CN101321522B - 环氧丁醇中间体的制备方法 - Google Patents

环氧丁醇中间体的制备方法 Download PDF

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Publication number
CN101321522B
CN101321522B CN2006800449743A CN200680044974A CN101321522B CN 101321522 B CN101321522 B CN 101321522B CN 2006800449743 A CN2006800449743 A CN 2006800449743A CN 200680044974 A CN200680044974 A CN 200680044974A CN 101321522 B CN101321522 B CN 101321522B
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formula
compound
hal
reacted
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Chinese (zh)
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CN101321522A (zh
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M·莫勒尔
徐林
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Basilea Pharmaceutica AG
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Basilea Pharmaceutica AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
CN2006800449743A 2005-12-01 2006-11-29 环氧丁醇中间体的制备方法 Active CN101321522B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05026163 2005-12-01
EP05026163.5 2005-12-01
PCT/CH2006/000671 WO2007062542A2 (en) 2005-12-01 2006-11-29 Process for the manufacture of epoxybutanol intermediates

Publications (2)

Publication Number Publication Date
CN101321522A CN101321522A (zh) 2008-12-10
CN101321522B true CN101321522B (zh) 2012-05-30

Family

ID=36178579

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800449743A Active CN101321522B (zh) 2005-12-01 2006-11-29 环氧丁醇中间体的制备方法

Country Status (19)

Country Link
US (2) US7816537B2 (https=)
EP (2) EP1954264B1 (https=)
JP (1) JP5329969B2 (https=)
KR (1) KR101191682B1 (https=)
CN (1) CN101321522B (https=)
AT (1) ATE444747T1 (https=)
AU (2) AU2006319657B2 (https=)
BR (1) BRPI0619120B1 (https=)
CA (2) CA2711852C (https=)
CY (1) CY1110588T1 (https=)
DE (1) DE602006009698D1 (https=)
DK (1) DK1954264T3 (https=)
ES (1) ES2333258T3 (https=)
HR (1) HRP20090675T1 (https=)
PL (1) PL1954264T3 (https=)
PT (1) PT1954264E (https=)
SI (1) SI1954264T1 (https=)
WO (1) WO2007062542A2 (https=)
ZA (1) ZA200804218B (https=)

