JP2010501498A - 抗vegf抗体による腫瘍治療 - Google Patents

抗vegf抗体による腫瘍治療 Download PDF

Info

Publication number
JP2010501498A
JP2010501498A JP2009524943A JP2009524943A JP2010501498A JP 2010501498 A JP2010501498 A JP 2010501498A JP 2009524943 A JP2009524943 A JP 2009524943A JP 2009524943 A JP2009524943 A JP 2009524943A JP 2010501498 A JP2010501498 A JP 2010501498A
Authority
JP
Japan
Prior art keywords
antibody
her2
treatment
cancer
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009524943A
Other languages
English (en)
Japanese (ja)
Inventor
フリース,トマス
ハスマン,マックス
ショイアー,ベルナー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37607207&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2010501498(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2010501498A publication Critical patent/JP2010501498A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
JP2009524943A 2006-08-21 2007-08-17 抗vegf抗体による腫瘍治療 Pending JP2010501498A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06017330 2006-08-21
PCT/EP2007/007276 WO2008022746A1 (en) 2006-08-21 2007-08-17 Tumor therapy with an anti-vegf antibody

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013103182A Division JP2013163687A (ja) 2006-08-21 2013-05-15 抗vegf抗体による腫瘍治療

Publications (1)

Publication Number Publication Date
JP2010501498A true JP2010501498A (ja) 2010-01-21

Family

ID=37607207

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009524943A Pending JP2010501498A (ja) 2006-08-21 2007-08-17 抗vegf抗体による腫瘍治療
JP2013103182A Withdrawn JP2013163687A (ja) 2006-08-21 2013-05-15 抗vegf抗体による腫瘍治療
JP2015160099A Ceased JP2015214582A (ja) 2006-08-21 2015-08-14 抗vegf抗体による腫瘍治療

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013103182A Withdrawn JP2013163687A (ja) 2006-08-21 2013-05-15 抗vegf抗体による腫瘍治療
JP2015160099A Ceased JP2015214582A (ja) 2006-08-21 2015-08-14 抗vegf抗体による腫瘍治療

Country Status (28)

Country Link
US (6) US20080050385A1 (enExample)
EP (2) EP2056874B1 (enExample)
JP (3) JP2010501498A (enExample)
KR (1) KR101136763B1 (enExample)
CN (1) CN101505792B (enExample)
AR (1) AR062419A1 (enExample)
AU (1) AU2007287794B2 (enExample)
BR (1) BRPI0715829A2 (enExample)
CA (1) CA2660681A1 (enExample)
CL (1) CL2007002404A1 (enExample)
CO (1) CO6150193A2 (enExample)
CR (1) CR10590A (enExample)
DK (1) DK2056874T3 (enExample)
ES (2) ES2392630T3 (enExample)
IL (2) IL196810A0 (enExample)
MA (1) MA30654B1 (enExample)
MX (1) MX2009001715A (enExample)
MY (1) MY150756A (enExample)
NO (1) NO20090450L (enExample)
NZ (1) NZ574580A (enExample)
PE (1) PE20080911A1 (enExample)
PL (1) PL2056874T3 (enExample)
RU (1) RU2528884C2 (enExample)
SG (1) SG174090A1 (enExample)
SI (1) SI2056874T1 (enExample)
TW (2) TW201107346A (enExample)
WO (1) WO2008022746A1 (enExample)
ZA (1) ZA200901200B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013163687A (ja) * 2006-08-21 2013-08-22 F Hoffmann La Roche Ag 抗vegf抗体による腫瘍治療
JP2015502543A (ja) * 2011-12-05 2015-01-22 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 乳癌治療向けベバシズマブ併用療法用血漿バイオマーカー

