CN101272760A - 用于供应矿质营养素的食品添加剂 - Google Patents
用于供应矿质营养素的食品添加剂 Download PDFInfo
- Publication number
- CN101272760A CN101272760A CNA2006800353806A CN200680035380A CN101272760A CN 101272760 A CN101272760 A CN 101272760A CN A2006800353806 A CNA2006800353806 A CN A2006800353806A CN 200680035380 A CN200680035380 A CN 200680035380A CN 101272760 A CN101272760 A CN 101272760A
- Authority
- CN
- China
- Prior art keywords
- acid
- food additive
- aforementioned
- calcium
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011707 mineral Substances 0.000 title claims abstract description 52
- 235000013373 food additive Nutrition 0.000 title claims abstract description 34
- 239000002778 food additive Substances 0.000 title claims abstract description 34
- 235000010755 mineral Nutrition 0.000 title claims description 49
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 18
- 239000000654 additive Substances 0.000 claims abstract description 6
- 230000000996 additive effect Effects 0.000 claims abstract description 6
- 230000004060 metabolic process Effects 0.000 claims abstract description 4
- 239000011575 calcium Substances 0.000 claims description 40
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 27
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 26
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 26
- 229960005069 calcium Drugs 0.000 claims description 26
- 229910052791 calcium Inorganic materials 0.000 claims description 26
- 239000002253 acid Substances 0.000 claims description 22
- 235000013305 food Nutrition 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 19
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 13
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 13
- 239000001527 calcium lactate Substances 0.000 claims description 13
- 235000011086 calcium lactate Nutrition 0.000 claims description 13
- 239000011777 magnesium Substances 0.000 claims description 13
- 229910052749 magnesium Inorganic materials 0.000 claims description 13
- 229940091250 magnesium supplement Drugs 0.000 claims description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 12
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 12
- 229960002401 calcium lactate Drugs 0.000 claims description 12
- 239000000174 gluconic acid Substances 0.000 claims description 12
- 235000012208 gluconic acid Nutrition 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 11
- 239000001630 malic acid Substances 0.000 claims description 11
- 235000011090 malic acid Nutrition 0.000 claims description 11
- 239000000047 product Substances 0.000 claims description 11
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 10
- 230000007935 neutral effect Effects 0.000 claims description 10
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 9
- 239000004227 calcium gluconate Substances 0.000 claims description 9
- 235000013927 calcium gluconate Nutrition 0.000 claims description 9
- 229960004494 calcium gluconate Drugs 0.000 claims description 9
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 9
- 235000015165 citric acid Nutrition 0.000 claims description 9
- 235000013361 beverage Nutrition 0.000 claims description 8
- 235000020188 drinking water Nutrition 0.000 claims description 8
- 239000003651 drinking water Substances 0.000 claims description 8
- 150000002500 ions Chemical class 0.000 claims description 8
- 235000019640 taste Nutrition 0.000 claims description 8
- 229910019142 PO4 Inorganic materials 0.000 claims description 7
- 150000001768 cations Chemical class 0.000 claims description 7
- -1 fluorion Chemical compound 0.000 claims description 7
- 239000010452 phosphate Substances 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 5
- 239000001110 calcium chloride Substances 0.000 claims description 5
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 5
- 239000004310 lactic acid Substances 0.000 claims description 5
- 235000014655 lactic acid Nutrition 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 229960002337 magnesium chloride Drugs 0.000 claims description 5
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 5
- 239000001755 magnesium gluconate Substances 0.000 claims description 5
