DE602006009698D1 - Verfahren zur herstellung von expoxybutanol-zwischenprodukten - Google Patents
Verfahren zur herstellung von expoxybutanol-zwischenproduktenInfo
- Publication number
- DE602006009698D1 DE602006009698D1 DE602006009698T DE602006009698T DE602006009698D1 DE 602006009698 D1 DE602006009698 D1 DE 602006009698D1 DE 602006009698 T DE602006009698 T DE 602006009698T DE 602006009698 T DE602006009698 T DE 602006009698T DE 602006009698 D1 DE602006009698 D1 DE 602006009698D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- expoxybutanol
- preparing
- intermediate products
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000006661 (C4-C6) heterocyclic group Chemical group 0.000 abstract 1
- QUGUFLJIAFISSW-UHFFFAOYSA-N 1,4-difluorobenzene Chemical compound FC1=CC=C(F)C=C1 QUGUFLJIAFISSW-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Chemical group 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05026163 | 2005-12-01 | ||
| PCT/CH2006/000671 WO2007062542A2 (en) | 2005-12-01 | 2006-11-29 | Process for the manufacture of epoxybutanol intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602006009698D1 true DE602006009698D1 (de) | 2009-11-19 |
Family
ID=36178579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602006009698T Active DE602006009698D1 (de) | 2005-12-01 | 2006-11-29 | Verfahren zur herstellung von expoxybutanol-zwischenprodukten |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7816537B2 (https=) |
| EP (2) | EP1954264B1 (https=) |
| JP (1) | JP5329969B2 (https=) |
| KR (1) | KR101191682B1 (https=) |
| CN (1) | CN101321522B (https=) |
| AT (1) | ATE444747T1 (https=) |
| AU (2) | AU2006319657B2 (https=) |
| BR (1) | BRPI0619120B1 (https=) |
| CA (2) | CA2711852C (https=) |
| CY (1) | CY1110588T1 (https=) |
| DE (1) | DE602006009698D1 (https=) |
| DK (1) | DK1954264T3 (https=) |
| ES (1) | ES2333258T3 (https=) |
| HR (1) | HRP20090675T1 (https=) |
| PL (1) | PL1954264T3 (https=) |
| PT (1) | PT1954264E (https=) |
| SI (1) | SI1954264T1 (https=) |
| WO (1) | WO2007062542A2 (https=) |
| ZA (1) | ZA200804218B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI483950B (zh) | 2009-09-21 | 2015-05-11 | Gilead Sciences Inc | 用於製備１’－取代碳核苷類似物之方法及中間物 |
| BR122020020745B8 (pt) | 2010-07-22 | 2023-10-31 | Gilead Sciences Inc | Composto antiviral para o tratamento de infecções por paramyxoviridae e composição farmacêutica que o compreende |
| HUE031679T2 (en) | 2012-08-07 | 2017-07-28 | Basilea Pharmaceutica Ag | Process for the preparation of isavuconazole or ravuconazole |
| WO2015150947A1 (en) | 2014-03-29 | 2015-10-08 | Wockhardt Limited | A process for the preparation of isavuconazole and its intermediates |
| TWI767201B (zh) | 2014-10-29 | 2022-06-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
| SI3349758T1 (sl) | 2015-09-16 | 2022-08-31 | Gilead Sciences, Inc. | Postopki za zdravljenje okužb z virusom arenaviridae |
| CN105367528A (zh) * | 2015-11-10 | 2016-03-02 | 南通诺泰生物医药技术有限公司 | 一种三唑类药物中间体(d)-1-(1-环烷仲胺基)-2-(2-四氢吡喃基)氧-1-丙酮类化合物及合成方法 |
| US10682368B2 (en) | 2017-03-14 | 2020-06-16 | Gilead Sciences, Inc. | Methods of treating feline coronavirus infections |
| AU2018262501B2 (en) | 2017-05-01 | 2020-12-10 | Gilead Sciences, Inc. | Crystalline forms of (S) 2 ethylbutyl 2 (((S) (((2R,3S,4R,5R) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
| WO2019014247A1 (en) | 2017-07-11 | 2019-01-17 | Gilead Sciences, Inc. | COMPOSITIONS COMPRISING POLYMERASE RNA INHIBITOR AND CYCLODEXTRIN FOR THE TREATMENT OF VIRAL INFECTIONS |