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02011379A (es) * 2000-05-19 2003-06-06 Genentech Inc Ensayo de deteccion de genes para mejorar la probabilidad de una respuesta efectiva a terapia de cancer con el antagonista erbb.
KR20190126461A (ko) 2004-07-22 2019-11-11 제넨테크, 인크. Her2 항체 조성물
JO3000B1 (ar) * 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
CN101115849A (zh) * 2004-12-07 2008-01-30 健泰科生物技术公司 选择her抑制剂疗法的患者
KR20200058588A (ko) 2005-01-21 2020-05-27 제넨테크, 인크. Her 항체의 고정 용량 투여법
MY152164A (en) 2005-02-23 2014-08-15 Genentech Inc Extending time to disease progression or survival in cancer patients
PE20070207A1 (es) * 2005-07-22 2007-03-09 Genentech Inc Tratamiento combinado de los tumores que expresan el her
KR20150039212A (ko) 2007-03-02 2015-04-09 제넨테크, 인크. 낮은 her3 발현을 기초로 한 her 이량체화 억제제에 대한 반응 예측
TWI472339B (zh) 2008-01-30 2015-02-11 Genentech Inc 包含結合至her2結構域ii之抗體及其酸性變異體的組合物
BRPI0812682A2 (pt) 2008-06-16 2010-06-22 Genentech Inc tratamento de cáncer de mama metastático
CN103153339B (zh) 2010-05-27 2021-05-04 根马布股份公司 针对her2表位的单克隆抗体
NZ604003A (en) 2010-05-27 2015-04-24 Genmab As Monoclonal antibodies against her2
CA2804348A1 (en) * 2010-07-19 2012-01-26 F. Hoffmann-La Roche Ag Blood plasma biomarkers for bevacizumab combination therapies for treatment of pancreatic cancer
MY162825A (en) * 2010-08-20 2017-07-31 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3)
AU2012245116A1 (en) 2011-04-20 2013-11-07 Genmab A/S Bispecific antibodies against HER2 and CD3
BR112014007521A8 (pt) 2011-10-14 2018-04-10 Genentech Inc método para estender a sobrevida livre de progressão em uma população com câncer de mama, artigo de fabricação, método para produção de um artigo de fabricação, para garantir o uso seguro e efetivo de pertuzumabe, de tratar câncer de mama, bolsa intravenosa, método de tratar câncer gástrico, de tratar adenocarcinoma do estômago e de melhora de sobrevida
US20150147340A1 (en) * 2012-03-30 2015-05-28 Fibrogen, Inc. Therapeutic methods for peritoneal carcinomatosis
EA201591643A1 (ru) 2013-04-16 2016-02-29 Дженентек, Инк. Варианты пертузумаба и их аналитическая характеристика
KR20160141857A (ko) 2014-04-25 2016-12-09 제넨테크, 인크. 트라스투주맙-mcc-dm1 및 퍼투주맙을 이용하는 초기 유방암의 치료방법
TW201619200A (zh) * 2014-10-10 2016-06-01 麥迪紐有限責任公司 人類化抗-ox40抗體及其用途
HUE068105T2 (hu) 2015-05-30 2024-12-28 Hoffmann La Roche Eljárások korábban kezeletlen her2-pozitív metasztatikus emlõrák kezelésére
WO2017087280A1 (en) 2015-11-16 2017-05-26 Genentech, Inc. Methods of treating her2-positive cancer
CN106729743B (zh) * 2015-11-23 2021-09-21 四川科伦博泰生物医药股份有限公司 抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用
TW202140776A (zh) * 2016-04-26 2021-11-01 美商美國泰福生技股份有限公司 細胞培養基
KR102313262B1 (ko) 2016-12-28 2021-10-14 제넨테크, 인크. 진행성 her2 발현 암의 치료
US10849849B2 (en) 2017-01-17 2020-12-01 Genentech Inc. Subcutaneous HER2 antibody formulations
ES2969041T3 (es) 2017-03-02 2024-05-16 Genentech Inc Tratamiento adyuvante del cáncer de mama positivo para HER2
AU2018258263A1 (en) 2017-04-24 2019-10-24 Genentech, Inc. ErbB2/Her2 mutations in the transmembrane or juxtamembrane domain
MX2022015884A (es) 2020-06-29 2023-04-03 Genentech Inc Combinacion de dosis fija de pertuzumab mas trastuzumab.
WO2022051721A1 (en) * 2020-09-04 2022-03-10 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Combination compositions and methods for treating cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006028936A2 (en) * 2004-09-02 2006-03-16 Genentech, Inc. Heteromultimeric molecules
WO2006042173A2 (en) * 2004-10-04 2006-04-20 Genentech, Inc. Modulators of hepatocyte growth factor activator