- 229960003035 magnesium gluconate Drugs 0.000 claims description 5
- 235000015778 magnesium gluconate Nutrition 0.000 claims description 5
- OVGXLJDWSLQDRT-UHFFFAOYSA-L magnesium lactate Chemical compound [Mg+2].CC(O)C([O-])=O.CC(O)C([O-])=O OVGXLJDWSLQDRT-UHFFFAOYSA-L 0.000 claims description 5
- 239000000626 magnesium lactate Substances 0.000 claims description 5
- 229960004658 magnesium lactate Drugs 0.000 claims description 5
- 235000015229 magnesium lactate Nutrition 0.000 claims description 5
- IAKLPCRFBAZVRW-XRDLMGPZSA-L magnesium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate;hydrate Chemical compound O.[Mg+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O IAKLPCRFBAZVRW-XRDLMGPZSA-L 0.000 claims description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 241001597008 Nomeidae Species 0.000 claims description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- 235000011054 acetic acid Nutrition 0.000 claims description 4
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims description 4
- 239000001639 calcium acetate Substances 0.000 claims description 4
- 235000011092 calcium acetate Nutrition 0.000 claims description 4
- 229960005147 calcium acetate Drugs 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000032050 esterification Effects 0.000 claims description 4
- 238000005886 esterification reaction Methods 0.000 claims description 4
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims description 4
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 4
- 239000011574 phosphorus Substances 0.000 claims description 4
- 229910052698 phosphorus Inorganic materials 0.000 claims description 4
- 239000006187 pill Substances 0.000 claims description 4
- 239000000829 suppository Substances 0.000 claims description 4
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 3
- 150000001450 anions Chemical class 0.000 claims description 3
- 235000015218 chewing gum Nutrition 0.000 claims description 3
- 229940112822 chewing gum Drugs 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 210000000214 mouth Anatomy 0.000 claims description 3
- 150000007524 organic acids Chemical class 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 239000010902 straw Substances 0.000 claims description 3
- 229940034610 toothpaste Drugs 0.000 claims description 3
- 239000000606 toothpaste Substances 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 229960005070 ascorbic acid Drugs 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 239000010941 cobalt Substances 0.000 claims description 2
- 229910017052 cobalt Inorganic materials 0.000 claims description 2
- 235000018417 cysteine Nutrition 0.000 claims description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- 235000011087 fumaric acid Nutrition 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 235000019605 sweet taste sensations Nutrition 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- 229940005605 valeric acid Drugs 0.000 claims description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 3
- 239000004575 stone Substances 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 1
- 235000019636 bitter flavor Nutrition 0.000 claims 1
- 229910052796 boron Inorganic materials 0.000 claims 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims 1
- 229940050410 gluconate Drugs 0.000 claims 1
- 239000013067 intermediate product Substances 0.000 claims 1
- 229940001447 lactate Drugs 0.000 claims 1
- 229910052744 lithium Inorganic materials 0.000 claims 1
- 229940049920 malate Drugs 0.000 claims 1
- 229960003975 potassium Drugs 0.000 claims 1
- 238000010926 purge Methods 0.000 claims 1
- 229910052711 selenium Inorganic materials 0.000 claims 1
- 239000011669 selenium Substances 0.000 claims 1
- 235000013618 yogurt Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 8
- 235000001465 calcium Nutrition 0.000 description 24
- 210000003296 saliva Anatomy 0.000 description 15
- 230000000694 effects Effects 0.000 description 11
- 229950006191 gluconic acid Drugs 0.000 description 11
- 210000003298 dental enamel Anatomy 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 230000008901 benefit Effects 0.000 description 8
