CN101389335A - 噻二唑化合物和使用方法 - Google Patents
噻二唑化合物和使用方法 Download PDFInfo
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- CN101389335A CN101389335A CNA2005800356937A CN200580035693A CN101389335A CN 101389335 A CN101389335 A CN 101389335A CN A2005800356937 A CNA2005800356937 A CN A2005800356937A CN 200580035693 A CN200580035693 A CN 200580035693A CN 101389335 A CN101389335 A CN 101389335A
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- Prior art keywords
- thiadiazoles
- indazole
- amine
- amino
- propyl group
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Classifications
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- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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| US61901004P | 2004-10-18 | 2004-10-18 | |
| US60/619,010 | 2004-10-18 |
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| CN101389335A true CN101389335A (zh) | 2009-03-18 |
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| CNA2005800356937A Pending CN101389335A (zh) | 2004-10-18 | 2005-10-18 | 噻二唑化合物和使用方法 |
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| JP (1) | JP4931823B2 (enExample) |
| KR (1) | KR20070073791A (enExample) |
| CN (1) | CN101389335A (enExample) |
| AU (1) | AU2005295441B2 (enExample) |
| BR (1) | BRPI0516609A (enExample) |
| CA (1) | CA2583217C (enExample) |
| EA (1) | EA012181B1 (enExample) |
| ES (1) | ES2400689T3 (enExample) |
| IL (1) | IL182203A0 (enExample) |
| MA (1) | MA29029B1 (enExample) |
| MX (1) | MX2007004551A (enExample) |
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| DE102007002717A1 (de) | 2007-01-18 | 2008-07-24 | Merck Patent Gmbh | Heterocyclische Indazolderivate |
| DE102007022565A1 (de) | 2007-05-14 | 2008-11-20 | Merck Patent Gmbh | Heterocyclische Indazolderivate |
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| DE102008038222A1 (de) | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | Indazol-5-carbonsäurehydrazid-derivate |
| DE102008038221A1 (de) | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | 7-Azaindolderivate |
| DE102008038220A1 (de) | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | Oxadiazolderivate |
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| US8729263B2 (en) | 2012-08-13 | 2014-05-20 | Novartis Ag | 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions |
| US9040712B2 (en) | 2013-01-23 | 2015-05-26 | Novartis Ag | Thiadiazole analogs thereof and methods for treating SMN-deficiency-related-conditions |
| EP2958902B1 (en) | 2013-02-19 | 2017-11-15 | Amgen Inc. | Cis-morpholinone and other compounds as mdm2 inhibitors for the treatment of cancer |
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| JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
| MX2020011652A (es) | 2013-07-31 | 2022-09-27 | Novartis Ag | Derivados de piridazina 1,4-disustituida, y su uso para el tratamiento de afecciones relacionadas con la deficiencia de smn. |
| PT3068393T (pt) | 2013-11-11 | 2022-06-14 | Amgen Inc | Terapia de combinação, incluindo um inibidor de mdm2 e um ou mais agentes farmaceuticamente ativos adicionais para o tratamento de cancros |
| ES2666130T3 (es) | 2013-12-19 | 2018-05-03 | Idorsia Pharmaceuticals Ltd | Derivados antibacterianos de 1H-indazol y 1H-indol |
| RU2624857C1 (ru) * | 2016-01-26 | 2017-07-07 | федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургская государственная химико-фармацевтическая академия" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФА Минздрава России) | Фармацевтическая композиция с противогрибковой активностью и способ ее получения |
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| KR20210135241A (ko) | 2019-02-05 | 2021-11-12 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱을 조절하는 방법 및 조성물 |
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-
2005
- 2005-10-18 MX MX2007004551A patent/MX2007004551A/es active IP Right Grant
- 2005-10-18 WO PCT/US2005/037374 patent/WO2006044860A2/en not_active Ceased
- 2005-10-18 AU AU2005295441A patent/AU2005295441B2/en not_active Ceased
- 2005-10-18 EP EP05812533A patent/EP1809282B1/en not_active Expired - Lifetime
- 2005-10-18 KR KR1020077008816A patent/KR20070073791A/ko not_active Ceased
- 2005-10-18 US US11/251,846 patent/US7354944B2/en not_active Expired - Lifetime
- 2005-10-18 ES ES05812533T patent/ES2400689T3/es not_active Expired - Lifetime
- 2005-10-18 BR BRPI0516609-8A patent/BRPI0516609A/pt not_active IP Right Cessation
- 2005-10-18 EA EA200700886A patent/EA012181B1/ru not_active IP Right Cessation
- 2005-10-18 JP JP2007537015A patent/JP4931823B2/ja not_active Expired - Fee Related
- 2005-10-18 CA CA2583217A patent/CA2583217C/en not_active Expired - Fee Related
- 2005-10-18 CN CNA2005800356937A patent/CN101389335A/zh active Pending
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2007
- 2007-03-26 IL IL182203A patent/IL182203A0/en unknown
- 2007-05-16 ZA ZA200703975A patent/ZA200703975B/xx unknown
- 2007-05-17 MA MA29916A patent/MA29029B1/fr unknown
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2008
- 2008-03-19 US US12/077,634 patent/US7700636B2/en active Active
- 2008-03-19 US US12/077,633 patent/US7919514B2/en active Active
Also Published As
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| US20080255145A1 (en) | 2008-10-16 |
| EA012181B1 (ru) | 2009-08-28 |
| BRPI0516609A (pt) | 2008-04-29 |
| US20060154961A1 (en) | 2006-07-13 |
| US20080269243A1 (en) | 2008-10-30 |
| WO2006044860A2 (en) | 2006-04-27 |
| CA2583217A1 (en) | 2006-04-27 |
| US7700636B2 (en) | 2010-04-20 |
| ES2400689T3 (es) | 2013-04-11 |
| CA2583217C (en) | 2011-05-31 |
| US7919514B2 (en) | 2011-04-05 |
| AU2005295441A1 (en) | 2006-04-27 |
| MX2007004551A (es) | 2007-05-23 |
| ZA200703975B (en) | 2009-01-28 |
| EP1809282A4 (en) | 2009-11-25 |
| EA200700886A1 (ru) | 2008-02-28 |
| WO2006044860A3 (en) | 2007-07-05 |
| JP2008516986A (ja) | 2008-05-22 |
| EP1809282B1 (en) | 2013-01-09 |
| IL182203A0 (en) | 2007-07-24 |
| EP1809282A2 (en) | 2007-07-25 |
| JP4931823B2 (ja) | 2012-05-16 |
| MA29029B1 (fr) | 2007-11-01 |
| KR20070073791A (ko) | 2007-07-10 |
| US7354944B2 (en) | 2008-04-08 |
| AU2005295441B2 (en) | 2009-04-23 |
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