CN101268085B - 用于硼中子俘获治疗的硼化合物 - Google Patents

用于硼中子俘获治疗的硼化合物 Download PDF

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Publication number
CN101268085B
CN101268085B CN2006800301784A CN200680030178A CN101268085B CN 101268085 B CN101268085 B CN 101268085B CN 2006800301784 A CN2006800301784 A CN 2006800301784A CN 200680030178 A CN200680030178 A CN 200680030178A CN 101268085 B CN101268085 B CN 101268085B
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CN
China
Prior art keywords
boron
compound
purposes
formula
tumour
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CN2006800301784A
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English (en)
Chinese (zh)
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CN101268085A (zh
Inventor
L-I·奥尔松
E·阿泽尔
A·埃克
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Anxilia Corp
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Hammercap AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Radiation-Therapy Devices (AREA)
CN2006800301784A 2005-08-19 2006-08-17 用于硼中子俘获治疗的硼化合物 Active CN101268085B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE0501847-8 2005-08-19
SE0501847 2005-08-19
SE0501903-9 2005-08-30
SE0501903A SE528407C2 (sv) 2005-08-19 2005-08-30 Borföreningar användbara vid BNCT
PCT/SE2006/000952 WO2007021234A1 (en) 2005-08-19 2006-08-17 Boron compounds useful in bnct

Publications (2)

Publication Number Publication Date
CN101268085A CN101268085A (zh) 2008-09-17
CN101268085B true CN101268085B (zh) 2012-06-20

Family

ID=37310298

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800301784A Active CN101268085B (zh) 2005-08-19 2006-08-17 用于硼中子俘获治疗的硼化合物

Country Status (8)

Country Link
US (1) US8183247B2 (https=)
EP (1) EP1915381B1 (https=)
JP (1) JP5053277B2 (https=)
CN (1) CN101268085B (https=)
RU (1) RU2423368C2 (https=)
SE (1) SE528407C2 (https=)
TW (1) TWI376381B (https=)
WO (1) WO2007021234A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007026701A1 (de) * 2007-06-01 2008-12-04 Universität Leipzig Neue chemische Verbindungen, deren Herstellung und deren Verwendung
CN101713740B (zh) * 2009-12-31 2012-05-02 中国原子能科学研究院 分光光度测量生物样品中bnct药物里硼含量的方法
CN104151339B (zh) * 2013-05-17 2017-05-03 中国科学院近代物理研究所 含硼吖啶衍生物、其制备方法和应用
JP6360113B2 (ja) * 2016-07-28 2018-07-18 ステラファーマ株式会社 ホウ素含有化合物
KR101903693B1 (ko) * 2016-11-28 2018-10-04 가천대학교 산학협력단 BSH 합성을 위한 티오피롤리딘을 이용한 Na2[B12H12] 반응
JP7154528B2 (ja) * 2017-08-25 2022-10-18 国立大学法人東京工業大学 ホウ素含有葉酸誘導体
WO2020180390A1 (en) * 2019-03-04 2020-09-10 TAE Life Sciences Borylated amino acid compositions for use in boron neutron capture therapy and methods thereof
CN112358494B (zh) * 2020-04-09 2021-09-28 南京大学 一种基于吖啶的碳硼烷衍生物及其在生物显影中的应用
CN112442095B (zh) * 2020-12-01 2022-07-22 上海科黛生物科技有限公司 一种维生素b12的精制方法及所得产品的应用
CN112979686B (zh) * 2021-02-08 2022-04-08 北京大学 一种新型硼携带剂、制备方法及其药物制剂
CN116874515B (zh) * 2023-05-10 2025-03-14 重庆高硼生物科技有限公司 一种氨基酸-bsh靶向杂合体化合物及其制备方法和应用
WO2025165163A1 (ko) * 2024-01-31 2025-08-07 (주)클리켐바이오 붕소중성자포획치료용 알부민 나노플랫폼 및 이를 포함하는 붕소중성자포획치료용 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1124821A (zh) * 1994-02-14 1996-06-19 肖冠英 同步齿带半潜传动全贯流水电机组
CN1154073A (zh) * 1994-06-27 1997-07-09 中子治疗有限公司 快中子治疗的硼中子捕获增强作用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272250A (en) 1992-07-10 1993-12-21 Spielvogel Bernard F Boronated phosphoramidate compounds
US6180766B1 (en) 1993-12-02 2001-01-30 Raymond F. Schinazi Nucleosides and oligonucleotides containing boron clusters
JP2685128B2 (ja) * 1995-07-21 1997-12-03 東北大学長 カルボラン含有ガドリニウム−ｄｔｐａ錯体、その中間体、およびこれらの製造方法
US6093382A (en) * 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
DE19905094C1 (de) 1999-02-01 2000-10-12 Schering Ag Gadolinium (III)-Komplexe sowie ihre Verwendung für Zweischritt Strahlentherapieformen und diese enthaltende pharmazeutische Mittel
JP2001233883A (ja) * 2000-02-22 2001-08-28 Okayama Pref Gov Shin Gijutsu Shinko Zaidan カゴ状ホウ素化合物担持ポルフィリン錯体
EP1364954A4 (en) 2001-02-09 2009-10-28 Hiroyuki Kagechika Dicarba closo DODECARBORANDERIVATE
CA2555597C (en) * 2004-02-13 2016-06-14 The University Of British Columbia Radiolabeled compounds and compositions, their precursors and methods for their production
JP2005343858A (ja) * 2004-06-07 2005-12-15 Mebiopharm Co Ltd ホウ素イオンクラスター脂質及びこれを用いたリポソーム
JP2006096870A (ja) * 2004-09-29 2006-04-13 Stella Chemifa Corp ホウ素含有化合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1124821A (zh) * 1994-02-14 1996-06-19 肖冠英 同步齿带半潜传动全贯流水电机组
CN1154073A (zh) * 1994-06-27 1997-07-09 中子治疗有限公司 快中子治疗的硼中子捕获增强作用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Xing Q.Pan ET AL.Boron-containing folate receptor-tageted liposomes as potential delivery agents for neutron capture therapy.《bioconjugate chem》.2002,第13卷435-442. *

Also Published As

Publication number Publication date
JP2009504732A (ja) 2009-02-05
CN101268085A (zh) 2008-09-17
TWI376381B (en) 2012-11-11
RU2008110472A (ru) 2009-09-27
JP5053277B2 (ja) 2012-10-17
EP1915381B1 (en) 2013-04-10
US20090227539A1 (en) 2009-09-10
EP1915381A1 (en) 2008-04-30
EP1915381A4 (en) 2011-02-09
SE0501903L (sv) 2006-11-07
RU2423368C2 (ru) 2011-07-10
US8183247B2 (en) 2012-05-22
WO2007021234A1 (en) 2007-02-22
TW200740833A (en) 2007-11-01
SE528407C2 (sv) 2006-11-07

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Effective date of registration: 20250318

Address after: Sweden

Patentee after: Anxilia Corp.

Country or region after: Sweden

Address before: Stockholm, Sweden

Patentee before: Hammercap AB

Country or region before: Sweden