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical class [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 8
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 7
- 229910001424 calcium ion Inorganic materials 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 230000008859 change Effects 0.000 description 6
- 235000009508 confectionery Nutrition 0.000 description 6
- 230000003993 interaction Effects 0.000 description 6
- 235000019658 bitter taste Nutrition 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 235000016709 nutrition Nutrition 0.000 description 5
- 230000035764 nutrition Effects 0.000 description 5
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 235000013405 beer Nutrition 0.000 description 4
- 239000001506 calcium phosphate Substances 0.000 description 4
- 229910000389 calcium phosphate Inorganic materials 0.000 description 4
- 235000011010 calcium phosphates Nutrition 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 235000012976 tarts Nutrition 0.000 description 4
- 235000013619 trace mineral Nutrition 0.000 description 4
- 239000011573 trace mineral Substances 0.000 description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical compound C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 3
- 229910001573 adamantine Inorganic materials 0.000 description 3
- 230000003197 catalytic effect Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 208000002925 dental caries Diseases 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 208000002064 Dental Plaque Diseases 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 229960000448 lactic acid Drugs 0.000 description 2
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 description 2
- 239000011654 magnesium acetate Substances 0.000 description 2
- 235000011285 magnesium acetate Nutrition 0.000 description 2
- 229940069446 magnesium acetate Drugs 0.000 description 2
- 159000000003 magnesium salts Chemical class 0.000 description 2
- 229940099690 malic acid Drugs 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000009938 salting Methods 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 230000036962 time dependent Effects 0.000 description 2
- ODIGIKRIUKFKHP-UHFFFAOYSA-N (n-propan-2-yloxycarbonylanilino) acetate Chemical compound CC(C)OC(=O)N(OC(C)=O)C1=CC=CC=C1 ODIGIKRIUKFKHP-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 206010006956 Calcium deficiency Diseases 0.000 description 1
- 235000021490 Caloric beverage Nutrition 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241001251068 Formica fusca Species 0.000 description 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 208000004547 Hallucinations Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 208000000913 Kidney Calculi Diseases 0.000 description 1
- 235000019738 Limestone Nutrition 0.000 description 1
- 206010029148 Nephrolithiasis Diseases 0.000 description 1
- NITOTOUWVKRSNV-UHFFFAOYSA-L O.C(C)(=O)[O-].[Ca+2].C(C)(=O)[O-].[Ca+2] Chemical compound O.C(C)(=O)[O-].[Ca+2].C(C)(=O)[O-].[Ca+2] NITOTOUWVKRSNV-UHFFFAOYSA-L 0.000 description 1
- GDRDRPDYYSTPLC-UHFFFAOYSA-L O.O.O.O.C(C)(=O)[O-].[Mg+2].C(C)(=O)[O-].[Mg+2] Chemical compound O.O.O.O.C(C)(=O)[O-].[Mg+2].C(C)(=O)[O-].[Mg+2] GDRDRPDYYSTPLC-UHFFFAOYSA-L 0.000 description 1
- DMGNFLJBACZMRM-UHFFFAOYSA-N O[P] Chemical compound O[P] DMGNFLJBACZMRM-UHFFFAOYSA-N 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 235000010678 Paulownia tomentosa Nutrition 0.000 description 1
- 240000002834 Paulownia tomentosa Species 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000003217 Tetany Diseases 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 206010072665 Tooth demineralisation Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 235000012970 cakes Nutrition 0.000 description 1
- 150000001669 calcium Chemical class 0.000 description 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 1
- 239000001354 calcium citrate Substances 0.000 description 1
- 229960004256 calcium citrate Drugs 0.000 description 1
- 229940041131 calcium lactate gluconate Drugs 0.000 description 1
