CN101348814A - 一种利用蛋白质等电点提高硫酸软骨素质量的方法 - Google Patents
一种利用蛋白质等电点提高硫酸软骨素质量的方法 Download PDFInfo
- Publication number
- CN101348814A CN101348814A CNA2008101247896A CN200810124789A CN101348814A CN 101348814 A CN101348814 A CN 101348814A CN A2008101247896 A CNA2008101247896 A CN A2008101247896A CN 200810124789 A CN200810124789 A CN 200810124789A CN 101348814 A CN101348814 A CN 101348814A
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- Prior art keywords
- chondroitin sulfate
- hour
- quality
- cartilage
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- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 21
- 229920001287 Chondroitin sulfate Polymers 0.000 title claims abstract description 20
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 title claims abstract description 18
- 229940059329 chondroitin sulfate Drugs 0.000 title claims abstract description 18
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 17
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 17
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 35
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 22
- 238000004062 sedimentation Methods 0.000 claims abstract description 22
- 108090000790 Enzymes Proteins 0.000 claims abstract description 16
- 102000004190 Enzymes Human genes 0.000 claims abstract description 16
- 239000011780 sodium chloride Substances 0.000 claims abstract description 11
- 238000000605 extraction Methods 0.000 claims abstract description 10
- 239000012043 crude product Substances 0.000 claims abstract description 6
- 238000009835 boiling Methods 0.000 claims abstract description 5
- 238000004140 cleaning Methods 0.000 claims abstract description 3
- 210000000845 cartilage Anatomy 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- 241000282894 Sus scrofa domesticus Species 0.000 claims description 11
- 210000000496 pancreas Anatomy 0.000 claims description 11
- 239000000706 filtrate Substances 0.000 claims description 10
- 239000000047 product Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- 238000000498 ball milling Methods 0.000 claims description 4
- 230000018044 dehydration Effects 0.000 claims description 4
- 238000006297 dehydration reaction Methods 0.000 claims description 4
- 239000002244 precipitate Substances 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 abstract description 19
- 108010019160 Pancreatin Proteins 0.000 abstract description 5
- 229940055695 pancreatin Drugs 0.000 abstract description 5
- 239000012535 impurity Substances 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 108091005804 Peptidases Proteins 0.000 description 7
- 102000035195 Peptidases Human genes 0.000 description 7
- 210000000988 bone and bone Anatomy 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 238000007254 oxidation reaction Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 238000004061 bleaching Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229940107200 chondroitin sulfates Drugs 0.000 description 2
- 208000029078 coronary artery disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 241000194108 Bacillus licheniformis Species 0.000 description 1
- 206010052895 Coronary artery insufficiency Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 208000004550 Postoperative Pain Diseases 0.000 description 1
- 206010039361 Sacroiliitis Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 238000013386 optimize process Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000015598 salt intake Nutrition 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- QTENRWWVYAAPBI-YCRXJPFRSA-N streptomycin sulfate Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](N=C(N)N)[C@H](O)[C@@H](N=C(N)N)[C@H](O)[C@H]1O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](N=C(N)N)[C@H](O)[C@@H](N=C(N)N)[C@H](O)[C@H]1O QTENRWWVYAAPBI-YCRXJPFRSA-N 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2008101247896A CN101348814B (zh) | 2008-09-03 | 2008-09-03 | 一种利用蛋白质等电点提高硫酸软骨素质量的方法 |
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CN2008101247896A CN101348814B (zh) | 2008-09-03 | 2008-09-03 | 一种利用蛋白质等电点提高硫酸软骨素质量的方法 |
Publications (2)
Publication Number | Publication Date |
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CN101348814A true CN101348814A (zh) | 2009-01-21 |
CN101348814B CN101348814B (zh) | 2012-03-14 |
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CN2008101247896A Expired - Fee Related CN101348814B (zh) | 2008-09-03 | 2008-09-03 | 一种利用蛋白质等电点提高硫酸软骨素质量的方法 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102659233A (zh) * | 2012-05-04 | 2012-09-12 | 泰祥集团技术开发有限公司 | 一种富蛋白废水中蛋白质的去除方法 |
CN103665188A (zh) * | 2013-11-23 | 2014-03-26 | 青岛九龙生物医药有限公司 | 碱-酶解法提取硫酸软骨素钠 |
CN105076725A (zh) * | 2015-09-02 | 2015-11-25 | 湖南伍星生物科技有限公司 | 一种提取软骨中硫酸软骨素联产氨基酸粉的工艺 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3271008B2 (ja) * | 1999-11-18 | 2002-04-02 | 独立行政法人産業技術総合研究所 | コンドロイチン硫酸類の製造方法 |
CN100417728C (zh) * | 2006-06-01 | 2008-09-10 | 扬州日兴生物化工制品有限公司 | 脱乙酰硫酸软骨素制备方法 |
-
2008
- 2008-09-03 CN CN2008101247896A patent/CN101348814B/zh not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102659233A (zh) * | 2012-05-04 | 2012-09-12 | 泰祥集团技术开发有限公司 | 一种富蛋白废水中蛋白质的去除方法 |
CN103665188A (zh) * | 2013-11-23 | 2014-03-26 | 青岛九龙生物医药有限公司 | 碱-酶解法提取硫酸软骨素钠 |
CN103665188B (zh) * | 2013-11-23 | 2016-04-13 | 青岛九龙生物医药有限公司 | 碱-酶解法提取硫酸软骨素钠 |
CN105076725A (zh) * | 2015-09-02 | 2015-11-25 | 湖南伍星生物科技有限公司 | 一种提取软骨中硫酸软骨素联产氨基酸粉的工艺 |
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CN101348814B (zh) | 2012-03-14 |
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Effective date of registration: 20090424 Address after: Code 5, new model street, Nanjing City, Jiangsu Province, China: 210009 Applicant after: Nanjing University of Technology Co-applicant after: Shuangfeng Shuangxing Biochemical Engineering Co., Ltd. Address before: Code 5, new model street, Nanjing City, Jiangsu Province, China: 210009 Applicant before: Nanjing University of Technology |
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Application publication date: 20090121 Assignee: HUNAN WUXING BIOLOGICAL TECHNOLOGY CO., LTD. Assignor: Nanjing University of Technology|Shuangfeng double star Biochemical Engineering Co., Ltd. Contract record no.: 2013430000072 Denomination of invention: Method for improving chondroitin sulfate quality by protein isoelectric point Granted publication date: 20120314 License type: Exclusive License Record date: 20130517 |
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