Voyager Therapeutics Inc | Aadc polynucleotides for the treatment of parkinson's disease |
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RU2727015C2 (ru) * | 2014-11-21 | 2020-07-17 | Дзе Юниверсити Оф Норт Каролина Эт Чепел Хилл | Векторы aav, нацеленные на центральную нервную систему |
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US20180044698A1 (en) * | 2015-02-19 | 2018-02-15 | University Of Florida Research Foundation, Incorporated | Site-specific integrating recombinant aav vectors for gene therapy and improved production methods |
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SG10202107733QA (en) | 2015-09-28 | 2021-09-29 | Univ North Carolina Chapel Hill | Methods and compositions for antibody-evading virus vectors |
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GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
HUE059941T2 (hu) | 2016-02-01 | 2023-01-28 | Bioverativ Therapeutics Inc | Optimalizált VIII-as faktor gének |
WO2017172772A1 (en) | 2016-03-28 | 2017-10-05 | Dimension Therapeutics | Methods of heat inactivation of adenovirus |
CA3021080A1 (en) * | 2016-04-16 | 2017-10-19 | University Of Florida Research Foundation, Incorporated | Methods of enhancing biological potency of baculovirus system-produced recombinant adeno-associated virus |
CA3012699C (en) * | 2016-04-21 | 2023-11-21 | Virovek, Inc | Aav production in insect cells, methods and compositions therefor |
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