- OLOZVPHKXALCRI-UHFFFAOYSA-L calcium malate Chemical compound [Ca+2].[O-]C(=O)C(O)CC([O-])=O OLOZVPHKXALCRI-UHFFFAOYSA-L 0.000 description 1
- 239000001362 calcium malate Substances 0.000 description 1
- 229940016114 calcium malate Drugs 0.000 description 1
- 235000011038 calcium malates Nutrition 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- ZQNPDAVSHFGLIQ-UHFFFAOYSA-N calcium;hydrate Chemical compound O.[Ca] ZQNPDAVSHFGLIQ-UHFFFAOYSA-N 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 235000014651 chocolate spreads Nutrition 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- GSOLWAFGMNOBSY-UHFFFAOYSA-N cobalt Chemical compound [Co][Co][Co][Co][Co][Co][Co][Co] GSOLWAFGMNOBSY-UHFFFAOYSA-N 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000001447 compensatory effect Effects 0.000 description 1
- 235000014510 cooky Nutrition 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- CPEPWXXWVALFCE-UHFFFAOYSA-J dicalcium 2-hydroxypropanoate Chemical compound [Ca+2].[Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O CPEPWXXWVALFCE-UHFFFAOYSA-J 0.000 description 1
- WGHSLKCFQCSEIA-UHFFFAOYSA-L dimagnesium dichloride hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].Cl[Mg]Cl WGHSLKCFQCSEIA-UHFFFAOYSA-L 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000009246 food effect Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000019990 fruit wine Nutrition 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011868 grain product Nutrition 0.000 description 1
- 235000015220 hamburgers Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000011167 hydrochloric acid Nutrition 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000006028 limestone Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- OVGXLJDWSLQDRT-CEOVSRFSSA-L magnesium;(2s)-2-hydroxypropanoate Chemical compound [Mg+2].C[C@H](O)C([O-])=O.C[C@H](O)C([O-])=O OVGXLJDWSLQDRT-CEOVSRFSSA-L 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 208000035824 paresthesia Diseases 0.000 description 1
- 150000004686 pentahydrates Chemical class 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001915 proofreading effect Effects 0.000 description 1
- 235000011962 puddings Nutrition 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000011833 salt mixture Substances 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
- Seasonings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
本发明涉及作为浓缩添加剂用于给人类代谢供应矿质营养素的食品添加剂。所述矿质营养素是离子化形式的盐-水合物熔化物的组分,并且所述的盐-水合物熔化物是盐-水系统,并且其含水量对应于主要水合离子的配位数。
Description
本发明涉及用于给人类代谢供应矿质营养素(mineral nutrients)的食品添加剂。
对人体而言,矿质营养素是生存所需的无机营养素。由于生物体自身不能产生这些营养素,所以它们必须从我们所食用的食物中供应。但是,正如维生素类那样,矿质营养素不是能源,这就意味着它们基本上不涉及能量代谢。
大多数矿质营养素是所谓的构建物质(building substances)或调节物质(regulator substances)。构建物质包括钙、磷和镁,调节物质包括碘、钠、钾、铁和氯。仅有少数矿质营养素同时具有上述两种性质。例如,磷在构建骨骼和牙齿中起作用,同时还在调节酸/碱平衡中起作用。
在人类有机体中,矿质营养素对于许多功能而言是必不可少的组分。对身体物质例如骨骼、牙齿和肌肉的发育而言,矿质营养素提供了强度和弹性。体液基本必需的性质受到作为电解质的溶解的矿质营养素的影响。其包括例如维持渗透压。
矿质营养素也是体内有机化合物的必需组分。碘是甲状腺激素的组分。钴包含在维生素B12中,血液的着色剂血红蛋白需要铁。
根据德国营养学会(Deutsche Gesellschaft für )的推荐,青少年和成人根据其年龄和性别,每天需要至少1000-1200mg钙、700-1250mg磷、350-400mg镁、12-15mg铁、150-200mg碘、7-10mg锌以及少量的其它矿质营养素(所谓的痕量元素)。人类有机体在其数千个世代的发展过程中已经适应了包含至少2/3植物组分的膳食。由K.Gedrich和G.Karg在德国慕尼黑工业大学(Munich University of Technology)进行的最新研究显示,德国实际膳食在充足供应矿质方面完全偏离了最佳的营养学:与推荐量相比,实际消耗的水果和蔬菜降低至一半,并且谷类产品和马铃薯降至2/3。在女性中,蔬菜的消耗量甚至降至1/3,然而在另一方面,肉、鱼和蛋的消耗量上升到推荐量的1.3倍。它们的地位已经被在厨房加工的或通过工业加工方式制备的食品取代。这些方式导致矿质营养素和痕量元素(经常是显著的)损失。这造成居民的矿质营养素平均供应急剧下降。
现有技术中已知有多种试图补救上述缺陷的食品添加剂。但是它们具有许多缺点。根据专利文件DE 10349050A1,将可键合的钙和磷酸盐引入食品中,例如水果味的橡皮糖(gummi candy)、明胶产品或其它糖果。缺点在于:当添加了推荐量的含有矿质营养素的添加剂后,它们在工业加工过程中沉淀成晶体,而且以难以接受的方式造成产品暗淡。如果蒸发浓缩混合物到晶体不再形成的量,则矿质营养素含量过低以至于所期望的效果降至近乎无意义的水平。
在上述方法中,不期望的结晶问题可以通过使用来自所述化合物或混合物的反应活性的钙供体来降低,其中可以另外加入酸和不同水平的钙复合物。但是该方法造成下述缺点,即,溶液中过高的含水量再次限制了可达到的钙浓度并因此再次将效能降至无意义的水平。
Jarcho在美国专利4,097,935中描述了可选择的推荐溶液。他建议将过饱和的羟磷灰石溶液作为漱口剂。对此,同样,可达到的浓度过低以至于仅能采用非常长时间地和不切实际地频繁冲洗来达到所期望的效果。
在美国专利4,080,440中,Digiulio描述了钙和磷酸根的低pH亚稳溶液。预期的作用机制是在pH升高后,钙和磷酸根沉淀在牙釉质的脱矿质的孔中,尤其是与起催化作用的氟离子一起使用时。此处的危险是牙釉质在预期效果之前已经由于低pH而变得脱矿化,并且将引起组织损伤。
根据美国专利4,606,912,Rudy尝试了应用含有钙离子来源和用于钙离子的螯合试剂的水性溶液。但是,由于难以控制螯合试剂,这是一种不切实际的方法。
在不同的变通方法中,Tung(美国专利5,037,639和5,268,167和5,437,857以及5,460,803)建议了包含钙盐、磷酸盐和碳酸盐的粉末。在溶于唾液后,该粉末沉淀为无定形的磷酸钙。但是其稳定性存在疑问。