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006692A1 (en) 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
DE122004000008I1 (de) 1991-06-14 2005-06-09 Genentech Inc Humanisierter Heregulin Antikörper.
DK1167384T3 (da) 1992-10-28 2007-04-10 Genentech Inc Vaskular endotheliel cellevækstfaktor antagonister
EP0907649A1 (en) 1996-06-27 1999-04-14 Pfizer Inc. Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors
CN100415772C (zh) 1996-10-18 2008-09-03 基因技术股份有限公司 抗ErbB2抗体
US20020032315A1 (en) 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
US6884879B1 (en) * 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
PT1695985E (pt) 1997-04-07 2011-06-06 Genentech Inc Métodos para formar anticorpos humanizados por mutagénese aleatória
DK1325932T5 (da) 1997-04-07 2005-10-03 Genentech Inc Anti-VEGF antistoffer
ZA9811162B (en) 1997-12-12 2000-06-07 Genentech Inc Treatment with anti-ERBB2 antibodies.
JPH11236333A (ja) 1997-12-30 1999-08-31 Pfizer Prod Inc 抗ガン剤として有用なイミダゾリン−4−オン誘導体
AU4079999A (en) 1998-05-15 1999-12-06 Imclone Systems Incorporated Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases
GEP20033001B (en) 1998-08-27 2003-06-25 Pfizer Prod Inc Alkynyl-Substituted Quinolin-2-One Derivatives Useful As Anticancer Agents
JP3494409B2 (ja) 1998-08-27 2004-02-09 ファイザー・プロダクツ・インク 抗がん剤として有用なアルキニル置換キノリン−2−オン誘導体
EP1135498B1 (en) 1998-11-18 2008-01-23 Genentech, Inc. Antibody variants with higher binding affinity compared to parent antibodies
EP1006113A1 (en) 1998-12-02 2000-06-07 Pfizer Products Inc. Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth
AU1687500A (en) 1998-12-16 2000-07-03 Kyowa Hakko Kogyo Co. Ltd. Antihuman vegf monoclonal antibody
JP4090200B2 (ja) 1999-02-11 2008-05-28 ファイザー・プロダクツ・インク 抗癌薬として有用なヘテロアリール置換キノリン−2−オン誘導体
US6586447B1 (en) 1999-04-01 2003-07-01 Pfizer Inc 3,3-disubstituted-oxindole derivatives useful as anticancer agents
ES2320311T3 (es) 1999-05-14 2009-05-21 Genentech, Inc. Tratamiento con anticuerpos anti-erbb2.
EP1189634B1 (en) 1999-06-25 2007-02-28 Genentech, Inc. Treating prostate cancer with anti-erbb2 antibodies
US6949245B1 (en) * 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
MXPA01013458A (es) 1999-06-25 2002-07-30 Genentech Inc Anticuerpos humanizados anti-erbb2 y tratamiento con anticuerpos anti-erbb2.
EP1106612B1 (en) 1999-11-30 2004-02-11 Pfizer Products Inc. Quinoline derivatives useful for inhibiting farnesyl protein transferase
UA75055C2 (uk) 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
HN2000000266A (es) 2000-01-21 2001-05-21 Pfizer Prod Inc Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
WO2003042402A2 (en) * 2001-11-13 2003-05-22 Dana-Farber Cancer Institute, Inc. Agents that modulate immune cell activation and methods of use thereof
AU2003222252A1 (en) 2002-03-12 2003-09-29 The General Hospital Corporation Use of signal transduction inhibitors and combination therapies for the prevention or treatment of cancer and angiogenesis related diseases
JP2005522514A (ja) 2002-04-10 2005-07-28 ジェネンテック・インコーポレーテッド 抗her2抗体改変体
MXPA05012723A (es) 2003-05-30 2006-02-08 Genentech Inc Tratamiento con anticuerpos anti-vgf.
US20040243207A1 (en) 2003-05-30 2004-12-02 Olson Donald R. Medical implant systems
KR20060069825A (ko) 2003-08-01 2006-06-22 제넨테크, 인크. 제한된 다양성을 갖는 항체 cdr 폴리펩티드 서열
US20050106667A1 (en) * 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
ATE554107T1 (de) 2003-12-19 2012-05-15 Genentech Inc Als therapeutika geeignete monovalente antikörperfragmente
BRPI0611766A2 (pt) * 2005-06-08 2011-12-20 Dana Farber Cancer Inst Inc métodos e composições para o tratamento de infecções persistentes e cáncer por inibição da rota de morte celular programada
TW200812615A (en) * 2006-03-22 2008-03-16 Hoffmann La Roche Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
DK2056874T3 (da) * 2006-08-21 2012-10-15 Hoffmann La Roche Tumorterapi med et anti-vegf-antistof
JP2013103182A (ja) * 2011-11-15 2013-05-30 Toray Ind Inc スパイラル型流体分離素子およびその製造方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006028936A2 (en) * 2004-09-02 2006-03-16 Genentech, Inc. Heteromultimeric molecules
WO2006042173A2 (en) * 2004-10-04 2006-04-20 Genentech, Inc. Modulators of hepatocyte growth factor activator