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TWI483950B (zh) 2009-09-21 2015-05-11 Gilead Sciences Inc 用於製備１’－取代碳核苷類似物之方法及中間物
BR122020020745B8 (pt) 2010-07-22 2023-10-31 Gilead Sciences Inc Composto antiviral para o tratamento de infecções por paramyxoviridae e composição farmacêutica que o compreende
HUE031679T2 (en) 2012-08-07 2017-07-28 Basilea Pharmaceutica Ag Process for the preparation of isavuconazole or ravuconazole
WO2015150947A1 (en) 2014-03-29 2015-10-08 Wockhardt Limited A process for the preparation of isavuconazole and its intermediates
TWI767201B (zh) 2014-10-29 2022-06-11 美商基利科學股份有限公司 絲狀病毒科病毒感染之治療
SI3349758T1 (sl) 2015-09-16 2022-08-31 Gilead Sciences, Inc. Postopki za zdravljenje okužb z virusom arenaviridae
CN105367528A (zh) * 2015-11-10 2016-03-02 南通诺泰生物医药技术有限公司 一种三唑类药物中间体(d)-1-(1-环烷仲胺基)-2-(2-四氢吡喃基)氧-1-丙酮类化合物及合成方法
US10682368B2 (en) 2017-03-14 2020-06-16 Gilead Sciences, Inc. Methods of treating feline coronavirus infections
AU2018262501B2 (en) 2017-05-01 2020-12-10 Gilead Sciences, Inc. Crystalline forms of (S) 2 ethylbutyl 2 (((S) (((2R,3S,4R,5R) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate
WO2019014247A1 (en) 2017-07-11 2019-01-17 Gilead Sciences, Inc. COMPOSITIONS COMPRISING POLYMERASE RNA INHIBITOR AND CYCLODEXTRIN FOR THE TREATMENT OF VIRAL INFECTIONS
WO2019031240A1 (ja) 2017-08-10 2019-02-14 住友化学株式会社 エポキシアルコール化合物の製造方法
US11660307B2 (en) 2020-01-27 2023-05-30 Gilead Sciences, Inc. Methods for treating SARS CoV-2 infections
JP7554841B2 (ja) 2020-03-12 2024-09-20 ギリアード サイエンシーズ， インコーポレイテッド １’－シアノヌクレオシドを調製する方法
WO2021207049A1 (en) 2020-04-06 2021-10-14 Gilead Sciences, Inc. Inhalation formulations of 1'-cyano substituted carbanucleoside analogs
CA3179226A1 (en) 2020-05-29 2021-12-02 Tomas Cihlar Remdesivir treatment methods
AU2021296841B2 (en) 2020-06-24 2025-01-23 Gilead Sciences, Inc. 1'-cyano nucleoside analogs and uses thereof
SI4204421T1 (sl) 2020-08-27 2024-07-31 Gilead Sciences, Inc., Spojine in postopki za zdravljenje virusnih okužb
IL315102A (en) 2022-03-02 2024-10-01 Gilead Sciences Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
US12357577B1 (en) 2024-02-02 2025-07-15 Gilead Sciences, Inc. Pharmaceutical formulations and uses thereof
CN115536643A (zh) * 2022-12-05 2022-12-30 南京桦冠生物技术有限公司 一种艾沙康唑类药物关键中间体的制备方法
CN119264078B (zh) * 2024-12-09 2025-08-01 浙江世佳科技股份有限公司 一种(5s,6r)-5,6-环氧-2-十七碳炔-1-醇的合成方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045008A1 (en) * 1998-03-06 1999-09-10 F. Hoffmann-La Roche Ag 3-[4-(4-cyanophenyl)thiazol-2-y)]-1-(1h-1,2,4-triazol-1-yl)-butan-2-ol derivatives having antifungal activity
WO1999052840A1 (en) * 1998-04-15 1999-10-21 Naeja Pharmaceutical Inc. Asymmetric synthesis of 2-aryl-1-substituted butan-2,3-diols
EP1083175A2 (en) * 1999-09-09 2001-03-14 Sankyo Company Limited Triazole derivatives having antifungal activity
EP1535914A1 (en) * 2002-06-20 2005-06-01 Sumitomo Chemical Company, Limited Processes for producing epoxytriazole derivative and intermediate therefor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3452213B2 (ja) * 1994-07-05 2003-09-29 エーザイ株式会社 抗真菌剤及びその製造方法
JP4627413B2 (ja) * 2003-05-06 2011-02-09 三井化学株式会社 １−アゾール−２−フェニル−２、３−プロパンジオール誘導体の製造法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045008A1 (en) * 1998-03-06 1999-09-10 F. Hoffmann-La Roche Ag 3-[4-(4-cyanophenyl)thiazol-2-y)]-1-(1h-1,2,4-triazol-1-yl)-butan-2-ol derivatives having antifungal activity
WO1999052840A1 (en) * 1998-04-15 1999-10-21 Naeja Pharmaceutical Inc. Asymmetric synthesis of 2-aryl-1-substituted butan-2,3-diols
EP1083175A2 (en) * 1999-09-09 2001-03-14 Sankyo Company Limited Triazole derivatives having antifungal activity
EP1535914A1 (en) * 2002-06-20 2005-06-01 Sumitomo Chemical Company, Limited Processes for producing epoxytriazole derivative and intermediate therefor

Also Published As

Publication number Publication date
US20110021794A1 (en) 2011-01-27
HRP20090675T1 (hr) 2010-01-31
PT1954264E (pt) 2009-12-23
JP2009517413A (ja) 2009-04-30
US7816537B2 (en) 2010-10-19
US8076494B2 (en) 2011-12-13
SI1954264T1 (sl) 2010-01-29
EP1954264A2 (en) 2008-08-13
DE602006009698D1 (de) 2009-11-19
BRPI0619120A2 (pt) 2011-09-13
WO2007062542A2 (en) 2007-06-07
BRPI0619120B1 (pt) 2023-10-10
PL1954264T3 (pl) 2010-02-26
CA2629092C (en) 2012-01-03
CN101321522A (zh) 2008-12-10
WO2007062542A3 (en) 2007-11-01
DK1954264T3 (da) 2010-01-11
EP2133345A1 (en) 2009-12-16
CA2629092A1 (en) 2007-06-07
KR20080075014A (ko) 2008-08-13
CA2711852C (en) 2011-10-04
CY1110588T1 (el) 2015-04-29
EP1954264B1 (en) 2009-10-07
AU2010203301B2 (en) 2012-06-21
AU2006319657A1 (en) 2007-06-07
ZA200804218B (en) 2009-01-28
US20090299073A1 (en) 2009-12-03
ES2333258T3 (es) 2010-02-18
CA2711852A1 (en) 2007-06-07
KR101191682B1 (ko) 2012-10-16
ATE444747T1 (de) 2009-10-15
JP5329969B2 (ja) 2013-10-30
AU2006319657B2 (en) 2010-08-12
AU2010203301A1 (en) 2010-08-12

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