普遍来说,牙釉质再矿质化的实例说明关于供应矿质营养素的添加剂的主要问题并未解决。在所讨论的实例中,三个最重要的缺点如下:
实际达到的钙离子和磷酸根离子的浓度对于有效作用而言过低,或
溶液水分过多并因此在很大程度上无效,或
pH显著偏离4.5的生理pH,损伤口腔、咽喉、胃和消化道的粘膜,和/或造成其非常难于掺入食品。
本发明的目的是通过生产含有可容易吸收形式的矿质营养素的食品添加剂来提供这些矿质营养素和痕量元素的充足供应。
该目的通过下述方式得以满足:矿质营养素是离子化形式的盐-水合物熔化物(salt hydrate melt)的组分,其中所述的盐-水合物熔化物是盐-水系统并且其含水量对应于主要水合离子(most hydrated ion)的配位数。
众所周知,配位数是离子周围最接近的相邻离子的数目,并且已知水合作用是H2O结合于离子。
该食品添加剂具有多个优点。根据其原理,可以提供人类有机体所需的几乎所有矿质营养素和痕量元素,尤其是以离子化形式来提供以便它们可以特别容易地被有机体处理。对于食品生产过程中的加工而言,最为重要的好处是盐-水合物熔化物以其无定形的固化形式可以被长期储存而不会变得不稳定,其可以容易地通过加入少量水和/或改变温度来调节其粘度以适应具体食品的生产过程。由于这两个参数对调节粘度均有效,因此对于在特定温度下的加工或其中粘度很重要的加工的适应不再成为问题。
对于将本发明的食品添加剂与其它食品结合而言,有利的是在生产中可以使用多种有机酸,如葡萄糖酸、乳酸、柠檬酸、醋酸、苹果酸、富马酸、戊酸、抗坏血酸、半胱氨酸、戊二酸或其它适用于食品的酸化剂,以及它们的盐。同样有利的是,在本发明的变通方法中可以使用无机酸根,即,例如氯离子、硫酸根、磷酸根、氟离子、碳酸根或它们的部分酯化衍生物。这导致了以下的优点:在与无机酸根如氯离子形成的盐的情况下,所述酸根具有低分子量。因此在最终产品中获得很高重量百分比的阳离子是可能的。例如,通过使用氯离子,终产品中阳离子的重量百分比可以显著增加,而同时保持粘度。阳离子占最终产品总重量的最大重量百分比主要是由阴离子的分子量和化合价所决定的。根据盐混合物的组成,得到不同的最大阳离子百分比理论值。如果分子量为M1、M2和M3的三种盐CaA1、CaA2和CaA3以分子百分比x1、x2和x3进行混合,其中x1+x2+x3=1,则所获Ca的最大摩尔浓度含量如下:
Camax.=1/(x1*M1+x2*M2+x3*M3)。
本发明的产品可以采用为根据上式计算出的最大可能矿质营养素含量的10%-95%的矿质营养素含量进行生产和加工。通过轻微改变水分含量,可以在较宽范围内改变粘度。
有利的是,所述盐-水合物熔化物的预期pH可以通过选择适宜的衍生物来预先确定。对于处在约6.5-7的生理范围内的食品而言,含有无机和有机酸盐的熔化物是适宜的。对于具有低pH(酸性)的食品而言,可以采用过量的酸制备盐-水合物熔化物。它们作为酸味食物(dishes)或糖果的添加剂是适宜的。酸性的盐-水合物熔化物甚至有可能将矿质营养素与硬糖的糖熔化物混合;由明胶和其它增稠剂制成的可咀嚼混合物同样可以添加矿质营养素来进行改善。
在生理学上中性的熔化物的实例有:乳酸钙和葡萄糖酸钙,或扩展为乳酸镁。为了提供钙的酸性熔化物,可以将乳酸钙用葡萄糖酸进行酸化。根据食品所需的口味,可以添加苹果酸或柠檬酸,或者苹果酸连同柠檬酸,以及其它批准的酸化剂。为了提供镁,可以使葡萄糖酸和乳酸钙的熔化物添加有镁盐,例如醋酸、葡萄糖酸、乳酸或盐酸的镁盐。切乎实际的实例包括酸味的可咀嚼混合物如水果味的橡皮糖,其中盐-水合物熔化物可以是葡萄糖酸钙、乳酸钙、苹果酸钙和柠檬酸钙的酸味混合物。
本发明的食品添加剂的另外优点是可以影响产品的口味。乳酸钙产生轻微的苦味,因而适于具有苦杏仁味的软饮料、混合饮料、布丁和食物(dishes),或《德国啤酒纯度法规》(German beer purity regulations)之外的苦味型啤酒。氯化钙或氯化镁引起强烈的苦味。带有微苦余味的微甜口味用醋酸钙组分获得;因此适于例如用于柑橘果酱、糖果和类似于苦柠檬的果汁饮料。对于其中影响味道是不利的应用,无味的葡萄糖酸镁或钙是占有优势的。在其中苦味受到欢迎的应用或者其中可以形成新的口味体验或使用适宜的香味进行掩盖的应用中,本发明的实施方案将发现其中无机酸盐用作阳离子来源的应用。选择使用例如具有强烈苦味的盐氯化镁和氯化钙具有下述优点:可以掺合相对而言非常高的重量百分比的矿质营养素。这特别对于氯化钙而言是非常有利的,因为正如上文所述的那样,钙是人生物体所需要的最大量的矿物质。
成人的有机体含有约1kg钙。其中99.9%的量储存于牙齿和骨骼中。为了构建和维持它们,根据性别和年龄经常需要最低1000至1200mg/天的钙,如上文所提及的那样。
在一项统计学相关研究中,经测定,在德国有2/3的成人每日的钙摄入量低于800mg/天。在其它因素中,骨骼脱钙(骨质疏松)和牙齿脱钙(龋齿)归因于此。
同样,肌肉缺钙可以导致在高强度工作期间颤抖和痉挛。在晚期,发生神经系统的兴奋性增强,症状还包括肌肉收缩(手足抽搐)和幻触,如刺痛或麻木感,或者感觉蚂蚁在皮肤上爬行(感觉异常)。根据这些缺乏症状,很明显在其它因素中钙负责肌肉和神经的动作电位。
在血液循环中钙也同样重要。此时它充当了所谓的凝血因子IV。
上述这些缺乏症状可以通过供应足够的钙离子来预防。
通过食品添加剂来进行校正是有利的,这还因为没有剂量过量所产生的问题。人体代谢仅吸收其功能所需的钙离子量。超出此量之外存在的钙离子自然地被身体排出。仅仅在极端过量并结合遗传倾向的情况下,在少数罕见的病例中观察到肾结石形成。但是,这种效应通常与极端的过量消耗有关,而极端的过量消耗可以被识别和及时终止。
钙作为食品添加剂的其它有利作用是所谓的牙齿再矿化:在食用可发酵性碳水化合物之后,牙菌斑的细菌所产生的酸增加。这造成唾液pH在牙齿周围区域降低。
通常情况下,即在pH6至pH7的pH下,唾液总是过饱和有所谓的羟磷灰石。这种溶解的物质修复釉质的缺损如最初的脱矿化或发裂。
如果过度酸化造成pH降至5.5以下,则唾液进入不饱和状态并且羟磷灰石从牙釉质中除去(脱矿化)。在此过程中,孔隙在牙釉质中出现,在晚期形成龋齿。
一旦唾液的pH再次升到pH5.5以上,唾液中的羟磷灰石将再次达到饱和限,以至由酸侵害造成的孔隙被唾液中溶解的矿物质重新填充(再矿化)。
如果由于过度频繁地食用含糖食物和/或由于对菌斑清除不充分使得脱矿化相的效果超过了再矿化相的效果,那么矿物质将不断地从牙釉质浸出。孔隙加深并且龋齿损伤出现。为了终止这种发展,在脱矿化相期间给唾液提供额外的钙离子是有帮助的。通过提高唾液中的钙浓度,唾液和菌斑之间的浓度梯度变小。这产生的作用是较少或没有钙从菌斑扩散至唾液中。这种扩散流甚至可以被逆转并引起牙釉质的强制性再矿化。
菌斑中钙浓度升高提供了其它优点。根据通常的在食用含糖食物后牙菌斑中pH随时间变化的曲线,如果钙浓度足够,那么牙釉质的再矿化在氟化物的催化作用下可以从孔的底部开始。在pH随时间保持不变的情况下,再矿化(尤其在氟化物浓度升高的情况下)基本上限制在20-100μm厚的最外面的表层。在不利的情况下,这可以导致在孔上形成帽。
本发明的另一个优点是矿质营养素的量,矿质营养素迄今还没有以这样的程度作为可行的添加剂转入牙膏、漱口剂、其它口腔卫生用品、唇膏、用于唇部的其它软膏或流体或者用于口服或直肠给药的医疗药物以及其它丸剂、胶囊剂或栓剂。在此,由于如下事实开辟了新的选项:食品添加剂的粘度可以通过添加水容易地调节,因此,经建立和验证的方法根本没有必要改变或者仅进行无足轻重的的改变。锌预防口臭的已知作用可以被容易地引入牙膏和漱口剂中。另外,盐-水合物熔化物具有很长的贮存期限。这种稳定性带来了将矿质营养素添加入人的食物或人的饮用水和饮料供应中的新的可能性。除了其它事物外,本发明还建议在饮料吸管内侧涂覆本发明的盐-水合物熔化物。流经该涂层的饮料造成储存在内层的含矿物质的盐-水合物熔化物不断减少。通过这种方式,饮料吸管变成了食品,当然,其需要相应地附上标签并标示出准确的有效期。
在这种想法的延用中,也可以对饮用水分配器、饮用水纯化装置或生产冰块的机器的内表面进行涂覆。
其它有利的应用包括与所有类型的饮料混合。该范围开始于用于供应液体的饮料,其优选具有低卡路里含量,具有不仅能够混入矿质营养素而且还能够调节口味的上述的可能性。在这类饮料的情况下,加入本发明的食品添加剂不会引起不期望的热量增加。
该可能范围的另一端是含卡路里的饮料,如奶、可可饮料、果酒或啤酒。在此,本发明的食品添加剂由于如下事实而是令人感兴趣的:在无味道的变通形式中,它不改变饮料的基本特征,但是带来了矿质营养素含量增加的额外的市场卖点。
这种想法的额外的创造性延用是:在上述机器或或类似机器中,经由输送管连接将含有矿质营养素的盐-水合物熔化物与来自贮器的饮料或饮用水混合。
该原则的一致应用带来了如下可能性:采用公共饮用水给水系统,通过以目标方式混入本发明的盐-水合物熔化物为整个群体提供矿质营养素。
令人很感兴趣的是如下可能性:由于矿物质含量增加,可以显著地提高非必需的食品如夹心巧克力、甘草糖、蛋糕、饼干、果酱、炸薯片和汉堡包在宣传中的地位。
在下文中,借助实施例将更详细地解释本发明的其它细节和特征。所述实施例不用于限制本发明,其仅用于解释本发明。附图说明如下:
图1是盐-水系统的配位和相互作用的表格说明;
图2显示了牙釉质中孔的再矿化。
具体而言,附图描述了以下内容:
图1概述了盐-水合物熔化物在从纯水至稀的盐溶液至水合的盐熔化物的分级中的图示结构。
在图的上半部,显示了分子排列的结构。水分子以H2O表示,阳离子以带有+号的圈表示,阴离子以带有-号的圈表示。
在其下一行给出了名称,其开始于纯水,至溶液,终止于浓的盐熔化物。
在第四行指示了三种不同的相互作用以及它们各自所估计的占总相互作用效应的部分。