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JPN5009012002; PEGRAM M: BREAST CANCER RESEARCH AND TREATMENT V88 N.SUPPL 1, 2004, P.S124-S125, NIJHOFF *
JPN5009012005; EPSTEIN M: 25TH ANNUAL SAN ANTONIO BREAST CANCER SYMPOSIUM V.76 SUPPL.1, 200212, P.S143 *
JPN6011060419; Seminars in Oncology, 2002, Vol.29, No.3, Suppl.11, pp.29-37 *
JPN6011060421; Clinical Cancer Research, 2006.02, pp.904-916 *
JPN6013000984; Nature biotechnology, 2005, Vol.23, No.9, pp.1147-1157 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013163687A (ja) * 2006-08-21 2013-08-22 F Hoffmann La Roche Ag 抗vegf抗体による腫瘍治療
JP2015502543A (ja) * 2011-12-05 2015-01-22 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 乳癌治療向けベバシズマブ併用療法用血漿バイオマーカー

Also Published As

Publication number Publication date
ZA200901200B (en) 2013-08-28
BRPI0715829A2 (pt) 2013-07-23
EP2056874A1 (en) 2009-05-13
TW200825106A (en) 2008-06-16
US20100285010A1 (en) 2010-11-11
DK2056874T3 (da) 2012-10-15
JP2015214582A (ja) 2015-12-03
ES2392630T3 (es) 2012-12-12
AU2007287794B2 (en) 2013-03-28
CN101505792A (zh) 2009-08-12
EP2441472B1 (en) 2015-06-10
IL238045A0 (en) 2015-05-31
ES2546066T3 (es) 2015-09-18
NZ574580A (en) 2011-12-22
CL2007002404A1 (es) 2008-04-18
SG174090A1 (en) 2011-09-29
RU2009110102A (ru) 2010-09-27
KR20090032136A (ko) 2009-03-31
EP2441472A1 (en) 2012-04-18
AU2007287794A1 (en) 2008-02-28
PL2056874T3 (pl) 2013-02-28
CN101505792B (zh) 2012-10-03
NO20090450L (no) 2009-02-27
MX2009001715A (es) 2009-02-25
TW201107346A (en) 2011-03-01
RU2528884C2 (ru) 2014-09-20
US20080050385A1 (en) 2008-02-28
MA30654B1 (fr) 2009-08-03
US20130183292A1 (en) 2013-07-18
AR062419A1 (es) 2008-11-05
CO6150193A2 (es) 2010-04-20
WO2008022746A1 (en) 2008-02-28
SI2056874T1 (sl) 2012-12-31
HK1134441A1 (en) 2010-04-30
IL196810A0 (en) 2011-08-01
US20110223159A1 (en) 2011-09-15
CR10590A (es) 2009-03-20
PE20080911A1 (es) 2008-08-15
MY150756A (en) 2014-02-28
CA2660681A1 (en) 2008-02-28
US20180251536A1 (en) 2018-09-06
JP2013163687A (ja) 2013-08-22
KR101136763B1 (ko) 2012-04-24
US20150239969A1 (en) 2015-08-27
EP2056874B1 (en) 2012-09-19

Similar Documents

Publication Publication Date Title
AU2007287794B2 (en) Tumor therapy with an anti-VEGF antibody
JP5795463B2 (ja) 血管内皮増殖因子に対する抗体と、2型ヒト上皮成長因子受容体に対する抗体を用いた腫瘍治療
AU2007229008B2 (en) Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
CN101405030B (zh) 针对血管内皮生长因子的抗体和针对人表皮生长因子2型受体的抗体在制备治疗肿瘤的试剂盒中的应用
HK1134441B (en) Tumor therapy with an anti-vegf antibody

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20111122

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120125

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120201

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120522

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130115