CN101395158A - 可作为激酶抑制剂的吡咯并三嗪苯胺前体药物化合物 - Google Patents

可作为激酶抑制剂的吡咯并三嗪苯胺前体药物化合物 Download PDF

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Publication number
CN101395158A
CN101395158A CNA2007800079168A CN200780007916A CN101395158A CN 101395158 A CN101395158 A CN 101395158A CN A2007800079168 A CNA2007800079168 A CN A2007800079168A CN 200780007916 A CN200780007916 A CN 200780007916A CN 101395158 A CN101395158 A CN 101395158A
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alkyl
methyl
compound
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C·刘
K·莱弗塞瑞斯
V·M·瓦塔哈拉
J·林
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Oncology (AREA)
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  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
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CNA2007800079168A 2006-03-07 2007-03-05 可作为激酶抑制剂的吡咯并三嗪苯胺前体药物化合物 Pending CN101395158A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77985106P 2006-03-07 2006-03-07
US60/779,851 2006-03-07

Publications (1)

Publication Number Publication Date
CN101395158A true CN101395158A (zh) 2009-03-25

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CNA2007800079168A Pending CN101395158A (zh) 2006-03-07 2007-03-05 可作为激酶抑制剂的吡咯并三嗪苯胺前体药物化合物

Country Status (17)

Country Link
US (2) US7572795B2 (https=)
EP (1) EP2001886A2 (https=)
JP (1) JP2009535295A (https=)
KR (1) KR20080107408A (https=)
CN (1) CN101395158A (https=)
AR (1) AR059778A1 (https=)
AU (1) AU2007223342A1 (https=)
BR (1) BRPI0708644A2 (https=)
CA (1) CA2645031A1 (https=)
EA (1) EA200801945A1 (https=)
IL (1) IL193653A0 (https=)
MX (1) MX2008011136A (https=)
NO (1) NO20083717L (https=)
PE (1) PE20080139A1 (https=)
TW (1) TW200804390A (https=)
WO (1) WO2007103839A2 (https=)
ZA (1) ZA200807459B (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102153558A (zh) * 2011-02-23 2011-08-17 扬州永济医药新技术有限公司 多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法
CN104507941A (zh) * 2012-07-31 2015-04-08 百时美施贵宝公司 芳基内酰胺激酶抑制剂
CN107001376A (zh) * 2014-12-09 2017-08-01 拜耳制药股份公司 治疗癌症的化合物
CN110590839A (zh) * 2018-06-13 2019-12-20 四川海思科制药有限公司 一种乐伐替尼衍生物及制备方法和用途

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KR101025675B1 (ko) * 2002-04-23 2011-03-30 브리스톨-마이어스 스큅 컴퍼니 키나제 억제제로서 유용한 피롤로-트리아진 아닐린 화합물
CN101395158A (zh) * 2006-03-07 2009-03-25 百时美施贵宝公司 可作为激酶抑制剂的吡咯并三嗪苯胺前体药物化合物
WO2009158450A1 (en) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Crystalline forms of ((((4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbonyl)(propyl)carbamoyl)oxy)methyl (4-(phosphonooxy)phenyl)acetate, preparation and use thereof
WO2009158446A2 (en) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Crystalline forms of ((((4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbonyl)(propyl)carbamoyl)oxy)methyl (4-(phosphonooxy)phenyl)acetate, method of preparation and use thereof
HRP20140640T1 (hr) * 2008-08-19 2014-11-21 Xenoport, Inc. Prolijekovi monometil estera fumarne kiseline, farmaceutski sastavi iz toga i postupci njihove uporabe
ES2539620T3 (es) 2008-12-19 2015-07-02 Cephalon, Inc. Pirrolotriazina como inhibidor de ALK y de JAK2
CA2937222C (en) * 2009-06-25 2019-06-04 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds
CN102596921B (zh) * 2009-09-29 2015-04-29 葛兰素集团有限公司 新化合物
MX2012003778A (es) * 2009-09-29 2012-06-01 Glaxo Group Ltd Compuestos novedosos.
CN102918045A (zh) 2010-03-31 2013-02-06 百时美施贵宝公司 作为蛋白激酶抑制剂的取代的吡咯并三嗪
WO2012031057A1 (en) 2010-09-01 2012-03-08 Bristol-Myers Squibb Company Bms- 582949 for the treatment of resistant rheumatic disease
AU2013305684B2 (en) 2012-08-22 2016-11-24 Xenoport, Inc. Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
US9050345B2 (en) 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
WO2014160633A1 (en) 2013-03-24 2014-10-02 Xenoport, Inc. Pharmaceutical compositions of dimethyl fumarate
WO2014197860A1 (en) 2013-06-07 2014-12-11 Xenoport, Inc. Method of making monomethyl fumarate
WO2014205392A1 (en) 2013-06-21 2014-12-24 Xenoport, Inc. Cocrystals of dimethyl fumarate
EP3041467A1 (en) 2013-09-06 2016-07-13 XenoPort, Inc. Crystalline forms of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate, methods of synthesis and use
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
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