在最后一行,数字表示各自的盐含量。
图1的各栏解释了盐-水系统的四个特征阶段:
在图左侧,从纯水开始,显示了已经进入最多5%盐含量的稀溶液的结构。在这种情况下,特异性相互作用(WW)主要针对水。
该表第三栏显示了盐含量至多10%的浓的盐溶液。在此,除了水-水相互作用外,离子-离子相互作用开始变得非常显著。作为另一个极端,该表最右侧一栏描述了100%的盐含量。其中不再存在水,即使是化合水也不存在。这是纯的盐熔化物,其中相互作用仅发生在盐离子之间。
在左起第四栏,如下表征了盐-水合物熔化物:在最上面一行,作为结构的阳离子完全被水分子包围。四个水分子的数目示例阳离子的配位数为4。由于水合物外套“较薄”,水分子对离子的屏蔽作用降低,所述屏蔽作用在结构中通过单虚线的圈表示。结果,离子间相互作用逐渐变得显著。在组成示意图中,离子与水分子之间的相互作用被描述为盐-水合物熔化物的主要相互作用。显而易见(第四栏底部),盐-水合物熔化物也具有一定程度的离子间相互作用。这部分图描述了盐-水合物熔化物的非常重要的特征,即存在三类不同的相互作用:
-水分子之间的相互作用
-离子与包围它的水分子之间的相互作用
-离子间相互作用
在该实例中,盐-水合物熔化物的盐含量表示为10至25%(mol%)。
图2中,绘制了两幅在牙釉质2中通过孔1的截面图。在上部实例图2a中,口腔唾液3的pH已经下降(由于碳水化合物发酵)低于pH5.5。所引起的唾液3中的羟磷灰石失衡吸引羟磷灰石离子,在图2a中以H+表示。当缺少其它来源时,所缺少的羟磷灰石将从牙釉质2中移出。在所述的具有随时间变化的pH曲线的结构中,结合口腔中磷酸钙的过量供应,羟磷灰石的不饱和通过唾液中的磷酸钙在氟化物的催化作用下进行代偿。由图2清楚地看出磷酸钙是如何进入孔的深处并形成羟磷灰石晶体4。该过程提供了牙齿的再矿化。
作为对比,图2b显示了pH在中性范围内随时间轻微变化的情况下,以氟化物作为催化剂的再矿化。由于在中性范围唾液的矿物质过饱和程度很高,晶体形成的过程主要发生在牙釉质表面;因为沉淀量与沉淀持续时间成比例,而扩散时间随扩散路程的平方而增加。由于沿着进入牙齿的路程沉淀,向较深层的扩散流就比较稀薄。到达较深层的矿物质较少。在孔的边缘,羟磷灰石晶体4形成了帽的形状。
下文显示了具有中性和酸性pH的溶化物的可能的组合物的一些实施例。以下化学品用于所有实施例:
乳酸钙 钙的五水合物 Fluka 21175
葡萄糖酸钙 D-葡萄糖酸钙一水合物 Fluka 21142
醋酸钙 醋酸钙水合物 Merck 1.09325
氯化镁 氯化镁六水合物 Merck 1.05833
乳酸镁 L-乳酸镁水合物 Fluka 63097
葡萄糖酸镁 D-葡萄糖酸镁水合物 Fluka 63106
醋酸镁 醋酸镁四水合物 Merck 1.05819
葡萄糖酸 (50%) Merck 8.22057
苹果酸 Merck 1.00382
柠檬酸 Merck 8.18707
实施例1
含有乳酸钙的中性pH熔化物
23.16g 乳酸钙
16.84g 葡萄糖酸钙
在室温下得到发亮、固体至可延展的熔化物(bright,firm to ductilemelt),含有2.54mol Ca/kg溶化物(对应于101g Ca/kg),含水量为约25%(w/w)。
实施例2
含有钙-镁乳酸根/葡萄糖酸根/氯离子的中性熔化物:
10.23g 乳酸钙
29.77g 葡萄糖酸钙
10.00g 氯化镁
在室温下得到发亮、固体至可延展的熔化物,含有1.92mol Ca/kg溶化物(对应于76.8g Ca/kg)和0.95mol镁/kg溶化物(对应于23.1g镁/kg)。
实施例3
含有钙和镁比例为3∶1(w/w)的pH中性的熔化物:
2.82g 乳酸钙
12.29g 葡萄糖酸钙
2.89g 醋酸钙
0.99g 乳酸镁
6.05g 葡萄糖酸镁
1.92g 醋酸镁
在室温下得到发亮、固体至可延展的熔化物,含有1.67mol Ca/kg溶化物(对应于67g Ca/kg)和0.83mol镁/kg溶化物(对应于21g镁/kg)。
实施例4
含有钙和镁比例为3∶1(w/w)的pH中性的熔化物:
3.25g 乳酸钙
9.44g 葡萄糖酸钙
5.31g 醋酸钙
1.16g 乳酸镁
4.74g 葡萄糖酸镁
3.39g 醋酸镁
在室温下得到发亮、固体至可延展的熔化物,含有2.01mol Ca/kg溶化物(对应于80g Ca/kg)和1.00mol镁/kg(对应于24.3g镁/kg),含水量为33%(w/w)。
实施例5
含有钙、乳酸、苹果酸和葡萄糖酸的酸性熔化物
25.00g 乳酸钙
9.42g 葡萄糖酸
1.61g 苹果酸
在室温下得到发亮、固体至可延展的熔化物,含有2.73mol Ca/kg溶化物(对应于109g Ca/kg)。
实施例6
含有钙、乳酸、苹果酸、葡萄糖酸和柠檬酸的酸性熔化物
25.00g 乳酸钙
9.42g 葡萄糖酸
1.61g 苹果酸
2.31g 柠檬酸
在室温下得到发亮、固体至可延展的熔化物,含有2.45mol Ca/kg溶化物(对应于98g Ca/kg)。含水量约27%(w/w)。
将试剂溶于处于沸点附近温度的尽可能少的水中,蒸发浓缩直至它们达到所需粘度。应用真空来加速该过程并产生更好的结果。
Claims (20)
1.作为浓缩添加剂用于给人类代谢供应矿质营养素的食品添加剂,其特征在于
-矿质营养素是离子化形式的盐-水合物熔化物的组分,其中
-所述的盐-水合物熔化物是盐-水系统,并且其含水量对应于主要水合离子的配位数。
2.根据权利要求1的食品添加剂,其特征在于所述矿质营养素是钙、镁、锌、钾、碘、铁、磷、钠、钴、硼、硒和/或锂。
3.根据前述权利要求任一项的食品添加剂,其特征在于所述矿质营养素作为有机酸和/或无机酸的盐以盐-水合物熔化物存在。
4.根据前述权利要求任一项的食品添加剂,其特征在于其中包含有机酸乳酸、葡萄糖酸、柠檬酸、醋酸、苹果酸、富马酸、戊酸、抗坏血酸、半胱氨酸、戊二酸的酸根或任意其它批准的酸化剂的酸根以及它们的部分酯化衍生物中的至少一种作为阴离子。
5.根据前述权利要求任一项的食品添加剂,其特征在于其中包含无机酸的酸根如氯离子、硫酸根、磷酸根、氟离子、碳酸根或它们的部分酯化衍生物中的至少一种作为阴离子。
6.根据前述权利要求任一项的食品添加剂,其特征在于其中包含无机酸和有机酸或它们的部分酯化衍生物的盐作为阳离子来源。
7.根据前述权利要求任一项的食品添加剂,其特征在于其pH在中性范围内,并且其中包含乳酸钙、葡萄糖酸钙和/或乳酸镁。
8.根据前述权利要求任一项的食品添加剂,其特征在于其pH在酸性范围内,并且其中包含葡萄糖酸、苹果酸、柠檬酸或其它批准用于食物的酸。
9.根据前述权利要求任一项的食品添加剂,其特征在于钙以乳酸盐、葡萄糖酸盐、苹果酸盐和/或柠檬酸盐的形式包含在化合物中。
10.根据前述权利要求任一项的食品添加剂,其特征在于镁以乳酸盐和/或醋酸盐的形式包含在化合物中。
11.根据前述权利要求任一项的食品添加剂,其特征在于其口味微苦并且其中包含乳酸盐。
12.根据前述权利要求任一项的食品添加剂,其特征在于其口味很苦并且其中包含氯化钙和/或氯化镁。
13.根据前述权利要求任一项的食品添加剂,其特征在于其口味是带有微苦余味的微甜口味并且其中包含醋酸钙。
14.根据前述权利要求任一项的食品添加剂,其特征在于其口味中性并且其中包含葡萄糖酸镁或葡萄糖酸钙。
15.根据前述权利要求任一项的食品添加剂,其特征在于矿质营养素的特定重量百分比非常高,并且其中包含氯化物如氯化钙或氯化镁。
16.根据前述权利要求任一项的食品添加剂,其特征在于其包含在牙膏、漱口剂、其它口腔卫生用品、唇膏、用于唇部的其它软膏或流体或者用于口服或直肠给药的医疗药物或者其它丸剂或栓剂中。
17.根据前述权利要求任一项的食品添加剂,其特征在于其应用于饮料吸管内侧或饮用水分配器、饮用水纯化装置或生产冰块的机器的内表面,和/或在于将其经由与这些表面连接的管与来自贮器的饮用液体混合。
18.生产前述权利要求任一项的食品添加剂的方法,其特征在于使用葡萄糖酸、乳酸、柠檬酸、醋酸、苹果酸或其它适于食品的酸。
19.前述权利要求任一项的食品添加剂的用途,其特征在于在生产食品、非必需的食品、咀嚼胶或其它意欲暂时留在口腔中或唇上的物质、饮料、医疗药物、其它丸剂或栓剂、口腔卫生用品或牙齿护理品中将其加入,和/或将其掺入用于上述物品的中间产品中。
20.前述权利要求任一项的食品添加剂的用途,其特征在于在生产饲料、舐盐石(salt lick stones)、医疗药物或其它丸剂、胶囊剂、栓剂或任意其它对动物口服或直肠给药的物质中将其以固体至液体形式加入,或者在于在饮用水的纯化过程中将其加入。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005040423A DE102005040423A1 (de) | 2005-08-25 | 2005-08-25 | Nahrungsmittelzusatz zur Versorgung mit Mineralstoffen |
DE102005040423.5 | 2005-08-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101272760A true CN101272760A (zh) | 2008-09-24 |
Family
ID=37420996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2006800353806A Pending CN101272760A (zh) | 2005-08-25 | 2006-08-23 | 用于供应矿质营养素的食品添加剂 |
