CN101505792B - 使用抗-vegf抗体的肿瘤疗法 - Google Patents

使用抗-vegf抗体的肿瘤疗法 Download PDF

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Publication number
CN101505792B
CN101505792B CN2007800308557A CN200780030855A CN101505792B CN 101505792 B CN101505792 B CN 101505792B CN 2007800308557 A CN2007800308557 A CN 2007800308557A CN 200780030855 A CN200780030855 A CN 200780030855A CN 101505792 B CN101505792 B CN 101505792B
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her2
antibody
cancer
treatment
patient
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Chinese (zh)
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CN101505792A (zh
Inventor
托马斯·弗里斯
马克斯·哈斯曼
维尔纳·朔伊尔
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F Hoffmann La Roche AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
CN2007800308557A 2006-08-21 2007-08-17 使用抗-vegf抗体的肿瘤疗法 Expired - Fee Related CN101505792B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06017330 2006-08-21
EP06017330.9 2006-08-21
PCT/EP2007/007276 WO2008022746A1 (en) 2006-08-21 2007-08-17 Tumor therapy with an anti-vegf antibody

Publications (2)

Publication Number Publication Date
CN101505792A CN101505792A (zh) 2009-08-12
CN101505792B true CN101505792B (zh) 2012-10-03

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CN2007800308557A Expired - Fee Related CN101505792B (zh) 2006-08-21 2007-08-17 使用抗-vegf抗体的肿瘤疗法

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US (6) US20080050385A1 (enExample)
EP (2) EP2056874B1 (enExample)
JP (3) JP2010501498A (enExample)
KR (1) KR101136763B1 (enExample)
CN (1) CN101505792B (enExample)
AR (1) AR062419A1 (enExample)
AU (1) AU2007287794B2 (enExample)
BR (1) BRPI0715829A2 (enExample)
CA (1) CA2660681A1 (enExample)
CL (1) CL2007002404A1 (enExample)
CO (1) CO6150193A2 (enExample)
CR (1) CR10590A (enExample)
DK (1) DK2056874T3 (enExample)
ES (2) ES2546066T3 (enExample)
IL (2) IL196810A0 (enExample)
MA (1) MA30654B1 (enExample)
MX (1) MX2009001715A (enExample)
MY (1) MY150756A (enExample)
NO (1) NO20090450L (enExample)
NZ (1) NZ574580A (enExample)
PE (1) PE20080911A1 (enExample)
PL (1) PL2056874T3 (enExample)
RU (1) RU2528884C2 (enExample)
SG (1) SG174090A1 (enExample)
SI (1) SI2056874T1 (enExample)
TW (2) TW200825106A (enExample)
WO (1) WO2008022746A1 (enExample)
ZA (1) ZA200901200B (enExample)

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NO20090450L (no) 2009-02-27
AU2007287794A1 (en) 2008-02-28
TW200825106A (en) 2008-06-16
EP2441472A1 (en) 2012-04-18
US20100285010A1 (en) 2010-11-11
DK2056874T3 (da) 2012-10-15
IL196810A0 (en) 2011-08-01
CN101505792A (zh) 2009-08-12
PE20080911A1 (es) 2008-08-15
US20180251536A1 (en) 2018-09-06
ZA200901200B (en) 2013-08-28
US20080050385A1 (en) 2008-02-28
AU2007287794B2 (en) 2013-03-28
TW201107346A (en) 2011-03-01
EP2441472B1 (en) 2015-06-10
ES2392630T3 (es) 2012-12-12
SG174090A1 (en) 2011-09-29
KR20090032136A (ko) 2009-03-31
US20150239969A1 (en) 2015-08-27
US20130183292A1 (en) 2013-07-18
NZ574580A (en) 2011-12-22
KR101136763B1 (ko) 2012-04-24
CO6150193A2 (es) 2010-04-20
RU2009110102A (ru) 2010-09-27
CA2660681A1 (en) 2008-02-28
JP2010501498A (ja) 2010-01-21
CL2007002404A1 (es) 2008-04-18
JP2013163687A (ja) 2013-08-22
MX2009001715A (es) 2009-02-25
IL238045A0 (en) 2015-05-31
SI2056874T1 (sl) 2012-12-31
ES2546066T3 (es) 2015-09-18
CR10590A (es) 2009-03-20
AR062419A1 (es) 2008-11-05
MA30654B1 (fr) 2009-08-03
RU2528884C2 (ru) 2014-09-20
HK1134441A1 (en) 2010-04-30
EP2056874B1 (en) 2012-09-19
MY150756A (en) 2014-02-28
WO2008022746A1 (en) 2008-02-28
JP2015214582A (ja) 2015-12-03
PL2056874T3 (pl) 2013-02-28
BRPI0715829A2 (pt) 2013-07-23
US20110223159A1 (en) 2011-09-15
EP2056874A1 (en) 2009-05-13

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