BRPI0708644A2 - compostos de pró-fármaco de anilina de pirrolotriazina úteis como inibidores de cinase - Google Patents

compostos de pró-fármaco de anilina de pirrolotriazina úteis como inibidores de cinase Download PDF

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Publication number
BRPI0708644A2
BRPI0708644A2 BRPI0708644-0A BRPI0708644A BRPI0708644A2 BR PI0708644 A2 BRPI0708644 A2 BR PI0708644A2 BR PI0708644 A BRPI0708644 A BR PI0708644A BR PI0708644 A2 BRPI0708644 A2 BR PI0708644A2
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formula
optionally substituted
original document
document page
see original
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BRPI0708644-0A
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English (en)
Portuguese (pt)
Inventor
Liu Chunjian
Leftheris Katherina
M. Vrudhula Vivekananda
Lin James
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Bristol-Myers Squibb Company
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Publication of BRPI0708644A2 publication Critical patent/BRPI0708644A2/pt

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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BRPI0708644-0A 2006-03-07 2007-03-05 compostos de pró-fármaco de anilina de pirrolotriazina úteis como inibidores de cinase BRPI0708644A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77985106P 2006-03-07 2006-03-07
US60/779,851 2006-03-07
PCT/US2007/063250 WO2007103839A2 (en) 2006-03-07 2007-03-05 Pyrrolotriazine aniline prodrug compounds useful as kinase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0708644A2 true BRPI0708644A2 (pt) 2011-06-07

Family

ID=38475749

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0708644-0A BRPI0708644A2 (pt) 2006-03-07 2007-03-05 compostos de pró-fármaco de anilina de pirrolotriazina úteis como inibidores de cinase

Country Status (17)

Country Link
US (2) US7572795B2 (https=)
EP (1) EP2001886A2 (https=)
JP (1) JP2009535295A (https=)
KR (1) KR20080107408A (https=)
CN (1) CN101395158A (https=)
AR (1) AR059778A1 (https=)
AU (1) AU2007223342A1 (https=)
BR (1) BRPI0708644A2 (https=)
CA (1) CA2645031A1 (https=)
EA (1) EA200801945A1 (https=)
IL (1) IL193653A0 (https=)
MX (1) MX2008011136A (https=)
NO (1) NO20083717L (https=)
PE (1) PE20080139A1 (https=)
TW (1) TW200804390A (https=)
WO (1) WO2007103839A2 (https=)
ZA (1) ZA200807459B (https=)

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WO2009158450A1 (en) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Crystalline forms of ((((4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbonyl)(propyl)carbamoyl)oxy)methyl (4-(phosphonooxy)phenyl)acetate, preparation and use thereof
WO2009158446A2 (en) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Crystalline forms of ((((4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbonyl)(propyl)carbamoyl)oxy)methyl (4-(phosphonooxy)phenyl)acetate, method of preparation and use thereof
HRP20140640T1 (hr) * 2008-08-19 2014-11-21 Xenoport, Inc. Prolijekovi monometil estera fumarne kiseline, farmaceutski sastavi iz toga i postupci njihove uporabe
ES2539620T3 (es) 2008-12-19 2015-07-02 Cephalon, Inc. Pirrolotriazina como inhibidor de ALK y de JAK2
CA2937222C (en) * 2009-06-25 2019-06-04 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds
CN102596921B (zh) * 2009-09-29 2015-04-29 葛兰素集团有限公司 新化合物
MX2012003778A (es) * 2009-09-29 2012-06-01 Glaxo Group Ltd Compuestos novedosos.
CN102918045A (zh) 2010-03-31 2013-02-06 百时美施贵宝公司 作为蛋白激酶抑制剂的取代的吡咯并三嗪
WO2012031057A1 (en) 2010-09-01 2012-03-08 Bristol-Myers Squibb Company Bms- 582949 for the treatment of resistant rheumatic disease
CN102153558B (zh) * 2011-02-23 2012-11-21 扬州永济医药新技术有限公司 多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法
US8901305B2 (en) * 2012-07-31 2014-12-02 Bristol-Myers Squibb Company Aryl lactam kinase inhibitors
AU2013305684B2 (en) 2012-08-22 2016-11-24 Xenoport, Inc. Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
US9050345B2 (en) 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
WO2014160633A1 (en) 2013-03-24 2014-10-02 Xenoport, Inc. Pharmaceutical compositions of dimethyl fumarate
WO2014197860A1 (en) 2013-06-07 2014-12-11 Xenoport, Inc. Method of making monomethyl fumarate
WO2014205392A1 (en) 2013-06-21 2014-12-24 Xenoport, Inc. Cocrystals of dimethyl fumarate
EP3041467A1 (en) 2013-09-06 2016-07-13 XenoPort, Inc. Crystalline forms of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate, methods of synthesis and use
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
MA41136A (fr) * 2014-12-09 2017-10-17 Bayer Pharma AG Composés pour le traitement d'un cancer
WO2017070135A1 (en) * 2015-10-20 2017-04-27 Bristol-Myers Squibb Company Prodrugs of 2-(4-(3-((4-amino-7-cyano-imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)piperaz in-1-yl)propanamide derivatives as ck2 inhibitors for the treatment of cancer
AU2017246228B2 (en) * 2016-04-04 2021-04-15 Chemocentryx, Inc. Soluble C5aR antagonists
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
WO2019071147A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD
EP3761983A1 (en) 2018-03-05 2021-01-13 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
CN110590839B (zh) * 2018-06-13 2022-04-05 四川海思科制药有限公司 一种乐伐替尼衍生物及制备方法和用途

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US20090156555A1 (en) 2009-06-18
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US7572795B2 (en) 2009-08-11
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CA2645031A1 (en) 2007-09-13
IL193653A0 (en) 2009-08-03
AR059778A1 (es) 2008-04-30
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