Country Status (16)
Country | Link |
---|---|
US (1) | US20080233232A1 (zh) |
EP (1) | EP1916987B1 (zh) |
JP (1) | JP2009505644A (zh) |
KR (1) | KR20080068642A (zh) |
CN (1) | CN101272760A (zh) |
AT (1) | ATE471140T1 (zh) |
AU (1) | AU2006284293B2 (zh) |
BR (1) | BRPI0615075A2 (zh) |
CA (1) | CA2620198A1 (zh) |
DE (4) | DE102005040423A1 (zh) |
EC (1) | ECSP088213A (zh) |
ES (1) | ES2344857T3 (zh) |
MX (1) | MX2008002668A (zh) |
PL (1) | PL1916987T3 (zh) |
RU (1) | RU2409991C2 (zh) |
WO (1) | WO2007022765A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102557227A (zh) * | 2012-03-12 | 2012-07-11 | 彭振业 | 一种钙镁富氢水添加剂及其制备方法 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITTO20070626A1 (it) * | 2007-09-06 | 2009-03-07 | Bruno Pirone | Dispositivo per produrre acqua potabile |
DE102008014226A1 (de) | 2008-03-16 | 2009-09-17 | MEDERER Süßwarenvertriebs GmbH | Remineralisierender Süßigkeitenzusatz und Süßigkeiten mit remineralisierendem Zusatz |
DE102008014225A1 (de) * | 2008-03-16 | 2009-09-17 | MEDERER Süßwarenvertriebs GmbH | Remineralisierende Zahnpflegemittel und Verfahren zu deren Herstellung |
DE102008014227A1 (de) * | 2008-03-16 | 2009-10-01 | Nova Dentalia Zahnpflege Gmbh | Remineralisierende Speichelersatzmittel und Verfahren zu deren Herstellung |
IL209640A0 (en) * | 2010-11-30 | 2011-02-28 | Semion Hlebnikov | Straw containing solution for treating side effects of alcohol consumption |
JP2015092834A (ja) * | 2013-11-08 | 2015-05-18 | ハウス食品株式会社 | 炭酸感を付与した経口組成物及び炭酸感付与剤 |
JP6461479B2 (ja) * | 2014-03-26 | 2019-01-30 | 元司 堀 | 浸漬物への水分移行防止方法 |
ITUB20160697A1 (it) * | 2016-02-12 | 2017-08-12 | Fernando Horacio Garcia | Sale iposodico solido e processo per ottenerlo |
WO2019168909A1 (en) * | 2018-03-01 | 2019-09-06 | Rich Products Corporation | Moisture-retentive composition |
JP7010509B2 (ja) * | 2020-01-15 | 2022-01-26 | 一般社団法人 Unical | 新規配合スポーツ飲料およびその調製のための顆粒剤 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2060601B2 (de) * | 1970-09-02 | 1980-05-22 | V. Berthelsen Industrial Commercial Co. A/S, Hellerup (Daenemark) | Nahrungsergänzungsmittel |
US4080440A (en) | 1974-12-13 | 1978-03-21 | The Procter & Gamble Company | Method for remineralizing tooth enamel |
US4097935A (en) | 1976-07-21 | 1978-07-04 | Sterling Drug Inc. | Hydroxylapatite ceramic |
US4606912A (en) | 1981-07-22 | 1986-08-19 | Caries Research Group Of Rochester, Inc. | Method of making a clear, stable aqueous mouthwash solution and the solution made by that method for the enhancement of cells of the oral cavity and the remineralization of teeth |
JPH02119761A (ja) * | 1988-10-28 | 1990-05-07 | Daiee Shokuhin Kogyo Kk | 乳酸カルシウム含有飲料及び固形製剤 |
US5037639A (en) | 1989-05-24 | 1991-08-06 | American Dental Association Health Foundation | Methods and compositions for mineralizing calcified tissues |
US5460803A (en) | 1989-05-24 | 1995-10-24 | American Dental Association Health Foundation | Methods and compositions for mineralizing and fluoridating calcified tissues |
JP2930737B2 (ja) * | 1990-12-27 | 1999-08-03 | 雪印乳業株式会社 | カルシウム強化食品およびその製造方法 |
DK0673913T3 (da) * | 1994-03-23 | 1999-09-20 | Madaus Ag | Calcium-alkalimetalcitratforbindelser samt deres anvendelse som lægemidler |
JPH08157380A (ja) * | 1994-12-02 | 1996-06-18 | Fuji Chem Ind Co Ltd | 非晶質クエン酸・有機酸・カルシウム組成物、及びその製造法 |
US5851578A (en) * | 1997-02-21 | 1998-12-22 | Soma Technologies | Clear or translucent liquid beverage with souluble fiber and nutrients |
US6159449A (en) * | 1997-04-03 | 2000-12-12 | Enamelon, Inc. | Dentifrice products and methods for remineralizing and/or mineralizing teeth |
JP3648587B2 (ja) * | 1998-03-04 | 2005-05-18 | サンスター株式会社 | 歯周病予防又は歯周病進行予防食品組成物 |
US6036985A (en) * | 1998-04-03 | 2000-03-14 | Nestec S.A. | Calcium complex and food fortified therewith |
GB2341798B (en) * | 1998-09-25 | 2001-03-14 | Brian Whittle Associates Ltd | Nutritional and pharmaceutical compositions comprising desiccants |
FI110474B (fi) * | 1999-01-27 | 2003-02-14 | Modulpo Salts Oy | Ravintofysiologinen suolatuote, sen käyttö ja menetelmä sen valmistamiseksi |
JP2004091442A (ja) * | 2002-09-04 | 2004-03-25 | Komatsuya Kagaku Kk | 水溶性クエン酸マグネシウム含水塩およびその製法 |
DE10349050A1 (de) | 2003-10-17 | 2005-05-12 | Nova Dentalia Zahnpflege Gmbh | Kaumasse zur Remineralisation von Zahnschmelz |
US20060280835A1 (en) * | 2004-08-25 | 2006-12-14 | Cadbury Adams Usa Llc. | Multi-modality flavored chewing gum compositions |
-
2005
- 2005-08-25 DE DE102005040423A patent/DE102005040423A1/de not_active Withdrawn
-
2006
- 2006-08-23 ES ES06775894T patent/ES2344857T3/es active Active
- 2006-08-23 AT AT06775894T patent/ATE471140T1/de active
- 2006-08-23 DE DE202006020443U patent/DE202006020443U1/de not_active Expired - Lifetime
- 2006-08-23 DE DE112006002212T patent/DE112006002212A5/de not_active Withdrawn
- 2006-08-23 AU AU2006284293A patent/AU2006284293B2/en not_active Ceased
- 2006-08-23 US US12/064,803 patent/US20080233232A1/en not_active Abandoned
- 2006-08-23 WO PCT/DE2006/001475 patent/WO2007022765A1/de active Application Filing
- 2006-08-23 JP JP2008527303A patent/JP2009505644A/ja active Pending
- 2006-08-23 CN CNA2006800353806A patent/CN101272760A/zh active Pending
- 2006-08-23 KR KR1020087006938A patent/KR20080068642A/ko not_active Application Discontinuation
- 2006-08-23 PL PL06775894T patent/PL1916987T3/pl unknown
- 2006-08-23 EP EP06775894A patent/EP1916987B1/de active Active
- 2006-08-23 MX MX2008002668A patent/MX2008002668A/es active IP Right Grant
- 2006-08-23 CA CA002620198A patent/CA2620198A1/en not_active Abandoned
- 2006-08-23 DE DE502006007234T patent/DE502006007234D1/de active Active
- 2006-08-23 RU RU2008106059/13A patent/RU2409991C2/ru not_active IP Right Cessation
- 2006-08-23 BR BRPI0615075-6A patent/BRPI0615075A2/pt not_active IP Right Cessation
-
2008
- 2008-02-22 EC EC2008008213A patent/ECSP088213A/es unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102557227A (zh) * | 2012-03-12 | 2012-07-11 | 彭振业 | 一种钙镁富氢水添加剂及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
DE102005040423A1 (de) | 2007-03-01 |
DE112006002212A5 (de) | 2008-05-21 |
PL1916987T3 (pl) | 2010-11-30 |
EP1916987A1 (de) | 2008-05-07 |
AU2006284293A1 (en) | 2007-03-01 |
KR20080068642A (ko) | 2008-07-23 |
AU2006284293B2 (en) | 2011-11-17 |
BRPI0615075A2 (pt) | 2011-05-03 |
ATE471140T1 (de) | 2010-07-15 |
MX2008002668A (es) | 2008-03-14 |
ES2344857T3 (es) | 2010-09-08 |
JP2009505644A (ja) | 2009-02-12 |
DE202006020443U1 (de) | 2008-09-04 |
WO2007022765A1 (de) | 2007-03-01 |
RU2008106059A (ru) | 2009-09-27 |
ECSP088213A (es) | 2008-04-28 |
DE502006007234D1 (de) | 2010-07-29 |
US20080233232A1 (en) | 2008-09-25 |
RU2409991C2 (ru) | 2011-01-27 |
CA2620198A1 (en) | 2007-03-01 |
EP1916987B1 (de) | 2010-06-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101272760A (zh) | 用于供应矿质营养素的食品添加剂 | |
AU782748B2 (en) | Calcium/calcium-magnesium fortified water, juices, beverages and other liquid food products | |
JP5283743B2 (ja) | 飲料組成物 | |
CN102366135B (zh) | 杨桃健康饮料及其制作方法 | |
CA2301136C (en) | Solid composition having reduced tooth erosion potential | |
CN101103830A (zh) | 一种南瓜、甜玉米饮料及其制备方法 | |
CA2343024A1 (en) | Low acid beverages supplemented with nutritional calcium sources | |
US20060246200A1 (en) | Hydroxyapatite in aqueous solution for bone health | |
CN105248646A (zh) | 一种含乳饮料及其制备方法 | |
CN1679628A (zh) | 牦牛骨髓钙片 | |
CN101060888B (zh) | 在唾液中无侵蚀可能性的酸性固体口服组合物及测定唾液中侵蚀可能性的方法 | |
CN1123607A (zh) | 含气乳饮品及其制造 | |
CN102342396B (zh) | 一种含木糖醇锌钙的口服液 | |
US20040213873A1 (en) | Mineral waters containing dissolved calcium, phosphorus and zinc | |
JP4347543B2 (ja) | 栄養強化メープルシロップ | |
KR20060124323A (ko) | 카라기난을 포함하는 액상커피 및 그 제조방법 | |
CN110338317A (zh) | 一种复合果汁红茶饮料及其制备方法 | |
GB2036529A (en) | Honey containing composition | |
EP2819529A1 (en) | Production process for a zinc enriched drinking water, composition and packaged water | |
CN1269989A (zh) | 酸枣饮品及其制作方法 | |
JPS61231990A (ja) | 清酒に米酢をブレンドしたアルコ−ル含有健康飲料 | |
CN1085055A (zh) | 一种饮料及制备方法 | |
CN107467442A (zh) | 一种黄金玉米饮料 | |
JP2001275617A (ja) | カルシウム及びマグネシム含有飲食品 | |
CN103749905A (zh) | 柚香芝麻软糖及其制作方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1119582 Country of ref document: HK |
|
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080924 |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1119582 Country of ref document: HK |