| WO2019031240A1 (ja) | 2017-08-10 | 2019-02-14 | 住友化学株式会社 | エポキシアルコール化合物の製造方法 |
| US11660307B2 (en) | 2020-01-27 | 2023-05-30 | Gilead Sciences, Inc. | Methods for treating SARS CoV-2 infections |
| JP7554841B2 (ja) | 2020-03-12 | 2024-09-20 | ギリアード サイエンシーズ， インコーポレイテッド | １’－シアノヌクレオシドを調製する方法 |
| WO2021207049A1 (en) | 2020-04-06 | 2021-10-14 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
| CA3179226A1 (en) | 2020-05-29 | 2021-12-02 | Tomas Cihlar | Remdesivir treatment methods |
| AU2021296841B2 (en) | 2020-06-24 | 2025-01-23 | Gilead Sciences, Inc. | 1'-cyano nucleoside analogs and uses thereof |
| SI4204421T1 (sl) | 2020-08-27 | 2024-07-31 | Gilead Sciences, Inc., | Spojine in postopki za zdravljenje virusnih okužb |
| IL315102A (en) | 2022-03-02 | 2024-10-01 | Gilead Sciences Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
| CN115536643A (zh) * | 2022-12-05 | 2022-12-30 | 南京桦冠生物技术有限公司 | 一种艾沙康唑类药物关键中间体的制备方法 |
| CN119264078B (zh) * | 2024-12-09 | 2025-08-01 | 浙江世佳科技股份有限公司 | 一种(5s,6r)-5,6-环氧-2-十七碳炔-1-醇的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3452213B2 (ja) * | 1994-07-05 | 2003-09-29 | エーザイ株式会社 | 抗真菌剤及びその製造方法 |
| AU2931399A (en) | 1998-03-06 | 1999-09-20 | F. Hoffmann-La Roche Ag | 3-(4-(4-cyanophenyl)thiazol-2-y))-1-(1h-1,2,4-triazol-1-yl) -butan-2-ol derivatives having antifungal activity |
| US6133485A (en) | 1998-04-15 | 2000-10-17 | Synphar Laboratories, Inc. | Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols |
| US6391903B1 (en) | 1999-09-09 | 2002-05-21 | Sankyo Company, Limited | Triazole derivatives having antifungal activity |
| US6884892B2 (en) | 2002-06-20 | 2005-04-26 | Sumitomo Chemical Company, Limited | Production methods of epoxytriazole derivative and intermediate therefor |
| JP4627413B2 (ja) * | 2003-05-06 | 2011-02-09 | 三井化学株式会社 | １−アゾール−２−フェニル−２、３−プロパンジオール誘導体の製造法 |
-
2006
- 2006-11-29 EP EP06804890A patent/EP1954264B1/en active Active
- 2006-11-29 HR HR20090675T patent/HRP20090675T1/hr unknown
- 2006-11-29 JP JP2008542575A patent/JP5329969B2/ja not_active Expired - Fee Related
- 2006-11-29 AU AU2006319657A patent/AU2006319657B2/en not_active Ceased
- 2006-11-29 CA CA2711852A patent/CA2711852C/en active Active
- 2006-11-29 CN CN2006800449743A patent/CN101321522B/zh active Active
- 2006-11-29 CA CA2629092A patent/CA2629092C/en active Active
- 2006-11-29 AT AT06804890T patent/ATE444747T1/de active
- 2006-11-29 EP EP09168177A patent/EP2133345A1/en not_active Withdrawn
- 2006-11-29 WO PCT/CH2006/000671 patent/WO2007062542A2/en not_active Ceased
- 2006-11-29 DE DE602006009698T patent/DE602006009698D1/de active Active
- 2006-11-29 PT PT06804890T patent/PT1954264E/pt unknown
- 2006-11-29 ES ES06804890T patent/ES2333258T3/es active Active
- 2006-11-29 SI SI200630502T patent/SI1954264T1/sl unknown
- 2006-11-29 PL PL06804890T patent/PL1954264T3/pl unknown
- 2006-11-29 US US12/085,617 patent/US7816537B2/en active Active
- 2006-11-29 BR BRPI0619120-7A patent/BRPI0619120B1/pt not_active IP Right Cessation
- 2006-11-29 DK DK06804890T patent/DK1954264T3/da active
- 2006-11-29 KR KR1020087015976A patent/KR101191682B1/ko active Active
-
2008
- 2008-05-15 ZA ZA200804218A patent/ZA200804218B/xx unknown
-
2009
- 2009-12-29 CY CY20091101343T patent/CY1110588T1/el unknown
-
2010
- 2010-07-23 AU AU2010203301A patent/AU2010203301B2/en not_active Ceased
- 2010-08-31 US US12/872,599 patent/US8076494B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |